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List of works by Hartmut Döhner

188Re or 90Y-labelled anti-CD66 antibody as part of a dose-reduced conditioning regimen for patients with acute leukaemia or myelodysplastic syndrome over the age of 55: results of a phase I-II study

scientific article published in August 2005

A comparison of the biodistribution and biokinetics of (99m)Tc-anti-CD66 mAb BW 250/183 and (99m)Tc-anti-CD45 mAb YTH 24.5 with regard to suitability for myeloablative radioimmunotherapy

scientific article published on 22 February 2003

A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy ⬇️

scientific article published on November 4, 2011

A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia

scientific article

A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).

scientific article

A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease

scientific article

A phase I trial investigating the Aurora B kinase inhibitor BI 811283 in combination with cytarabine in patients with acute myeloid leukaemia

scientific article published on 19 November 2018

A phase I/II study of sunitinib and intensive chemotherapy in patients over 60 years of age with acute myeloid leukaemia and activating FLT3 mutations.

scientific article

A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises

scientific article published on 07 February 2017

A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia

scientific article

ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group

scientific article

Acute Myeloid Leukemia

scientific article

Acute myeloid leukaemia

scientific article published on November 2006

Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations

scientific article published on 01 April 2005

Acute myeloid leukemia with mutated nucleophosmin 1: an immunogenic acute myeloid leukemia subtype and potential candidate for immune checkpoint inhibition

scientific article published on 21 September 2017

Adoptive transfer and selective reconstitution of streptamer‐selected cytomegalovirus‐specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation ⬇️

scientific article published on December 6, 2010

Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer

All-trans retinoic acid as adjunct to intensive treatment in younger adult patients with acute myeloid leukemia: results of the randomized AMLSG 07-04 study

scientific article

Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism

scholarly article

Allogeneic hematopoietic cell transplantation for high-risk CLL: 10-year follow-up of the GCLLSG CLL3X trial

scientific article published on 17 July 2017

Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials

scientific article

Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial

scientific article published in July 2010

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia

scientific article published on November 2012

Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.

scientific article

Analysis of NPM1 splice variants reveals differential expression patterns of prognostic value in acute myeloid leukemia

scientific article published on 3 August 2017

Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci

scientific article published in August 2010

Antagonizing inactivated tumor suppressor genes and activated oncogenes by a versatile transgenesis system: application in mantle cell lymphoma

scientific article published on 24 April 2006

Associations between dyadic coping and supportive care needs: findings from a study with hematologic cancer patients and their partners

scientific article published on 16 December 2016

Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations

scientific article

Automated screening for genomic imbalances using matrix-based comparative genomic hybridization

scientific article published in January 2002

Azacitidine for Front-Line Therapy of Patients with AML: Reproducible Efficacy Established by Direct Comparison of International Phase 3 Trial Data with Registry Data from the Austrian Azacitidine Registry of the AGMT Study Group

scientific article

Azacitidine improves clinical outcomes in older patients with acute myeloid leukaemia with myelodysplasia-related changes compared with conventional care regimens

scientific article published on 14 December 2017

Azacitidine in adult patients with acute myeloid leukemia

scientific article published on 03 June 2017

BCL2-938C>A polymorphism and disease progression in chronic lymphocytic leukemia

scientific article published in November 2009

BRAFmutations in chronic lymphocytic leukemia ⬇️

scientific article published on November 20, 2012

Bendamustine and rituximab in combination with lenalidomide in patients with chronic lymphocytic leukemia

scientific article published on 8 December 2015

Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group

scientific article

Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group

scientific article

Bone marrow transplantation nephropathy after an intensified conditioning regimen with radioimmunotherapy and allogeneic stem cell transplantation.

scientific article published in February 2006

CD34 cell selection of peripheral blood progenitor cells using the CliniMACS device for allogeneic transplantation: clinical results in 102 patients

scientific article published in August 2004

CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling

scientific article

CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations

scientific article

Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy.

scientific article published in August 2002

Cancer vaccines for patients with acute myeloid leukemia--definition of leukemia-associated antigens and current clinical protocols targeting these antigens

scientific article published on December 2006

Capillary electrophoretic analysis of genomic DNA methylation levels

scientific article

Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia

scientific article published on 24 May 2013

Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia

scientific article (publication date: 20 August 2003)

Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells

scientific article published on 18 August 2009

Chromosomal abnormalities in cancer

scientific article published on August 2008

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype

scientific article published on 27 October 2017

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

scientific article published on 23 May 2017

Chronic lymphocytic leukemia and treatment resistance in cancer: the role of the p53 pathway

scientific article published on 21 December 2008

Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8+ T-cell responses and are lacking costimulatory molecules.

