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List of works by Cheng Chen

A Dual Photochemically Active Molecule Showing Distributable Reactivity Based on Anion-Assisted Coordination Assembly

scientific article published on 15 August 2017

A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro

scientific article (publication date: 15 February 2017)

A rare variant at 11p13 is associated with tuberculosis susceptibility in the Han Chinese population

scientific article published on April 2016

Anion-controlled photochromism of two bipyridinium-based coordination polymers and nondestructive luminescence readout

scientific article published on 13 March 2017

Characterization of selective and potent PI3Kδ inhibitor (PI3KDIN- 015) for B-Cell malignances

scientific article published on 12 April 2016

Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors

scientific article published on 9 December 2015

Crystal Structures of Two Coronavirus ADP-Ribose-1''-Monophosphatases and Their Complexes with ADP-Ribose: a Systematic Structural Analysis of the Viral ADRP Domain

scientific article

Crystallization and preliminary X-ray diffraction studies of infectious bronchitis virus nonstructural protein 9.

scientific article

Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor

scientific article

Crystallization and preliminary crystallographic study of Porcine epidemic diarrhea virus main protease in complex with an inhibitor

scientific article

Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor

scientific article

Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode

scientific article

Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML)

scientific article

Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia

scientific article published on 2 December 2015

Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myel

scientific article published on 20 January 2016

Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding

scientific article published on 14 December 2016

Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKI

scientific article published on 22 August 2016

Discovery of N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs).

scientific article published on 14 April 2016

Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK

scientific article published on 18 August 2017

Discovery of a Highly Selective STK16 Kinase Inhibitor

scientific article

Discovery of susceptibility loci associated with tuberculosis in Han Chinese

scientific article

Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study

scientific article published on 9 June 2017

Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML.

scientific article published on 11 April 2016

Erratum: Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro

scientific article published on 11 April 2017

Evaluation of GeneXpert MTB/RIF for detection of pulmonary tuberculosis at peripheral tuberculosis clinics

scientific article published on 28 February 2017

Expression, crystallization and preliminary crystallographic study of human coronavirus HKU1 nonstructural protein 9.

scientific article published on 28 April 2009

Expression, crystallization and preliminary crystallographic study of the functional mutant (N60K) of nonstructural protein 9 from Human coronavirus HKU1.

scientific article

Flexible Viologen-Based Porous Framework Showing X-ray Induced Photochromism with Single-Crystal-to-Single-Crystal Transformation

scientific article published on 30 August 2017

High Latent TB Infection Rate and Associated Risk Factors in the Eastern China of Low TB Incidence

scientific article published on 27 October 2015

Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease

scientific article (publication date: 18 October 2016)

Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus.

scientific article published on 13 March 2017

Post-cycloaddition modification of a porous MOF for improved GC separation of ethanol and water

scientific article published on 22 May 2017

Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction

scientific article

Purification, crystallization and preliminary X-ray analysis of nonstructural protein 2 (nsp2) from avian infectious bronchitis virus ⬇️

scientific article published on May 24, 2012

Purification, crystallization and preliminary crystallographic analysis of avian infectious bronchitis virus nsp3 ADRP domain

scientific article published on 9 August 2008

Recent progress in the discovery of inhibitors targeting coronavirus proteases

scientific article published on 19 February 2016

Self-assembled hydrophobin for producing water-soluble and membrane permeable fluorescent dye.

scientific article published on 15 March 2016

Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies

scientific article published on 18 July 2016

Structural basis for dimerization and RNA binding of avian infectious bronchitis virus nsp9.

scientific article published on 3 March 2017

Structural basis of Zika virus helicase in recognizing its substrates

scientific article (publication date: August 2016)

Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding

scientific article published on 25 May 2020

Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

scientific article published on 7 March 2016

Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1

scientific article

Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors

scientific article published on 9 June 2017

The conformational changes of Zika virus methyltransferase upon converting SAM to SAH.

scientific article published on 21 January 2017

The crystal structure of Zika virus helicase: basis for antiviral drug design

scientific article

Vitamin D receptor gene polymorphisms on the risk of tuberculosis, a meta-analysis of 29 case-control studies

scientific article

Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro

scientific article (publication date: 21 March 2017)

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