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List of works by Laurence Mather

(Re)introducing medicinal cannabis.

scientific article published in December 2013

1994 John J. Bonica Lecture. The clinical effects of morphine pharmacology

scientific article published on July 1, 1995

A SHEEP PREPARATION FOR STUDYING INTERACTIONS BETWEEN BLOOD FLOW AND DRUG DISPOSITION. I: PHYSIOLOGICAL PROFILE

scientific article published on 01 September 1984

A comparison of morphine, pethidine and fentanyl in the postsurgical patient-controlled analgesia environment.

scientific article published in January 1996

A sheep preparation for studying interactions between blood flow and drug disposition. III: Effects of general and spinal anaesthesia on regional blood flow and oxygen tensions.

scientific article published in November 1984

A sheep preparation for studying interactions between blood flow and drug disposition. VI: Effects of general or subarachnoid anaesthesia on blood flow and chlormethiazole disposition.

scientific article published in November 1986

Absorption and bioavailability of oral erythromycin ⬇️

scientific article published on August 1, 1981

Acute toxicity of local anesthetics: underlying pharmacokinetic and pharmacodynamic concepts.

scientific article

An assessment of methods for sampling blood to characterize rapidly changing blood drug concentrations ⬇️

scientific article published on September 1, 1991

An integrated study of pharmacokinetics and pharmacodynamics of chlormethiazole in healthy young volunteers.

scientific article published on March 1981

Anaesthetic or "Antiaesthetic" or "Antaesthetic"? Correspondence From Andrew Buchanan, MD, to James Simpson, MD, Concerning a Name for the Agents Producing Insensibility

scientific article published on 28 October 2018

Anatomical-physiological approaches in pharmacokinetics and pharmacodynamics.

scientific article

Arterial and pulmonary arterial concentrations of the enantiomers of bupivacaine after epidural injection in elderly patients.

scientific article published in April 1998

Arterial and venous plasma levels of bupivacaine following epidural and intercostal nerve blocks

scientific article published in July 1976

Arterial and venous plasma levels of bupivacaine following peripheral nerve blocks

scientific article published on November 1976

Barbiturates for acute neurological and neurosurgical emergencies--do they still have a role?

scientific article

Bupivacaine (Marcaine): an evaluation of its tissue and systemic toxicity in humans

scientific article published on January 1, 1977

Bupivacaine binding to plasma protein fractions ⬇️

scientific article published on October 1, 1978

Bupivacaine enantiomer pharmacokinetics after intercostal neural blockade in liver transplantation patients

scientific article published on February 1995

Calculation of the permeability coefficient should take into account the fact that most drugs are weak electrolytes.

scientific article published in November 2001

Cannabinoid pharmacotherapy: past, present and future.

scientific article

Cardiotoxicity with modern local anaesthetics: is there a safer choice?

scientific article

Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep

scientific article published in April 1998

Cardiovascular and subjective central nervous system effects of long-acting local anaesthetics in man

scientific article published on August 1, 1979

Cardiovascular effects and regional clearances of intravenous ropivacaine in sheep

scientific article published in June 1990

Central nervous system toxicity attributable to epidural ropivacaine hydrochloride.

scientific article published in April 1998

Chlormethiazole infusion in elderly patients undergoing spinal anaesthesia.

scientific article published in June 1984

Clinical pharmacokinetics applied to patients with intractable pain: studies with pethidine

scientific article published on 01 July 1982

Clinical pharmacokinetics of fentanyl and its newer derivatives.

scientific article

Clinical pharmacokinetics of local anaesthetics.

scientific article

Comments on "Nebulised fentanyl for post operative pain relief, a prospective double blind controlled randomised clinical trial"

scientific article published on March 2014

Comparative disposition of morphine-3-glucuronide during separate intravenous infusions of morphine and morphine-3-glucuronide in sheep. Importance of the kidney

scientific article published on 01 March 1995

Determination of defensin HNP-1, HNP-2, and HNP-3 in human saliva by using LC/MS

scientific article published on 01 June 2000

Determination of drug action

scientific article published on 01 August 1980

Determination of ketorolac enantiomers in plasma using enantioselective liquid chromatography on an alpha 1-acid glycoprotein chiral stationary phase and ultraviolet detection.