scientific article

Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia

scientific article published on 29 September 2017

Clinical and functional implications of microRNA mutations in a cohort of 935 patients with myelodysplastic syndromes and acute myeloid leukemia

scientific article published on 31 December 2014

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).

scientific article

Clinical research within the German competence net "acute and chronic leukemias"

scientific article published in May 2006

Clinicopathologic correlations of genomic gains and losses in follicular lymphoma

scientific article published in December 2002

Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia

scientific article published on 23 May 2013

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation

Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias ⬇️

scientific article published on April 19, 2011

Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy

scientific article

Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells

scientific article

Continuous high dosing of lenalidomide in relapsed, refractory or older newly diagnosed acute myeloid leukemia patients not suitable for other treatment options - results from a phase I study

scholarly article by Marie Luise Hütter-Krönke et al published February 2019 in Haematologica

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

scientific article published on 19 March 2019

Cytogenetic evolution of follicular lymphoma

scientific article

Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B.

scientific article

Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care

article

Cytogenetics and molecular cytogenetics in multiple myeloma

scientific article published on 16 June 2006

DNA damage-induced transcriptional program in CLL: biological and diagnostic implications for functional p53 testing.

scientific article

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

scientific article published on 18 January 2016

Dasatinib exerts an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigens

scientific article published on 10 July 2008

Dasatinib inhibits the proliferation and function of CD4+CD25+ regulatory T cells

scientific article published on 7 November 2008

Dendritic cells generated from acute myeloid leukemia (AML) blasts maintain the expression of immunogenic leukemia associated antigens

scientific article published on 31 December 2004

Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group

scientific article published on 24 September 2012

Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial.

scientific article published on 30 July 2009

Detection of mutant NPM1 mRNA in acute myeloid leukemia using custom gene expression arrays

scientific article published on April 2013

Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia

scientific article

Development of a real‐time RT‐PCR assay for the quantification of the most frequent MLL/AF9 fusion types resulting from translocation t(9;11)(p22;q23) in acute myeloid leukemia ⬇️

scientific article published on November 1, 2003

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

scientific article

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

scientific article (publication date: 30 October 2009)

Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation

scientific article published on 30 September 2014

Disclosure of Candidate Genes in Acute Myeloid Leukemia With Complex Karyotypes Using Microarray-Based Molecular Characterization

Disruption of C/EBPalpha function in acute myeloid leukemia

scientific article published in December 2004

Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes.

scientific article

Donor lymphocyte infusion induces polyspecific CD8(+) T-cell responses with concurrent molecular remission in acute myeloid leukemia with NPM1 mutation

scientific article published on 17 December 2012

Dose Intensity of Chemotherapy in Patients With Relapsed Hodgkin's Lymphoma ⬇️

scientific article published on October 25, 2010

Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia

scientific article

Dyadic Coping of Patients with Haemato-Oncological Diseases and their Partners: Discrepancy Indexes and Association with Social Support and Psychological Distress

scientific article published on 28 September 2017

Dyadic coping of patients with hematologic malignancies and their partners and its relation to quality of life - a longitudinal study

scientific article published on 22 June 2016

Efficient transient genetic labeling of human CD34+ progenitor cells for in vivo application

scientific article published on March 2006

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia

scientific article published on 12 February 2018

Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO).

scientific article published on 31 October 2017

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.

scientific article

Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes

scientific article

Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia

scientific article

Expression of human leucocyte antigens and co-stimulatory molecules on blasts of patients with acute myeloid leukaemia

scientific article published on March 2003

Expression of tumor-associated antigens in acute myeloid leukemia: Implications for specific immunotherapeutic approaches

scientific article

FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors

scientific article

First demonstration of leukemia imaging with the proliferation marker 18F-fluorodeoxythymidine

scientific article

First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia

scientific article published on 15 July 2009

Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia

scientific article

Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy

scientific article

From pathogenesis to treatment of chronic lymphocytic leukaemia

scientific article published on 03 December 2009

Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study

scientific article published on 26 January 2010

Gene expression factors as predictors of genetic risk and survival in chronic lymphocytic leukemia

scientific article

Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

scientific article

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.

scientific article published on 20 March 2014

Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemia.

