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List of works by Yee-Sin Leo

423. Ten-Year Experience of Burkholderia pseudomallei Infections in a Singapore Tertiary Hospital

A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach

scientific article published on 06 June 2017

A prospective case-control study to investigate retinal microvascular changes in acute dengue infection

scientific article

A prospective observational study of the prevalence and risk factors for colonization by antibiotic resistant bacteria in patients at admission to hospital in Singapore

scientific article

Accuracy and User-Acceptability of HIV Self-Testing Using an Oral Fluid-Based HIV Rapid Test ⬇️

scientific article published on September 17, 2012

Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: challenges in determining a SARS diagnosis

scientific article

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity

scientific article published on 30 January 2018

Assessing Sensitivity and Specificity of Surveillance Case Definitions for Zika Virus Disease

scientific article (publication date: April 2017)

Assessing changes in knowledge, attitude and practices on dengue diagnosis and management among primary care physicians after the largest dengue epidemic in Singapore

scientific article

Association Between Increased Vascular Nitric Oxide Bioavailability and Progression to Dengue Hemorrhagic Fever in Adults

scientific article published on 2 March 2015

Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2

scientific article published on 27 May 2021

Asymptomatic SARS coronavirus infection among healthcare workers, Singapore

scientific article

Blood pressure trend in hospitalized adult dengue patients

scientific article published on 01 July 2020

COVID-19 in Singapore-Current Experience: Critical Global Issues That Require Attention and Action

scientific article published on 20 February 2020

Causes of death and factors associated with early death among human immunodeficiency virus (HIV)-infected persons in Singapore: pre-highly active antiretroviral therapy (HAART) and Peri-HAART.

scientific article published on December 2012

Causes of death in hospitalised HIV-infected patients at a National Referral Centre in Singapore: a retrospective review from 2008 to 2010.

scientific article published on December 2012

Challenges in dengue fever in the elderly: atypical presentation and risk of severe dengue and hospital-acquired infection [corrected].

scientific article

Chikungunya Outbreak, Singapore, 2008

scientific article published in May 2009

Clinical and epidemiological predictors of transmission in Severe Acute Respiratory Syndrome (SARS).

scientific article

Clinical and laboratory findings of SARS in Singapore.

scientific article

Clinical evaluation of a low cost, in-house developed real-time RT-PCR human immunodeficiency virus type 1 (HIV-1) quantitation assay for HIV-1 infected patients

scientific article

Clinical evaluation of an in-house human immunodeficiency virus (HIV) genotyping assay for the detection of drug resistance mutations in HIV-1 infected patients in Singapore

scientific article published on December 1, 2012

Clinical features of patients with Zika and dengue virus co-infection in Singapore

scientific article published on 23 March 2017

Clinical outcome and genetic differences within a monophyletic Dengue virus type 2 population

scientific article

Clinical relevance and discriminatory value of elevated liver aminotransferase levels for dengue severity

scientific article

Comparability of different methods for estimating influenza infection rates over a single epidemic wave

scientific article

Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study

scientific article

Correlation of clinical illness with viremia in Zika virus disease during an outbreak in Singapore.

scientific article

Critical care for dengue in adult patients: an overview of current knowledge and future challenges

scientific article published on October 2016

Current and nano-diagnostic tools for dengue infection

scientific article published on June 1, 2011

Current management of severe dengue infection

scientific article

Decision Tree Algorithms Predict the Diagnosis and Outcome of Dengue Fever in the Early Phase of Illness

scientific article

Dengue in the elderly: a review

scientific article

Dengue knowledge, attitudes, and practices among primary care physicians in Singapore

scientific article published on December 2011

Dengue research in Singapore marking the inaugural ASEAN Dengue Day

scientific article published on December 1, 2011

Dengue serotype cross-reactive, anti-e protein antibodies confound specific immune memory for 1 year after infection

scientific article

Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, singapore

scientific article published on 30 March 2015

Dengue virus activates polyreactive, natural IgG B cells after primary and secondary infection

scientific article

Derivation and validation of an accurate estimation of CD4 counts from the absolute lymphocyte count in virologically suppressed and immunologically reconstituted HIV infected adults

scientific article published on 13 August 2015

Detection of viral respiratory pathogens in mild and severe acute respiratory infections in Singapore

scientific article published on 20 February 2017

Development and evaluation of baculovirus-expressed Chikungunya virus E1 envelope proteins for serodiagnosis of Chikungunya infection

scientific article published on 29 May 2014

Development of standard clinical endpoints for use in dengue interventional trials: introduction and methodology

article

Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study

scientific article

Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: A matched case-control study

scientific article

Diagnosing dengue at the point-of-care: utility of a rapid combined diagnostic kit in Singapore

scientific article

Diagnostic Accuracy of Parameters for Zika and Dengue Virus Infections, Singapore

scientific article published in December 2017

Differences in clinical and psychiatric outcomes between prevalent HIV-1 molecular subtypes in a multiethnic Southeast Asian sample

scientific article published on 30 July 2015

Differential clinical outcome of dengue infection among patients with and without HIV infection: a matched case-control study

scientific article published on 30 March 2015

Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

scientific article published on 21 July 2020

Discovery and Validation of Prognostic Biomarker Models to Guide Triage among Adult Dengue Patients at Early Infection

scientific article

Early Dengue infection and outcome study (EDEN) - study design and preliminary findings.

