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List of works by Konstanze Döhner

A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy ⬇️

scientific article published on November 4, 2011

A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).

scientific article

A phase I/II study of sunitinib and intensive chemotherapy in patients over 60 years of age with acute myeloid leukaemia and activating FLT3 mutations

scientific article

A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia

scientific article

ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group

scientific article

Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages

scientific article published on 17 September 2012

Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations

scientific article published on 01 April 2005

Acute myeloid leukemia. Introduction

scientific article published on 01 August 2008

All-trans retinoic acid as adjunct to intensive treatment in younger adult patients with acute myeloid leukemia: results of the randomized AMLSG 07-04 study

scientific article

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia

scientific article published on November 2012

Analysis of NPM1 splice variants reveals differential expression patterns of prognostic value in acute myeloid leukemia

scientific article published on 3 August 2017

Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group

scientific article

Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure

scientific article

CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling

scientific article

CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations

scientific article

Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia

scientific article published on 21 December 2016

Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis

scientific article

Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model

scholarly article

Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia ⬇️

scientific article published on May 24, 2013

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype

scientific article published on 27 October 2017

Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8+ T-cell responses and are lacking costimulatory molecules.

scientific article

Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia

scientific article published on 29 September 2017

Clinical and functional implications of microRNA mutations in a cohort of 935 patients with myelodysplastic syndromes and acute myeloid leukemia

scientific article published on 31 December 2014

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG) ⬇️

scientific article published on April 30, 2013

Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia ⬇️

scientific article published on May 23, 2013

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation

Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells

scientific article

Core-binding factor acute myeloid leukemia: can we improve on HiDAC consolidation?

scientific article

Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B.

scientific article

DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acu

scientific article published on 26 May 2015

Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group

scientific article published on 24 September 2012

Detection of mutant NPM1 mRNA in acute myeloid leukemia using custom gene expression arrays

scientific article published on April 2013

Development of a real‐time RT‐PCR assay for the quantification of the most frequent MLL/AF9 fusion types resulting from translocation t(9;11)(p22;q23) in acute myeloid leukemia ⬇️

scientific article published on November 1, 2003

Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation

scientific article published on 30 September 2014

Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes

scientific article

Disclosure of Candidate Genes in Acute Myeloid Leukemia With Complex Karyotypes Using Microarray-Based Molecular Characterization

Disease evolution and outcomes in familial AML with germline CEBPA mutations

scientific article published on 10 July 2015

Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients: retrospective assessment in 1470 patients

scientific article

Effect of mutation order on myeloproliferative neoplasms

scientific article

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia

scientific article published on 12 February 2018

Evaluating the impact of genetic and epigenetic aberrations on survival and response in acute myeloid leukemia patients receiving epigenetic therapy

scientific article

Expression of tumor-associated antigens in acute myeloid leukemia: Implications for specific immunotherapeutic approaches

scientific article

Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

scientific article

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial

scientific article published on 20 March 2014

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

scientific article published on 07 May 2007

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

scientific article

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations

scientific article published on 23 May 2014

Genomic Classification and Prognosis in Acute Myeloid Leukemia

scientific article

Genomics of Acute Myeloid Leukemia Diagnosis and Pathways

scientific article

Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype

scientific article

Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia ⬇️

scientific article published on April 9, 2012

High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia

scientific article

High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics

scientific article

High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations ⬇️

scientific article published on January 10, 2012

High-resolution single-nucleotide polymorphism array-profiling in myeloproliferative neoplasms identifies novel genomic aberrations

scientific article

Human chromosome 7: DNA sequence and biology

scientific article

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

scientific article published on 21 June 2010

Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study

scientific article published on 4 February 2013

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

scientific article published in December 2007

Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase

scientific article

Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut) ⬇️

scientific article published on August 8, 2013

Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

scientific article published on 01 January 2020

Impact of new prognostic markers in treatment decisions in acute myeloid leukemia

scientific article published on March 2009

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.

scientific article published on 24 October 2008

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial

scientific article published on 31 October 2016

Inactivating CUX1 mutations promote tumorigenesis

scientific article

Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells

scientific article

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms

scientific article published on 3 November 2011

Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome.

