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List of works by Alec N. Salt

ATP-gamma-S shifts the operating point of outer hair cell transduction towards scala tympani.

scientific article published on July 2005

CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear

scientific article published in 2021

Calibration of ion-selective microelectrodes for use with high levels of interfering ions ⬇️

scientific article published on July 1, 1991

Cochlear action potential tuning curves recorded with a derived response technique.

scientific article published in September 1990

Cochlear compound action potentials from high-level tone bursts originate from wide cochlear regions that are offset toward the most sensitive cochlear region

scientific article published on 23 January 2019

Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images.

scientific article

Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration.

scientific article published on 25 January 2006

Cochlear pharmacokinetics with local inner ear drug delivery using a three-dimensional finite-element computer model.

scientific article published on 17 November 2006

Communication pathways to and from the inner ear and their contributions to drug delivery.

scientific article published on 19 December 2017

Comparison between the effects of continuous and impact noise on cochlear potentials in guinea pigs

scientific article published on 01 June 1981

Comparison of endolymph cross-sectional area measured histologically with that measured in vivo with an ionic volume marker

scientific article published on 01 November 1995

Construction of a simple auditory stimulus polarity indicator ⬇️

scientific article published on December 1, 1983

Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid.

scientific article published in August 2003

Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss

scientific article

Demonstration of a longitudinal concentration gradient along scala tympani by sequential sampling of perilymph from the cochlear apex.

scientific article

Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols.

scientific article

Detection and quantification of endolymphatic hydrops in the guinea pig cochlea by magnetic resonance microscopy.

scientific article

Dexamethasone and Dexamethasone Phosphate Entry into Perilymph Compared for Middle Ear Applications in Guinea Pigs

scientific article published on 29 November 2018

Dexamethasone levels and base-to-apex concentration gradients in the scala tympani perilymph after intracochlear delivery in the guinea pig.

scientific article published on June 2012

Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements.

scientific article

Direct entry of gadolinium into the vestibule following intratympanic applications in Guinea pigs and the influence of cochlear implantation

scientific article

Displacements of the organ of Corti by gel injections into the cochlear apex.

scientific article

Distribution of dexamethasone and preservation of inner ear function following intratympanic delivery of a gel-based formulation.

scientific article

Drug Diffusion to the Apex of the Human Cochlea? A Comment on "Kang WS, Nguyen K, McKenna CE, Sewell WF, McKenna MJ, Jung DH. Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones".

scientific article

Drug delivery into the cochlear apex: Improved control to sequentially affect finely spaced regions along the entire length of the cochlear spiral

scientific article

Effect of artificial endolymph injection into the cochlear duct on perilymph potassium.

scientific article published on 24 February 2010

Effect of infrasound on cochlear damage from exposure to a 4 kHz octave band of noise

journal article published in 2007

Effects of exposure to noise on ion movement in guinea pig cochlea

scientific article published on December 1, 1979

Effects of exposure to noise on permeability to potassium of the endolymph-perilymph barrier in guinea pigs.

scientific article

Effects of hypothermia on ionic movement in the guinea pig cochlea.

scientific article

Effects of noise on cochlear potentials and endolymph potassium concentration recorded with potassium-selective electrodes

scientific article published on December 1, 1979

Electrochemical profile for potassium ions across the cochlear hair cell membranes of normal and noise-exposed guinea pigs

scientific article published on 01 August 1983

Endolymph volume changes during osmotic dehydration measured by two marker techniques

scientific article published on 01 October 1995

Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans.

scientific article published on February 2009

Estimating the operating point of the cochlear transducer using low-frequency biased distortion products

scientific article

Evaluation of Procedures to Reduce Fluid Flow in the Fistulized Guinea-pig Cochlea ⬇️

scientific article published on January 1, 1991

Fixation-induced shrinkage of Reissner's membrane and its potential influence on the assessment of endolymph volume

scientific article published on 01 December 1997

Gentamicin concentration gradients in scala tympani perilymph following systemic applications.

scientific article

Guest editorial: drug delivery for treatment of inner ear disease: current state of knowledge

scientific article published on 01 April 2010

Hearing Changes After Intratympanic Steroids for Secondary (Salvage) Therapy of Sudden Hearing Loss: A Meta-Analysis Using Mathematical Simulations of Drug Delivery Protocols

scientific article published on 01 August 2018

Hearing Changes After Intratympanically Applied Steroids for Primary Therapy of Sudden Hearing Loss: A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols.