scientific article published on November 2006

Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection

scientific article published on March 2012

Early clearance of Chikungunya virus in children is associated with a strong innate immune response

scientific article published on 16 May 2016

Early clinical and laboratory risk factors of intensive care unit requirement during 2004-2008 dengue epidemics in Singapore: a matched case-control study

scientific article

Early diagnosis of dengue disease severity in a resource-limited Asian country

scientific article

Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein

scientific article

Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore

scientific article

Economics of neuraminidase inhibitor stock piling for pandemic influenza, Singapore

scientific article

Effects of early oseltamivir therapy on viral shedding in 2009 pandemic influenza A (H1N1) virus infection.

scientific article

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial

scientific article

Emergence of oseltamivir-resistant pandemic (H1N1) 2009 virus within 48 hours

scientific article

Entomologic and virologic investigation of Chikungunya, Singapore

scientific article

Epidemiological risk factors for adult dengue in Singapore: an 8-year nested test negative case control study

scientific article

Epidemiology and Relative Severity of Influenza Subtypes in Singapore in the Post-Pandemic Period from 2009 to 2010.

scientific article published on 23 September 2017

Epidemiology of travel-associated pandemic (H1N1) 2009 infection in 116 patients, Singapore.

scientific article

Ertapenem for treatment of extended-spectrum beta-lactamase-producing and multidrug-resistant gram-negative bacteraemia

scientific article published in October 2008

Evaluation of Chikungunya diagnostic assays: differences in sensitivity of serology assays in two independent outbreaks

scientific article

Evaluation of the NS1 Rapid Test and the WHO Dengue Classification Schemes for Use as Bedside Diagnosis of Acute Dengue Fever in Adults ⬇️

scientific article published on February 1, 2011

Evaluation of universal methicillin-resistant Staphylococcus aureus screening using nasal polymerase chain reaction compared with nasal, axilla, and groin and throat and perianal cultures in a hospital setting.

scientific article

Factors influencing infection by pandemic influenza A(H1N1)pdm09 over three epidemic waves in Singapore.

scientific article

Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

scientific article

Group B Streptococcus Sequence Type 283 Disease Linked to Consumption of Raw Fish, Singapore

scientific article

Haemorrhagic fever with renal syndrome in Singapore

scientific article published in May 2013

Healthcare workers and HIV health issues

scientific article published on July 2008

High Yield of HIV Testing in Dengue-Like Febrile Illness in Singapore

article

High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore

scientific article

Higher risk of infection with dengue at the weekend among male Singaporeans

scientific article

IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity

scientific article (publication date: 2009)

Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates

scientific article published on 23 September 2011

Immunogenicity and safety of recombinant tetravalent dengue vaccine (CYD-TDV) in individuals aged 2-45 y: Phase II randomized controlled trial in Singapore

scientific article published on 16 August 2012

Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.

scientific article

Implications of discordance in world health organization 1997 and 2009 dengue classifications in adult dengue

scientific article

Imported chloroquine-resistant Plasmodium vivax in Singapore: case report and literature review.

scientific article

Improving the clinical diagnosis of influenza--a comparative analysis of new influenza A (H1N1) cases

scientific article

Increased rate of CD4+ T-cell decline and faster time to antiretroviral therapy in HIV-1 subtype CRF01_AE infected seroconverters in Singapore

scientific article

Influenza disease burden in adults by subtypes following the initial epidemic of pandemic H1N1 in Singapore ⬇️

scientific article published on August 31, 2011

Influenza excess mortality from 1950-2000 in tropical Singapore.

scientific article

Investigational use of ribavirin in the treatment of severe acute respiratory syndrome, Singapore, 2003.

scientific article

Laboratory-Acquired Severe Acute Respiratory Syndrome

scientific article (publication date: 22 April 2004)

