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List of works by Emilio Perucca

A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy

scientific article published in July 2005

A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy

scientific article published in May 2011

A multiparametric investigation of daytime sleepiness and psychomotor functions in epileptic patients treated with phenobarbital and sodium valproate: a comparative controlled study ⬇️

scientific article published on May 1, 1993

A new classification is born

scientific article

A pharmacological and clinical review on topiramate, a new antiepileptic drug ⬇️

scientific article published on April 1, 1997

A prospective study of direct medical costs in a large cohort of consecutively enrolled patients with refractory epilepsy in Italy

scientific article published on 4 June 2015

A simple and rapid HPLC-UV method for the determination of retigabine in human plasma

scientific article

A young woman with recurring seizures

scientific article published on 01 July 2011

Active control trials: endpoints beyond conventional efficacy and tolerability measures

scientific article

Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: a randomized controlled study

scientific article published in February 2002

Addressing overtreatment in patients with refractory epilepsy at a tertiary referral centre in Brazil ⬇️

scientific article published on 01 March 2011

Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial

scientific article published on November 2003

Advocacy for children with epilepsy: Leveraging the WHA resolution. Advocacy Task Force, Commission of Pediatrics, International League Against Epilepsy.

scientific article published on 14 May 2018

Age-related changes in pharmacokinetics: predictability and assessment methods

scientific article published on January 2007

An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly

scientific article published on 11 June 2007

An introduction to antiepileptic drugs

scientific article

An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy

scientific article published on 27 April 2016

Analysis of topiramate and its metabolites in plasma and urine of healthy subjects and patients with epilepsy by use of a novel liquid chromatography-mass spectrometry assay

scientific article published in June 2003

Antiepileptic Drugs as a Cause of Worsening Seizures ⬇️

scientific article published on January 1, 1998

Antiepileptic drug selection for people with HIV/AIDS: evidence-based guidelines from the ILAE and AAN.

scientific article published on January 2012

Antiepileptic drug therapy: does mechanism of action matter?

scientific article published on 16 July 2011

Antiepileptic drug use and epileptic seizures in nursing home residents in the Province of Pavia, Italy: A reappraisal 12 years after a first survey

scientific article

Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats

scientific article published on 31 December 2007

Antiepileptic drugs and intrauterine death: A prospective observational study from EURAP.

scientific article published on 17 July 2015

Antiepileptic drugs and quality of life in the elderly: results from a randomized double-blind trial of carbamazepine and lamotrigine in patients with onset of epilepsy in old age.

scientific article published on 9 February 2010

Availability of antiepileptic drugs across Europe

scientific article

Birth defects after prenatal exposure to antiepileptic drugs

scientific article

CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects

scientific article published on 03 June 2015

Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

scientific article published on 31 December 2017

Cardiac function and antiepileptic drug treatment in the elderly: a comparison between lamotrigine and sustained-release carbamazepine.

scientific article published on 23 March 2009

Challenges in the clinical development of new antiepileptic drugs

article

Changes in lamotrigine pharmacokinetics during pregnancy and the puerperium

scientific article published in August 2008

Changes in the disposition of oxcarbazepine and its metabolites during pregnancy and the puerperium

scientific article published in March 2006

Classification as autonomic versus sensory seizures

scientific article published on 29 July 2019

Classification of the epilepsies: New concepts for discussion and debate-Special report of the ILAE Classification Task Force of the Commission for Classification and Terminology.

scientific article

Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age.

scientific article

Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age: an update

scientific article

Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs

scientific article

Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs

scientific article

Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs

scientific article

Clinically relevant drug interactions with antiepileptic drugs

scientific article published in March 2006

Commentary: Message from the ILAE president.

scientific article

Commentary: why an international epilepsy day?

scientific article published on 17 November 2014

Commission on Outcome Measurement in Epilepsy, 1994–1997: Final Report ⬇️

scientific article published on February 1, 1998

Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry

scientific article published in June 2018

Current trends in antiepileptic drug therapy

scientific article

Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

scientific article

Designing clinical trials to assess antiepileptic drugs as monotherapy : difficulties and solutions

scientific article published on January 2008

Determinants of health-related quality of life in pharmacoresistant epilepsy: results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments

scientific article published in December 2011

Developing clinical practice guidelines for epilepsy: A report from the ILAE Epilepsy Guidelines Working Group

scientific article

Development and Validation of an HPLC-UV Assay for the Therapeutic Monitoring of the New Antiepileptic Drug Perampanel in Human Plasma