scientific article

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

scientific article published on 07 May 2007

Genetics and risk-stratified approach to therapy in chronic lymphocytic leukemia

scientific article published on September 2007

Genetics, gene expression, and targeted therapies in chronic lymphocytic leukemia

scientific article published on October 2006

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations

scientific article published on 23 May 2014

Genomic Classification and Prognosis in Acute Myeloid Leukemia

scientific article

Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions

scientific article published on 13 April 2004

Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes

scientific article published on July 2004

Genomic applications in the clinic: use in treatment paradigm of acute myeloid leukemia

scientific article published on January 2013

Genomics of Acute Myeloid Leukemia Diagnosis and Pathways

scientific article

Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene status: implications of minimal residual disease measurement with quantitative PCR.

scientific article published on 17 June 2004

Guidelines for diagnosis, indications for treatment, response assessment and supportive management of chronic lymphocytic leukemia

scientific article published on 14 March 2018

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

scientific article

HLA-identical sibling allogeneic transplants versus chemotherapy in acute myelogenous leukemia with t(8;21) in first complete remission: collaborative study between the German AML Intergroup and CIBMTR.

scientific article published on 20 December 2007

Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia ⬇️

scientific article published on April 9, 2012

Hidden gene amplifications in aggressive B-cell non-Hodgkin lymphomas detected by microarray-based comparative genomic hybridization

scientific article published in March 2003

High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia

scientific article

High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma

scientific article

High-dose daunorubicin in older patients with acute myeloid leukemia

scientific article

High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations ⬇️

scientific article published on January 10, 2012

High-resolution single-nucleotide polymorphism array-profiling in myeloproliferative neoplasms identifies novel genomic aberrations

scientific article

High-throughput detection of nuclear factor-kappaB activity using a sensitive oligo-based chemiluminescent enzyme-linked immunosorbent assay

scientific article published on July 2010

Human chromosome 7: DNA sequence and biology

scientific article

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

scientific article published on 21 June 2010

INPART - a psycho-oncological intervention for partners of patients with haemato-oncological disease - study protocol

scientific article published on 05 September 2019

Identification and characterization of epitopes of the receptor for hyaluronic acid-mediated motility (RHAMM/CD168) recognized by CD8+ T cells of HLA-A2-positive patients with acute myeloid leukemia

scientific article published on 12 April 2005

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

scientific article published in December 2007

Immune modulatory agents in hematopoietic malignancies ⬇️

scientific article published on 08 June 2011

Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut).

scientific article published in August 2013

Impact of Genetic Features on Treatment Decisions in AML ⬇️

scientific article published on January 1, 2011

Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

scientific article published on 01 January 2020

Impact of different post-remission strategies on quality of life in patients with acute myeloid leukemia.

scientific article published on 10 May 2008

Impact of fluoroquinolone prophylaxis on reduced infection-related mortality among patients with neutropenia and hematologic malignancies

scientific article published on 11 March 2005

Impact of telomere length on the outcome of allogeneic stem cell transplantation for poor-risk chronic lymphocytic leukaemia: results from the GCLLSG CLL3X trial

scientific article published on 8 July 2016

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.

scientific article published on 24 October 2008

Implication of the molecular characterization of acute myeloid leukemia

scientific article published on January 2007

Importance of genetics in chronic lymphocytic leukemia ⬇️

scientific article published on March 23, 2011

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial.

scientific article published on 31 October 2016

Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial

scientific article

Inactivating CUX1 mutations promote tumorigenesis

scientific article

Incidence rates of treatment-emergent adverse events and related hospitalization are reduced with azacitidine compared with conventional care regimens in older patients with acute myeloid leukemia

scientific article published on 14 October 2016

Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advances

scientific article published on March 2007

Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome.

scientific article published on 14 July 2009

Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia ⬇️

scientific article published on August 31, 2011

Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial

scientific article

Intensive induction is effective in selected octogenarian acute myeloid leukemia patients: prognostic significance of karyotype and selected molecular markers used in the European LeukemiaNet classification

scientific article published on 04 October 2013

Interactions between comorbidity and treatment of chronic lymphocytic leukemia: results of German Chronic Lymphocytic Leukemia Study Group trials

scientific article

International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

scientific article published on 18 May 2015

KIT mutations confer a distinct gene expression signature in core binding factor leukaemia

scientific article published on 08 January 2010

Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling

scientific article published on 14 April 2016

Lenalidomide maintenance after first-line therapy for high-risk chronic lymphocytic leukaemia (CLLM1): final results from a randomised, double-blind, phase 3 study

scientific article published on 12 September 2017

Lenalidomide treatment of chronic lymphocytic leukaemia patients reduces regulatory T cells and induces Th17 T helper cells

scientific article published on 30 November 2009

Leukemia research in Germany: the Competence Network Acute and Chronic Leukemias

scientific article published on 15 March 2016

Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells

scientific article

Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial

scientific article published on 20 October 2015

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

scientific article

MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.

scientific article published on 22 June 2016

MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.

scientific article

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

scientific article

Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet

scholarly article by Miguel A Sanz et al published 11 April 2019 in Blood

Metronomic treatment with low-dose trofosfamide leads to a long-term remission in a patient with docetaxel-refractory advanced metastatic prostate cancer

scientific article published on 11 April 2010

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia

scientific article published on 7 December 2017

MicroRNA expression-based outcome prediction in acute myeloid leukemia: novel insights through cross-platform integrative analyses

scientific article published on 28 July 2016

MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development

scientific article published on 09 September 2016

Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial

scientific article published on 01 October 2020

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

scientific article published on 23 June 2017

Minimal Residual Disease Assessment Improves Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia (CLL) Who Achieve Partial Response: Comprehensive Analysis of Two Phase III Studies of the German CLL Study Group

scientific article published on 29 August 2016

Molecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML.

scientific article published on January 2011

Molecular diagnostics in chronic lymphocytic leukemia - pathogenetic and clinical implications

scientific article published on May 2008

Molecular dissection of valproic acid effects in acute myeloid leukemia identifies predictive networks

scientific article published on 16 June 2016

Molecular genetics and its clinical relevance

scientific article published in August 2004

Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications

scientific article published on 10 January 2011

Molecular imaging of proliferation in malignant lymphoma.

scientific article published in November 2006

Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group

scientific article

Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up

scientific article

Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL).

scientific article published on March 2010

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

scientific article

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

scientific article

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

scientific article

Mutations driving CLL and their evolution in progression and relapse

scientific article published on 14 October 2015

Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications

scientific article published on 13 December 2013

NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib

scientific article published on 18 September 2017

NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG.

scientific article published on 2 July 2013

Neoplastic meningitis in patients with acute myeloid leukemia scheduled for allogeneic hematopoietic stem cell transplantation ⬇️

scientific article published on July 27, 2010

Nurse-like cells show deregulated expression of genes involved in immunocompetence.

scientific article published on 25 May 2011

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

Outcome of advanced chronic lymphocytic leukemia following different first-line and relapse therapies: a meta-analysis of five prospective trials by the German CLL Study Group (GCLLSG).

scientific article published on 27 August 2015

P53 and microRNAs in chronic lymphocytic leukemia

PRAME-induced inhibition of retinoic acid receptor signaling-mediated differentiation--a possible target for ATRA response in AML without t(15;17).

scientific article published on 26 February 2013

PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia

scientific article published on 10 June 2014

Peptide vaccination in the presence of adjuvants in patients after hematopoietic stem cell transplantation with CD4+ T cell reconstitution elicits consistent CD8+ T cell responses

scientific article

Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia

scientific article

Phase I dose-escalation trial investigating volasertib as monotherapy or in combination with cytarabine in patients with relapsed/refractory acute myeloid leukaemia

scientific article published on 08 June 2018

Phase I/II study on cytarabine and idarubicin combined with escalating doses of clofarabine in newly diagnosed patients with acute myeloid leukaemia and high risk for induction failure (AMLSG 17-10 CIARA trial)

scientific article published on 01 October 2018

Poor efficacy and tolerability of R-CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformation

scientific article

Precision oncology for acute myeloid leukemia using a knowledge bank approach

scientific article

Prognosis of acute myeloid leukemia patients up to 60 years of age exhibiting trisomy 8 within a non-complex karyotype: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup

scientific article

Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup

scientific article

Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group

scientific article

Prognostic impact of minimal residual disease in CBFB-MYH11-positive acute myeloid leukemia

scientific article published on 12 July 2010

Prognostic importance of histone methyltransferase MLL5 expression in acute myeloid leukemia

scientific article

Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

scientific article published on 8 August 2002

Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

scientific article

Prognostic significance of serum cystatin C in multiple myeloma ⬇️

scientific article published on March 18, 2012

Prognostic value of minimal residual disease quantification by real-time reverse transcriptase polymerase chain reaction in patients with core binding factor leukemias

scientific article published on December 2003

Progranulin is a novel independent predictor of disease progression and overall survival in chronic lymphocytic leukemia

scientific article

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells

scientific article published on 09 December 2016

Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk

scientific article

Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair

scientific article published on 21 September 2017

Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia

scientific article

Quantitative DNA methylation predicts survival in adult acute myeloid leukemia

scientific article

Quantitative analyses of DAPK1 methylation in AML and MDS

scientific article

Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients

scientific article

Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms

scientific article published on 7 March 2013

Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial.

