Search filters

List of works by Donald F Smee

(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).

scientific article published on 21 February 2010

2'-Fluoro-2'-deoxycytidine is a broad-spectrum inhibitor of bunyaviruses in vitro and in phleboviral disease mouse models

scientific article published on 16 October 2018

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

scientific article

A heterocyclic molecule with significant activity against dengue virus

scientific article

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

scientific article (publication date: 20 December 2009)

A recombinant, infectious human parainfluenza virus type 3 expressing the enhanced green fluorescent protein for use in high-throughput antiviral assays

scientific article published on 2 February 2009

A review of compounds exhibiting anti-orthopoxvirus activity in animal models

scientific article

A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses

scientific article

Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice

scientific article

Activities of oseltamivir and ribavirin used alone and in combination against infections in mice with recent isolates of influenza A (H1N1) and B viruses

scientific article published in January 2006

Activity of T-705 in a Hamster Model of Yellow Fever Virus Infection in Comparison with That of a Chemically Related Compound, T-1106

scientific article

Activity of a Phenolic Dibenzylsulfide against New World Arenavirus Infections ⬇️

scientific article published on January 29, 2014

Activity of isatine-sulfadimidine derivatives against 2009 pandemic H1N1 influenza virus in cell culture.

scientific article

Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever

scientific article

An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses

scientific article published on 10 January 2017

Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides

scientific article published in January 2004

Anti-influenza virus activities of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N-(4,6-dimethyl-2-pyrimidin-2-yl)benzenesulphonamide and its derivatives

scientific article published in January 2006

Antiviral Research - 15th International Conference. HBV and HCV therapies. 17-21 March 2002, Prague, Czech Republic.

scientific article published in May 2002

Antiviral Research--16th International Congress: HBV and HCV. 27 April-1 May 2003, Savannah, GA, USA.

scientific article published in June 2003

Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus

scientific article published in January 2008

Antivirally active ribavirin analogues--4,5-disubstituted 1,2,3-triazole nucleosides: biological evaluation against certain respiratory viruses and computational modelling

scientific article published on 29 January 2014

BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model

scientific article

Broad-spectrum inhibitor of viruses in the Flaviviridae family

scientific article published on 28 July 2005

C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection

scientific article (publication date: June 2008)

Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice

scientific article published on 5 May 2006

Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice

scientific article

Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses

scientific article

Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin

scientific article

Combinations of L-NG-monomethyl-arginine and oseltamivir against pandemic influenza A virus infections in mice

scientific article

Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice ⬇️

scientific article published on March 10, 2012

Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice

scientific article

Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters.

scientific article published on January 2006

Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice

scientific article

Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds

scientific article published in October 2002

Comparison of three dimensional synergistic analyses of percentage versus logarithmic data in antiviral studies

scientific article

Correlation between breakdown of the blood–brain barrier and disease outcome of viral encephalitis in mice

scientific article

Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication

scientific article published on January 2002

D282, a Non-Nucleoside Inhibitor of Influenza Virus Infection that Interferes with de novo Pyrimidine Biosynthesis ⬇️

scientific article published on August 21, 2012

Development of a New Tacaribe Arenavirus Infection Model and Its Use to Explore Antiviral Activity of a Novel Aristeromycin Analog ⬇️

scientific article published on September 16, 2010

Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment

scientific article published on 21 February 2008

Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen

scientific article

Effect of T-705 treatment on western equine encephalitis in a mouse model

scientific article (publication date: June 2009)

Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models

scientific article

Effective Oral Favipiravir (T-705) Therapy Initiated after the Onset of Clinical Disease in a Model of Arenavirus Hemorrhagic Fever ⬇️

scientific article published on October 11, 2011

Effects of TheraMax on Influenza Virus Infections in Cell Culture and in Mice ⬇️

scientific article published on July 4, 2011

Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection

scientific article published on 30 May 2006

Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice

scientific article published on 09 March 2009

Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice

scientific article published in May 2004

Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses

scientific article

Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice

scientific article

Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model

scientific article

Efficacy of Combined Therapy with Amantadine, Oseltamivir, and Ribavirin In Vivo against Susceptible and Amantadine-Resistant Influenza A Viruses ⬇️

scientific article published on January 23, 2012

Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus

scientific article

Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models

scientific article

Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice

scientific article published on 28 December 2006

Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents

scientific article

Enhanced efficacy of cidofovir combined with vaccinia immune globulin in treating progressive cutaneous vaccinia virus infections in immunosuppressed hairless mice

scientific article

Error-prone replication of West Nile virus caused by ribavirin

scientific article

Evaluation of antiviral therapies in respiratory and neurological disease models of Enterovirus D68 infection in mice