scientific article published in August 1994

Determination of pharmacokinetic constants after multiple infusions of drugs.

scientific article published in October 1982

Development of a model for integrated pharmacokinetic and pharmacodynamic studies of intravenous anaesthetic agents: applications to minaxolone.

scientific article published in January 1981

Diclofenac increases the accumulation of kynurenate following tryptophan pretreatment in the rat: a possible factor contributing to its antihyperalgesic effect

scientific article published in January 2003

Direct cardiac effects of coronary site-directed thiopental and its enantiomers: a comparison to propofol in conscious sheep.

scientific article

Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep

scientific article

Direct measurement of chlormethiazole extraction by liver, lung and kidney in man

scientific article

Disposition of mepivacaine and bupivacaine enantiomers in sheep.

scientific article published in September 1991

Disposition of morphine and its 3- and 6-glucuronide metabolites during morphine infusion in the sheep

scientific article published on 01 November 1993

Do the pharmacodynamics of the nonsteroidal anti-inflammatory drugs suggest a role in the management of postoperative pain?

scientific article

Dr Snow killed a bird: The genesis of pharmacokinetics and pharmacodynamics in anaesthesia.

scientific article published on March 2017

Dr. Daniel C. Moore--in appreciation.

scientific article published in March 2012

Effects of CNS site-directed carotid arterial infusions of bupivacaine, levobupivacaine, and ropivacaine in sheep.

scientific article published in August 2002

Effects of extradural block: comparison of the properties, circulatory effects and pharmacokinetics of etidocaine and bupivacaine

scientific article published on June 1, 1976

Effects of imposed acid-base derangement on the cardiovascular effects and pharmacokinetics of bupivacaine and thiopental.

scientific article

Effects of peridural block: V. Properties, circulatory effects, and blood levels of etidocaine and lidocaine

scientific article published on April 1, 1975

Electroencephalographic effects of thiopentone and its enantiomers in the rat: correlation with drug tissue distribution.

scientific article

Enantioselectivity of thiopental distribution into the central neural tissue of rats: an interaction with halothane.

scientific article

Enhancement of cisplatin efficacy by thalidomide in a 9L rat gliosarcoma model.

scientific article

Epidural analgesia reduces the release of amino acids from peripheral tissues in the ebb phase of the metabolic response to major upper abdominal surgery.

scientific article published in February 1999

Epidural morphine

scientific article published on 01 May 1980

Factors influencing ketorolac-associated perioperative renal dysfunction.

scientific article published on May 1998

Failure of IV atropine to abolish nasal irritation caused by chlormethiazole infusion in elderly patients undergoing spinal anaesthesia.

scientific article published in May 1984

Failure of the nitrous oxide tissue equilibration method for the determination of brain and myocardial blood flow under controlled conditions

scientific article published on April 1, 1992

Glutamate and kynurenate in the rat central nervous system following treatments with tail ischaemia or diclofenac.

scientific article published in January 2000

Hepatic clearance of local anesthetics in man.

scientific article published in April 1977

High-performance liquid chromatographic determination of thiopentone enantiomers in sheep plasma

scientific article published in November 1995

Highly sensitive gas chromatographic-mass spectrometric method for morphine determination in plasma that is suitable for pharmacokinetic studies.

scientific article published in May 1997

Hydromorphone-3-glucuronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide.

scientific article published in June 2001

Improved method for morphine determination in biological fluids and tissues: rapid, sensitive and selective.

scientific article published in September 1990

Individual responder analyses for pain: does one dose fit all?

scientific article published on 13 September 2005

Influence of acute upper respiratory tract infection on the absorption of inhaled insulin using the AERx insulin Diabetes Management System.

scientific article published in May 2005

Influence of renal failure on the disposition of morphine, morphine-3-glucuronide and morphine-6-glucuronide in sheep during intravenous infusion with morphine

scientific article published on 01 August 1997

Intersubject and dose-related variability after intravenous administration of erythromycin.

scientific article

Lack of effect of high doses of inhaled morphine on exercise endurance in chronic obstructive pulmonary disease

scientific article published on 01 October 1997

Lack of whole-body pharmacokinetic differences of halothane enantiomers in the rat.