scientific article

Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in Guinea pigs

scientific article

Inner ear drug delivery through a cochlear implant: Pharmacokinetics in a Macaque experimental model

scientific article published in 2021

Interpretation of endolymph flow results: a comment on 'Longitudinal flow of endolymph measured by distribution of tetraethylammonium and choline in scala media'

scientific article published on 01 June 1988

Intracochlear Drug Injections through the Round Window Membrane: Measures to Improve Drug Retention.

scientific article

Large endolymphatic potentials from low-frequency and infrasonic tones in the guinea pig.

scientific article published in March 2013

Local drug delivery to the inner ear: Principles, practice, and future challenges

scientific article published on 28 June 2018

Local inner-ear drug delivery and pharmacokinetics.

scientific article

Longitudinal endolymph movements and endocochlear potential changes induced by stimulation at infrasonic frequencies

scientific article published on 01 August 1999

Longitudinal endolymph movements induced by perilymphatic injections

scientific article published on 01 September 1998

Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs ⬇️

scientific article published on December 8, 2011

Morphological changes of the endolymphatic sac induced by microinjection of artificial endolymph into the cochlea

scientific article published on 01 December 1999

Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid.

scientific article published on 24 March 2015

Perilymph composition in scala tympani of the cochlea: influence of cerebrospinal fluid.

scientific article published in November 1989

Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.

scientific article

Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs.

scientific article

Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal.

scientific article

Perilymph sampling from the cochlear apex: a reliable method to obtain higher purity perilymph samples from scala tympani.

scientific article published on 28 November 2005

Permeability changes of the blood-labyrinth barrier measured in vivo during experimental treatments.

scientific article published in August 1992

Permeability of the round window membrane is influenced by the composition of applied drug solutions and by common surgical procedures

scientific article published on October 2008

Permeability to potassium of the endolymph-perilymph barrier and its possible relation to hair cell function.

scientific article published on January 1980

Permeation Enhancers for Intratympanically-applied Drugs Studied Using Fluorescent Dexamethasone as a Marker.

scientific article published on 11 April 2018

Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications

scientific article published on 11 March 2018

Principles of local drug delivery to the inner ear.

scientific article

Progress in cochlear physiology after Békésy

scientific article

Quantitative anatomy of the guinea pig endolymphatic sac

scientific article published on 01 December 2002

Quantitative anatomy of the round window and cochlear aqueduct in guinea pigs ⬇️

scientific article published on December 1, 2001

Quantitative differences in endolymphatic calcium and endocochlear potential between pigmented and albino guinea pigs.

scientific article published in November 1997

Quantitative interpretation of corticosteroid pharmacokinetics in inner fluids using computer simulations.

scientific article published in August 2003

Radial communication between the perilymphatic scalae of the cochlea. I: Estimation by tracer perfusion ⬇️

scientific article published on November 1, 1991

Radial communication between the perilymphatic scalae of the cochlea. II: Estimation by bolus injection of tracer into the sealed cochlea

scientific article published on 01 November 1991

Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30.

scientific article published in August 2008

Responses of the endolymphatic sac to perilymphatic injections and withdrawals: evidence for the presence of a one-way valve.

scientific article

Simulation of application strategies for local drug delivery to the inner ear.

scientific article published on 26 October 2006

Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph.

scientific article

Tetramethylammonium for in vivo marking of the cross-sectional area of the scala media in the guinea pig cochlea ⬇️

scientific article published on January 1, 1992

The Effect of Cerebrospinal Fluid Pressure on Perilymphatic Flow in the Opened Cochlea

scientific article published on 01 January 1979

The auditory nerve overlapped waveform (ANOW) originates in the cochlear apex

scientific article

The effect of raising the scala tympani potassium concentration on the tone-induced cochlear responses of the guinea pig

scientific article published on June 1, 1979

The endolymphatic sinus is a possible detector of endolymph volume status.

scientific article published on 8 December 2006

The influence of transducer operating point on distortion generation in the cochlea.

scientific article published in March 2004

Time course of endolymph volume increase in experimental hydrops measured in vivo with an ionic volume marker

scientific article published on 01 April 1994

Volume flow rate of perilymph in the guinea-pig cochlea.

scientific article published in September 1988

Water permeability of the mammalian cochlea: functional features of an aquaporin-facilitated water shunt at the perilymph-endolymph barrier.

scientific article

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