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List of works by Basil Rapoport

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The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim

scientific article
The thyrotropin receptor in Graves' disease

scientific article published on October 2007
Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor

scientific article
Breaking Tolerance to Thyroid Antigens: Changing Concepts in Thyroid Autoimmunity

scientific article published on December 4, 2013
The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction

scientific article published on 24 January 2008
Thyrotropin-Blocking Autoantibodies and Thyroid-Stimulating Autoantibodies: Potential Mechanisms Involved in the Pendulum Swinging from Hypothyroidism to Hyperthyroidism or Vice Versa

scientific article published on January 1, 2013
Schistosoma mansoni and alpha-galactosylceramide: prophylactic effect of Th1 Immune suppression in a mouse model of Graves' hyperthyroidism

scientific article
Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization

scientific article published on 16 October 2008
Insight into Graves' hyperthyroidism from animal models

scientific article
The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells

scientific article
Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine

scientific article published in April 2003
Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity

scientific article published in February 2007
Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies?

scientific article published in July 2004
Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies

scientific article
Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease

scientific article published on 09 December 2008
Thyroid peroxidase as an autoantigen

scientific article published on October 2007
A Unique Mouse Strain That Develops Spontaneous, Iodine-Accelerated, Pathogenic Antibodies to the Human Thyrotrophin Receptor

scientific article published on March 30, 2015
Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens

scientific article published on 05 March 2009
Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease

scientific article published on 23 October 2003
Graves' Hyperthyroidism Is Antibody-Mediated But Is Predominantly a Th1-Type Cytokine Disease

scientific article published on September 11, 2014
The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors

scientific article published in May 2003
Targeted expression of the human thyrotropin receptor A-subunit to the mouse thyroid: insight into overcoming the lack of response to A-subunit adenovirus immunization

scientific article
Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice

scientific article published on 27 December 2007
Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice

scientific article published on 16 March 2006
Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus

scientific article published in May 2006
Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties

scientific article published on 3 April 2008
A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain

scientific article published on 19 March 2009
Breaking Tolerance in Transgenic Mice Expressing the Human TSH Receptor A-Subunit: Thyroiditis, Epitope Spreading and Adjuvant as a ‘Double Edged Sword’

scientific article published on September 7, 2012
Dissociation between iodide-induced thyroiditis and antibody-mediated hyperthyroidism in NOD.H-2h4 mice

scientific article published on 30 September 2004
Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activity

scientific article published in September 2003
TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective

scientific article published on 22 January 2016
Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies

scientific article published on 23 April 2009
Evidence That the Thyroid-stimulating Hormone (TSH) Receptor Transmembrane Domain Influences Kinetics of TSH Binding to the Receptor Ectodomain

scientific article published on December 28, 2010
Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice

scientific article published on 16 June 2010
Immune deviation away from Th1 in interferon-gamma knockout mice does not enhance TSH receptor antibody production after naked DNA vaccination

scientific article published in April 2002
A major role for non-major histocompatibility complex genes but not for microorganisms in a novel murine model of Graves' hyperthyroidism

scientific article published in March 2003
Thyrotropin (TSH) Receptor Residue E251 in the Extracellular Leucine-Rich Repeat Domain Is Critical for Linking TSH Binding to Receptor Activation

scientific article published on February 24, 2010
Relationship between Thyrotropin Receptor Hinge Region Proteolytic Posttranslational Modification and Receptor Physiological Function

scientific article published on November 24, 2010
Critical Differences between Induced and Spontaneous Mouse Models of Graves' Disease with Implications for Antigen-Specific Immunotherapy in Humans

scientific article
Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease

scientific article published on April 9, 2015
Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies

scientific article published on 18 May 2004
Evidence that human thyroid cells express uncleaved, single-chain thyrotropin receptors on their surface

scientific article published on 23 February 2006
Exceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease

scientific article
Thyroid antigens, not central tolerance, control responses to immunization in BALB/c versus C57BL/6 mice

scientific article
Affinity-enrichment of thyrotropin receptor autoantibodies from Graves' patients and normal individuals provides insight into their properties and possible origin from natural antibodies

scientific article published in September 2004
Variable Suppression of Serum Thyroxine in Female Mice of Different Inbred Strains by Triiodothyronine Administered in Drinking Water

scientific article published on October 1, 2010
Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies

scientific article
Sex, genetics, and the control of thyroxine and thyrotropin in mice

scientific article
Human autoantibodies modulate the T cell epitope repertoire but fail to unmask a pathogenic cryptic epitope

scientific article
Insight into Thyroid-Stimulating Autoantibody Interaction with the Thyrotropin Receptor N-Terminus Based on Mutagenesis and Re-Evaluation of Ambiguity in This Region of the Receptor Crystal Structure

scientific article published on August 11, 2011

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