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List of works by Achim Hoerauf

A niche for Wolbachia

scientific article

A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro

scientific article

Activity of ceftobiprole against Staphylococcus spec. isolates derived from foreign body associated infections

scientific article published on 31 January 2018

AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster

scientific article published on 4 August 2017

Analysis of Transmission of MRSA and ESBL-E among Pigs and Farm Personnel

scientific article

Animated documentation of the filaria dance sign (FDS) in bancroftian filariasis

scientific article

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis

scientific article

Antibiotic therapy in murine filariasis (Litomosoides sigmodontis): comparative effects of doxycycline and rifampicin on Wolbachia and filarial viability ⬇️

scientific article published on May 1, 2003

Antibiotics for the treatment of onchocerciasis and other filarial infections.

scientific article

Assessment of microfilarial loads in the skin of onchocerciasis patients after treatment with different regimens of doxycycline plus ivermectin

scientific article

Bancroftian filariasis--absence of Wolbachia after doxycycline treatment.

scientific article

CCL17 controls mast cells for the defense against filarial larval entry

scientific article

Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism

scientific article published on 29 July 2016

Co-activation through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and induces IL-17 secretion in Treg: B cell co-cultures

scientific article published on 25 March 2013

Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon

scientific article

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

scientific article

Complete Genome Sequence of the Corallopyronin A-Producing Myxobacterium Corallococcus coralloides B035

scholarly article published 25 April 2019

Corallopyronin A - a promising antibiotic for treatment of filariasis

scientific article published on 04 September 2013

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo ⬇️

scientific article published on May 14, 2012

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

scientific article published on 07 December 2020

Correction: ESBL Detection: Comparison of a Commercially Available Chromogenic Test for Third Generation Cephalosporine Resistance and Automated Susceptibility Testing in Enterobactericeae.

scientific article published on 7 June 2018

Correction: Prevalence of Lymphatic Filariasis and Treatment Effectiveness of Albendazole/ Ivermectin in Individuals with HIV Co-infection in Southwest-Tanzania

scientific article published on 26 August 2016

Developing a community-led SMS reporting tool for the rapid assessment of lymphatic filariasis morbidity burden: case studies from Malawi and Ghana

scientific article published on 16 May 2015

Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses

scientific article published on 25 July 2015

Differential display of genes expressed in the filarial nematode Litomosoides sigmodontis reveals a putative phosphate permease up-regulated after depletion of Wolbachia endobacteria

scientific article

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

scientific article published on 01 May 2019

Does helminth elimination promote or prevent malaria?

scientific article published in February 2007

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

scientific article published on 6 May 2015

Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production

scientific article (publication date: November 2003)

Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms

scientific article published on April 2003

Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators

scientific article published on 13 February 2018

Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment

scientific article

Drugs and Targets to Perturb the Symbiosis of Wolbachia and Filarial Nematodes

Effect of Wuchereria bancrofti infection on HIV incidence in southwest Tanzania: a prospective cohort study

scientific article published on 2 August 2016

Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents

scholarly article published by Samuel Wanji in 2019

Effects of 6-week azithromycin treatment on the Wolbachia endobacteria of Onchocerca volvulus

scientific article

Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus

scientific article

Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

scientific article

Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections

scientific article published in 2019

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

scientific article

Elimination of lymphatic filariasis in South East Asia

scientific article published in the British Medical Journal

Epidemiology of Mansonella perstans in the middle belt of Ghana

scientific article published on 07 January 2017

Eradication of methicillin-resistant Staphylococcus aureus and of Enterobacteriaceae expressing extended-spectrum beta-lactamases on a model pig farm

scientific article published on 4 September 2015

Escherichia coli-induced immune paralysis is not exacerbated during chronic filarial infection

scientific article published on May 2015

Evidence against Wolbachia symbiosis in Loa loa

scientific article

Expansion of NK cells with reduction of their inhibitory Ly-49A, Ly-49C, and Ly-49G2 receptor-expressing subsets in a murine helminth infection: contribution to parasite control

scientific article published on May 2002

Extracellular Onchocerca-derived small RNAs in host nodules and blood

scientific article

Filaria-induced IL-10 suppresses murine cerebral malaria

scientific article published on 24 April 2010

Filarial infection induces protection against P. berghei liver stages in mice

scientific article published on 19 November 2008

Frequent detection of worm movements in onchocercal nodules by ultrasonography

scientific article

Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases

scientific article published on 24 November 2015

Genome-wide transcriptome induced by nickel in human monocytes

scientific article published on 28 July 2016

Helminth Protection against Autoimmune Diabetes in Nonobese Diabetic Mice Is Independent of a Type 2 Immune Shift and Requires TGF-β ⬇️

scientific article published on December 14, 2011

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model

scientific article

Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?

scientific article

Highly sensitive and specific detection of Giardia duodenalis, Entamoeba histolytica, and Cryptosporidium spp. in human stool samples by the BD MAX™ Enteric Parasite Panel

scientific article published on 19 December 2017

IL-4/5 signalling plays an important role during Litomosoides sigmodontis infection, influencing both immune system regulation and tissue pathology in the thoracic cavity

scientific article published on 28 August 2017

Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus

scientific article

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis

scientific article (publication date: 2012)

Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda).

scientific article

Immunomodulatory effects of myeloid-derived suppressor cells in diseases: Role in cancer and infections

scientific article published on 4 July 2017

In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites

scientific article published on 13 October 2014

Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis

scientific article

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner ⬇️

scientific article published on May 12, 2011

Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms

scientific article

Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives

scientific article published on 2 October 2015

Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis

scientific article

Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis

scientific article published on 11 October 2002

Is there a risk of filarial infection during long-term missions in Haiti?

scientific article

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

scientific journal article

Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host

scientific article

Localization of a filarial phosphate permease that is up-regulated in response to depletion of essential Wolbachia endobacteria

scientific article

Long-term release of antibiotics by carbon nanotube-coated titanium alloy surfaces diminish biofilm formation by Staphylococcus epidermidis

scientific article published on 20 January 2017

Lymphatic filariasis and onchocerciasis ⬇️

scientific article published on August 23, 2010

Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule

scientific article

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

scientific article

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

scientific article

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial

scientific article

Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine

scientific article published in October 2009

Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti

scientific article

Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate and adaptive immune responses

scientific article

Mass drug treatment for lymphatic filariasis and onchocerciasis ⬇️

scientific article published on November 1, 2003

Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice

scientific article

Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes

scientific article published on April 2010

Morbidity management and surveillance of lymphatic filariasis disease and acute dermatolymphangioadenitis attacks using a mobile phone-based tool by community health volunteers in Ghana

scientific article published on 12 November 2020

Multivariable Regression Analysis in Schistosoma mansoni-Infected Individuals in the Sudan Reveals Unique Immunoepidemiological Profiles in Uninfected, egg+ and Non-egg+ Infected Individuals

scientific article

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

scientific article published on 10 December 2002

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

scientific article published on 22 December 2016

Neutrophil extracellular trap formation in supragingival biofilms

scientific article

New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria

scientific article

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

scientific article published on 16 September 2009

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

scientific article

Of mice, cattle, and humans: the immunology and treatment of river blindness

scientific article

On the taxonomic status of the intracellular bacterium Wolbachia pipientis: should this species name include the intracellular bacteria of filarial nematodes?

scientific article published on August 2007

Onchocerciasis

scientific article

Onchocerciasis control: vision for the future from a Ghanian perspective

scientific article published on 21 January 2009

Onchocerciasis: the Role of Wolbachia Bacterial Endosymbionts in Parasite Biology, Disease Pathogenesis, and Treatment ⬇️

scientific article published on July 1, 2011

Orientia tsutsugamushi is highly susceptible to the RNA polymerase switch region inhibitor Corallopyronin A in vitro and in vivo

scientific article published on 22 January 2018

Patency of Litomosoides sigmodontis infection depends on Toll-like receptor 4 whereas Toll-like receptor 2 signalling influences filarial-specific CD4(+) T-cell responses

scientific article published on 30 December 2015

Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes

scientific article

Porphyromonas gingivalis Outer Membrane Vesicles Induce Selective Tumor Necrosis Factor Tolerance in a Toll-Like Receptor 4- and mTOR-Dependent Manner

scientific article

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

scientific article published on 01 March 2019

Prevalence of Lymphatic Filariasis and Treatment Effectiveness of Albendazole/ Ivermectin in Individuals with HIV Co-infection in Southwest-Tanzania

scientific article

RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype.

scientific article

Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent Brugia malayi Infections: a study in Indonesian transmigrants

scientific article

Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline.

scientific article

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

scientific article

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

scientific article

Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes

scientific article

Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2.

scientific article

Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host ⬇️

scientific article published on January 11, 2012

Risk factors for epilepsy in Bas-Uélé Province, Democratic Republic of the Congo: a case-control study ⬇️

scientific article published on 19 May 2016

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

scientific article

Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti

scientific article published on 9 November 2017

Specific K39 antibody response and its persistence after treatment in patients with imported leishmaniasis

scientific article

Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria

scientific article (publication date: 2015)

Strong expression of TGF-beta in human host tissues around subcutaneous Dirofilaria repens

scientific article published on September 2010

Successful long-term maintenance of Mansonella perstans in an in vitro culture system

scientific article

Synergism of gamma interferon and interleukin-5 in the control of murine filariasis

scientific article

T regulatory-1 cells induce IgG4 production by B cells: role of IL-10.

scientific article

The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections

scientific article

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

scientific article

The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicine

scientific article

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization ⬇️

scientific article published on February 21, 2012

The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4.

scientific article

The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta).

scientific article published on 12 May 2009

The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness

scientific article

The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis.

scientific article published on 29 July 2010

The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda).

scientific article published on January 2002

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

scientific article published on 23 December 2014

Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta

scientific article published on November 2008

Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia

scientific article published on 30 March 2010

Update on the biology and ecology of Culicoides species in the South-West region of Cameroon with implications on the transmission of Mansonella perstans

article

Update on the distribution of Mansonella perstans in the southern part of Cameroon: influence of ecological factors and mass drug administration with ivermectin

scientific article published on 31 May 2016

Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG).

scientific article

Wolbachia bacterial endosymbionts of filarial nematodes

scientific article

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article published in 2008

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article

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