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List of works by Michael Andreeff

1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53.

scientific article

2-Chlorodeoxyadenosine and cytarabine combination therapy for idiopathic hypereosinophilic syndrome

scientific article

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

scientific article published on 23 August 2005

A Phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia

scientific article

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

scientific article published on 12 January 2006

A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia

scientific article

A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.

scientific article published on 23 March 2017

A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas

scientific article

A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies

scientific article published in December 2008

A phase II study of omacetaxine mepesuccinate for patients with higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia after failure of hypomethylating agents

scientific article published on 15 November 2018

A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia

scientific article published on June 2012

A randomized trial of liposomal daunorubicin and cytarabine versus liposomal daunorubicin and topotecan with or without thalidomide as initial therapy for patients with poor prognosis acute myelogenous leukemia or myelodysplastic syndrome

scientific article published in March 2003

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

scientific article published on March 2006

ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukaemias with diverse drug-resistance mechanisms

scientific article published on 20 November 2007

AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth

scientific article

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

scientific article published on 16 February 2016

Abstract 1339: Upregulation of the glutathione detoxification pathway protects against cytotoxicity induced by the alkylating agent, 2-chloroethyl ethyl sulfide (CEES)

Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer

scientific article

Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells

scientific article published in January 2007

Activation of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells ⬇️

scientific article published on September 15, 2003

Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death

scientific article published on August 2005

Acute Myeloid Leukemia Cells Acquire Stem Cell Features in the Bone Marrow Microenvironment

Advances in gene transfer into haematopoietic stem cells by adenoviral vectors

scientific article

An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML

scientific article published on 23 January 2019

An in vivo propagated human acute myeloid leukemia expressing ABCA3.

scientific article published in March 2004

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

scientific article published on 14 September 2017

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

scientific article published on 04 March 2016

Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities

scientific article published in November 2017

Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin

scientific article

Antileukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody Conjugate, in Acute Myeloid Leukemia

scientific article published on 17 January 2017

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

scientific article published in June 2015

Apoptosis in leukemias: regulation and therapeutic targeting

scientific article published on January 2010

Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia

scientific article

BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells

scientific article published on 13 August 2013

BH3 profiling discriminates response to cytarabine-based treatment of acute myelogenous leukemia

scientific article published on 03 October 2013

Bcl-B expression in human epithelial and nonepithelial malignancies

scientific article

Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.

scientific article

Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells

scientific article published on 20 January 2017

Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang

scientific article published on June 2016

Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors

Buparlisib, a PI3K inhibitor, demonstrates acceptable tolerability and preliminary activity in a phase I trial of patients with advanced leukemias

scientific article published on 27 September 2016

Bystander Transfer of Functional Human CD40 Ligand from Gene-Modified Fibroblasts to B-Chronic Lymphocytic Leukemia Cells ⬇️

scientific article published on April 10, 2003

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha

scientific article

CDDO-imidazolide mediated inhibition of malignant cell growth in Waldenström macroglobulinemia

scientific article published on 12 May 2008

CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia

scientific article

CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia ⬇️

scientific article published on May 8, 2013

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure

scientific article published on 28 October 2008

CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells

scientific article published on January 2008

Cancer stem cell definitions and terminology: the devil is in the details

scientific article published on 11 October 2012

Case series of patients with acute myeloid leukemia receiving hypomethylation therapy and retrospectively found to have IDH1 or IDH2 mutations

scientific article

Cell-surface expression of neuron-glial antigen 2 (NG2) and melanoma cell adhesion molecule (CD146) in heterogeneous cultures of marrow-derived mesenchymal stem cells

scientific article published on 30 May 2013

Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK

scientific article

Changes associated with the development of resistance to imatinib (STI571) in two leukemia cell lines expressing p210 Bcr/Abl protein

scientific article published on April 2004

Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia

scientific article

Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma

scientific article published on 19 September 2013

Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia

scientific article published on 27 April 2018

Clofarabine Plus Low-Dose Cytarabine Is as Effective as and Less Toxic Than Intensive Chemotherapy in Elderly AML Patients

scientific article published on 24 November 2015

Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients ≤60 years with newly diagnosed acute myeloid leukemia

scientific article

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics

scientific article published on 21 October 2020

Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells

scientific article published on 15 December 2015

Combinatorial inhibition of focal adhesion kinase and BCL-2 enhances anti-leukemia activity of venetoclax in acute myeloid leukemia

scientific article published on 13 May 2020

Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial

scientific article

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

scientific article published on September 2016

Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia

scientific article published on 8 June 2017

Comparative Effects of Volutrauma and Atelectrauma on Lung Inflammation in Experimental Acute Respiratory Distress Syndrome

scientific article published on 31 March 2016

Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth? ⬇️

scientific article published on January 1, 2011

Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells

scientific article published on 15 August 2012

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

scientific article published on December 2006

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

scientific article published on 16 July 2008

Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment

scientific article published on 05 June 2013

Correlation between CXCR4 and Homing or Engraftment of Acute Myelogenous Leukemia

article

Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML

scientific article published on 10 March 2009

DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia

scientific article published on 22 June 2016

Decreased sensitivity of 17p‐deleted chronic lymphocytic leukemia cells to a small molecule BCL‐2 antagonist ABT‐737 ⬇️

scientific article published on July 14, 2011

Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells

scientific article published on November 2005

Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells

scientific article

Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging

scientific article

Discovery and clinical introduction of first-in-class imipridone ONC201.

scientific article published on September 2016

Discovery and functional implications of a miR-29b-1/miR-29a cluster polymorphism in acute myeloid leukemia

scientific article published on 12 December 2017

Disruption of Wnt/β-catenin exerts anti-leukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia

scientific article published on 20 February 2018

Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival

scientific article published on 15 March 2018

Dose-dependent histological alterations in the rat lung following intravenous application of Re-188-labeled microspheres

scientific article

Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis

scientific article published on August 2004

Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies

scientific article published on 24 January 2012

ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia

scientific article

Early detection of transformation to BPDCN in a patient with MDS

Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia

scientific article

Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells

scientific article published on November 2006

Effects of PPARγ Ligands on Leukemia

scientific article published on 21 May 2012

Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia.

scientific article published in October 2003

Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Non-randomized, Open-label, Phase 2 Study

scientific article published on 08 November 2018

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation

scientific article published on 16 March 2015

Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survival

scientific article published in January 2004

Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells

scientific article

Eradication of CML stem cells

scientific article published on 23 November 2016

Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells

scientific article

Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO).

scientific article published on 7 January 2004

Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies

scientific article published on 09 January 2003

Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML

scientific article

Expression of CD40 ligand (CD154) in B and T lymphocytes of Hodgkin disease: potential therapeutic significance

scientific article published in January 2002

Expression of inducible Bcl-X(S) in myeloid leukemia: compensatory upregulation of Bcl-X(L) and Bcl-2 prevents apoptosis and chemosensitization

scientific article

Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein

scientific article published on 3 June 2015

Fludarabine and mitoxantrone for patients with chronic lymphocytic leukemia

scientific article published in June 2004

Focal Adhesion Kinase as a Potential Target in AML and MDS.

scientific article published on 7 March 2017

Functional blocks in caspase activation pathways are common in leukemia and predict patient response to induction chemotherapy

scientific article published in March 2003

Functional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling

scientific article

Functional proteomic profiling of AML predicts response and survival

scientific article

Ga-68- and Cu-64-Labeled NOTA-Albumin Conjugates for PET Sentinel Lymph Node Imaging

Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-gamma expression

scientific article published on April 2004

Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure

scientific article published in December 2005

High Expression of Human Homologue of Murine Double Minute 4 and the Short Splicing Variant, HDM4-S, in Bone Marrow in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

scientific article published on April 2016

High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia

scientific article published on 28 June 2017

Higher levels of spontaneous breathing induce lung recruitment and reduce global stress/strain in experimental lung injury

scientific article published in March 2014

Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta24-RGD to human gliomas

scientific article

Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas

scientific article published in April 2005

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

scientific article

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

scientific article published on 24 November 2015

IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells

scientific article

Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results.

scientific article

Implementation of a Pan-Genomic Approach to Investigate Holobiont-Infecting Microbe Interaction: A Case Report of a Leukemic Patient with Invasive Mucormycosis

scientific article published on 10 November 2015

Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML.

scientific article published on 04 March 2014

Improvement in clinical outcome of FLT3 ITD mutated acute myeloid leukemia patients over the last one and a half decade

scientific article

Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells

scientific article published on 5 April 2005

Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma

scientific article

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias

scientific article published in December 2006

Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine

scientific article published in Scientific Reports

Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

scientific article published on 4 June 2015

Inhibition of constitutively activated nuclear factor-kappaB radiosensitizes human melanoma cells.

scientific article published on August 2004

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia

scientific article published on 19 May 2022

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

scientific article published on May 2008

Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma

scientific article published on June 2007

Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo

scientific article published in October 2002

Initial Report of a Phase I Study of LY2510924, Idarubicin, and Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia ⬇️

Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes

scientific article published in Nature Communications

Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells

scientific article published on 19 November 2015

Investigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemia

scientific article

Isolation and perivascular localization of mesenchymal stem cells from mouse brain

scientific article published on September 2010

Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress

scientific article

Janus kinase 2 variants associated with the transformation of myeloproliferative neoplasms into acute myeloid leukemia

scientific article published on 27 February 2019

Laser nanothermolysis of human leukemia cells using functionalized plasmonic nanoparticles

scientific article

Leukemia cell mobilization with G-CSF plus plerixafor during busulfan-fludarabine conditioning for allogeneic stem cell transplantation

scientific article published on 13 April 2015

Liposomal Grb2 antisense oligodeoxynucleotide (BP1001) in patients with refractory or relapsed haematological malignancies: a single-centre, open-label, dose-escalation, phase 1/1b trial

scientific article published on 14 March 2018

Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab

scientific article published on 21 December 2016

Loss of expression of both miR-15/16 loci in CML transition to blast crisis

scientific article published on 16 March 2021

Low levels of ABCG2 expression in adult AML blast samples

scientific article published on 25 July 2002

Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens

scholarly article by George Z Rassidakis et al published 19 October 2018 in Blood Cancer Journal

MDA-7/IL-24-based cancer gene therapy: translation from the laboratory to the clinic

scientific article

MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation

scientific article published on 6 October 2015

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

scientific article published on 12 July 2005

MEK blockade converts AML differentiating response to retinoids into extensive apoptosis

scientific article published on 31 October 2006

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

scientific article

MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells

scientific article published on 04 July 2016

MYC protein expression is an important prognostic factor in acute myeloid leukemia

scientific article published on 09 May 2018

Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression

scientific article published on 29 August 2017

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

scientific article published on 16 March 2006

Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage

scientific article published in 2023

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

scientific article

Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment

scientific article published on 2 October 2012

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

scientific article

Mechanisms of drug resistance in AML.

scientific article

Mesenchymal CD44 Expression Contributes to the Acquisition of an Activated Fibroblast Phenotype via TWIST Activation in the Tumor Microenvironment ⬇️

scientific article published on 09 July 2013

Mesenchymal Stem Cells Differentiate into Osteoblasts in the Presence of AML Cells through Up-regulation of RUNX2 and Induce Chemo-resistance

article by V. Lokesh Battula et al published June 2015 in Clinical Lymphoma, Myeloma & Leukemia

Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway

scientific article published on 27 May 2015

Mesenchymal Stem Cells Overexpressing IFN-β Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model ⬇️

scientific article published on March 19, 2010

Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression

scientific article

Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles

scientific article published on July 2007

Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells

scientific article

Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents

Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment

scientific article published on September 2010

Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas

scientific article published on 20 February 2017

Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a

scientific article

MicroRNA 29b functions in acute myeloid leukemia

scientific article

MicroRNA fingerprints during human megakaryocytopoiesis

scientific article

MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

scientific article

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

scientific article published on 11 February 2009

Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs

scientific article

Mitochondrial Uncoupling and the Reprograming of Intermediary Metabolism in Leukemia Cells ⬇️

scientific article published on April 2, 2013

Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism

scientific article published on 03 March 2009

Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells

scientific article published on April 2007

Mitotic deregulation by survivin in ErbB2-overexpressing breast cancer cells contributes to Taxol resistance

scientific article published on February 2009

Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes

scientific article published on 18 May 2016

Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemia

scientific article published on 09 July 2012

More than 1 TP53 abnormality is a dominant characteristic of pure erythroid leukemia.

scientific article

Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia

scientific article

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia ⬇️

scientific article published on January 1, 2002

Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors

scientific article

On the Reliability of Automatic Volume Delineation in Low-Contrast [(18)F]FMISO-PET Imaging

scientific article published on January 2016

Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma

scientific article

Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis

scholarly article by Phuong M Le et al published 18 October 2018 in Haematologica

Outcomes with lower intensity therapy in TP53-mutated acute myeloid leukemia

scientific article published on 17 January 2018

Outcomes with sequential FLT3-inhibitor-based therapies in patients with AML

scientific article published on 08 October 2020

Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.

scientific article

Oxygen sensing mesenchymal progenitors promote neo-vasculogenesis in a humanized mouse model in vivo

scientific article (publication date: 2012)

PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment

scientific article published on 18 August 2013

PML-RARalpha is associated with leptin-receptor induction: the role of mesenchymal stem cell-derived adipocytes in APL cell survival

scientific article

PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.

scientific article published on 4 September 2007

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

scientific article published on 21 February 2017

Peripheral blood blast clearance is an independent prognostic factor for survival and response to acute myeloid leukemia induction chemotherapy

scientific article published on 30 July 2016

Persistence of minimal residual disease assessed by multiparameter flow cytometry is highly prognostic in younger patients with acute myeloid leukemia

scientific article published on 22 September 2016

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

scientific article published on 17 November 2005

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

scientific article

Pharmacological activation of wild-type p53 in the therapy of leukemia

scientific article published on 17 June 2016

Phase 1 Study of combinatorial sorafenib, G-CSF, and plerixafor treatment in relapsed/refractory, FLT3-ITD-mutated acute myelogenous leukemia patients

scientific article published on 22 July 2020

Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation

scientific article published on 23 April 2013

Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia

scientific article published on 11 May 2016

Phase I study of sorafenib in patients with refractory or relapsed acute leukemias

scientific article

Phase I trial and correlative laboratory studies of bryostatin 1 (NSC 339555) and high-dose 1-B-D-arabinofuranosylcytosine in patients with refractory acute leukemia.

scientific article

Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia

scientific article

Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia

scientific article

Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia

scientific article published on 03 August 2009

Phase I/II trial of nanomolecular liposomal annamycin in adult patients with relapsed/refractory acute lymphoblastic leukemia

scientific article published on 10 June 2013

Phase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome

scientific article

Phase II study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and GM-CSF (FACPGM) in patients with Richter's syndrome or refractory lymphoproliferative disorders

scientific article

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia

scientific article published in February 2002

Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia

scientific article published on 31 March 2011

Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients

scientific article

Platelet senescence and phosphatidylserine exposure

scientific article

Platelet-derived growth factor BB mediates the tropism of human mesenchymal stem cells for malignant gliomas

scientific article

Platelets promote mitochondrial uncoupling and resistance to apoptosis in leukemia cells: a novel paradigm for the bone marrow microenvironment

scientific article

Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapy

scientific article

Preclinical and early clinical evaluation of the oral AKT inhibitor, MK-2206, for the treatment of acute myelogenous leukemia

scientific article published on 28 February 2014

Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102.

scientific article

Predictive gene signatures determine tumor sensitivity to MDM2 inhibition

scientific article published on 28 February 2018

Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid

scientific article published on November 2014

Prognosis of patients with intermediate risk IPSS-R myelodysplastic syndrome indicates variable outcomes and need for models beyond IPSS-R

scientific article published on 26 September 2018

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

scientific article published on 5 April 2013

Prognostic significance of alterations in IDH enzyme isoforms in patients with AML treated with high-dose cytarabine and idarubicin

scientific article

Prognostic significance of baseline FLT3-ITD mutant allele level in acute myeloid leukemia treated with intensive chemotherapy with/without sorafenib

scientific article published on 24 June 2019

Proliferation and apoptosis in acute and chronic leukemias and myelodysplastic syndrome

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Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104

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Protection against 2-chloroethyl ethyl sulfide (CEES) — induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway ⬇️

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Proteomic profiling identifies distinct protein patterns in acute myelogenous leukemia CD34+CD38- stem-like cells

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Publisher Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics

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Quantitative analysis of regional lung ventilation and perfusion PET with (68)Ga-labelled tracers

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Radiation protection in radiosynovectomy of the knee

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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

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Regulation and targeting of Eg5, a mitotic motor protein in blast crisis CML: overcoming imatinib resistance

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Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

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Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells

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Relapse risk and survival in patients with FLT3 mutated acute myeloid leukemia undergoing stem cell transplantation

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Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia

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Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia

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Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia

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Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase

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Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies

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Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

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Role of MSC-derived galectin 3 in the AML microenvironment

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Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia

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Role of peroxisome proliferator-activated receptor-gamma in hematologic malignancies

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SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer

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SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia

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SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome

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ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway

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Safety and pharmacokinetics of the antisense oligonucleotide (ASO) LY2181308 as a single-agent or in combination with idarubicin and cytarabine in patients with refractory or relapsed acute myeloid leukemia (AML) ⬇️

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Salvage therapy using FLT3 inhibitors may improve long-term outcome of relapsed or refractory AML in patients with FLT3-ITD

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Selection of chronic lymphocytic leukemia binding peptides ⬇️

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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

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Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression

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Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

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Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML.

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Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia

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Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

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Single-Cell Mass Cytometry of Acute Myeloid Leukemia and Leukemia Stem/Progenitor Cells

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Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series.

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Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells

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Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

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Sorafenib Combined with 5-azacytidine in Older Patients with Untreated FLT3-ITD Mutated Acute Myeloid Leukemia

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Spontaneous migration of acute promyelocytic leukemia cells beneath cultured bone marrow adipocytes with matched expression of the major histocompatibility complex.

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Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy

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Stromal Cells Derived from Visceral and Obese Adipose Tissue Promote Growth of Ovarian Cancers

scientific article published on 28 August 2015

Studying the right cell in acute myelogenous leukemia: dynamic changes of apoptosis and signal transduction pathway protein expression in chemotherapy resistant ex-vivo selected "survivor cells".

scientific article published in December 2006

Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome

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Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

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Survivorship in AML - a landmark analysis on the outcomes of acute myelogenous leukemia patients after maintaining complete remission for at least 3 years

scientific article published on 05 August 2020

Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells

scientific article published on 29 September 2015

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

scientific article published in May 2002

Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents

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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

scientific article published in December 2017

Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells

scientific article published in February 2006

TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells

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TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells ⬇️

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TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment

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Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells ⬇️

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Targeting autophagy to overcome chemoresistance in acute myleogenous leukemia

scientific article published on 31 October 2016

Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth

scientific article published on 24 October 2013

Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1

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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment ⬇️

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Targeting the leukemia microenvironment

scientific article published on June 2007

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

scientific article published on 27 October 2008

Tetra-O-methyl nordihydroguaiaretic acid inhibits growth and induces death of leukemia cells independent of Cdc2 and survivin

scientific article published on April 2007

The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo

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The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations

scientific article published on 28 January 2016

The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma

scientific article published on 29 August 2017

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

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The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr Mice ⬇️

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The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells

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The authors reply

The combinatorial complexity of cancer precision medicine

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The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia

scientific article published on 30 November 2018

The effect of calcium channel blockers on the outcome of acute myeloid leukemia

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The elusive chronic myeloid leukemia stem cell: does it matter and how do we eliminate it?

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The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives ⬇️

scientific article published on February 8, 2012

The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies.

scientific article published on June 2003

The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) induces apoptosis in Mycosis fungoides/Sézary syndrome cells

scientific article published on August 2004

The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling

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The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias ⬇️

scientific article published on August 24, 2010

The organic arsenic derivative GMZ27 induces PML-RARα-independent apoptosis in myeloid leukemia cells

scientific article published on July 2012

The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells

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The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

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The synthetic triterpenoid, CDDO, suppresses alloreactive T cell responses and reduces murine early acute graft-versus-host disease mortality

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The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore

scientific article published on February 2007

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

scientific article published in October 2002

The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation

scientific article published on July 2008

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies

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Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches

scientific article published on 25 July 2009

Therapy of bone metastases with radium-223. German guidelines

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Treated secondary acute myeloid leukemia: a distinct high-risk subset of AML with adverse prognosis

scientific article published on 19 July 2017

Treatment of FLT3-ITD-positive acute myeloid leukemia relapsing after allogeneic stem cell transplantation with sorafenib

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Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate

scientific article published on 9 October 2003

Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations

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Triapine and cytarabine is an active combination in patients with acute leukemia or myelodysplastic syndrome

scientific article published on 14 February 2006

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

scientific article published on 23 March 2006

Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells

scientific article published on September 2009

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

scientific article published on 10 January 2008

Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma

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Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia

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Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment

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Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia

scientific article published on 23 February 2015

Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells

scientific article published on 13 October 2005

Venetoclax with Decitabine Versus Intensive Chemotherapy in Acute Myeloid Leukemia: A Propensity Score Matched Analysis Stratified by Risk of Treatment-related Mortality

scientific article published on 02 December 2020

Vosaroxin in combination with decitabine in newly diagnosed older patients with acute myeloid leukemia or high-risk myelodysplastic syndrome

scientific article published on 20 July 2017

XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38− cells in a phase 1/2 study of patients with relapsed/refractory AML ⬇️

scientific article published on January 1, 2011

XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells ⬇️

scientific article published on May 10, 2013

p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12 ⬇️

scientific article published on August 25, 2011

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