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List of works by Thérèse Di Paolo

A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.

scientific article published on 15 March 2016

Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment

scientific article published in January 2002

BDNF levels are not related with levodopa-induced dyskinesias in MPTP monkeys

scientific article published in January 2010

Basal ganglia group II metabotropic glutamate receptors specific binding in non-human primate model of L-Dopa-induced dyskinesias

scientific article published on 16 August 2007

Basal ganglia serotonin 1B receptors in parkinsonian monkeys with L-DOPA-induced dyskinesia

scientific article

Brain α7 nicotinic acetylcholine receptors in MPTP-lesioned monkeys and parkinsonian patients

scientific article published on 30 March 2016

Changes in 5-HT1A receptor binding and G-protein activation in the rat brain after estrogen treatment: comparison with tamoxifen and raloxifene

scientific article

Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy

scientific article

Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications

scientific article published in March 2003

Chronic estrogenic drug treatment increases preproenkephalin mRNA levels in the rat striatum and nucleus accumbens

scientific article published in April 2005

Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys

scientific article published on 10 June 2013

Cut-off phenomenon in the protective effect of alcohols against lysophosphatidylcholine-induced calcium overload

scientific article published on 21 May 2005

DHEA improves symptomatic treatment of moderately and severely impaired MPTP monkeys

scientific article

Defective dentate nucleus GABA receptors in essential tremor

scientific article

Dehydroepiandrosterone (DHEA) such as 17beta-estradiol prevents MPTP-induced dopamine depletion in mice

scientific article published in January 2003

Differential protective properties of estradiol and tamoxifen against methamphetamine-induced nigrostriatal dopaminergic toxicity in mice

scientific article published in January 2005

Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys

scientific article published in February 2006

Dopamine transporter as a marker of neuroprotection in methamphetamine-lesioned mice treated acutely with estradiol

scientific article published on 9 July 2004

ERbeta mediates the estradiol increase of D2 receptors in rat striatum and nucleus accumbens

scientific article

Effect of L-Dopa on metabotropic glutamate receptor 5 in the brain of parkinsonian monkeys

scientific article published in February 2010

Effect of a chronic treatment with 17β-estradiol on striatal dopamine neurotransmission and the Akt/GSK3 signaling pathway in the brain of ovariectomized monkeys

scientific article published on 16 July 2011

Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys

scientific article published on 19 July 2014

Effect of chronic estradiol, tamoxifen or raloxifene treatment on serotonin 5-HT1A receptor

scientific article published in April 2003

Effect of chronic l-DOPA treatment on 5-HT(1A) receptors in parkinsonian monkey brain

scientific article published on 24 August 2012

Effect of estradiol on striatal dopamine activity of female hemiparkinsonian monkeys

scientific article

Effect of estrogen receptor agonists treatment in MPTP mice: evidence of neuroprotection by an ER alpha agonist

scientific article published in December 2004

Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides

scientific article

Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice

scientific article published on 2 October 2017

Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys

scientific article published on 13 January 2010

Effects of ovariectomy and estradiol on acoustic startle responses in rats

scientific article published in December 2002

Effects of progesterone administered after MPTP on dopaminergic neurons of male mice

scientific article published on 9 February 2017

Estradiol and brain serotonin reuptake transporter in long-term ovariectomized parkinsonian monkeys

scientific article

Estradiol and dehydroepiandrosterone potentiate levodopa-induced locomotor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys

scientific article published in June 2003

Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy

scientific article published on 7 December 2010

Estrogen and SERM neuroprotection in animal models of Parkinson's disease

scientific article published on 22 April 2008

Estrogen receptors and gonadal steroids in vulnerability and protection of dopamine neurons in a mouse model of Parkinson's disease

scientific article published on 11 May 2011

Estrogenic modulation of brain activity: implications for schizophrenia and Parkinson's disease.

scientific article

Estrogenic properties of raloxifene, but not tamoxifen, on D2 and D3 dopamine receptors in the rat forebrain

scientific article published in October 2002

Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (Mpp+) towards dopaminergic mesencephalic neurones in primary culture

scientific article published in January 2002

Evidence for Sprouting of Dopamine and Serotonin Axons in the Pallidum of Parkinsonian Monkeys.

scientific article published on 15 May 2018

GPER1-mediated immunomodulation and neuroprotection in the myenteric plexus of a mouse model of Parkinson's disease

scientific article published on 4 June 2015

Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems.

scientific article published on 15 July 2009

Human brain dopamine metabolism in levodopa-induced dyskinesia and wearing-off

scientific article published in June 2004

Implication of GPER1 in neuroprotection in a mouse model of Parkinson's disease

scientific article published on 28 June 2012

Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias

scientific article

Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice

scientific article published on 24 January 2006

In memoriam: Paul J. Bedard, MD PhD (1942-2014).

