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List of works by Malú Gámez Tansey

A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson's disease and potential molecular targets ⬇️

scientific article published on May 28, 2013

AAV-dominant negative tumor necrosis factor (DN-TNF) gene transfer to the striatum does not rescue medium spiny neurons in the YAC128 mouse model of Huntington's disease

scientific article

Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration

scientific article published on 13 February 2015

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

scientific article published on 8 January 2018

Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1 −/− mice ⬇️

scientific article published on April 28, 2013

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

scientific article

Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease

scientific article published on November 2007

Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease

scientific article published on September 2006

Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells

scientific article

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson's disease

scientific article published on 18 August 2017

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons ⬇️

scientific article published on September 13, 2012

Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice

scientific article published in September 2016

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study

scientific article published on 22 April 2015

Critical role of regulator G-protein signaling 10 (RGS10) in modulating macrophage M1/M2 activation

scientific article

Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease

scientific article

Does neuroinflammation fan the flame in neurodegenerative diseases?

scientific article

Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120) ⬇️

scientific article published on April 28, 2013

Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists

scientific article

GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival

scientific article

GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family ⬇️

scientific article published on May 12, 1998

Inactivation of TNF signaling by rationally designed dominant-negative TNF variants

scientific article

Inflammation in neuropsychiatric disease

scientific article published on 18 December 2009

Inflammatory mechanisms contribute to microembolism-induced anxiety-like and depressive-like behaviors

scientific article published on 27 January 2016

Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells

scientific article

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

scientific article

Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats

scientific article published on 15 July 2008

Isolation of murine postnatal brain microglia for phenotypic characterization using magnetic cell separation technology

scientific article published on January 2013

LRRK2 levels in immune cells are increased in Parkinson's disease

scientific article

Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.

scientific article

Microglia isolation from adult mouse brain

scientific article published on January 2013

Microglial phenotypes in Parkinson's disease and animal models of the disease

scientific article published on 20 April 2016

Modeling neuroinflammatory pathogenesis of Parkinson’s disease

scientific article published on January 1, 2010

Myosin Light Chain Kinase Phosphorylation: Regulation of the Ca2+ Sensitivity of Contractile Elements ⬇️

scientific article published on January 1, 1991

Myosin phosphorylation in smooth and skeletal muscles: regulation and function.

scientific article published on January 1990

Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease? ⬇️

scientific article published on August 1, 2012

Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer's disease.

scientific article

Neuroinflammation in Parkinson's disease

scientific article published on 10 October 2009

Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?

scientific article published on January 2008

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

scientific article

Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention

scientific article published on 17 July 2007

Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

scientific article (publication date: 24 June 1997)

Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord

scientific article published in January 2006

Parkin deficiency increases vulnerability to inflammation-related nigral degeneration

scientific article published on October 2008

Parkinsonism without dopamine neuron degeneration in aged l-dopa-responsive dystonia knockin mice

scientific article

Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats

scientific article published on January 2014

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

scientific article

Persephin, a novel neurotrophic factor related to GDNF and neurturin

scientific article

Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization

scientific article published on November 1993

Physiology of RGS10 in Neurons and Immune Cells

scientific article published on April 2015

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

scientific article published on May 2013

Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge

scientific article published on 16 January 2012

Quantitative Analysis of the Detergent-Insoluble Brain Proteome in Frontotemporal Lobar Degeneration Using SILAC Internal Standards ⬇️

scientific article published on April 4, 2012

RGS10 Negatively Regulates Platelet Activation and Thrombogenesis

scientific article

RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis

scientific article published on February 2016

RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells

scientific article

RNF11 modulates microglia activation through NF-κB signalling cascade ⬇️

scientific article published on September 11, 2012

Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer's (HEART) Trial

scientific article published on 12 December 2017

Regulation of microglia effector functions by tumor necrosis factor signaling

scientific article published on 11 October 2011

Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response

scientific article published on August 2008

Regulator of G-protein signaling-10 negatively regulates NF-κB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats

scientific article published in August 2011

Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions

scientific article published on February 2014

Stool immune profiles evince gastrointestinal inflammation in Parkinson's disease

scientific article published on 23 March 2018

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

scientific article published on 17 October 2008

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?

scientific article

The neuro-glial properties of adipose-derived adult stromal (ADAS) cells are not regulated by Notch 1 and are not derived from neural crest lineage

scientific article

The role of innate and adaptive immunity in Parkinson's disease

scientific article published on January 2013

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

scientific article published on 12 May 2008

Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia

scientific article

Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

scientific article published on 27 July 2016

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

scientific article

Tumor necrosis factor-neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility

scientific article

Workshop summary: roles of the TNF family in neuronal development, function and pathology

scientific article published in January 2011

c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway.

scientific article

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson's Disease Pathogenesis

scholarly article by Laura M Butkovich et al published 2018 in Frontiers in Neuroscience

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