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List of works by Yuetsu Tanaka

A CD63 mutant inhibits T-cell tropic human immunodeficiency virus type 1 entry by disrupting CXCR4 trafficking to the plasma membrane

scientific article published on April 2008

A functional CD8+ cell assay reveals individual variation in CD8+ cell antiviral efficacy and explains differences in human T-lymphotropic virus type 1 proviral load

scientific article

A novel HSP90 inhibitor, 17-DMAG, induces Tax down-regulation and its oral administration to ATL-model mice intervenes against the infiltration property of the ATL-like lymphocytes and provides extended survival period.

scientific article published on 7 January 2014

A novel and simple method for generation of human dendritic cells from unfractionated peripheral blood mononuclear cells within 2 days: its application for induction of HIV-1-reactive CD4(+) T cells in the hu-PBL SCID mice

scientific article

A novel mother-to-child human T-cell leukaemia virus type 1 (HTLV-1) transmission model for investigating the role of maternal anti-HTLV-1 antibodies using orally infected mother rats

scientific article published on February 2017

A recombinant vesicular stomatitis virus encoding HIV-1 receptors and human OX40 ligand efficiently eliminates HIV-1–infected CD4-positive T cells expressing OX40 ⬇️

scientific article published on January 21, 2011

Aberrant expression of the transcription factor Twist in adult T-cell leukemia

scientific article

Absolute quantification of HTLV-1 basic leucine zipper factor (HBZ) protein and its plasma antibody in HTLV-1 infected individuals with different clinical status

scientific article published on 27 April 2016

Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells

scientific article

Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells

scientific article

Activation of mTOR by human T‐cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin‐2‐independent growth ⬇️

scientific article published on November 28, 2011

Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein: a novel in vitro model of the growth of acute ATL cells

scientific article

Advantage of higher-avidity CTL specific for Tax against human T-lymphotropic virus-1 infected cells and tumors ⬇️

scientific article published on October 8, 2011

Altered pattern in viral mRNA expression of Iranian type HTLV-1 leading to enhanced viral expression.

scientific article published on 7 January 2014

Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene).

scientific article published on September 2008

Aurora kinase inhibitor AZD1152 negatively affects the growth and survival of HTLV-1-infected T lymphocytes in vitro

scientific article published in October 2010

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

scientific article

Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway

scientific article published on February 2007

Complete prevention of HTLV-1 infection in humanized mice (hu-PBL SCID) by a neutralizing monoclonal antibody to envelope gp46.

scientific article

Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor

scientific article published on 6 December 2017

Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells

scientific article

Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines

scientific article published on 12 September 2005

Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB

scholarly article by Bidhan Sarkar et al published 5 March 2019 in Scientific Reports

Different cytokine production in tax-expressing cells between patients with human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis and asymptomatic HTLV-I carriers

scientific article published on 13 March 2003

Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP

article

Dynamics of memory and naïve CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1.

scientific article

EZH2 dependent epigenetic landscape in adult T cell leukemia and Tax immortalized cells.

scientific article

Elimination of human T cell leukemia virus type-1-infected cells by neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies against human t cell leukemia virus type-1 envelope gp46.

scientific article published on 10 March 2014

Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes.

scientific article published on 14 April 2005

Enhancement of OX40-induced apoptosis by TNF coactivation in OX40-expressing T cell lines in vitro leading to decreased targets for HIV type 1 production

scientific article

Epigenetic deregulation of Ellis Van Creveld confers robust Hedgehog signaling in adult T-cell leukemia

scientific article published on 8 September 2014

Establishment of a primary effusion lymphoma cell line (RM-P1) and in vivo growth system using SCID mice

scientific article published on August 2002

Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide

scientific article published in December 2007

Expression of the c-Met proto-oncogene and its possible involvement in liver invasion in adult T-cell leukemia.

scientific article published in January 2003

Failure in activation of the canonical NF-κB pathway by human T-cell leukemia virus type 1 Tax in non-hematopoietic cell lines

scientific article published on 18 June 2013

FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia.

scientific article published in November 2009

Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

scientific article published on January 2005

Generation of direct antigen-sandwich enzyme-linked immune-sorbent assays (ELISA) for quantitation of HTLV-1 gp46, p24, Tax and related host cellular antigens OX40, OX40L and CD25.

scientific article published on 7 January 2014

HTLV-1 Tax induces Th1 master regulator T-bet and thus IFN-γ in CD4+CCR4+ T-cells of virus-associated myelopathy patients.

scientific article published on 28 August 2015

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse.

scientific article published on 3 June 2009

Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells

scientific article published on 11 July 2016

High frequencies of Th1-type CD4(+) T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

scientific article published on May 2002

High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response

scientific article published on 19 December 2007

High resolution lectin microarray system for the ATL cell-typing and the evaluation of anti-cancer efficacy of medications.

scientific article

Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection

scientific article published on 15 August 2006

Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells ⬇️

scientific article published on September 29, 2012

Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction

scientific article

Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3.

