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List of works by Margaret von Mehren

A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors

scientific article

A phase I dose-escalation study of danusertib (PHA-739358) administered as a 24-hour infusion with and without granulocyte colony-stimulating factor in a 14-day cycle in patients with advanced solid tumors

scientific article

A phase I study of single-agent nilotinib or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors

scientific article

Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenibvsplacebo in TKI-refractory metastatic GIST

article

Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial

scientific article

Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

scientific article published in January 2018

Adolescent and young adult oncology, version 2.2014.

scientific article

Adolescent and young adult oncology. Clinical practice guidelines in oncology

scientific article published in September 2012

Advances and Challenges on Management of Gastrointestinal Stromal Tumors.

scientific article published on 7 May 2018

An unusual site of metastasis from gastrointestinal stromal tumor ⬇️

scientific article published on December 31, 2010

Analysis of KIT mutations in sporadic and familial gastrointestinal stromal tumors: therapeutic implications through protein modeling

scientific article published in May 2005

Association of Dasatinib With Progression-Free Survival Among Patients With Advanced Gastrointestinal Stromal Tumors Resistant to Imatinib.

scientific article

Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors.

scientific article published on November 2006

Biodistribution and Radiation Dosimetry of the Integrin Marker 18F-RGD-K5 Determined from Whole-Body PET/CT in Monkeys and Humans ⬇️

scientific article published on April 12, 2012

Bone cancer

scientific article

Challenges in the treatment of angiosarcoma: a single institution experience

scientific article published on 15 April 2014

Colorectal cancer vaccines: what we know and what we don't yet know

scientific article

Combination chemotherapy and ALVAC-CEA/B7.1 vaccine in patients with metastatic colorectal cancer

scientific article

Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor

scientific article published in July 2016

Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033.

scientific article published on 09 February 2017

Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncol

scientific article published on 27 October 2008

Correlations between imatinib pharmacokinetics, pharmacodynamics, adherence, and clinical response in advanced metastatic gastrointestinal stromal tumor (GIST): an emerging role for drug blood level testing?

scientific article

Cost effectiveness of imatinib mesylate in the treatment of advanced gastrointestinal stromal tumours

scientific article published in January 2007

Differential expression of cysteine dioxygenase 1 in complex karyotype liposarcomas

scientific article published on 06 April 2014

Distress and Financial Distress in Adults With Cancer: An Age-Based Analysis

scientific article

Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour.

scientific article published on 5 May 2016

Doxorubicin resistance in a novel in vitro model of human pleomorphic liposarcoma associated with alternative lengthening of telomeres

scientific article

Drug repurposing identifies a synergistic combination therapy with imatinib mesylate for gastrointestinal stromal tumor

scientific article

Effective antibody therapy induces host-protective antitumor immunity that is augmented by TLR4 agonist treatment ⬇️

scientific article published on August 13, 2011

Efficacy and Safety of Regorafenib in Patients With Metastatic and/or Unresectable GI Stromal Tumor After Failure of Imatinib and Sunitinib: A Multicenter Phase II Trial ⬇️

scientific article published on May 21, 2012

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

scientific article (publication date: 15 August 2002)

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

scientific article

Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules

scientific article

Efficacy and safety of trabectedin or dacarbazine in patients with advanced uterine leiomyosarcoma after failure of anthracycline-based chemotherapy: Subgroup analysis of a phase 3, randomized clinical trial

scientific article

Efficacy of trabectedin for the treatment of liposarcoma

scientific article published on 12 September 2016

Emerging drugs for the treatment of gastrointestinal stromal tumour

scientific article published on 29 November 2017

Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imaging

scientific article published on 22 April 2014

GIST treatment options after tyrosine kinase inhibitors

scientific article

Gastrointestinal Stromal Tumors

scientific article published on 8 December 2017

Gastrointestinal stromal tumors, version 2.2014.

scientific article published on June 2014

Gastrointestinal stromal tumors: a paradigm for molecularly targeted therapy

scientific article published on January 2003

Gastrointestinal stromal tumors: management of metastatic disease and emerging therapies

scientific article published on October 2013

Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor

scientific article

Head and neck sarcomas: a comprehensive cancer center experience

scientific article published on 15 July 2013

Hepatic safety analysis of trabectedin: results of a pharmacokinetic study with trabectedin in patients with hepatic impairment and experience from a phase 3 clinical trial

scientific article published on 27 November 2017

High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors

scientific article

Imatinib plasma levels are correlated with clinical benefit in patients with unresectable/metastatic gastrointestinal stromal tumors.

scientific article

Imatinib-refractory gastrointestinal stromal tumors: the clinical problem and therapeutic strategies

scientific article

Immunogenicity for CD8+ and CD4+ T cells of 2 formulations of an incomplete freund's adjuvant for multipeptide melanoma vaccines

scientific article

Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors

scholarly article

Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene

scientific article published on 4 March 2018

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

scientific article

Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT.

scientific article

Long-term results of adjuvant imatinib mesylate in localized, high-risk, primary gastrointestinal stromal tumor: ACOSOG Z9000 (Alliance) intergroup phase 2 trial

scientific article

Management of Gastrointestinal Stromal Tumors

scientific article

Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study

scientific article

Mechanisms of mammalian target of rapamycin inhibition in sarcoma: present and future

scientific article published on August 2007

Microscopically positive margins for primary gastrointestinal stromal tumors: analysis of risk factors and tumor recurrence.

scientific article

Molecular Subtypes of KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic

scientific article

Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

scientific article

Molecular mechanisms of action of imatinib mesylate in human ovarian cancer: a proteomic analysis

scientific article published on May 2008

Monoclonal antibody therapy for cancer

scientific article

Multi-platform profiling of over 2000 sarcomas: identification of biomarkers and novel therapeutic targets

scientific article published on May 2015

Multiple mechanisms of telomere maintenance exist in liposarcomas.

scientific article

NCCN Task Force report: optimal management of patients with gastrointestinal stromal tumor (GIST)--expansion and update of NCCN clinical practice guidelines

scientific article published on May 2004

NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors

scientific article

New Therapeutic strategies for soft tissue sarcomas ⬇️

scientific article published on December 1, 2003

New drugs and combinations for the treatment of soft-tissue sarcoma: a review ⬇️

scientific article published on November 23, 2012

New therapeutic approaches for advanced gastrointestinal stromal tumors

scientific article published on February 2009

New therapeutics for soft-tissue sarcomas in adults.

scientific article published in January 2007

New therapies in soft tissue and bone sarcomas

scientific article published on April 1, 2011

Nilotinib: a novel, selective tyrosine kinase inhibitor

scientific article published on April 2011

Other targetable sarcomas

scientific article

Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors

scientific article published on 29 October 2012

Patterns of Chemotherapy Administration in High-Risk Soft Tissue Sarcoma and Impact on Overall Survival

scientific article published on November 2015

Perioperative tyrosine kinase inhibitors for GIST: standard ... or an idea that needs further investigation?

scientific article published on January 2009

Peripheral primitive neuroectodermal tumor of the dura in a 51-year-old woman following intensive treatment for breast cancer

scientific article

Perspective on updated treatment guidelines for patients with gastrointestinal stromal tumors

scientific article

Pharmacotherapy of gastrointestinal stromal tumours

scientific article

Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors

scientific article

Phase 2 Southwest Oncology Group‐directed intergroup trial (S0505) of sorafenib in advanced soft tissue sarcomas ⬇️

scientific article published on July 12, 2011

Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor

scientific article

Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations ⬇️

scientific article published on July 5, 2012

Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase

scientific article published on 10 December 2010

Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma

scientific article

Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1.

scientific article published on April 2007

Phase I study of the safety and pharmacokinetics of trabectedin with docetaxel in patients with advanced malignancies

scientific article published on 20 March 2015

Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665.

scientific article published on January 2009

Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132.

scientific article published on 28 December 2011

Randomized Clinical Trials in Gastrointestinal Stromal Tumors.

scientific article

Randomized multicenter trial of the effects of melanoma-associated helper peptides and cyclophosphamide on the immunogenicity of a multipeptide melanoma vaccine

scientific article

Regorafenib Induces Rapid and Reversible Changes in Plasma Nitric Oxide and Endothelin-1 ⬇️

scientific article published on July 12, 2012

Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors.

scientific article published in August 2003

Role of new chemotherapy agents in soft tissue sarcoma

scientific article published on March 2005

SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma

scientific article

Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib

scientific article published on 8 January 2004

Soft Tissue Sarcoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology

scientific article

Soft Tissue Sarcoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

scientific article published in May 2018

Soft tissue sarcoma clinical practice guidelines in oncology

scientific article published on March 2005

Soft tissue sarcoma, version 2.2012: featured updates to the NCCN guidelines

scientific article

Soft tissue sarcoma, version 2.2014.

scientific article

Succinate dehydrogenase deficiency in a PDGFRA mutated GIST.

scientific article published on 2 August 2017

Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors

scientific article published on 17 May 2013

Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic

scientific article published on 28 December 2016

Targeted therapy with imatinib: hits and misses?

scientific article published on 15 November 2004

Telomerase suppresses formation of ALT-associated single-stranded telomeric C-circles

scientific article published on 15 March 2013

The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors

scientific article published on 07 October 2008

The role of adjuvant and neoadjuvant therapy in gastrointestinal stromal tumors

scientific article

Towards global consensus in the treatment of gastrointestinal stromal tumor

scientific article published on February 2010

ZNF-Mediated Resistance to Imatinib Mesylate in Gastrointestinal Stromal Tumor ⬇️

scientific article published on January 25, 2013

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