List of works - Annamaria Vezzani

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta

scientific article published on 24 October 2008

A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine

scientific article

A systems-level analysis highlights microglial activation as a modifying factor in common forms of human epilepsy

Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development.

scientific article published on 16 March 2011

Acute encephalopathy with inflammation-mediated status epilepticus

scientific article

Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis

scientific article published in April 2009

Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?

scientific article

Astrocyte immune responses in epilepsy

scientific article published on 13 February 2012

Basic mechanisms of MCD in animal models

scientific article published on 10 September 2009

Basic mechanisms of status epilepticus due to infection and inflammation

scientific article published in December 2009

Before epilepsy unfolds: finding the epileptogenesis switch

scientific article

Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis

scientific article

Brain Autonomous Mechanisms of Seizure-Induced BBB Dysfunction

scientific article published on March 2012

Brain Inflammation and Seizures

scientific article published on March 2004

Brain inflammation as a biomarker in epilepsy

scientific article published on October 2011

Brain inflammation in epilepsy: experimental and clinical evidence

scientific article

Common data elements and data management: Remedy to cure underpowered preclinical studies

scientific article

Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.

scientific article

Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development

scientific article published on 5 October 2006

Disulfide-containing high mobility group box-1 promotes N-methyl-D-aspartate receptor function and excitotoxicity by activating Toll-like receptor 4-dependent signaling in hippocampal neurons

scientific article published on 3 January 2014

Does brain inflammation mediate pathological outcomes in epilepsy?

scientific article published on January 2014

Editorial: Experimental Models of Epilepsy and Related Comorbidities

Epigenetic control of epileptogenesis by miR-146a

scientific article published on 4 June 2017

Epilepsy and brain inflammation

scientific article published on October 2011

Epilepsy and inflammation in the brain: overview and pathophysiology

scientific article published on January 2014

Epileptic encephalitis: the role of the innate and adaptive immune system

scientific article published on May 2012

Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers

scientific article

Epileptogenic role of astrocyte dysfunction

scientific article published on March 2008

Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder

scientific article published in November 2002

Febrile Infection-Related Epilepsy Syndrome: Clinical Review and Hypotheses of Epileptogenesis

scientific article

Febrile infection-related epilepsy syndrome treated with anakinra

scientific article published on 22 October 2016

Finding a better drug for epilepsy: antiinflammatory targets

scientific article published on 12 June 2012

Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis

scientific article

Functional role of proinflammatory and anti-inflammatory cytokines in seizures.

scientific article published in January 2004

GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis

scientific article

General conclusions

scientific article published on May 2011

Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development

scientific article published in December 2003

Glia and epilepsy: excitability and inflammation

scientific article published on 05 January 2013

Glia as a source of cytokines: implications for neuronal excitability and survival

scientific article published on January 2008

Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide

scientific article published in January 2005

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

scientific article

ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy

scientific article published on January 2010

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

scientific article

IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence.

scientific article published on 30 May 2011

Immunity and Inflammation in Epilepsy

scientific article published on 18 December 2015

In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance

scientific article

Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy

scientific article published in July 2006

Infections, inflammation and epilepsy

scientific article published on 30 September 2015

Inflammation and Epilepsy: preclinical findings and potential clinical translation

scientific article

Inflammation and epilepsy

scientific article published on January 2005

Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release

scientific article published in July 2008

Inflammatory response and glia activation in developing rat hippocampus after status epilepticus

scientific article published in January 2005

Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet

scientific article published on 24 November 2017

Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats

scientific article published in April 2006

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy

scientific article published on 31 August 2007

Innate immunity and inflammation in temporal lobe epilepsy: new emphasis on the role of complement activation

scientific article published on May 2008

Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production

scientific article published on 29 May 2008

Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma

scientific article

Interleukin-1beta contributes to the generation of experimental febrile seizures

scientific article

Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice

scientific article

Introduction to the 2nd Meeting on Immunity and Inflammation in Epilepsy (IIE2016).

scientific article

Leukocyte-endothelial adhesion mechanisms in epilepsy: cheers and jeers

scientific article published on July 2009

Modulation of neuronal excitability by immune mediators in epilepsy

scientific article

NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning

scientific article

Neurology--the next 10 years

scientific article

Neuronal hyperexcitability and seizures are associated with changes in glial-neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation

scientific article published on 19 November 2010

Neuropeptide Y and Y1 receptors in kindling epileptogenesis

scientific article published on May 2004

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

scientific article

New roles for interleukin-1 Beta in the mechanisms of epilepsy

scientific article published on March 2007

Novel concepts in epileptogenesis and its prevention

scientific article published on April 2014

On demand up-regulation of therapeutic genes in the brain: fiction or reality?

scientific article

Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy?

scientific article published in August 2004

Pilocarpine-induced seizures revisited: what does the model mimic?