scientific article published in January 2000

Letter: Life expectancy

scientific article published on 01 September 1974

Letter: Plasma protein binding of bupivacaine and its interaction with other drugs in man

scientific article published on September 1, 1975

Lidocaine and bupivacaine mixtures for epidural blockade

scientific article published in March 1982

Local anaesthetics and their current clinical use.

scientific article published on September 1979

Meperidine and other basic drugs: general method for their determination in plasma

scientific article published on 01 February 1974

Meperidine kinetics in man; Intravenous injection in surgical patients and volunteers ⬇️

scientific article published on January 1, 1975

Minaxolone, a new steroidal anesthetic. Pharmacokinetics and organ extraction in sheep ⬇️

scientific article published on November 1, 1980

Minaxolone, clinical effects and pharmacokinetics. Subanaesthetic infusion regimen.

scientific article published in June 1981

Morphine pharmacokinetics after pulmonary administration from a novel aerosol delivery system.

scientific article published in December 1997

Multiple intramuscular injections: a major source of variability in analgesic response to meperidine.

scientific article published in February 1980

Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep.

scientific article published in September 1989

Nausea and vomiting in the postoperative patient-controlled analgesia environment.

scientific article published on August 1997

On Dr Dick Climie and Dr Jack Thomas, and the genesis of chemical-clinical pharmacology in Australian anaesthesia research

scientific article published on 01 March 2018

Opioid agonists: Modes of application and dosing regimens.

scientific article

PCA or PAA?

scientific article published on 01 May 1990

Patient-controlled analgesia. Pharmacokinetic and therapeutic considerations

scientific article

Pethidine clearance during continuous intravenous infusions in postoperative patients.

scientific article

Pethidine revisited: plasma concentrations and effects after intramuscular injection

scientific article published on December 1, 1975

Pharmacodynamics of minaxolone, a new steroidal anesthetic ⬇️

scientific article published on May 1, 1981

Pharmacokinetics and Biotransformation of Local Anesthetics ⬇️

scientific article published on January 1, 1978

Pharmacokinetics and patient-controlled analgesia.

scientific article

Pharmacokinetics in Renal Failure ⬇️

scientific article published on November 1, 1983

Pharmacokinetics of EMLA cream 5% application to oral mucosa.

scientific article

Pharmacokinetics of bupivacaine enantiomers in sheep: influence of dosage regimen and study design.

scientific article published in December 1994

Pharmacokinetics of meperidine infusion

scientific article published on 01 November 1982

Pharmacokinetics of minaxolone.

scientific article published in February 1980

Pharmacokinetics of thiopental enantiomers during and following prolonged high-dose therapy

scientific article published in December 1999

Pharmacokinetics of thiopentone enantiomers following intravenous injection or prolonged infusion of rac-thiopentone

scientific article

Pharmacology of local anaesthetic agents. Pharmacokinetics of local anaesthetic agents

scientific article published on February 1, 1975

Pharmacology of opioids. Part 1. Basic aspects

scientific article published on 01 April 1986

Pharmacology of opioids. Part 2. Clinical aspects

scientific article published on 01 April 1986

Physiological and biochemical consequences of electroimobilisation in conscious sheep

scientific article published on 01 February 1990

Placental transfer of lignocaine following lumbar epidural administration.

scientific article published in December 1968

Plasma concentrations of the stereoisomers of prilocaine after administration of the racemate: implications for toxicity?

scientific article published in September 1990

Plasma lignocaine concentrations following topical aerosol application ⬇️

scientific article published in May 1969

Postoperative course of plasma protein binding of lignocaine, ropivacaine and bupivacaine in sheep

scientific article published on April 1, 1992

Postoperative pain

scientific article published on 01 November 1978

Preoperative dextromethorphan reduces intraoperative but not postoperative morphine requirements after laparotomy.

scientific article published on November 1998

Propofol: assay and regional mass balance in the sheep

scientific article published in November 1989

Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery ⬇️

scientific article published on July 1, 1998

Pulmonary insulin administration using the AERx system: physiological and physicochemical factors influencing insulin effectiveness in healthy fasting subjects.

scientific article

Rate of formation of norpethidine from pethidine

scientific article published on 01 March 1981

Relationship between blood meperidine concentrations and analgesic response: a preliminary report.

scientific article published in December 1980

Renal dysfunction associated with the perioperative use of diclofenac

scientific article

Safety of combined use of local anesthetic infiltration and reinfusion drains in total knee arthroplasty.

