Search filters

List of works by Kazutoyo Miura

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys

scientific article

A Phase 1 study of the blood-stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals

scientific article published on 15 May 2009

A chimeric Plasmodium falciparum merozoite surface protein vaccine induces high titers of parasite growth inhibitory antibodies

scientific article published on 29 July 2013

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission

scientific article

A glycoprotein from Spirometra erinaceieuropaei plerocercoids suppresses osteoclastogenesis and proinflammatory cytokine gene expression

scientific article

A malaria vaccine adjuvant based on recombinant antigen binding to liposomes

scientific article published on 08 October 2018

A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection

scientific article published on 22 May 2017

A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults

scientific article

A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali

scientific article published on 25 March 2009

A slot blot immunoassay for quantitative detection of Plasmodium falciparum circumsporozoite protein in mosquito midgut oocyst

scientific article

An N-terminal Pfs230 domain produced in baculovirus as a biological active transmission-blocking vaccine candidate

scientific article

An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines

scientific article published on 09 September 2016

Anaemia in a phase 2 study of a blood stage falciparum malaria vaccine

scientific article

Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP

scientific article

Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting plasmodium falciparum growth, as determined by the in vitro growth inhibition assay

scientific article published on 13 May 2009

Antigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malaria

scientific article

Assessment of Antibodies Induced by Multivalent Transmission-Blocking Malaria Vaccines

scientific article published in January 2017

Assessment of Pfs25 expressed from multiple soluble expression platforms for use as transmission-blocking vaccine candidates

scientific article published on 11 August 2016

Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure

scientific article

ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans

scientific article

Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection

scientific article published on 13 October 2016

Combination of RTS,S and Pfs25-IMX313 Induces a Functional Antibody Response Against Malaria Infection and Transmission in Mice

article

Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial

scientific article

Comparative assessment of An. gambiae and An. stephensi mosquitoes to determine transmission-reducing activity of antibodies against P. falciparum sexual stage antigens

scientific article published on 17 October 2017

Comparison of biological activity of human anti-apical membrane antigen-1 antibodies induced by natural infection and vaccination

scientific article published on December 2008

Correction: Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1.

scientific article

Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines

scientific article

Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen

scientific article published on 6 September 2011

Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes

scientific article

Effect of red blood cell variants on childhood malaria in Mali: a prospective cohort study

scientific article published on 24 March 2015

Effects of age, hemoglobin type and parasite strain on IgG recognition of Plasmodium falciparum-infected erythrocytes in Malian children

scientific article

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens ⬇️

scientific article

Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology

scientific article

Erratum: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

scientific article published in Nature Communications

Evaluation of a Plasmodium-specific carrier protein to enhance production of recombinant Pfs25, a leading transmission-blocking vaccine candidate

scientific article published on 9 October 2017

Expression of full-length Plasmodium falciparum P48/45 in P. berghei blood stages: A method to express and evaluate vaccine antigens

article by Ahmad Syibli Othman et al published 24 July 2018 in Molecular and Biochemical Parasitology

Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen

scientific article

Functional comparison of Plasmodium falciparum transmission-blocking vaccine candidates by the standard membrane-feeding assay

scientific article published on 16 September 2013

Hematological Indices in Malian Children Change Significantly During a Malaria Season and with Increasing Age: Implications for Malaria Epidemiological Studies

scientific article published on 13 June 2016

High Plasmodium falciparum longitudinal prevalence is associated with high multiclonality and reduced clinical malaria risk in a seasonal transmission area of Mali

scientific article

Host age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study.

scientific article

Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission

scientific article published on 4 December 2017

Immune characterization of Plasmodium falciparum parasites with a shared genetic signature in a region of decreasing transmission

scientific article

Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

scientific article published on 18 July 2013

Immunity to recombinant plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity

scientific article

Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria

scientific article

Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeys

scientific article published on 15 March 2016

Immunological responses against Plasmodium falciparum Apical Membrane Antigen 1 vaccines vary depending on the population immunized

scientific article

Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate

scientific article (publication date: 5 April 2017)

Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians

scientific article

Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

scientific article

Improving malaria control in West Africa: interruption of transmission as a paradigm shift

scientific article published on 28 November 2011

In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized

scientific article

In vitro growth-inhibitory activity and malaria risk in a cohort study in mali

scientific article

Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection

scientific article

Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission

scientific article published on 11 January 2018

Measuring precision in bioassays: Rethinking assay validation

scientific article published on 19 October 2017

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.

scientific article published on 16 November 2017

Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut

scientific article (publication date: 28 January 2014)

Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines

scientific article

Naturally acquired antibodies specific for Plasmodium falciparum reticulocyte-binding protein homologue 5 inhibit parasite growth and predict protection from malaria

scientific article published on 16 October 2013

New adenovirus-based vaccine vectors targeting Pfs25 elicit antibodies that inhibit Plasmodium falciparum transmission

scientific article

Non-Apical Membrane Antigen 1 (AMA1) IgGs from Malian Children Interfere with Functional Activity of AMA1 IgGs as Judged by Growth Inhibition Assay ⬇️

scientific article published on June 13, 2011

Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.

scientific article published on 19 February 2013

Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical membrane antigen-1.

scientific article

Phase 1 safety and immunogenicity trial of the Plasmodium falciparum blood-stage malaria vaccine AMA1-C1/ISA 720 in Australian adults

scientific article

Phase 1 study in malaria naïve adults of BSAM2/Alhydrogel®+CPG 7909, a blood stage vaccine against P. falciparum malaria

scientific article

Phase 1 study of a combination AMA1 blood stage malaria vaccine in Malian children

scientific article

Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria

scientific article

Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51.

scientific article

Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adults

scientific article (publication date: 22 January 2010)

Phase 1 vaccine trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malaria

scientific article published in May 2005

Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors

scientific article published on 23 August 2011

Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors

scientific article (publication date: 2012)

Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P

scientific article (publication date: 3 April 2012)

Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine design

scholarly article

Progress and prospects for blood-stage malaria vaccines

scientific article published on 13 January 2016

Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assays

scientific article

RALP1 is a rhoptry neck erythrocyte-binding protein of Plasmodium falciparum merozoites and a potential blood-stage vaccine candidate antigen

scientific article published on 03 September 2013

Relationship between Malaria Incidence and IgG Levels to Plasmodium falciparum Merozoite Antigens in Malian Children: Impact of Hemoglobins S and C ⬇️

scientific article published on March 28, 2013

Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults

article

Standardization of the antibody-dependent respiratory burst assay with human neutrophils and Plasmodium falciparum malaria

scientific article

Strong concordance between percent inhibition in oocyst and sporozoite intensities in a Plasmodium falciparum standard membrane-feeding assay

scholarly article published by Kazutoyo Miura in 2019

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

scientific article published in Nature Communications

Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45

scientific article published in Nature Communications

Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region

scientific article

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate

scientific article

Suppression of IP-10/CXCL10 gene expression in LPS- and/or IFN-γ-stimulated macrophages by parasite-secreted products

scientific article published on March 2012

TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25.

scientific article

The IC(50) of anti-Pfs25 antibody in membrane-feeding assay varies among species

scientific article

The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections

scientific article

The S. aureus 4-oxalocrotonate tautomerase SAR1376 enhances immune responses when fused to several antigens

scientific article

The TLR9 agonist CpG fails to enhance the acquisition of Plasmodium falciparum-specific memory B cells in semi-immune adults in Mali

scientific article published on 25 August 2009

The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals

scientific article

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

scientific article

The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages

scientific article (publication date: 12 December 2014)

Transmission-blocking activity induced by malaria vaccine candidates Pfs25/Pvs25 is a direct and predictable function of antibody titer

scientific article

Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assay

scientific article published on 29 June 2016

Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum

scientific article

Vaccine design via nonnegative lasso-based variable selection

scientific article

What goes around comes around: modeling malaria transmission from humans back to mosquitos.

scientific article published on 12 March 2018

posttranslational modification of recombinant Plasmodium falciparum apical membrane antigen 1: impact on functional immune responses to a malaria vaccine candidate

scientific article

Paulina is supported by:

About Paulina

Help