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List of works by David I Watkins

A dominant role for CD8+-T-lymphocyte selection in simian immunodeficiency virus sequence variation

scientific article published on December 2004

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

scientific article

A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques

scientific article

A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules

scientific article

A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge

scientific article

AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape

scientific article

Acute HIV infection with rapid progression to AIDS.

scientific article

Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection

scientific article published in May 2002

Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes

scientific article published on January 2005

Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing Gag

scientific article

Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications

scientific article published on 3 May 2005

Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers

scientific article

Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L

scientific article

CD8 + T Cell Recognition of Cryptic Epitopes Is a Ubiquitous Feature of AIDS Virus Infection ⬇️

scientific article published on August 25, 2010

CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmission

scientific article published on 28 September 2011

CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation

scientific article published on 14 November 2007

CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too little

scientific article

CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

scientific article

Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons

scientific article published on 16 March 2016

Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity

scientific article

Characterization of the peptide-binding specificity of Mamu-B*17 and identification of Mamu-B*17-restricted epitopes derived from simian immunodeficiency virus proteins

scientific article

Chinese origin rhesus macaque major histocompatibility complex class I molecules promiscuously present epitopes from SIV associated with molecules of Indian origin; implications for immunodominance and viral escape

scientific article

Comparison of vaccine strategies using recombinant env-gag-pol MVA with or without an oligomeric Env protein boost in the SHIV rhesus macaque model

scientific article

Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL.

scientific article

Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques

scientific article published on 2 April 2008

Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hosts

scientific article

Cytotoxic Capacity of SIV-Specific CD8+ T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques ⬇️

scientific article published on February 28, 2013

Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial

scientific article

Cytotoxic T-lymphocyte escape monitoring in simian immunodeficiency virus vaccine challenge studies

scientific article published in September 2002

DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4⁺ T cells, but few subdominant epitope-specific CD8⁺ T cells

scientific article

Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys

scientific article published on 24 July 2017

Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaques

scientific article published on September 2011

Differences between T cell epitopes recognized after immunization and after infection

scientific article published on October 2002

Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein

scientific article published on 2 July 2008

Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection

scientific article

Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic

scientific article

Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection

scientific article

Efficacy of multivalent adenovirus-based vaccine against simian immunodeficiency virus challenge

scientific article

Escape from CD8(+) T cell responses in Mamu-B*00801(+) macaques differentiates progressors from elite controllers

scientific article published on 02 March 2012

Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?

scientific article

Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication

scientific article

Extraepitopic compensatory substitutions partially restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic-T-lymphocyte response

scientific article published on March 2004

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques.

scientific article published on 24 April 2018

Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection

scholarly article

Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression

scientific article published in March 2007

GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo

scientific article published in 2011

Genomic epidemiology reveals multiple introductions of Zika virus into the United States ⬇️

scientific article

HIV and SIV CTL escape: implications for vaccine design

scientific article published in August 2004

HIV pathogenesis: the first cut is the deepest

scientific article published in May 2005

HIV vaccine design: insights from live attenuated SIV vaccines

scientific article

Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Basic HIV vaccine development.

scientific article

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo ⬇️

scientific article published on October 25, 2012

Identification of seventeen new simian immunodeficiency virus-derived CD8+ T cell epitopes restricted by the high frequency molecule, Mamu-A*02, and potential escape from CTL recognition

scientific article published in October 2004

Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression f

article

Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques.

scientific article published on 11 April 2007

Immunogenicity of seven new recombinant yellow fever viruses 17D expressing fragments of SIVmac239 Gag, Nef, and Vif in Indian rhesus macaques

scientific article

Impact of MHC class I diversity on immune control of immunodeficiency virus replication

scientific article

Improved genetic stability of recombinant yellow fever 17D virus expressing a lentiviral Gag gene fragment

scientific article published on 08 February 2014

Induction of anti-simian immunodeficiency virus cellular and humoral immune responses in rhesus macaques by peptide immunogens: correlation of CTL activity and reduction of cell-associated but not plasma virus load following challenge ⬇️

scientific article published on January 1, 2002

Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques

scientific article

Is an HIV vaccine possible?

scientific article published in August 2009

Localized populations of CD8 MHC class I tetramer SIV-specific T cells in lymphoid follicles and genital epithelium

scientific article

Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after nonsterile protection by a cytotoxic T-lymphocyte-based vaccine

scientific article published on 7 March 2007

MHC polymorphism: AIDS susceptibility in non-human primates

scientific article

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus

scientific article published on 06 October 2008

Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge

scientific article

Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses

scientific article published on August 2003

Mamu-B*08-positive macaques control simian immunodeficiency virus replication

scientific article

Multiple introductions of Zika virus into the United States revealed through genomic epidemiology

scientific article

Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.

