List of works - David Keays

A gene-driven ENU-based approach to generating an allelic series in any gene

scientific article

A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves

scientific article published on 22 January 2020

A pachygyria-causing alpha-tubulin mutation results in inefficient cycling with CCT and a deficient interaction with TBCB.

scientific article

A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse

scientific article published on 02 November 2020

An iron-rich organelle in the cuticular plate of avian hair cells

scientific article published on 25 April 2013

Behavioural characterisation of the robotic mouse mutant

scientific article

Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition

scientific article published on 24 January 2017

Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons

scientific article

Comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans".

scientific article published on 13 April 2018

Correction: Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes

scientific article published on 19 November 2015

Cryptochrome: The magnetosensor with a sinister side?

article

Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry

scientific article published in May 2004

Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway

scientific article

Ectopic otoconial formation in the lagena of the pigeon inner ear

scientific article published on 02 August 2018

Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited

scientific article

Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens

scientific article published on 3 March 2006

Exome sequencing can detect pathogenic mosaic mutations present at low allele frequencies ⬇️

scientific article published on December 1, 2011

Feasibility of scaling from pilot to process scale

scientific article published in March 2007

Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits

scientific article

Is magnetogenetics the new optogenetics?

scientific article published on 23 May 2017

Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).

scientific article

Lidocaine is a nocebo treatment for trigeminally mediated magnetic orientation in birds

scholarly article by Svenja Engels et al published August 2018 in Journal of the Royal Society Interface

Magnetoreception-A sense without a receptor

scientific article published on 23 October 2017

Microtubules and neurodevelopmental disease: the movers and the makers

scientific article published on January 2014

Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes

scientific article (publication date: 2013)

Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type

scientific article

Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation

scientific article published on 16 January 2014

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans

scientific article published on 8 January 2018

Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans

scientific article

Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia

scientific article published on 03 October 2016

Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria

scientific article

Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis

scientific article published on 22 February 2016

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities

scientific article

N-ethyl-N-nitrosourea mouse mutants in the dissection of behavioural and psychiatric disorders

scientific article published on November 2003

Neuronal circuits and the magnetic sense: central questions

scientific article published on 09 November 2020

Neuronal migration: unraveling the molecular pathway with humans, mice, and a fungus

scientific article published on 15 July 2007

New semidominant mutations that affect mouse development

scientific journal article

No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening

scientific article

Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans

scientific article published on 01 August 2018

Revised testing procedures do not elicit magnetoreceptive behavior in C. elegans

Scalable Technology for the Extraction of Pharmaceutics (STEP): The transition from academic knowhow to industrial reality ⬇️

scientific article published on January 12, 2011

Scalable technology for the extraction of pharmaceutics: outcomes from a 3 year collaborative industry/academia research programme

scientific article published on 18 January 2013

Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance

scientific article published on 15 November 2017

The Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons

scientific article published on 23 June 2015

The Role of Tuba1a in Adult Hippocampal Neurogenesis and the Formation of the Dentate Gyrus

The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor

scientific article published on 12 August 2020

The identification and characterisation of novel ENU induced behavioural mouse mutants

doctoral thesis by David Keays

Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor

scientific article

Tuba8 is expressed at low levels in the developing mouse and human brain

scientific article published on May 2010

Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability

scientific journal article

List of works by David Keays

A gene-driven ENU-based approach to generating an allelic series in any gene

A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves

A pachygyria-causing alpha-tubulin mutation results in inefficient cycling with CCT and a deficient interaction with TBCB.

A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse

An iron-rich organelle in the cuticular plate of avian hair cells

Behavioural characterisation of the robotic mouse mutant

Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition

Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons

Comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans".

Correction: Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes

Cryptochrome: The magnetosensor with a sinister side?

Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry

Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway

Ectopic otoconial formation in the lagena of the pigeon inner ear

Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited

Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens

Exome sequencing can detect pathogenic mosaic mutations present at low allele frequencies ⬇️

Feasibility of scaling from pilot to process scale

Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits

Is magnetogenetics the new optogenetics?

Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).

Lidocaine is a nocebo treatment for trigeminally mediated magnetic orientation in birds

Magnetoreception-A sense without a receptor

Microtubules and neurodevelopmental disease: the movers and the makers

Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes

Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type

Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans

Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans

Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia

Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria

Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities

N-ethyl-N-nitrosourea mouse mutants in the dissection of behavioural and psychiatric disorders

Neuronal circuits and the magnetic sense: central questions

Neuronal migration: unraveling the molecular pathway with humans, mice, and a fungus

New semidominant mutations that affect mouse development

No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening

Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans

Revised testing procedures do not elicit magnetoreceptive behavior in C. elegans

Scalable Technology for the Extraction of Pharmaceutics (STEP): The transition from academic knowhow to industrial reality ⬇️

Scalable technology for the extraction of pharmaceutics: outcomes from a 3 year collaborative industry/academia research programme

Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance

The Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons

The Role of Tuba1a in Adult Hippocampal Neurogenesis and the Formation of the Dentate Gyrus

The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor

The identification and characterisation of novel ENU induced behavioural mouse mutants

Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor

Tuba8 is expressed at low levels in the developing mouse and human brain

Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability