List of works - Manuela Neumann

A harmonized classification system for FTLD-TDP pathology

scientific article

A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition

scientific article

A new subtype of frontotemporal lobar degeneration with FUS pathology

scientific article

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

scientific article

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration

scientific article

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease

scientific article

Advances in understanding the molecular basis of frontotemporal dementia

scientific article published on 26 June 2012

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice

scientific article published on 26 July 2006

An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies

scientific article published on 22 March 2006

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.

scientific article

Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers

scientific article published on 2 May 2014

Beta-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

scientific article published in August 2003

Body mass index is associated with biological CSF markers of core brain pathology in Alzheimer's disease

scientific article published on 13 January 2012

Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease.

scientific article published in August 2005

Clinical and pathological continuum of multisystem TDP-43 proteinopathies

scientific article published on February 2009

Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations.

scientific article published in August 2007

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

scientific article

Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies

scientific article published on June 2008

Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment

scientific article published in March 2005

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia

scientific article

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

scientific article published on 6 October 2013

Distinct pathological subtypes of FTLD-FUS.

scientific article

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions

scientific article published on 11 July 2008

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

scientific article published on 5 June 2008

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

scientific article published on 21 January 2009

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy

scientific article

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations

scientific article

FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis

scientific article published on 13 December 2011

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration

scientific article

FUS pathology in basophilic inclusion body disease

scientific article

Frontotemporal dementia: from molecular mechanisms to therapy.

scientific article published in August 2016

Frontotemporal lobar degeneration: demographic characteristics of 353 patients

scientific article published on June 2005

Fused in Sarcoma Neuropathology in Neurodegenerative Disease

scientific article published on 17 January 2017

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

scientific article

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

scientific article published on 24 May 2002

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

scientific article

Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype

scientific article published on 26 July 2012

Malignant optic glioma - the spectrum of disease in a case series

scientific article published on 26 May 2015

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

scientific article

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

scientific article

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.

scientific article published on 5 November 2007

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

scientific article

Molecular neuropathology of TDP-43 proteinopathies

scientific article published on 09 January 2009

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

scientific article published on 15 June 2016

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.

scientific article published on 19 February 2016

Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS.

scientific article published on 28 April 2013

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

scientific article published on 9 June 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

scientific article published on 20 July 2016

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

scientific article

Neuropathological background of phenotypical variability in frontotemporal dementia

scientific article published on 26 May 2011

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

scientific article

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

scientific article published on 18 November 2008

Novel PS1 mutation in a Bavarian kindred with familial Alzheimer disease.

scientific article published in October 2004

Novel cases of amyotrophic lateral sclerosis after treatment of cerebral arteriovenous malformationss

scientific article

Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43.

scientific article published on 21 May 2011

Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy

scientific article published on March 2005

PART is part of Alzheimer disease

scientific article

Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis

scientific article published on 18 October 2016

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation

scientific article published on 21 May 2011

Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies

scientific article published on October 2006

Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease

scientific article published on 26 February 2004

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

scientific article published on 06 January 2009

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

scientific article

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers

scientific article published on 15 September 2015

Reappraisal of TDP-43 pathology in FTLD-U subtypes

scientific article published on 2 May 2017

Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.

scientific article published in December 2004

Reply: PRKAR1B mutations are a rare cause of FUS negative neuronal intermediate filament inclusion disease

scientific article published on 19 November 2014

Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43)

scientific article published on 4 May 2012

Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

scientific article

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

scientific article published on 7 April 2008

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

scientific article

TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.

scientific article published on 18 December 2007

TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis

scientific article

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions

scientific article published in July 2007

TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations

scientific article published in February 2007

TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.

scientific article

TDP-43 pathology and cognition in ALS: A prospective clinicopathologic correlation study

scientific article published on 3 August 2016

TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis

scientific article published on October 2007

TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease

scientific article

TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions

scientific article published in March 2007

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

scientific article published on 19 January 2014

Tau protein, Abeta42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies

scientific article published on 5 January 2005

The 20S proteasome isolated from Alzheimer's disease brain shows post-translational modifications but unchanged proteolytic activity

scientific article published on 5 February 2007

The amyloid-beta (Abeta) peptide pattern in cerebrospinal fluid in Alzheimer's disease: evidence of a novel carboxyterminally elongated Abeta peptide

scientific article published in January 2003

The molecular basis of frontotemporal dementia

scientific article published on 29 July 2009

The neuropathology associated with repeat expansions in the C9ORF72 gene

scientific article published on 20 December 2013

The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration

scientific article

Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome

scientific article

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone

scientific article published on 10 February 2010

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations

scientific article published on 28 July 2012

Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations

scientific article published on September 2008

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

scientific article

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

scientific article published on 5 February 2013

List of works by Manuela Neumann

A harmonized classification system for FTLD-TDP pathology

A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition

A new subtype of frontotemporal lobar degeneration with FUS pathology

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease

Advances in understanding the molecular basis of frontotemporal dementia

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice

An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.

Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers

Beta-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

Body mass index is associated with biological CSF markers of core brain pathology in Alzheimer's disease

Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease.

Clinical and pathological continuum of multisystem TDP-43 proteinopathies

Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations.

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies

Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

Distinct pathological subtypes of FTLD-FUS.

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations

FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration

FUS pathology in basophilic inclusion body disease

Frontotemporal dementia: from molecular mechanisms to therapy.

Frontotemporal lobar degeneration: demographic characteristics of 353 patients

Fused in Sarcoma Neuropathology in Neurodegenerative Disease

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype

Malignant optic glioma - the spectrum of disease in a case series

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

Molecular neuropathology of TDP-43 proteinopathies

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.

Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS.

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

Neuropathological background of phenotypical variability in frontotemporal dementia

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

Novel PS1 mutation in a Bavarian kindred with familial Alzheimer disease.

Novel cases of amyotrophic lateral sclerosis after treatment of cerebral arteriovenous malformationss

Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43.

Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy

PART is part of Alzheimer disease

Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation

Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies

Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers

Reappraisal of TDP-43 pathology in FTLD-U subtypes

Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.

Reply: PRKAR1B mutations are a rare cause of FUS negative neuronal intermediate filament inclusion disease

Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43)

Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.

TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions

TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations

TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.

TDP-43 pathology and cognition in ALS: A prospective clinicopathologic correlation study

TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis

TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease