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List of works by Alice Fabarius

Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

scientific article published on 31 October 2018

Accurate quantification of chromosomal lesions via short tandem repeat analysis using minimal amounts of DNA

scientific article published on 9 June 2017

Aneuploidy and cancer: from correlation to causation

scientific article

Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells

scientific article published on February 2004

Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies

scientific article published on 03 October 2019

Cancer drug resistance: the central role of the karyotype

scientific article published on February 2007

Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function

scientific article

Centrosome aberrations after nilotinib and imatinib treatment in vitro are associated with mitotic spindle defects and genetic instability

Centrosome aberrations and G1 phase arrest after in vitro and in vivo treatment with the SRC/ABL inhibitor dasatinib

scientific article

Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability ⬇️

scientific article published on May 5, 2013

Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene

scientific article published in February 2007

Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

scientific article published on 18 June 2015

Comprehensive mutational profiling in advanced systemic mastocytosis

scientific article published on 19 August 2013

Correction: High-risk additional chromosomal abnormalities at low blast counts herald death by CML

scientific article published on 10 September 2020

DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia

scientific article published on 11 February 2020

DNA microarray-based detection and identification of fungal pathogens in clinical samples from neutropenic patients

scientific article published on 22 August 2007

Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV.

scientific article

Defining therapy goals for major molecular remission in chronic myeloid leukemia: results of the randomized CML Study IV.

scientific article published on 26 February 2018

Detection of centrosome aberrations in disease-unrelated cells from patients with tumor treated with tyrosine kinase inhibitors

scientific article published on 16 April 2010

Diagnostic challenges in the work up of hypereosinophilia: pitfalls in bone marrow core biopsy interpretation

scientific article published on 22 January 2016

Diagnostic performance of the molecular BCR-ABL1 monitoring system may impact on inclusion of CML patients in stopping trials

Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial.

scientific article

Distinct characteristics of e13a2 versus e14a2 BCR-ABL1 driven chronic myeloid leukemia under first-line therapy with imatinib

scientific article

Dynamics of cytogenetic aberrations in Philadelphia chromosome positive and negative hematopoiesis during dasatinib therapy of chronic myeloid leukemia patients after imatinib failure

article

Effect of ABCG2, OCT1, and ABCB1 (MDR1) Gene Expression on Treatment-Free Remission in a EURO-SKI Subtrial

scientific article published on 8 February 2018

Effects of imatinib mesylate in patients with polycythemia vera: results of a phase II study

scientific article

Equivalence of BCR-ABL transcript levels with complete cytogenetic remission in patients with chronic myeloid leukemia in chronic phase

scientific article published on 22 June 2014

Functional imaging with dual-energy computed tomography for supplementary non-invasive assessment of mast cell burden in systemic mastocytosis

scientific article published in 2022

Fusion of PDGFRB to MPRIP, CPSF6, and GOLGB1 in three patients with eosinophilia-associated myeloproliferative neoplasms

scientific article

Genomic instability in context of the chromosomal theory.

scientific article

HERV-E-Mediated Modulation of PLA2G4A Transcription in Urothelial Carcinoma ⬇️

scientific article published on November 7, 2012

High-risk additional chromosomal abnormalities at low blast counts herald death by CML

scientific article published on 07 May 2020

Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms

scientific article published in May 2014

Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV

article

Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase

scientific article

Immunofluorescence Microscopy of γH2AX and 53BP1 for Analyzing the Formation and Repair of DNA Double-strand Breaks

scientific article published on 3 November 2017

Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV.

scientific article published on 28 October 2011

Impact of centralized evaluation of bone marrow histology in systemic mastocytosis.

scientific article

Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML study IV.

scientific article

Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML.

scientific article published on 18 September 2015

Importance of adequate diagnostic work-up for correct diagnosis of advanced systemic mastocytosis

scientific article published on 15 May 2020

Incidence and prognostic impact of cytogenetic aberrations in patients with systemic mastocytosis

scientific article published on 17 January 2018

Increase of DNA damage and alteration of the DNA damage response in myelodysplastic syndromes and acute myeloid leukemias

scientific article

Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

scientific article

Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy ⬇️

scientific article published on May 1, 2003

KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis

scientific article published on 11 January 2019

KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance

scientific article

Leukocyte DNA damage after reduced and conventional absorbed radiation doses using 3rd generation dual-source CT technology

scientific article

Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes

scientific article published on 27 September 2014

MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis

scientific article published on 11 September 2019

Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay

scientific article published on 12 August 2015

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

scientific article

Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit

scientific article published on 3 April 2014

Orders of Magnitude Change in Phenotype Rate Caused by Mutation.

scientific article

Response and progression on midostaurin in advanced systemic mastocytosis: KIT D816V and other molecular markers

scientific article published on 19 April 2017

Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion genes

scientific article published on 12 April 2020

SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3.

scientific article

Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study

scientific article

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients

scientific article published on 06 April 2020

Smoking Increases Transcription of Human Endogenous Retroviruses in a Newly Established in Vitro Cell Model and in Normal Urothelium ⬇️

scientific article published on August 1, 2010

Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea

scientific article

Specific clones of spontaneously evolving karyotypes generate individuality of cancers

scientific article

The KIT D816V expressed allele burden for diagnosis and disease monitoring of systemic mastocytosis.

scientific article

The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib ⬇️

scientific article published on August 3, 2012

The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value for treatment-free remission in chronic myeloid leukemia patients treated with imatinib

scientific article published in February 2024

The benefit of quality control charts (QCC) for routine quantitative BCR-ABL1 monitoring in chronic myeloid leukemia.

scientific article

The chromosomal basis of cancer.

scientific article published in January 2005

The clinical and molecular diversity of mast cell leukemia with or without associated hematologic neoplasm

scientific article published on 2 March 2017

Treatment-free remission in FIP1L1-PDGFRA-positive myeloid/lymphoid neoplasms with eosinophilia after imatinib discontinuation

scientific article published on 01 February 2020

Urine from current smokers induces centrosome aberrations and spindle defects in vitro in nonmalignant human cell lines ⬇️

scientific article published on December 1, 2010

Variable transcriptional activity of endogenous retroviruses in human breast cancer

scientific article (publication date: February 2008)

Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.

scientific article published on 27 October 2013

c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia

scientific article published on 2 March 2016

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