Lack of efficacy of prophylactic platelet transfusion for severe thrombocytopenia in adults with acute uncomplicated dengue infection

scientific article

Longitudinal analysis of the human antibody response to Chikungunya virus infection: implications for serodiagnosis and vaccine development

scientific article

Longitudinal study of cellular and systemic cytokines signatures define the dynamics of a balanced immune environment in disease manifestation in Zika virus-infected patients

scientific article published on 16 April 2018

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response

scientific article

Low antibody titers 5 years after vaccination with the CYD-TDV dengue vaccine in both pre-immune and naïve vaccinees

scientific article published on 18 February 2016

MDR TB transmission, Singapore

scientific article published in July 2013

Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection

scientific article published on October 2013

Mapping infectious disease hospital surge threats to lessons learnt in Singapore: a systems analysis and development of a framework to inform how to DECIDE on planning and response strategies

scientific article published on 4 September 2017

Membrane feeding of dengue patient's blood as a substitute for direct skin feeding in studying Aedes-dengue virus interaction

scientific article

Molecular characterization of immunoglobulin (Ig) genes reveals that plasmablasts generated during heterologous secondary dengue infections and circulating memory B cells after recovery are of distinct origin

article

Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01_AE/B recombinant forms

scientific article

Naturally acquired human Plasmodium knowlesi infection, Singapore

scientific article

Neurology of the H1N1 pandemic in Singapore: a nationwide case series of children and adults.

scientific article

Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients

scholarly article by Siti Naqiah Amrun et al published 2019 in Clinical & translational immunology

Older age at initial presentation to human immunodeficiency virus (HIV) care and treatment at the Communicable Disease Centre (CDC) in Singapore, 2006 to 2011.

scientific article published in December 2012

Opt-out of voluntary HIV testing: a Singapore hospital's experience

scientific article

Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

scientific article published on 18 August 2021

Pandemic (H1N1) 2009 influenza in HIV-infected adults: clinical features, severity, and outcome

scientific article published on 11 August 2010

Pandemic (H1N1) 2009 surveillance and prevalence of seasonal influenza, Singapore

scientific article

Pandemic (H1N1) 2009: clinical and laboratory findings of the first fifty cases in Singapore.

scientific article

Passive immune therapy and other immunomodulatory agents for the treatment of severe influenza: Systematic review and meta-analysis

scientific article published on 16 November 2019

Persistence of Zika virus in conjunctival fluid of convalescence patients

scientific article published on 11 September 2017

Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor

scientific article

Phylodynamic profile of HIV-1 subtype B, CRF01_AE and the recently emerging CRF51_01B among men who have sex with men (MSM) in Singapore

scientific article

Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool

scientific article published on 07 September 2016

Plasmablasts generated during repeated dengue infection are virus glycoprotein-specific and bind to multiple virus serotypes

scientific article published on 14 November 2012

Predictive tools for severe dengue conforming to World Health Organization 2009 criteria

scientific article

Predictive value of proteinuria in adult dengue severity

scientific article

Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults

scientific article

Preparing for introduction of a dengue vaccine: recommendations from the 1st Dengue v2V Asia-Pacific Meeting

scientific article published on 22 August 2011

Prevalence of and risk factors for MRSA colonization in HIV-positive outpatients in Singapore

scientific article published on 6 November 2012

Profiles of antibody responses against severe acute respiratory syndrome coronavirus recombinant proteins and their potential use as diagnostic markers

scientific article published on March 2004

Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial

scientific article (publication date: March 2017)

Prophylactic platelets in dengue: survey responses highlight lack of an evidence base

scientific article

Rate of decline of antibody titers to pandemic influenza A (H1N1-2009) by hemagglutination inhibition and virus microneutralization assays in a cohort of seroconverting adults in Singapore

scientific article

Reducing hypersensitivity reactions with HLA-B*5701 genotyping before abacavir prescription: clinically useful but is it cost-effective in Singapore?

scientific article published on February 2015

Review of a two-year methicillin-resistant Staphylococcus aureus screening program and cost-effectiveness analysis in Singapore

scientific article published on 29 September 2015

Review of human infections with avian influenza H5N1 and proposed local clinical management guideline.

scientific article

Risk factors and time-trends of cytomegalovirus (CMV), syphilis, toxoplasmosis and viral hepatitis infection and seroprevalence in human immunodeficiency virus (HIV) infected patients

scientific article published on December 2013

Risk factors for concurrent bacteremia in adult patients with dengue

scientific article published on 4 August 2015

Risk factors for fatality among confirmed adult dengue inpatients in Singapore: a matched case-control study

scientific article

Risk factors for pandemic (H1N1) 2009 seroconversion among adults, Singapore, 2009

scientific article

Risk factors for pandemic (H1N1) 2009 virus seroconversion among hospital staff, Singapore

scientific article

SARS transmission and hospital containment

scientific article published in March 2004

Safety and cost savings of reducing adult dengue hospitalization in a tertiary care hospital in Singapore

