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List of works by Carole A Long

A Chimeric Plasmodium falciparum Merozoite Surface Protein Vaccine Induces High Titers of Parasite Growth Inhibitory Antibodies ⬇️

scientific article published on July 29, 2013

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys

scientific article

A Phase 1 study of the blood-stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals

scientific article published on 15 May 2009

A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence

scientific article

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission

scientific article

A malaria vaccine adjuvant based on recombinant antigen binding to liposomes

scientific article published on 08 October 2018

A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection

scientific article published on 22 May 2017

A multigene family that interacts with the amino terminus of plasmodium MSP-1 identified using the yeast two-hybrid system

scientific article

A new malaria antigen produces partial protection against Plasmodium yoelii challenge ⬇️

scientific article published on September 14, 2011

A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720

scientific article (publication date: 2011)

A phase 1 trial of PfCP2.9: an AMA1/MSP1 chimeric recombinant protein vaccine for Plasmodium falciparum malaria

scientific article published on 16 October 2008

A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria

scientific article

A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults

scientific article

A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum

scientific article

A slot blot immunoassay for quantitative detection of Plasmodium falciparum circumsporozoite protein in mosquito midgut oocyst

scientific article

Addition of CpG ODN to recombinant Pseudomonas aeruginosa ExoProtein A conjugates of AMA1 and Pfs25 greatly increases the number of responders

scientific article published on 27 March 2008

Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

scientific article

Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults

scientific article (publication date: 2011)

Age-Related Differences in Naturally Acquired T Cell Memory to Plasmodium falciparum Merozoite Surface Protein 1 ⬇️

scientific article published on September 16, 2011

Allele specificity of gamma interferon responses to the carboxyl-terminal region of Plasmodium falciparum merozoite surface protein 1 by Kenyan adults with naturally acquired immunity to malaria

scientific article

An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines

scientific article published on 09 September 2016

Analysis of antibodies directed against merozoite surface protein 1 of the human malaria parasite Plasmodium falciparum

scientific article

Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP

scientific article

Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting plasmodium falciparum growth, as determined by the in vitro growth inhibition assay

scientific article published on 13 May 2009

Antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A and to the C terminus of merozoite surface protein 1 correlate with reduced placental malaria in Cameroonian women

scientific article published on March 2004

Antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model

scientific article

Antigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malaria

scientific article

Assessment of Antibodies Induced by Multivalent Transmission-Blocking Malaria Vaccines

scientific article published in January 2017

Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure

scientific article

Assessment of transmission-blocking activity of candidate Pvs25 vaccine using gametocytes from chimpanzees

scientific article published in February 2006

Biochemical and immunological characterization of bacterially expressed and refolded Plasmodium falciparum 42-kilodalton C-terminal merozoite surface protein 1.

scientific article

Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection

scientific article

ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans

scientific article

Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection

scientific article published on 13 October 2016

Characterization of a protective Escherichia coli-expressed Plasmodium falciparum merozoite surface protein 3 indicates a non-linear, multi-domain structure

scientific article published on 27 November 2008

Clinical Evaluation Of New Viral Vectored Vaccines Targeting The Plasmodium Falciparum Blood-Stage Antigens; Msp1 And Ama1

scientific article published in 2011

Combination of RTS,S and Pfs25-IMX313 Induces a Functional Antibody Response Against Malaria Infection and Transmission in Mice

article

Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial

scientific article

Comparative assessment of An. gambiae and An. stephensi mosquitoes to determine transmission-reducing activity of antibodies against P. falciparum sexual stage antigens

scientific article published on 17 October 2017

Comparison of biological activity of human anti-apical membrane antigen-1 antibodies induced by natural infection and vaccination

scientific article published on December 2008

Comparison of immunogenicity of five MSP1-based malaria vaccine candidate antigens in rabbits

scientific article published on 25 November 2008

Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: a strategy for enhancing immunogenicity of malaria vaccine candidates

scientific article published on 13 March 2007

Correction: Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1.

scientific article

Corrigendum to “Efficient extraction of vaccines formulated in aluminum hydroxide gel by including surfactants in the extraction buffer” [Vaccine 30 (2012) 189–194]

scholarly article by Daming Zhu et al published May 2013 in Vaccine

Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens.