scientific article

Selective spinal analgesia

scientific article published on 01 May 1979

Should epinephrine be used to treat local anesthetic-induced cardiotoxicity?

scientific article published in May 1994

Simultaneous quantitation of morphine and paraben preservatives in morphine injectables

scientific article published on 01 November 1978

Spinal narcotics and respiratory depression ⬇️

scientific article published on August 18, 1979

Stereochemistry in anaesthetic and analgetic drugs.

scientific article

Stereochemistry in clinical medicine: a neurological perspective.

scientific article published on November 2003

Studies on absorption of a newly developed enteric-coated erythromycin base

scientific article published on 01 October 1977

Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats.

scientific article published in May 2007

Systemic and regional pharmacokinetics of levobupivacaine and bupivacaine enantiomers in sheep.

scientific article published in April 1998

Systemic availability of orally administered meperidine

scientific article published on 01 November 1976

Thalidomide enantiomers: determination in biological samples by HPLC and vancomycin-CSP.

scientific article published in February 2006

The Statistical Package for the Social Sciences (SPSS) as an adjunct to pharmacokinetic analysis.

scientific article published in April 1983

The acute toxicity of local anesthetics

scientific article published on 26 August 2010

The binding of bupivacaine to maternal and foetal plasma proteins

scientific article published on 01 May 1971

The development and clinical use of patient-controlled analgesia.

scientific article published on November 1988

The effect of diclofenac on the expression of spinal cord c-fos-like immunoreactivity after ischemia-reperfusion-induced acute hyperalgesia in the rat tail.

scientific article published in May 2000

The effect of duration of dose delivery with patient-controlled analgesia on the incidence of nausea and vomiting after hysterectomy

scientific article

The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia I: block characteristics and cardiovascular effects

scientific article published on September 1, 1976

The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: Pharmacokinetics

scientific article published on October 1, 1976

The effects of general anaesthesia on tocainide clearance in the sheep

scientific article published in July 1987

The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury

scientific article

The hemodynamic effects of intravenous bolus doses of meperidine in conscious sheep

scientific article published in March 1994

The in vitro uptake and metabolism of lignocaine, procainamide and pethidine by tissues of the hindquarters of sheep

scientific article published in January 1991

The in vivo blood, fat and muscle concentrations of lignocaine and bupivacaine in the hindquarters of sheep

scientific article published in January 1991

The incidence of postoperative pain in children

scientific article published on 01 March 1983

The induction-delivery interval at Caesarean sections ⬇️

scientific article published on August 1, 1972

The influence of age upon opioid analgesic use in the patient‐controlled analgesia (PCA) environment ⬇️

scientific article published on October 1, 1997

The intravenous toxicity and clearance of bupivacaine in man ⬇️

scientific article published on November 1, 1971

The pharmacokinetics of meperidine in the myocardium of conscious sheep

scientific article published in November 1994

The pharmacological relief of pain--contemporary issues

scientific article published on June 1, 1992

The placental transfer of alcuronium. A preliminary report

scientific article published on 01 April 1969

The relationship between the myocardial kinetics of meperidine and its effect on myocardial contractility: model-independent analysis and optimal regional model.

scientific article published in August 1999

The site of action of epidural fentanyl: what can be learned by studying the difference between infusion and bolus administration? The importance of history, one hopes.

scientific article published in November 2003

The use of mass balance principles to describe regional drug distribution and elimination.

scientific article published in February 1988

Thiopental is a competitive inhibitor at the human alpha7 nicotinic acetylcholine receptor

scientific article

Tissue uptake of ketamine and norketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion.

scientific article

Tolerability of large-dose intravenous levobupivacaine in sheep.

scientific article published in September 2000

Transfer of pethidine to CSF following intravenous administration

scientific article published on 01 August 1981

Trends in the pharmacology of opioids: implications for the pharmacotherapy of pain.

scientific article

Two-stage infusion of chlormethiazole for basal sedation.

scientific article published in November 1981

Variables of patient-controlled analgesia. 1. Bolus size.

scientific article published in January 1989

Variables of patient-controlled analgesia. 3: Test of an infusion-demand system using alfentanil.

scientific article published in June 1990

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