scientific article published on 31 October 2018

Evaluation of cell viability dyes in antiviral assays with RNA viruses that exhibit different cytopathogenic properties

scientific article published on 27 March 2017

Evaluation of imiquimod for topical treatment of vaccinia virus cutaneous infections in immunosuppressed hairless mice ⬇️

scientific article published on March 23, 2011

Exacerbation of Influenza Virus Infections in Mice by Intranasal Treatments and Implications for Evaluation of Antiviral Drugs ⬇️

scientific article published on October 1, 2012

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

scientific article

Identification of active antiviral compounds against a New York isolate of West Nile virus

scientific article

Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly

scientific article

Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand

scholarly article

In vitro activity of favipiravir and neuraminidase inhibitor combinations against oseltamivir-sensitive and oseltamivir-resistant pandemic influenza A (H1N1) virus.

scientific article

In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections ⬇️

scientific article published on September 8, 2011

Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice

scientific article published on 9 March 2010

Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor

scientific article

Influenza Virus H1N1 inhibition by serine protease inhibitor (serpin) antithrombin III

scientific article

Inhibition of Influenza a Virus Replication by Antagonism of a PI3K-AKT-mTOR Pathway Member Identified by Gene-Trap Insertional Mutagenesis ⬇️

scientific article published on May 14, 2012

Inhibition of adenovirus serotype 14 infection by octadecyloxyethyl esters of (S)-[(3-hydroxy-2-phosphonomethoxy)propyl]- nucleosides in vitro

scientific article published on 07 August 2018

Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin

scientific article

Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine

scientific article published in January 2004

Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand

scientific article

Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells

scientific article published on 10 April 2008

Interferon alfacon-1 protects hamsters from lethal pichinde virus infection

scientific article

Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells

scientific article

Isolation and identification of compounds from Kalanchoe pinnata having human alphaherpesvirus and vaccinia virus antiviral activity.

scientific article published on December 2017

Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice

scientific article published on 14 April 2010

Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses ⬇️

scientific article

Maporal Virus as a Surrogate for Pathogenic New World Hantaviruses and its Inhibition by Favipiravir ⬇️

scientific article published on May 12, 2011

Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders

scientific article published on 9 January 2008

Methods for evaluation of antiviral efficacy against influenza virus infections in animal models

scientific article published on January 2013

Mutations in influenza virus M1 CCHH, the putative zinc finger motif, cause attenuation in mice and protect mice against lethal influenza virus infection

scientific article

Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype

scientific article

Neutralizing Viruses in Suspensions by Copper Oxide-Based Filters

scientific article (publication date: July 2007)

Novel 3-sulphonamido-quinazolin-4(3H)-one derivatives: microwave-assisted synthesis and evaluation of antiviral activities against respiratory and biodefense viruses

scientific article

Orthopoxvirus inhibitors that are active in animal models: an update from 2008 to 2012.

scientific article published on September 2013

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication

scientific article

Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza

scientific article (publication date: June 2002)

Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin

scientific article

Progress in the discovery of compounds inhibiting orthopoxviruses in animal models

scientific article published on January 2008

Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes

scientific article published on 06 January 2006

Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters

scientific article

Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.

scientific article

Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds

scientific article published on 07 April 2016

Synergistic combinations of favipiravir and oseltamivir against wild-type pandemic and oseltamivir-resistant influenza A virus infections in mice.

scientific article

Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones

scientific article published on 6 June 2013

Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and ha

scientific article

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections.

scientific article

T-705 (favipiravir) inhibition of arenavirus replication in cell culture

scientific article

The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice

scientific article published on 7 March 2016

The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses

scientific article

The use of plethysmography in determining the severity of lung pathology in a mouse model of minimally lethal influenza virus infection

scientific article published on 14 May 2014

Therapy and Long-Term Prophylaxis of Vaccinia Virus Respiratory Infections in Mice with an Adenovirus-Vectored Interferon Alpha (mDEF201) ⬇️

scientific article published on October 13, 2011

Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice

scientific article published on 3 August 2004

Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances

scientific article published on 12 May 2011

Treatment of Venezuelan equine encephalitis virus infection with (−)-carbodine

scientific article

Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

scientific article

Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin

scientific article

Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug

scientific article

Treatment of mannan-enhanced influenza B virus infections in mice with oseltamivir, ribavirin and viramidine

scientific article published in September 2004

Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents ⬇️

scientific article published on July 15, 2012

Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro

scientific article

Triple combination of oseltamivir, amantadine, and ribavirin displays synergistic activity against multiple influenza virus strains in vitro.

scientific article

Use of plethysmography in assessing the efficacy of antivirals in a mouse model of pandemic influenza A virus

scientific article published on August 17, 2011

Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control

scientific article

Paulina is supported by:

About Paulina

Help