scientific article published in September 2006

Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines

scientific article

Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen

scientific article published on 6 September 2011

Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes

scientific article

Effect of red blood cell variants on childhood malaria in Mali: a prospective cohort study

scientific article published on 24 March 2015

Effective induction of high-titer antibodies by viral vector vaccines

scientific article published on 27 July 2008

Effects of age, hemoglobin type and parasite strain on IgG recognition of Plasmodium falciparum-infected erythrocytes in Malian children

scientific article

Efficient extraction of vaccines formulated in aluminum hydroxide gel by including surfactants in the extraction buffer

scientific article published on 19 November 2011

Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study

scientific article

Engineering the chloroplast targeted malarial vaccine antigens in Chlamydomonas starch granules

scientific article (publication date: 15 December 2010)

Enhanced antibody production in mice to the malaria antigen AMA1 by CPG 7909 requires physical association of CpG and antigen

scientific article

Enhancement of functional antibody responses to AMA1-C1/Alhydrogel, a Plasmodium falciparum malaria vaccine, with CpG oligodeoxynucleotide

scientific article published on 4 January 2006

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens ⬇️

scientific article

Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology

scientific article

Erratum: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

scientific article published in Nature Communications

Evaluation of a Plasmodium-specific carrier protein to enhance production of recombinant Pfs25, a leading transmission-blocking vaccine candidate

scientific article published on 9 October 2017

Evaluation of the Immunogenicity and Vaccine Potential of Recombinant Plasmodium falciparum Merozoite Surface Protein 8 ⬇️

scientific article published on May 14, 2012

Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine

scientific article

Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Plasmodium falciparum merozoite surface protein-1 in vaccinated volunteers

scientific article published on February 2008

Expression of full-length Plasmodium falciparum P48/45 in P. berghei blood stages: A method to express and evaluate vaccine antigens

article by Ahmad Syibli Othman et al published 24 July 2018 in Molecular and Biochemical Parasitology

Fetal immune responses to Plasmodium falciparum antigens in a malaria-endemic region of Cameroon.

scientific article published in March 2007

Formulation of vaccines containing CpG oligonucleotides and alum

scientific article

Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen

scientific article

Functional comparison of Plasmodium falciparum transmission-blocking vaccine candidates by the standard membrane-feeding assay

scientific article published on 16 September 2013

Hematological Indices in Malian Children Change Significantly During a Malaria Season and with Increasing Age: Implications for Malaria Epidemiological Studies

scientific article published on 13 June 2016

High Plasmodium falciparum longitudinal prevalence is associated with high multiclonality and reduced clinical malaria risk in a seasonal transmission area of Mali

scientific article

High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high Plasmodium falciparum transmission

scientific article published on 13 February 2012

Host age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study.

scientific article

Humoral and Cellular Immunity to Plasmodium falciparum Merozoite Surface Protein 1 and Protection From Infection With Blood-Stage Parasites ⬇️

scientific article published on March 28, 2013

Identification and characterization of the Plasmodium yoelii PyP140/RON4 protein, an orthologue of Toxoplasma gondii RON4, whose cysteine-rich domain does not protect against lethal parasite challenge infection

scientific article

Immune Responses in Malaria

scientific article published on 7 April 2017

Immune characterization of Plasmodium falciparum parasites with a shared genetic signature in a region of decreasing transmission

scientific article

Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

scientific article published on 18 July 2013

Immunity to recombinant plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity

scientific article

Immunization of Aotus monkeys with recombinant cysteine-rich interdomain region 1 alpha protects against severe disease during Plasmodium falciparum reinfection

scientific article published on 30 January 2006

Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria

scientific article

Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeys

scientific article published on 15 March 2016

Immunogenicity of self-associated aggregates and chemically cross-linked conjugates of the 42 kDa Plasmodium falciparum merozoite surface protein-1

scientific article

Immunological responses against Plasmodium falciparum Apical Membrane Antigen 1 vaccines vary depending on the population immunized

scientific article

Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate

scientific article (publication date: 5 April 2017)

Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians

scientific article

Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

scientific article

Improving malaria control in West Africa: interruption of transmission as a paradigm shift

scientific article published on 28 November 2011

In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized

scientific article

In vitro growth-inhibitory activity and malaria risk in a cohort study in mali

scientific article

In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic response

scientific article

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model

scientific article

Induction of transmission-blocking immunity in Aotus monkeys by vaccination with a Plasmodium vivax clinical grade PVS25 recombinant protein

scientific article published in November 2005

Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection

scientific article

Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission

scientific article published on 11 January 2018

Malaria Vaccines: Recent Advances and New Horizons

scientific article published on 11 July 2018

Malaria vaccines and human immune responses

scientific article published on 2 June 2016

Members of the merozoite surface protein 7 family with similar expression patterns differ in ability to protect against Plasmodium yoelii malaria

scientific article published on February 2004

Merozoite surface protein 3 and protection against malaria in Aotus nancymai monkeys

scientific article

Montanide ISA 720 vaccines: quality control of emulsions, stability of formulated antigens, and comparative immunogenicity of vaccine formulations

scientific article

Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut

scientific article (publication date: 28 January 2014)