scientific article published on 6 October 2016

Development of new antiepileptic drugs: challenges, incentives, and recent advances

scientific article published on September 2007

Development of new treatment approaches for epilepsy: unmet needs and opportunities

scientific article published on August 2013

Dilazep: an inhibitor of adenosine uptake with intrinsic calcium antagonistic properties ⬇️

scientific article published on July 1, 1983

Disposition of sodium valproate in epileptic patients ⬇️

scientific article published on June 1, 1978

Does Carbamazepine Have a Narrow Therapeutic Plasma Concentration Range? ⬇️

scientific article published on February 1, 1998

Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials

scientific article published on 26 May 2020

Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

scientific article

Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study

scientific article

Effect of Active and Passive Cigarette Smoking on CYP1A2-Mediated Phenacetin Disposition in Chinese Subjects ⬇️

scientific article published on 01 August 1998

Effect of a single oral dose of propranolol on essential tremor: A double-blind controlled study ⬇️

scientific article published on February 1, 1983

Effect of atenolol, metoprolol, and propranolol on isoproterenol-induced tremor and tachycardia in normal subjects

scientific article published on April 1, 1981

Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia ⬇️

scientific article published on May 1, 1998

Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trials

scientific article

Effect of low-dose phenobarbitone on five indirect indices of hepatic microsomal enzyme induction and plasma lipoproteins in normal subjects [letter] ⬇️

scientific article published on October 1, 1981

Epilepsy after head injury

scientific article

Epilepsy and comorbidity: infections and antimicrobials usage in relation to epilepsy management ⬇️

scientific article published on January 1, 2003

Epilepsy in elderly people: management issues.

scientific article

Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force

scientific article

Epilepsy: new advances

scientific article published on 24 September 2014

Epilepsy: seizures, syndromes, and survival

scientific article

Epileptic Disorders to become the educational journal of the ILAE ⬇️

scientific article published on 01 June 2013

Evaluation of drug treatment outcome in epilepsy: a clinical perspective

scientific article published on October 1, 1997

Evaluations and awards at the fifth European Congress of Epileptology, Madrid, 6-10 October 2002.

scientific article published in April 2004

Extended-release formulations of antiepileptic drugs: rationale and comparative value

scientific article

Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy

scientific article published on 15 July 2015

Factors determining response to antiepileptic drugs in randomized controlled trials. A systematic review and meta-analysis

scientific article published on 26 January 2011

Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias

scientific article published on April 2007

Final safety, tolerability, and seizure outcomes in patients with focal epilepsy treated with adjunctive perampanel for up to 4 years in an open-label extension of phase III randomized trials: Study 307.

scientific article published on 25 March 2018

From clinical trials of antiepileptic drugs to treatment.

scientific article published on 10 July 2018

From global campaign to global commitment: The World Health Assembly's Resolution on epilepsy

scientific article published on 22 September 2015

Gender issues in antiepileptic drug treatment

scientific article published on 20 May 2014

Genetic basis for idiosyncratic reactions to antiepileptic drugs

scientific article published on April 2009

Genetic testing to prevent adverse reactions to antiepileptic drugs: Primum non nocere

scientific article published on 29 December 2017

Heterogeneous Contribution of Microdeletions in the Development of Common Generalized and Focal epilepsies

Heterogeneous contribution of microdeletions in the development of common generalised and focal epilepsies

scientific article published on 29 July 2017

Hormone replacement therapy in women with epilepsy

scientific article published in May 2007

How long for epilepsy remission in the ILAE definition?

scientific article published in August 2017

ILAE Commission Report: Evaluations and Awards at the 4th European Congress of Epileptology, Florence, 7–12 October 2000 ⬇️

scientific article published on October 1, 2001

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

scientific article

ILAE official report: a practical clinical definition of epilepsy

scientific article

ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes

scientific article published in July 2006

ILAE-Klassifikation der Epilepsien: Positionspapier der ILAE-Kommission für Klassifikation und Terminologie

article

Identification of new epilepsy treatments: Issues in preclinical methodology ⬇️

scientific article published on January 31, 2012

Idiosyncratic adverse reactions to antiepileptic drugs

scientific article published on 26 March 2007

Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatography

scientific article

In Memoriam: Hanneke De Boer (1946-2015).

scientific article published in January 2016

In memoriam: Harry Meinardi (February 20, 1932-December 20, 2013).