scientific article published on September 2009

Plasticity of somatostatin and somatostatin sst2A receptors in the rat dentate gyrus during kindling epileptogenesis

scientific article published on May 2004

Preventing epileptogenesis: A realistic goal?

scientific article

Proteomic profiling of epileptogenesis in a rat model: Focus on inflammation

scientific article published on 11 December 2015

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

scientific article

Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

scientific article published on October 2003

Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors

scientific article

Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats

scientific article

Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain

scientific journal article

The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors

scientific journal article

The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission

scientific article

The dual role of TNF-α and its receptors in seizures

scientific article published on 23 May 2013

The promise of gene therapy for the treatment of epilepsy

scientific article published on December 2007

The role of cytokines in the pathophysiology of epilepsy

scientific article published on 20 May 2008

The role of inflammation in epilepsy

scientific article published on 07 December 2010

The role of inflammation in epileptogenesis

scientific article published on 13 April 2012

The toll receptor family: from microbial recognition to seizures

scientific article published on January 2006

Therapeutic potential of new antiinflammatory drugs

scientific article published on October 2011

Tissue plasminogen activator, neuroserpin, and seizures

scientific article published on July 2005

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

scientific article published on 28 March 2010

Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors

scientific article published in June 2005

VEGF and seizures: cross-talk between endothelial and neuronal environments

scientific article published on March 2005

VEGF as a target for neuroprotection

scientific article published on September 2008

List of works by Annamaria Vezzani

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta

A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine

A systems-level analysis highlights microglial activation as a modifying factor in common forms of human epilepsy

Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development.

Acute encephalopathy with inflammation-mediated status epilepticus

Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis

Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?

Astrocyte immune responses in epilepsy

Basic mechanisms of MCD in animal models

Basic mechanisms of status epilepticus due to infection and inflammation

Before epilepsy unfolds: finding the epileptogenesis switch

Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis

Brain Autonomous Mechanisms of Seizure-Induced BBB Dysfunction

Brain Inflammation and Seizures

Brain inflammation as a biomarker in epilepsy

Brain inflammation in epilepsy: experimental and clinical evidence

Common data elements and data management: Remedy to cure underpowered preclinical studies

Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.

Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development

Disulfide-containing high mobility group box-1 promotes N-methyl-D-aspartate receptor function and excitotoxicity by activating Toll-like receptor 4-dependent signaling in hippocampal neurons

Does brain inflammation mediate pathological outcomes in epilepsy?

Editorial: Experimental Models of Epilepsy and Related Comorbidities

Epigenetic control of epileptogenesis by miR-146a

Epilepsy and brain inflammation

Epilepsy and inflammation in the brain: overview and pathophysiology

Epileptic encephalitis: the role of the innate and adaptive immune system

Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers

Epileptogenic role of astrocyte dysfunction

Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder

Febrile Infection-Related Epilepsy Syndrome: Clinical Review and Hypotheses of Epileptogenesis

Febrile infection-related epilepsy syndrome treated with anakinra

Finding a better drug for epilepsy: antiinflammatory targets

Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis

Functional role of proinflammatory and anti-inflammatory cytokines in seizures.

GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis

General conclusions

Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development

Glia and epilepsy: excitability and inflammation

Glia as a source of cytokines: implications for neuronal excitability and survival

Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence.

Immunity and Inflammation in Epilepsy

In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance

Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy

Infections, inflammation and epilepsy

Inflammation and Epilepsy: preclinical findings and potential clinical translation

Inflammation and epilepsy

Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release

Inflammatory response and glia activation in developing rat hippocampus after status epilepticus

Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet

Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy

Innate immunity and inflammation in temporal lobe epilepsy: new emphasis on the role of complement activation

Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production

Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma

Interleukin-1beta contributes to the generation of experimental febrile seizures

Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice

Introduction to the 2nd Meeting on Immunity and Inflammation in Epilepsy (IIE2016).

Leukocyte-endothelial adhesion mechanisms in epilepsy: cheers and jeers

Modulation of neuronal excitability by immune mediators in epilepsy

NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning

Neurology--the next 10 years

Neuronal hyperexcitability and seizures are associated with changes in glial-neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation

Neuropeptide Y and Y1 receptors in kindling epileptogenesis

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

New roles for interleukin-1 Beta in the mechanisms of epilepsy

Novel concepts in epileptogenesis and its prevention

On demand up-regulation of therapeutic genes in the brain: fiction or reality?

Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy?

Pilocarpine-induced seizures revisited: what does the model mimic?

Plasticity of somatostatin and somatostatin sst2A receptors in the rat dentate gyrus during kindling epileptogenesis

Preventing epileptogenesis: A realistic goal?

Proteomic profiling of epileptogenesis in a rat model: Focus on inflammation

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors