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List of works by Basil Rapoport

"Hijacking" the thyrotropin receptor: A chimeric receptor-lysosome associated membrane protein enhances deoxyribonucleic acid vaccination and induces Graves' hyperthyroidism

scientific article

A major role for non-major histocompatibility complex genes but not for microorganisms in a novel murine model of Graves' hyperthyroidism

scientific article published in March 2003

A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain

scientific article published on 19 March 2009

A unique mouse strain that develops spontaneous, iodine-accelerated, pathogenic antibodies to the human thyrotrophin receptor

scientific article

Aberrant Iodine Autoregulation Induces Hypothyroidism in a Mouse Strain in the Absence of Thyroid Autoimmunity.

scientific article

Affinity-enrichment of thyrotropin receptor autoantibodies from Graves' patients and normal individuals provides insight into their properties and possible origin from natural antibodies

scientific article published in September 2004

An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens

scientific article

Antibodies focused on the human autoantibody immunodominant region are induced by B lymphocytes that constitutively express thyroid peroxidase diverted to the major histocompatibility complex II pathway

scientific article published in April 2006

Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies

scientific article

Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies

scientific article published on 23 April 2009

Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus

scientific article published in May 2006

Boris Catz, MD (1923-2013).

scientific article published in July 2013

Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'.

scientific article

Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity

scientific article

Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease

scientific article

Critical Differences between Induced and Spontaneous Mouse Models of Graves' Disease with Implications for Antigen-Specific Immunotherapy in Humans

scientific article

Crystal structure of a TSH receptor monoclonal antibody: insight into Graves' disease pathogenesis

scientific article

Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells

scientific article published on 10 April 2015

Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies

scientific article

Dissociation between iodide-induced thyroiditis and antibody-mediated hyperthyroidism in NOD.H-2h4 mice

scientific article published on 30 September 2004

Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice

scientific article

Does thyrotropin cleave its cognate receptor?

scientific article published on 28 August 2003

Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice

scientific article published on 16 June 2010

Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease

scientific article published on 9 April 2015

Evidence that human thyroid cells express uncleaved, single-chain thyrotropin receptors on their surface

scientific article published on 23 February 2006

Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease

scientific article published on 09 December 2008

Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activity

scientific article published in September 2003

Evidence that the complement control protein-epidermal growth factor-like domain of thyroid peroxidase lies on the fringe of the immunodominant region recognized by autoantibodies

scientific article

Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain

scientific article

Evidence that the thyrotropin receptor protease is membrane-associated and is not within lipid rafts

scientific article published in October 2004

Exceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease

scientific article

Gene expression profiles differ markedly in mouse strains that are (or are not) susceptible to hyperthyroidism induced using thyrotropin receptor-expressing adenovirus

scientific article published in November 2005

Genes Outside the Major Histocompatibility Complex Locus Are Linked to the Development of Thyroid Autoantibodies and Thyroiditis in NOD.H2h4 Mice

scientific article published on 17 January 2017

Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function

scientific article published on March 2013

Graves' hyperthyroidism and the hygiene hypothesis in a mouse model

scientific article published on 12 August 2004

Graves' hyperthyroidism is antibody-mediated but is predominantly a Th1-type cytokine disease

scientific article

HLA-DR3 transgenic mice immunized with adenovirus encoding the thyrotropin receptor: T cell epitopes and functional analysis of the CD40 Graves' polymorphism

scientific article published in December 2006

Half a century after the discovery of thyroid autoimmunity: the impact of molecular biology.

scientific article published in October 2007

Human autoantibodies modulate the T cell epitope repertoire but fail to unmask a pathogenic cryptic epitope

scientific article

Human monoclonal thyroglobulin autoantibodies: epitopes and immunoglobulin genes

scientific article

Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties

scientific article published on 3 April 2008

Immune deviation away from Th1 in interferon-gamma knockout mice does not enhance TSH receptor antibody production after naked DNA vaccination

scientific article published in April 2002

Immunoglobulin heavy chain variable region and major histocompatibility region genes are linked to induced graves' disease in females from two very large families of recombinant inbred mice

scientific article

Insight into Graves' hyperthyroidism from animal models

scientific article

Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure

scientific article

Long term persistence of thyrotropin receptor antibodies in wild-type and transgenic mice in a Graves' disease model

scientific article published on 10 April 2012

Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease

scientific article published on 23 October 2003

Naked deoxyribonucleic acid vaccination induces recognition of diverse thyroid peroxidase T cell epitopes

scientific article published on 3 May 2004

Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptor

scientific article

Peptide scanning for thyrotropin receptor T-cell epitopes in mice vaccinated with naked DNA.

scientific article

Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine

scientific article published in April 2003

Probing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational forms

scientific article

Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice

scientific article published on 16 March 2006

Reflections on Thyroid Autoimmunity: A Personal Overview from the Past into the Future

article

Relationship between Thyrotropin Receptor Hinge Region Proteolytic Posttranslational Modification and Receptor Physiological Function ⬇️

scientific article published on November 24, 2010

Relationship between thyroid peroxidase T cell epitope restriction and antibody recognition of the autoantibody immunodominant region in human leukocyte antigen DR3 transgenic mice

scientific article

Review and hypothesis: does Graves' disease develop in non-human great apes?

scientific article

Role of self-tolerance and chronic stimulation in the long-term persistence of adenovirus-induced thyrotropin receptor antibodies in wild-type and transgenic mice

scientific article

Schistosoma mansoni and alpha-galactosylceramide: prophylactic effect of Th1 Immune suppression in a mouse model of Graves' hyperthyroidism

scientific article

Sex, genetics, and the control of thyroxine and thyrotropin in mice

scientific article

Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice

scientific article published on 27 December 2007

Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens

scientific article published on 05 March 2009

Subclinical Nonautoimmune Hyperthyroidism in a Family Segregates with a Thyrotropin Receptor Mutation with Weakly Increased Constitutive Activity ⬇️

scientific article published on October 7, 2010

Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity.

scientific article published in February 2007

TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective

scientific article published on 22 January 2016

TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective.

scientific article

Targeted expression of the human thyrotropin receptor A-subunit to the mouse thyroid: insight into overcoming the lack of response to A-subunit adenovirus immunization.

scientific article

Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity

scientific article published in April 2003

The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors

scientific article published in May 2003

The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells

scientific article

The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim

scientific article

The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activation

scientific article

The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction

scientific article published on 24 January 2008

The thyrotropin receptor in Graves' disease

scientific article published on October 2007

Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies

scientific article

Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

scientific article published on 20 December 2017

Thyroid Hemiagenesis in a Thyroiditis Prone Mouse Strain

article published in 2018

Thyroid antigens, not central tolerance, control responses to immunization in BALB/c versus C57BL/6 mice

scientific article

Thyroid autoantibodies are rare in nonhuman great apes and hypothyroidism cannot be attributed to thyroid autoimmunity

scientific article published on 03 October 2013

Thyroid peroxidase as an autoantigen

scientific article published on October 2007

Thyroid stimulating monoclonal antibodies: overcoming the road blocks and the way forward

scientific article published on July 2004

Thyroid stimulation does not require antibodies with identical epitopes but does involve recognition of a critical conformation at the N terminus of the thyrotropin receptor A-subunit

scientific article published in April 2004

Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor

scientific article

Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation

scientific article

Thyrotropin Receptor-DNA Vaccination of Transgenic Mice Expressing HLA-DR3 or HLA-DQ6b ⬇️

scientific article published on October 1, 2003

Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa

scientific article published on January 2013

Variable Effects of Dietary Selenium in Mice That Spontaneously Develop a Spectrum of Thyroid Autoantibodies

scientific article published on 25 August 2017

Variable Suppression of Serum Thyroxine in Female Mice of Different Inbred Strains by Triiodothyronine Administered in Drinking Water ⬇️

scientific article published on October 1, 2010

Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization

scientific article published on 16 October 2008

Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies?

scientific article published in July 2004

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