scientific article published on 7 March 2014

Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine

scientific article published in November 2005

Influence of aging on serum phenytoin concentrations: a pharmacokinetic analysis based on therapeutic drug monitoring data

scientific article

Influence of dosage, age, and co-medication on plasma topiramate concentrations in children and adults with severe epilepsy and preliminary observations on correlations with clinical response

scientific article published in December 2003

Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy ⬇️

scientific article published on 01 February 2011

Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction

scientific article published in August 2002

Innovative monotherapy trial designs for the assessment of antiepileptic drugs: a critical appraisal ⬇️

scientific article published on 01 March 1998

Interaction between fluoxetine and haloperidol: pharmacokinetic and clinical implications

scientific article published on 01 April 1997

Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs

scientific article

Interlaboratory variability in the quantification of new generation antiepileptic drugs based on external quality assessment data

scientific article

Interpretation of Drug Levels: Relevance of Plasma Protein Binding ⬇️

scientific article published on January 1, 1979

Is a separate monotherapy indication warranted for antiepileptic drugs?

scientific article published on December 2015

Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders

scientific article (publication date: 2009)

Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology

scientific article published on January 2009

Major birth defects after exposure to newer-generation antiepileptic drugs

scientific article published in August 2011

Marketed new antiepileptic drugs: are they better than old-generation agents?

scientific article

Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy

scientific article published in November 2017

Measurement of seizure freedom in adjunctive therapy studies in refractory partial epilepsy: the levetiracetam experience.

scientific article published on June 2006

Modification of phenytoin clearance by valproic acid in normal subjects ⬇️

scientific article published on December 1, 1979

NICE guidance on newer drugs for epilepsy in adults

scientific article published in May 2004

Navigating toward fetal and maternal health: the challenge of treating epilepsy in pregnancy.

scientific article

New and forthcoming anti-epileptic drugs

scientific article published on April 2011

Not all that glitters is gold: A guide to the critical interpretation of drug trials in epilepsy

scientific article published on 27 July 2016

Novel frontiers in epilepsy treatments: preventing epileptogenesis by targeting inflammation

scientific article

Novel medications for epilepsy

scientific article

Optimal choice of antiseizure medication: Agreement among experts and validation of a web-based decision support application

scientific article published on 06 December 2020

Optimizing antiepileptic drug treatment in tumoral epilepsy

scientific article published on December 2013

Overtreatment in epilepsy: adverse consequences and mechanisms

scientific article

Overtreatment in epilepsy: how it occurs and how it can be avoided

scientific article

Patterns of prescription of antiepileptic drugs in patients with refractory epilepsy at tertiary referral centres in Italy

scientific article published on October 2010

Perampanel effects in the WAG/Rij rat model of epileptogenesis, absence epilepsy, and comorbid depressive-like behavior

scientific article published on 18 December 2016

Perampanel for adjunctive treatment of partial-onset seizures: a pooled dose-response analysis of phase III studies

scientific article

Perampanel, a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial-onset seizures: interim results from phase III, extension study 307.

scientific article published on 20 August 2012

Pharmacokinetic and metabolic investigation of topiramate disposition in healthy subjects in the absence and in the presence of enzyme induction by carbamazepine

scientific article published in March 2005

Pharmacokinetic variability of new antiepileptic drugs at different ages

scientific article published in December 2005

Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience

scientific article

Pharmacological problems in the management of epilepsy in children ⬇️

scientific article published on June 1, 1995

Pharmacology of antiepileptic drugs during pregnancy and lactation

scientific article published on November 2007

Phenobarbital pharmacokinetics in old age: a case-matched evaluation based on therapeutic drug monitoring data

scientific article

Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: reply to Beyenburg et al., 2009.

scientific article published in May 2010

Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical response

scientific article published in October 2002

Plasma gabapentin concentrations in children with epilepsy: influence of age, relationship with dosage, and preliminary observations on correlation with clinical response

scientific article

Preface

Pregabalin for the management of partial epilepsy

scientific article published in December 2008

Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical and early clinical development

scientific article published on 14 November 2020

Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). II. Drugs in more advanced clinical development

scientific article published on 09 November 2020

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development

scientific article published on 01 October 2018

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). II. Drugs in more advanced clinical development

scientific article published on 01 October 2018

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).

scientific article published on 23 January 2017

Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII).

scientific article published on 19 January 2015

Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII)

scientific article

Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI)

scientific article

Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX).