Multiplex assay for simultaneous measurement of antibodies to multiple Plasmodium falciparum antigens

scientific article

Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines

scientific article

Naturally acquired antibodies specific for Plasmodium falciparum reticulocyte-binding protein homologue 5 inhibit parasite growth and predict protection from malaria

scientific article published on 16 October 2013

Non-Apical Membrane Antigen 1 (AMA1) IgGs from Malian Children Interfere with Functional Activity of AMA1 IgGs as Judged by Growth Inhibition Assay ⬇️

scientific article published on June 13, 2011

Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.

scientific article published on 19 February 2013

Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical membrane antigen-1.

scientific article

Parasitology. Malaria--from infants to genomics to vaccines

scientific article published in July 2002

Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria

scientific article

Phase 1 safety and immunogenicity trial of the Plasmodium falciparum blood-stage malaria vaccine AMA1-C1/ISA 720 in Australian adults

scientific article

Phase 1 study in malaria naïve adults of BSAM2/Alhydrogel®+CPG 7909, a blood stage vaccine against P. falciparum malaria

scientific article

Phase 1 study of two merozoite surface protein 1 (MSP1(42)) vaccines for Plasmodium falciparum malaria

scientific article

Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria

scientific article

Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51.

scientific article

Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adults

scientific article (publication date: 22 January 2010)

Phase 1 vaccine trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malaria

scientific article published in May 2005

Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.

scientific article

Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors

scientific article published on 23 August 2011

Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors

scientific article (publication date: 2012)

Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria

scientific article

Plasmodium falciparum apical membrane antigen 1 vaccine elicits multifunctional CD4 cytokine-producing and memory T cells

scientific article published on 08 July 2009

Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity

scientific article published on 28 February 2013

Plasmodium vivax: transmission-blocking immunity in a malaria-endemic area of Colombia

scientific article

Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine design

scholarly article

Preparation, crystallization and preliminary X-ray analysis of a complex between the Plasmodium vivax sexual stage 25 kDa protein Pvs25 and a malaria transmission-blocking antibody Fab fragment

scientific article published on 20 October 2004

Protection induced by Plasmodium falciparum MSP1(42) is strain-specific, antigen and adjuvant dependent, and correlates with antibody responses

scientific article

Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assays

scientific article

RALP1 is a rhoptry neck erythrocyte-binding protein of Plasmodium falciparum merozoites and a potential blood-stage vaccine candidate antigen

scientific article published on 03 September 2013

Relationship between Malaria Incidence and IgG Levels to Plasmodium falciparum Merozoite Antigens in Malian Children: Impact of Hemoglobins S and C ⬇️

scientific article published on March 28, 2013

Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults

article

Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes

scientific article published on 19 November 2011

Serologic imprint of dengue virus in urban Haiti: characterization of humoral immunity to dengue in infants and young children

scientific article

Standardization of the antibody-dependent respiratory burst assay with human neutrophils and Plasmodium falciparum malaria

scientific article

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

scientific article published on 13 January 2014

Strong concordance between percent inhibition in oocyst and sporozoite intensities in a Plasmodium falciparum standard membrane-feeding assay

scholarly article published by Kazutoyo Miura in 2019

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

scientific article published in Nature Communications

Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region

scientific article

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate

scientific article

Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex

scholarly article

T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein

scientific article

TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25.

scientific article

The IC(50) of anti-Pfs25 antibody in membrane-feeding assay varies among species

scientific article

The S. aureus 4-oxalocrotonate tautomerase SAR1376 enhances immune responses when fused to several antigens

scientific article

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

scientific article

The clinical-grade 42-kilodalton fragment of merozoite surface protein 1 of Plasmodium falciparum strain FVO expressed in Escherichia coli protects Aotus nancymai against challenge with homologous erythrocytic-stage parasites

scientific article

The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms

scientific article published on 4 December 2005

The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages

scientific article (publication date: 12 December 2014)

Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1

scientific article (publication date: 2011)

Transmission-blocking activity induced by malaria vaccine candidates Pfs25/Pvs25 is a direct and predictable function of antibody titer

scientific article

Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assay

scientific article published on 29 June 2016

Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malaria

scientific article

Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum

scientific article

posttranslational modification of recombinant Plasmodium falciparum apical membrane antigen 1: impact on functional immune responses to a malaria vaccine candidate

scientific article

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