List of works by Neal G. Copeland

A DNA transposon-based approach to validate oncogenic mutations in the mouse

scientific article (publication date: 16 December 2008)

A comprehensive SNP-based genetic analysis of inbred mouse strains.

scientific article published in July 2005

A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis

scientific article

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice

scientific article published on 06 October 2009

A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice

scientific article

A simple procedure for the efficient derivation of mouse ES cells

scientific article published on January 2010

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

scientific article

A vector for expressing foreign genes in the brains and hearts of transgenic mice

scientific article published in December 1996

APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

scientific article published in August 2004

Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias

scientific article published on 11 February 2002

An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis ⬇️

scientific article published on May 1, 2010

Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq

scientific article published in August 2016

Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b

scientific article

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells

scientific article

BCL11B is required for positive selection and survival of double-positive thymocytes

scientific journal article

BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary

scientific journal article

Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c

scientific article

Bcl11a is essential for lymphoid development and negatively regulates p53.

scientific article

Bcl11a is essential for normal lymphoid development ⬇️

scientific article published on April 28, 2003

Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development

scientific article published on 4 April 2012

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis

scientific article

Cell of origin strongly influences genetic selection in a mouse model of T-ALL

scientific article published on 9 August 2011

Common sites of retroviral integration in mouse hematopoietic tumors identified by high-throughput, single nucleotide polymorphism-based mapping and bacterial artificial chromosome hybridization

scientific article

Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins

scientific article

Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis

scientific article published on 16 June 2005

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages

scientific article published on 8 April 2013

Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature

scientific article published on 9 September 2003

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

scientific article

Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease

scientific article

Deciphering the genetic landscape of cancer--from genes to pathways

scientific article published on 07 October 2009

Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development

scientific article published on March 2002

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

scientific article published in Nature

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

scientific article published on 6 April 2011

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

scientific article published on 4 February 2002

EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation

scientific article published on 15 July 2013

Early B-cell factor-associated zinc-finger gene is a frequent target of retroviral integration in murine B-cell lymphomas

scientific article published in April 2004

Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors

scientific article published on 19 January 2012

Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.

scientific article published on 20 February 2009

Erratum: A comprehensive genetic map of the mouse genome

scientific article published in Nature

Erratum: Novel myosin heavy chain encoded by murine dilute coat colour locus

scientific article published in Nature

Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein

scientific article

Evolution of the regulators of G-protein signaling multigene family in mouse and human

scientific article (publication date: February 2002)

Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site

scientific article

Gene therapy insertional mutagenesis insights

scientific article published in January 2004

Genetic control of myeloproliferation in BXH-2 mice

scientific article published on 20 November 2003

Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas

scientific article

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

scholarly article

Harnessing transposons for cancer gene discovery ⬇️

scientific article published on September 16, 2010

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

scientific article

Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)

scientific article

Highly restricted expression of Cre recombinase in cerebellar Purkinje cells

scientific article published in September 2004

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

scientific article

Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells

scientific journal article

Identification of FoxR2 as an oncogene in medulloblastoma

scientific article published on 5 March 2014

Identification of Vangl2 and Scrb1 as planar polarity genes in mammals

scientific journal article

Identification of an organelle receptor for myosin-Va

scientific journal article

Identification of beta-carotene 15, 15'-monooxygenase as a peroxisome proliferator-activated receptor target gene

scientific article published on 20 May 2003

Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model

scientific article

Identification of new tumor suppressor genes in triple-negative breast cancer

scientific article published on 19 July 2017

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis

scientific article

Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells

scientific article published on 18 August 2005

Interallelic complementation at the mouse Mitf locus.

scientific article

Isolation and characterization of the mouse ubiquitin-specific protease Usp15

scientific journal article

Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti

scientific article

KRAS-related proteins in pancreatic cancer

scientific article

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways

scientific article published on 21 January 2014

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism

scientific article published in Nature

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

scientific article

Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse ⬇️

scientific article published on January 1, 1997

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

scientific article

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

scientific article

Melanocyte stem cell maintenance and hair graying

scientific article

Melanocytes and the microphthalmia transcription factor network

scientific article

Melanoregulin regulates a shedding mechanism that drives melanosome transfer from melanocytes to keratinocytes

scientific article

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects

scientific article

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

scientific article

Molecular cloning of mouse collectin liver 1

scientific journal article

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Mouse coat color mutations: from fancy mice to functional genomics

scientific article

Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression

scientific article

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy

scientific article

Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells

scientific article published on 26 November 2012

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

scientific article (publication date: 15 January 2004)

Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality

scientific article

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

scientific article

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

scientific article

Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease

scientific article published on 21 August 2008

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

scientific article

Pillars article: lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. 1992.

scientific article published in December 2012

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin

scientific article

Project reading

scientific article published in Nature

RTCGD: retroviral tagged cancer gene database

scientific article

Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion

scientific article published on 10 June 2010

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

scientific article

Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6

scientific journal article

SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers

scientific article published on 20 October 2017

Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse

scientific article published on October 2013

Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells

scientific article

Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10

scientific article

Significant differences between mouse and human trophinins are revealed by their expression patterns and targeted disruption of mouse trophinin gene

scientific article published in February 2002

Simple and highly efficient BAC recombineering using galK selection

scientific article

Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups

scientific article published on 28 October 2013

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

scientific article published on 15 March 2012

Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discovery

scientific article published on 20 December 2013

Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development

scientific article published on 22 March 2016

Sleeping beauty: a novel cancer gene discovery tool

scientific article

Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR.

scientific article published on 4 October 2005

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia

scientific article published on 30 August 2011

Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2.

scientific article published on 5 April 2018

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma

scientific article

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

scientific article (publication date: November 2002)

Synergy in science: an interview with Neal Copeland and Nancy Jenkins. Interviewed by Sarah Allan

scientific article published on November 2012

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

scientific article

Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency

scientific article

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

scientific journal article

The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.

scientific article published on 08 July 2009

The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.

scientific article published on 8 September 2010

The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway

scientific journal article

The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation

scientific article published on January 2004

The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background

scientific article

The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue

scientific article published on 27 July 2009

The tetraspanin protein peripherin-2 forms a complex with melanoregulin, a putative membrane fusion regulator

scientific article published on February 2007

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

scientific article published on 11 May 2015

Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients

scientific article

Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes

scientific journal article

Transgenic mice expressing Cre-recombinase specifically in retinal rod bipolar neurons

scientific article published in October 2005

Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification

scientific article published on March 2017

Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma.

scientific article

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression

scientific article published on 5 January 2015

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

scientific article

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells

scientific article

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma

scientific article published on 13 April 2015

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

scholarly article published on 26 March 2013

Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice

scientific article

Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma

scientific article

Visualization and identification of IL-7 producing cells in reporter mice

scientific article

Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality

scientific article published on 20 October 2009

Zfp423 is required for normal cerebellar development

scientific article

Zfp521 Is a Target Gene and Key Effector of Parathyroid Hormone-Related Peptide Signaling in Growth Plate Chondrocytes ⬇️

scientific article published on October 19, 2010

cDNA Cloning, Expression Analysis, and Mapping of the MouseNedd4Gene

article

dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice

scientific journal article

p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia

scientific article

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