scientific article published on 14 July 2009

Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia ⬇️

scientific article published on August 31, 2011

Intermediate-risk acute myeloid leukemia therapy: current and future

scientific article

JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone

scientific article published on 16 August 2012

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

KIT mutations confer a distinct gene expression signature in core binding factor leukaemia

scientific article published on 08 January 2010

MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.

scientific article published on 22 June 2016

MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.

scientific article

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2 ⬇️

scientific article published on May 6, 2013

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia

scientific article published on 7 December 2017

MicroRNA expression-based outcome prediction in acute myeloid leukemia: novel insights through cross-platform integrative analyses

scientific article published on 28 July 2016

MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development

scientific article published on 09 September 2016

Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial

scientific article published on 01 October 2020

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

scientific article published on 23 June 2017

Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML.

scientific article published on 18 April 2017

Molecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML.

scientific article published on January 2011

Molecular dissection of valproic acid effects in acute myeloid leukemia identifies predictive networks

scientific article published on 16 June 2016

Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms

scientific article published on 7 September 2010

Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group

scientific article

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

scientific article

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

scientific article

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

scientific article

Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications

scientific article published on 13 December 2013

NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG.

scientific article published on 2 July 2013

PBX3 is an important cofactor of HOXA9 in leukemogenesis

scientific article published on 20 December 2012

PRAME-induced inhibition of retinoic acid receptor signaling-mediated differentiation--a possible target for ATRA response in AML without t(15;17).

scientific article published on 26 February 2013

Precision oncology for acute myeloid leukemia using a knowledge bank approach

scientific article

Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup

scientific article

Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group

scientific article

Prognostic impact of minimal residual disease in CBFB-MYH11-positive acute myeloid leukemia

scientific article published on 12 July 2010

Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics

scientific article published on August 2008

Prognostic importance of histone methyltransferase MLL5 expression in acute myeloid leukemia

scientific article

Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

scientific article published on 8 August 2002

Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

scientific article

Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair

scientific article published on 21 September 2017

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

scholarly article

Quantitative DNA methylation predicts survival in adult acute myeloid leukemia

scientific article

Quantitative analyses of DAPK1 methylation in AML and MDS

scientific article

Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms ⬇️

scientific article published on March 7, 2013

RUNX1 Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group ⬇️

scientific article published on February 22, 2011

Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

scientific article

Rare occurrence of the JAK2 V617F mutation in AML subtypes M5, M6, and M7.

scientific article published on February 2006

Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

scientific article

SEURAT: visual analytics for the integrated analysis of microarray data

scientific article

STAT1 activation in association with JAK2 exon 12 mutations

scientific article published on 3 December 2015

Salvage therapy with high-dose cytarabine and mitoxantrone in combination with all-trans retinoic acid and gemtuzumab ozogamicin in acute myeloid leukemia refractory to first induction therapy

scientific article published on April 2016

Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG) ⬇️

scientific article published on October 31, 2012

Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia

scientific article published on 28 December 2009

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

scientific article published on 02 July 2016

Stromal niche cells protect early leukemic FLT3-ITD+ progenitor cells against first-generation FLT3 tyrosine kinase inhibitors.

scientific article

Symptom burden profile in myelofibrosis patients with thrombocytopenia: Lessons and unmet needs

scientific article published on 14 October 2017

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

scientific article

TET genes: new players in DNA demethylation and important determinants for stemness

scientific article

TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group ⬇️

scientific article published on March 19, 2012

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML ⬇️

scientific article published on December 31, 2012

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

scientific article

The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML.

scientific article

The oligodendrocyte lineage transcription factor 2 (OLIG2) is epigenetically regulated in acute myeloid leukemia

scientific article published on 28 July 2017

The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia

scientific article

The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA ⬇️

scientific article published on July 17, 2013

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.

scientific article published on 17 January 2012

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

scientific article

V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis

scientific article published on 17 November 2005

VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice

scientific article published on 24 November 2016

Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients

scientific article

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