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List of works by William Plunkett

2-Chlorodeoxyadenosine and cytarabine combination therapy for idiopathic hypereosinophilic syndrome

scientific article

A phase I/II randomized trial of clofarabine or fludarabine added to idarubicin and cytarabine for adults with relapsed or refractory acute myeloid leukemia

scientific article published on 18 July 2017

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

scientific article published on 30 August 2005

A randomized phase 2 study of idarubicin and cytarabine with clofarabine or fludarabine in patients with newly diagnosed acute myeloid leukemia

scientific article

A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia

scientific article published on November 2006

ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance

scientific article published on October 2008

Action of (E)-2′-Deoxy-2′-(fluoromethylene)cytidine on DNA Metabolism: Incorporation, Excision, and Cellular Response ⬇️

scientific article published on January 1, 2002

Arginine addiction in AML.

scientific article

Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine

scientific article

CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death

scientific article published on 09 September 2019

Cellular and clinical pharmacology of fludarabine

scientific article

Clofarabine in adult acute leukemias: clinical success and pharmacokinetics

scientific article published in October 2004

Clofarabine in leukemia

scientific article

Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia ⬇️

scientific article published on October 9, 2003

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

scientific article published on 30 November 2016

DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor

scientific article

Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe

scientific article published on 23 February 2016

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

scientific article published on 17 September 2009

Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia

scientific article

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

scientific article published on 23 June 2008

Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal

scientific article published on 5 September 2006

Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemia

scientific article published on 22 October 2015

Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents

scientific article published on 16 January 2003

GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma

scientific article

H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation

scientific article published on 3 April 2007

HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia

scientific article published on 08 February 2016

Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia

scientific article

Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.

scientific article

Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine

scientific article published in September 2002

Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism

scientific article

Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials

scientific article published on May 2007

Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia

scientific article published in October 2002

Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer

scientific article

Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels

scientific article

Killing of Chronic Lymphocytic Leukemia by the Combination of Fludarabine and Oxaliplatin Is Dependent on the Activity of XPF Endonuclease ⬇️

scientific article published on July 15, 2011

Long-term follow-up results of the combination of topotecan and cytarabine and other intensive chemotherapy regimens in myelodysplastic syndrome

scientific article published in March 2006

Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab)

scientific article

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

scientific article published on 16 March 2006

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia

scientific article published on 20 February 2009

Mechanism-Based Drug Combinations with the DNA Strand-Breaking Nucleoside Analog CNDAC.

scientific article published on 29 July 2016

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

scientific article

Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation

scientific article

New nucleoside analogues in clinical development

scientific article published on January 1, 2002

Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia

scientific article

Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome

scientific article published on 26 April 2010

Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: a randomised phase 2 study

scientific article

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

scientific article published on 17 November 2005

Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias.

scientific article published in December 2003

Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia

scientific article

Phase I and extension study of clofarabine plus cyclophosphamide in patients with relapsed/refractory acute lymphoblastic leukemia

scientific article

Phase I and pharmacodynamic study of Triapine, a novel ribonucleotide reductase inhibitor, in patients with advanced leukemia

scientific article published in December 2003

Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma

scientific article published on 17 May 2010

Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome

scientific article published on 23 November 2009

Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers.

scientific article published in March 2003

Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies

scientific article

Phase I trial of nelarabine in indolent leukemias

scientific article

Phase I-II clinical trial of oxaliplatin, fludarabine, cytarabine, and rituximab therapy in aggressive relapsed/refractory chronic lymphocytic leukemia or Richter syndrome

scientific article

Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia

scientific article published in January 2008

Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues

scientific article

Population pharmacokinetics of clofarabine, a second-generation nucleoside analog, in pediatric patients with acute leukemia

scientific article published in November 2004

Prolonged infusion of gemcitabine: clinical and pharmacodynamic studies during a phase I trial in relapsed acute myelogenous leukemia

scientific article published in February 2002

Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair

scientific article

Repair of DNA damage induced by the novel nucleoside analogue CNDAG through homologous recombination

scientific article published on 18 February 2020

Responses in Mantle Cell Lymphoma Cells to SNS-032 Depend on the Biological Context of Each Cell Line ⬇️

scientific article published on July 27, 2010

Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias

scientific article published on 14 October 2004

Sapacitabine for cancer ⬇️

scientific article published on February 14, 2012

Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation

scientific article published on 18 December 2008

Strategy to induce apoptosis and circumvent resistance in chronic lymphocytic leukaemia

scientific article published on March 2010

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia ⬇️

scientific article published on February 19, 2012

Superoxide dismutase as a target for the selective killing of cancer cells

scientific article published in Nature

TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors

scientific article

TRIM24 links a non-canonical histone signature to breast cancer

scientific article

Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations

scientific article

Targeting BTK through microRNA in chronic lymphocytic leukemia

scientific article published on 17 October 2016

Targeting DNA repair in chronic lymphocytic leukemia cells with a novel acyclic nucleotide analogue, GS-9219.

scientific article published on 12 May 2009

The role of DNA repair in chronic lymphocytic leukemia pathogenesis and chemotherapy resistance

scientific article published on September 2007

The role of clofarabine in hematologic and solid malignancies--development of a next-generation nucleoside analog

scientific article

Trabectedin Reveals a Strategy of Immunomodulation in Chronic Lymphocytic Leukemia

scientific article published on 17 September 2019

Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

scientific article published on 21 June 2005

Transport properties of pancreatic cancer describe gemcitabine delivery and response

scientific article published on 10 March 2014

Twice-daily fludarabine and cytarabine combination with or without gentuzumab ozogamicin is effective in patients with relapsed/refractory acute myeloid leukemia, high-risk myelodysplastic syndrome, and blast- phase chronic myeloid leukemia

scientific article published on 24 April 2012

UCN-01 (7-hydroxystaurosporine) inhibits DNA repair and increases cytotoxicity in normal lymphocytes and chronic lymphocytic leukemia lymphocytes.

scientific article published in February 2002

miRNAs and their potential for use against cancer and other diseases

scientific article published on October 2007

microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival

scientific article published on 14 April 2010

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