scientific article published on 31 January 2015

Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias

scientific article published in February 2002

Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias

scientific article published on 19 March 2004

Interaction of adenosine receptors with other receptors from therapeutic perspective in Parkinson's disease

scientific article published on January 2014

Levodopa response motor complications--GABA receptors and preproenkephalin expression in human brain

scientific article

Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease

scientific article published in December 2003

Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of L-Dopa in parkinsonian monkeys

scientific article

MPEP, an mGlu5 receptor antagonist, reduces the development of L-DOPA-induced motor complications in de novo parkinsonian monkeys: biochemical correlates

scientific article published on 31 July 2012

Male/Female differences in neuroprotection and neuromodulation of brain dopamine

scientific article

Membrane cholesterol removal and replenishment affect rat and monkey brain monoamine transporters

scientific article

Metabotropic glutamate receptor type 5 in levodopa-induced motor complications

scientific article published on 29 December 2009

Metabotropic glutamate receptors as therapeutic targets in Parkinson's disease: An update from the last 5 years of research

scientific article published on 4 April 2016

Metabotropic glutamate receptors for Parkinson's disease therapy

scientific article published on 19 June 2013

Modeling dyskinesia in animal models of Parkinson disease

scientific article published on 27 January 2013

Naltrexone in the short-term decreases antiparkinsonian response to l-Dopa and in the long-term increases dyskinesias in drug-naïve parkinsonian monkeys

scientific article published on 29 March 2005

Natural Phytoestrogens

Neuroactive gonadal drugs for neuroprotection in male and female models of Parkinson's disease

scientific article published on 17 December 2015

Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1.

scientific article published on 17 April 2015

Neuroprotective Effect of Progesterone in MPTP-Treated Male Mice

scientific article

Neuroprotective actions of sex steroids in Parkinson's disease

scientific article published on 03 May 2009

Neuroprotective and immunomodulatory effects of raloxifene in the myenteric plexus of a mouse model of Parkinson's disease

scientific article published on 16 August 2016

Non-human primate models of PD to test novel therapies

scientific article published on 8 April 2017

Normalization of GABAA receptor specific binding in the substantia nigra reticulata and the prevention of L-dopa-induced dyskinesias in MPTP parkinsonian monkeys

scientific article published in February 2008

Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover

scientific article published on 07 August 2006

Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid

scientific article published on 25 July 2009

Pharmacological Treatments Inhibiting Levodopa-Induced Dyskinesias in MPTP-Lesioned Monkeys: Brain Glutamate Biochemical Correlates

scientific article

Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice

scientific article

Plasmalogen precursor analog treatment reduces levodopa-induced dyskinesias in parkinsonian monkeys

scientific article published on 11 March 2015

Plasmalogen precursor mitigates striatal dopamine loss in MPTP mice

scientific article

Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys

scientific article published on 26 January 2006

Potentiation of response to low doses of levodopa in MPTP-injected monkeys by chemical unilateral subthalamotomy

scientific article

Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders

scientific article published on 23 July 2010

Prevention of dyskinesia by an NMDA receptor antagonist in MPTP monkeys: effect on adenosine A2A receptors

scientific article

Prevention of levodopa-induced dyskinesias by a selective NR1A/2B N-methyl-D-aspartate receptor antagonist in parkinsonian monkeys: implication of preproenkephalin

scientific article

Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

scientific article

Raloxifene activates G protein-coupled estrogen receptor 1/Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice.

scientific article

Regulation of striatal preproenkephalin mRNA levels in MPTP-lesioned mice treated with estradiol

scientific article

Relevance of the MPTP primate model in the study of dyskinesia priming mechanisms

scientific article

Repurposing sex steroids and related drugs as potential treatment for Parkinson's disease

scientific article published on 9 April 2018

Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complications

scientific article (publication date: December 2007)

Role of estrogen receptors in neuroprotection by estradiol against MPTP toxicity

scientific article

Safinamide reduces dyskinesias and prolongs L-DOPA antiparkinsonian effect in parkinsonian monkeys

scientific article published on 9 February 2013

Selective estrogen receptor-alpha but not -beta agonist treatment modulates brain alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

scientific article published in October 2006

Sex and temporally-dependent effects of methamphetamine toxicity on dopamine markers and signaling pathways

scientific article published on 21 February 2012

Sex differences in methamphetamine toxicity in mice: effect on brain dopamine signaling pathways

scientific article published on 13 January 2011

Signaling pathways mediating the neuroprotective effects of sex steroids and SERMs in Parkinson's disease

scientific article published on March 2012

Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors

scientific article published on 16 February 2018

Steroids-dopamine interactions in the pathophysiology and treatment of CNS disorders

scientific article published on June 2010

Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys

scientific article published on 16 December 2009

Subthalamotomy in the treatment of Parkinson's disease: clinical aspects and mechanisms of action

scientific article

Subthalamotomy-induced changes in dopamine receptors in parkinsonian monkeys

scientific article

Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity

scientific article published on 14 July 2007

The 5α-reductase inhibitor Dutasteride but not Finasteride protects dopamine neurons in the MPTP mouse model of Parkinson's disease

scientific article

The number of striatal cholinergic interneurons expressing calretinin is increased in parkinsonian monkeys

scientific article

The plasmalogen precursor analog PPI-1011 reduces the development of L-DOPA-induced dyskinesias in de novo MPTP monkeys

scientific article

Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias

scientific article

mGlu5, Dopamine D2 and Adenosine A2A Receptors in L-DOPA-induced Dyskinesias

scientific article

mGluR5 metabotropic glutamate receptors and dyskinesias in MPTP monkeys

scientific article published on 13 March 2007

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