scientific article

Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing

scientific article

Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species

scientific article

Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans

scientific article published on June 2008

Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication

scientific article published on 29 November 2006

Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes

scientific article published on 15 July 2009

Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL.

scientific article published on 21 December 2017

Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication

scientific article

Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation

scientific article

Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques

scientific article published on 10 November 2006

Potent Plasmablast-Derived Antibodies Elicited by the National Institutes of Health Dengue Vaccine

scientific article published on 6 September 2017

Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection

scientific article

Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine

scientific article

Prior Dengue virus exposure shapes T cell immunity to Zika virus in humans

scientific article published on 4 October 2017

Protection against High-Dose Highly Pathogenic Mucosal SIV Challenge at Very Low Serum Neutralizing Titers of the Antibody-Like Molecule CD4-IgG2 ⬇️

scientific article published on July 27, 2012

Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection

scientific article published on 06 April 2009

Public health. A sound rationale needed for phase III HIV-1 vaccine trials

scientific article

Pyrosequencing reveals restricted patterns of CD8+ T cell escape-associated compensatory mutations in simian immunodeficiency virus

scientific article published on 12 October 2011

Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost

scientific article

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque

scientific article published on 13 May 2017

Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequences

scientific article

Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques

scientific article

Reduction of CD4+T CellsIn VivoDoes Not Affect Virus Load in Macaque Elite Controllers ⬇️

scientific article published on May 18, 2011

Relevance of studying T cell responses in SIV-infected rhesus macaques

scientific article published on 27 October 2008

Repeated low-dose mucosal simian immunodeficiency virus SIVmac239 challenge results in the same viral and immunological kinetics as high-dose challenge: a model for the evaluation of vaccine efficacy in nonhuman primates

scientific article published on March 2004

Reversion of CTL escape–variant immunodeficiency viruses in vivo

article

Rhesus Macaques Vaccinated with , , and Manifest Early Control of SIVmac239 Replication

scholarly article by Mauricio A Martins et al published 15 August 2018 in Journal of Virology

Robust, vaccine-induced CD8(+) T lymphocyte response against an out-of-frame epitope

scientific article

Simian T Lymphotropic Virus 1 Infection of Papio anubis: tax Sequence Heterogeneity and T Cell Recognition

scientific article

Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid

scientific article

Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication

scientific article published on 24 January 2007

Synchronous infection of SIV and HIV in vitro for virology, immunology and vaccine-related studies

scientific article published on 21 January 2010

T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challenge

scientific article

Tat(28-35)SL8-specific CD8+ T lymphocytes are more effective than Gag(181-189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay

scientific article

Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

scientific article

The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge

scientific article

The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape

scientific article published on 27 December 2006

The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication

scientific article

The hope for an HIV vaccine based on induction of CD8+ T lymphocytes--a review

scientific article

The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques--implications for recombinant vaccine design

scientific article

The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers

scientific article

The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages

scientific article published on 8 February 2012

The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion.

scientific article

The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infection

scientific article

The role of MHC class I gene products in SIV infection of macaques

scientific article

Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity

scientific article

Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses ⬇️

scientific article published on May 1, 2011

Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication

scientific article

Unparalleled complexity of the MHC class I region in rhesus macaques

scientific article

Update on progress in HIV vaccine development ⬇️

scientific article published on June 1, 2012

Use of a Recombinant Gamma-2 Herpesvirus Vaccine Vector against Dengue Virus in Rhesus Monkeys

scientific article published on 7 June 2017

Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239

scientific article

Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection

scientific article

Vaccine-induced CD8+ T cells control AIDS virus replication

scientific article published on 30 September 2012

Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239

scientific article

Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge

scientific article published on 29 April 2009

Viremia control following antiretroviral treatment and therapeutic immunizationduring primary SIV251 infection of macaques

article

Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus

scientific article published on May 2008

What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Rigorous Simian Immunodeficiency Virus Vaccine Trials Can Be Instructive

scientific article published on 27 March 2017

Within-host evolution of CD8+-TL epitopes encoded by overlapping and non-overlapping reading frames of simian immunodeficiency virus

scientific article

Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice

scholarly article by Byoung-Shik Shim et al published 2 July 2019 in mBio

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

scientific article

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