scientific article

Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII)

scientific article

Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X).

scientific article

Propranolol and sotalol as antagonists of isoproterenol-enhanced physiologic tremor

scientific article published on September 1, 1981

Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects

scientific article published on 01 June 1991

Rapid onset of seizure suppression with pregabalin adjunctive treatment in patients with partial seizures

scientific article published in June 2009

Recommendations of the Italian League against Epilepsy working group on generic products of antiepileptic drugs

scientific article published on January 2006

Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients ⬇️

scientific article published on July 1, 1979

Reflections on monotherapy trials for epilepsy - Authors' reply

scientific article

Relationship between adverse effects of antiepileptic drugs, number of coprescribed drugs, and drug load in a large cohort of consecutive patients with drug-refractory epilepsy

scientific article published on 20 April 2010

Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy

scientific article published on 20 June 2020

Relative bioavailability and pharmacokinetics of two oral formulations of docosahexaenoic acid/eicosapentaenoic acid after multiple-dose administration in healthy volunteers

scientific article published on 16 January 2009

Response: Cannabidiol antiseizure activity and its interactions with clobazam: "It's déjà vu all over again" Yogi Berra

scientific article published on 05 July 2020

Reversible Pseudoatrophy of the Brain and Mental Deterioration Associated with Valproate Treatment ⬇️

scientific article published on January 1, 1998

Revisiting phenobarbital for epilepsy

scientific article published on November 2004

Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy

scientific article published in July 2008

Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry

scientific article

Seizure detection and neuromodulation: A summary of data presented at the XIII conference on new antiepileptic drug and devices (EILAT XIII).

scientific article

Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study

scientific article published on 5 February 2015

Serum carbamazepine concentrations in elderly patients: a case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data

scientific article

Six-year follow-up study on the efficacy and safety of vigabatrin in patients with epilepsy

scientific article published on September 1, 1992

Spuriously high values of unbound drug fraction in serum as determined by the new ultrafree anticonvulsant drug filters [letter] ⬇️

scientific article published on November 1, 1981

The International League Against Epilepsy at the threshold of its second century: year 1

scientific article

The International League Against Epilepsy at the threshold of its second century: year 2.

scientific article published on January 2012

The Pathophysiological Basis of Drug Toxicity ⬇️

scientific article published on 01 January 1980

The Written Declaration on Epilepsy: an important achievement for Europe and beyond

scientific article published on 3 December 2011

The cost benefit ratio of enantiomeric drugs ⬇️

scientific article published on January 1, 1995

The current state of epilepsy guidelines: A systematic review

scientific article

The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?

scientific article

The impact of enzyme-inducing antiepileptic drugs on antiretroviral drug levels: a case-control study

scientific article

The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data

scientific article

The ketogenic diet: from molecular mechanisms to clinical effects

scientific article

The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: the PuLsE (Open Prospective Randomized Long-term Effectiveness) trial

scientific article

The pharmacogenomics of epilepsy

scientific article published on September 2015

The pharmacological treatment of epilepsy in adults

scientific article published on May 2011

The treatment of the first seizure: the risks

scientific article published on January 2008

Topiramate pharmacokinetics in children and adults with epilepsy: a case-matched comparison based on therapeutic drug monitoring data

scientific article

Total and non-protein-bound fractions of 3,4-dihydroxyphenylalanine ⬇️

scientific article published on April 1, 1998

Translating monotherapy trials into clinical practice: a look into the abyss

scientific article published on October 2003

Treatment of epilepsy in developing countries

scientific article published on June 2007

Treatment of status epilepticus in adults: guidelines of the Italian League against Epilepsy

scientific article published in January 2006

Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes

scientific article published on 25 January 2013

Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug

scientific article

Visual field loss in patients with refractory partial epilepsy treated with vigabatrin: final results from an open-label, observational, multicentre study

scientific article published in November 2009

What can we learn from clinical trials of anticonvulsant drugs in epilepsy?

scientific article

What clinical trial designs have been used to test antiepileptic drugs and do we need to change them?* ⬇️

scientific article published on June 1, 2012

What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS-1209, and topiramate

scientific article published on December 2009

When clinical trials make history: demonstrating efficacy of new antiepileptic drugs as monotherapy

scientific article published on October 2010

When the past challenges the present: are older antiepileptic drugs still the best choice in childhood absence epilepsy?

scientific article published in May 2010

Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP.

scientific article published on 20 June 2016

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