scientific article published on March 2004

Human T-cell leukemia virus type 1 tax dysregulates beta-catenin signaling

scientific article published on 18 August 2006

Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line

scientific article published on 2 December 2006

Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/l

scientific article published on 18 August 2017

Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules

scientific article published on 22 September 2008

Human T-lymphotropic virus, type 1, tax protein triggers microtubule reorientation in the virological synapse

scientific article

Human T-lymphotropic virus-1 visualized at the virological synapse by electron tomography

scientific article

Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP.

scientific article published on 28 August 2015

IFN-α suppresses HTLV-1 expression via PKR in infected cells and renders them susceptible to AZT through p53 activation in AZT/IFN-α treatment.

scientific article published on 7 January 2014

Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2.

scientific article published on 17 September 2009

Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses ⬇️

scientific article published on October 22, 2011

Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease

scientific article

Impairment of in vitro generation of monocyte-derived human dendritic cells by inactivated human immunodeficiency virus-1: Involvement of type I interferon produced from plasmacytoid dendritc cells

scientific article published on 15 March 2010

In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax

scientific article published on 26 January 2008

Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

scientific article published on 7 May 2013

Induction of protective immune responses against R5 human immunodeficiency virus type 1 (HIV-1) infection in hu-PBL-SCID mice by intrasplenic immunization with HIV-1-pulsed dendritic cells: possible involvement of a novel factor of human CD4(+) T-ce

scientific article published on August 2003

Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

scientific article published on 9 April 2006

Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells

scientific article published in April 2007

Inhibition of the tax-dependent human T-lymphotropic virus type I replication in persistently infected cells by the fluoroquinolone derivative k-37.

scientific article published on June 2002

Interleukin-4-transgenic hu-PBL-SCID mice: a model for the screening of antiviral drugs and immunotherapeutic agents against X4 HIV-1 viruses

scientific article

Kinetics and intracellular compartmentalization of HTLV-1 gene expression

scientific article published on 6 June 2011

Knockdown of synapse-associated protein Dlg1 reduces syncytium formation induced by human T-cell leukemia virus type 1.

scientific article

Low frequency of CD94/NKG2A+ T lymphocytes in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis, but not in asymptomatic carriers

scientific article

MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia

scientific article

MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells

scientific article

Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy

scientific article published on 7 August 2014

NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-kappaB signal pathway

scientific article published on March 2006

Natural OX40L expressed on human T cell leukemia virus type-I-immortalized T cell lines interferes with infection of activated peripheral blood mononuclear cells by CCR5-utilizing human immunodeficiency virus

scientific article published on 18 November 2013

Neural bystander damage by infiltrating virus-infected T cells and the cytotoxic T lymphocytes in HTLV-I-associated neurological disease

Neuraminidase enhances the initial steps of human T-cell leukemia virus type 1 replication

scientific article published on 3 November 2009

Neutralizing antibodies against human T cell leukemia virus type-I (HTLV-1) eradicate HTLV-1 in combination with autologous peripheral blood mononuclear cells via antibody-dependent cellular cytotoxicity while preventing new infection

scientific article published on 7 January 2014

Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity

scientific article published in June 2009

Overexpression of caveolin-1 in adult T-cell leukemia

scientific article

PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line

scientific article published on January 2004

Presentation of a new H-2D(k)-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin

scientific article published on March 2002

Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status

scientific article published on 17 July 2017

Rapid induction of OX40 ligand on primary T cells activated under DNA-damaging conditions

scientific article

Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy

scientific article published on 18 July 2008

Reduced Tim-3 Expression on Human T-lymphotropic Virus Type I (HTLV-I) Tax-specific Cytotoxic T Lymphocytes in HTLV-I Infection ⬇️

scientific article published on April 1, 2011

Reduced Tim-3 expression on HTLV-I Tax-specific cytotoxic T lymphocytes in HTLV-I infection

scientific article published on 6 June 2011

Retraction Note: Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells ⬇️

scientific article published on January 6, 2011

Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo

scientific article published on 26 October 2006

Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton

scientific article

Successful development of novel monoclonal antibodies against HTLV-1 bZIP factor and their applications in studying the pathogenesis of HAM/TSP

article

Suppression of CCR5-Tropic HIV Type 1 Infection by OX40 Stimulation via Enhanced Production of β-Chemokines ⬇️

scientific article published on September 21, 2010

The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis

scientific article published on 4 December 2017

The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation

scientific article

The neutralizing function of the anti-HTLV-1 antibody is essential in preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/γcnull (NOG) mice

scientific article

The plasticity of HTLV-1 infected CD4+CD25+CCR4+ T-cells through HTLV-1 tax in HAM/TSP.

scientific article

Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax.

scientific article published on July 2005

Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication

scientific article published on 27 March 2013

c‐Maf suppresses human T‐cell leukemia virus type 1 Tax by competing for CREB‐binding protein ⬇️

scientific article published on February 15, 2011

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