scientific article

RUNX1 Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group ⬇️

scientific article published on February 22, 2011

Raising hematology's European voice: the importance of calling yourself a hematologist ⬇️

scientific article published on April 1, 2012

Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

scientific article

Rare occurrence of the JAK2 V617F mutation in AML subtypes M5, M6, and M7.

scientific article published on February 2006

Receptor for hyaluronan acid-mediated motility (RHAMM) is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia

scientific article (publication date: September 2002)

Recognition of familial myeloid neoplasia in adults

scientific article

Reconstitution of CD40 and CD80 in dendritic cells generated from blasts of patients with acute myeloid leukemia.

scientific article

Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial

scientific article

Results of a multicenter phase II trial for older patients with c-Kit-positive acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) using low-dose Ara-C and Imatinib

scientific article published in March 2007

Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

scientific article

Risk categories and refractory CLL in the era of chemoimmunotherapy

scientific article published on 06 March 2012

Risk stratification in chronic lymphocytic leukemia

scientific article

SYK carries no activating point mutations in patients with chronic lymphocytic leukaemia (CLL).

scientific article

Salvage therapy with high-dose cytarabine and mitoxantrone in combination with all-trans retinoic acid and gemtuzumab ozogamicin in acute myeloid leukemia refractory to first induction therapy

scientific article published on April 2016

Second-line therapies of patients initially treated with fludarabine and cyclophosphamide or fludarabine, cyclophosphamide and rituximab for chronic lymphocytic leukemia within the CLL8 protocol of the German CLL Study Group

scientific article published on 12 June 2013

Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG) ⬇️

scientific article published on October 31, 2012

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

scientific article

Serum microRNAs as a novel class of biomarkers: a comprehensive review of the literature

scientific article published on 25 October 2010

Significance of age in acute myeloid leukemia patients younger than 30 years: a common analysis of the pediatric trials AML-BFM 93/98 and the adult trials AMLCG 92/99 and AMLSG HD93/98A.

scientific article published in February 2008

Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia

scientific article published on 28 December 2009

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

scientific article published on 02 July 2016

Soluble CD14 is a novel monocyte-derived survival factor for chronic lymphocytic leukemia cells, which is induced by CLL cells in vitro and present at abnormally high levels in vivo

scientific article published on 26 July 2010

Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status

scientific article published on 29 November 2005

Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group

scientific article

T-cell reconstitution after allogeneic stem cell transplantation: assessment by measurement of the sjTREC/βTREC ratio and thymic naive T cells

scientific article published on 12 April 2013

TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group ⬇️

scientific article published on March 19, 2012

TP53 mutation and survival in chronic lymphocytic leukemia

scientific article

TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial

scientific article published on 22 February 2013

Targeted therapies through microRNAs: pulp or fiction?

scientific article published on April 2012

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33 ⬇️

scientific article published on March 26, 2012

Telomere length in poor-risk chronic lymphocytic leukemia: associations with disease characteristics and outcome

scientific article published on 24 October 2017

The European Hematology Association Roadmap for European Hematology Research: a consensus document

scientific article

The European LeukemiaNet: achievements and perspectives

scientific article

The MDM2 -309 T/G promoter single nucleotide polymorphism does not alter disease characteristics in chronic lymphocytic leukemia.

scientific article published on 27 May 2008

The genomic landscape of core-binding factor acute myeloid leukemias

scientific article

The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia

scientific article

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

scientific article

The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML.

scientific article

The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status

scientific article published on 11 December 2003

The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia

scientific article

The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA.

scientific article published on 17 July 2013

Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation - a Comparison of Eculizumab Therapy and Conventional Therapy

scientific article

Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes

scientific article

Treatment resistance in chronic lymphocytic leukemia: the role of the p53 pathway

scientific article published on March 2009

Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis

scientific article published in November 2002

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

scientific article

V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia.

scientific article published in August 2002

V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis

scientific article published on 17 November 2005

VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice

scientific article published on 24 November 2016

Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients

scientific article

Value of comparative genomic hybridization and fluorescence in situ hybridization for molecular diagnostics in multiple myeloma

scientific article published in July 2003

mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies

scientific article (publication date: 20 February 2004)

miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells

scientific article

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