scientific article

Safety and potential efficacy of cyclooxygenase-2 inhibitors in coronavirus disease 2019

scientific article published on 26 July 2020

Self-reported pain intensity with the numeric reporting scale in adult dengue

scientific article

Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patients

scientific article

Serological response in RT-PCR confirmed H1N1-2009 influenza a by hemagglutination inhibition and virus neutralization assays: an observational study

scientific article

Serological response to trivalent inactivated influenza vaccine in HIV-infected adults in Singapore

scientific article published on 17 February 2017

Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts

scientific article

Severe acute respiratory syndrome and pulmonary tuberculosis

scientific article published on 27 May 2004

Severe community-acquired Acinetobacter baumannii pneumonia: an emerging highly lethal infectious disease in the Asia-Pacific

scientific article published in November 2009

Severe neutropenia in dengue patients: prevalence and significance

scientific article

Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection

scientific article

Simple clinical and laboratory predictors of Chikungunya versus dengue infections in adults

scientific article

Spatial epidemiology and climatic predictors of paediatric dengue infections captured via sentinel site surveillance, Phnom Penh Cambodia 2011-2012

scientific article

Staphylococcus aureusand topical fusidic acid use: results of a clinical audit on antimicrobial resistance

Strategy in managing anticoagulation therapy following prosthetic heart valve replacement in a patient with dengue fever

scientific article published on 2 August 2015

Streptococcus pneumoniae bacteraemia in a young man with pandemic influenza A (H1N1) 2009

scientific article published on 01 April 2010

Surveillance of H1N1-related neurological complications

scientific article published in February 2010

Teacher led school-based surveillance can allow accurate tracking of emerging infectious diseases - evidence from serial cross-sectional surveys of febrile respiratory illness during the H1N1 2009 influenza pandemic in Singapore

scientific article

The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barré syndrome

scholarly article by Thirugnanam Umapathi et al published 2 August 2018 in Journal of the Peripheral Nervous System

The absolute lymphocyte count accurately estimates CD4 counts in HIV-infected adults with virologic suppression and immune reconstitution

scientific article published on 2 November 2014

The avian influenza vaccine Emerflu. Why did it fail?

scientific article

The combination of type I IFN, TNF-α, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus

scientific article published on 15 October 2014

The early clinical features of dengue in adults: challenges for early clinical diagnosis

scientific article

The immune response to 6-monthly versus annual standard dose inactivated trivalent influenza vaccination in older people: study protocol for a randomised clinical trial

scientific article published on 10 February 2017

The outbreak of SARS at Tan Tock Seng Hospital--relating epidemiology to control.

scientific article

The sequential introduction of HIV-1 subtype B and CRF01AE in Singapore by sexual transmission: accelerated V3 region evolution in a subpopulation of Asian CRF01 viruses

scientific article published in December 2002

The structural basis for serotype-specific neutralization of dengue virus by a human antibody

scientific article

Transmission modes of severe acute respiratory syndrome coronavirus 2 and implications on infection control: a review

scientific article published on 30 July 2020

Type I IFNs and IL-18 regulate the antiviral response of primary human γδ T cells against dendritic cells infected with Dengue virus

scientific article published on 2 March 2015

Ultrasensitive cDNA Detection of Dengue Virus RNA Using Electrochemical Nanoporous Membrane-Based Biosensor ⬇️

scientific article published on August 23, 2012

User acceptability and feasibility of self-testing with HIV rapid tests

scientific article published in August 2007

Utilities and limitations of the World Health Organization 2009 warning signs for adult dengue severity

scientific article

Utility of 16S ribosomal DNA sequencing in the diagnosis of Staphylococcus lugdunensis native valve infective endocarditis: case report and literature review

scientific article published on 17 May 2009

Utility of warning signs in guiding admission and predicting severe disease in adult dengue

scientific article

Validation of probability equation and decision tree in predicting subsequent dengue hemorrhagic fever in adult dengue inpatients in Singapore

scientific article

Validation of the Medical Outcomes Study HIV Health Survey as a measure of quality of life in HIV-infected patients in Singapore

scientific article published in July 2002

Viperin restricts chikungunya virus replication and pathology

scientific article

Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore

scientific article published on 18 January 2018

Virus-specific RNA and antibody from convalescent-phase SARS patients discharged from hospital

scientific article published in October 2004

Virus-specific T lymphocytes home to the skin during natural dengue infection

scientific article published on March 2015

When less is more: can we abandon prophylactic platelet transfusion in Dengue fever?

scientific article

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

scientific article published on 16 October 2020

Zika virus has arrived in Singapore

scientific article published on 15 November 2016

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