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List of works by Susanne Schnittger

A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia

scientific article published on May 2007

A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia.

scientific article

A comparison of donor lymphocyte infusions or imatinib mesylate for patients with chronic myelogenous leukemia who have relapsed after allogeneic stem cell transplantation.

scientific article

A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases

A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device

scientific article published in February 2007

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia

scientific article published in November 2002

A new prognostic score for patients with acute myeloid leukemia based on cytogenetics and early blast clearance in trials of the German AML Cooperative Group

scientific article published on April 2004

A novel hierarchical prognostic model of AML solely based on molecular mutations

scientific article published on 20 August 2012

A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).

scientific article

A patient with a 20-year lag phase between JAK2-V617F+ myeloproliferation and NPM1-mutated AML arguing against a common origin of disease

scientific article published on 11 August 2011

A rare but specific subset of adult AML patients can be defined by the cytogenetically cryptic NUP98–NSD1 fusion gene ⬇️

scientific article published on August 14, 2012

A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

scientific article

AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes.

scientific article published in June 2005

AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases

scientific article

AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients.

scientific article published on 16 December 2014

AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features

scientific article published on 8 May 2009

AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features.

scientific article

ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome ⬇️

scientific article published on September 11, 2012

Activating CBL mutations are associated with a distinct MDS/MPN phenotype

scientific article

Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics

scientific article published on 7 May 2013

Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%.

scientific article published on 11 March 2014

Acute myeloid leukemia (AML) with t(8;21)(q22;q22) relapsing as AML with t(3;21)(q26;q22).

scientific article

Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile

scientific article

Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles

scientific article

Additional mutations in SRSF2, ASXL1 and/or RUNX1 identify a high-risk group of patients with KIT D816V(+) advanced systemic mastocytosis

scientific article published on 14 October 2015

Advanced age and high initial WBC influence the outcome of inv(3) (q21q26)/t(3;3) (q21;q26) positive AML.

scientific article published in November 2007

Age, not therapy intensity, determines outcomes of adults with acute myeloid leukemia

scientific article published on 11 March 2016

Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group

scientific article

Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV.

scientific article published on 18 November 2009

Amount of bone marrow blasts is strongly correlated to NPM1 and FLT3-ITD mutation rate in AML with normal karyotype ⬇️

scientific article published on May 31, 2011

Amplification of EVI1 on cytogenetically cryptic double minutes as new mechanism for increased expression of EVI1.

scientific article published on 28 February 2014

An accumulation of cytogenetic and molecular genetic events characterizes the progression from MDS to secondary AML: an analysis of 38 paired samples analyzed by cytogenetics, molecular mutation analysis and SNP microarray profiling ⬇️

scientific article published on January 14, 2011

Analysis for loss of heterozygosity on chromosome arm 13q by STR analysis or SNP sequencing can replace analysis of FLT3-ITD to detect patients with prognostically adverse AML.

scientific article published on 3 September 2014

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

scientific article

Analysis of site-specific transgene integration following cotransduction with recombinant adeno-associated virus and a rep encodingplasmid

scientific article published in February 2003

Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential.

scientific article published on 26 March 2007

Array-based comparative genomic hybridization detects copy number variations with prognostic relevance in 80% of ALL with normal karyotype or failed chromosome analysis

scientific article

Associations between imatinib resistance conferring mutations and Philadelphia positive clonal cytogenetic evolution in CML.

scientific article published on October 2010

Atypical mRNA fusions in PML-RARA positive, RARA-PML negative acute promyelocytic leukemia.

scientific article published in May 2010

BAALC expression: a suitable marker for prognostic risk stratification and detection of residual disease in cytogenetically normal acute myeloid leukemia

scientific article published on 10 January 2014

BCR-ABL1-positive and JAK2 V617F-positive clones in 23 patients with both aberrations reveal biologic and clinical importance.

scientific article

BRAF mutations in hairy-cell leukemia

scientific article

BRCC3 mutations in myeloid neoplasms

scientific article published on 22 May 2015

Balanced chromosome abnormalities inv(16) and t(15;17) in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop.

scientific article published in April 2002

Blast count and cytogenetics correlate and are useful parameters for the evaluation of different phases in chronic myeloid leukemia.

scientific article

CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia ⬇️

scientific article published on March 21, 2011

Characterisation of extramedullary relapse in patients with chronic myeloid leukemia in advanced disease after allogeneic stem cell transplantation

scientific article published in April 2009

Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis

scientific article published on 23 November 2008

Characterization of NPM1-mutated AML with a history of myelodysplastic syndromes or myeloproliferative neoplasms ⬇️

scientific article published on January 14, 2011

Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9)

scientific article (publication date: 26 April 2002)

Clinical features and course of refractory anemia with ring sideroblasts associated with marked thrombocytosis

scientific article

Clinical impact of FLT3 mutation load in acute promyelocytic leukemia with t(15;17)/PML-RARA ⬇️

scientific article published on August 22, 2011

Clinical utility gene card for: hereditary thrombocythemia

scientific article published on 5 June 2013

Clinical utility of multiparameter flow cytometry in the diagnosis of 1013 patients with suspected myelodysplastic syndrome: correlation to cytomorphology, cytogenetics, and clinical data

scientific article

Comparison of cytogenetic clonal evolution patterns following allogeneic hematopoietic transplantation versus conventional treatment in patients at relapse of AML.

scientific article published on 14 June 2010

Comparison of genetic and clinical aspects in patients with acute myeloid leukemia and myelodysplastic syndromes all with more than 50% of bone marrow erythropoietic cells ⬇️

scientific article published on May 23, 2011

Comparison of mRNA abundance quantified by gene expression profiling and percentage of positive cells using immunophenotyping for diagnostic antigens in acute and chronic leukemias

scientific article published on November 2006

Comprehensive mutational profiling in advanced systemic mastocytosis

scientific article published on 19 August 2013

Conventional cytogenetics of myeloproliferative diseases other than CML contribute valid information

scientific article published on 4 February 2005

Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis.

scientific article published on 12 February 2014

Correlation of flow cytometrically determined expression of ZAP-70 using the SBZAP antibody with IgVH mutation status and cytogenetics in 1,229 patients with chronic lymphocytic leukemia

scientific article published in November 2009

Correlation of protein expression and gene expression in acute leukemia

scientific article published on September 2003

Cyclin D1 (CCND1) messenger RNA expression as assessed by real-time PCR contributes to diagnosis and follow-up control in patients with mantle cell lymphoma

scientific article published on 20 September 2013

Dasatinib and Azacitidine Followed by Haploidentical Stem Cell Transplant for Chronic Myeloid Leukemia with Evolving Myelodysplasia: A Case Report and Review of Treatment Options. ⬇️

scientific article

Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV.

scientific article

Detailed analysis of FLT3 expression levels in acute myeloid leukemia.

scientific article

Detection of JAK2 exon 12 mutations in 15 patients with JAK2V617F negative polycythemia vera

scientific article published on March 2009

Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia

scientific article published in July 2010

Detection of minimal residual disease in unselected patients with acute myeloid leukemia using multiparameter flow cytometry for definition of leukemia-associated immunophenotypes and determination of their frequencies in normal bone marrow.

scientific article

Determination of relapse risk based on assessment of minimal residual disease during complete remission by multiparameter flow cytometry in unselected patients with acute myeloid leukemia

scientific article published on 29 July 2004

Development and validation of a real-time quantification assay to detect and monitor BRAFV600E mutations in hairy cell leukemia ⬇️

scientific article published on February 13, 2012

Development of AML with t(8;21)(q22;q22) and RUNX1-RUNX1T1 fusion following Philadelphia-negative clonal evolution during treatment of CML with Imatinib

scientific article published in February 2009

Diagnostic pathways in acute leukemias: a proposal for a multimodal approach

scientific article published on 14 February 2007

Diagnostic tool for the identification of MLL rearrangements including unknown partner genes

scientific article

Diagnostic tools in the indications for allogeneic stem cell transplantation in myelodysplastic syndromes

scientific article published on 30 September 2009

Distinct characteristics of e13a2 versus e14a2 BCR-ABL1 driven chronic myeloid leukemia under first-line therapy with imatinib

scientific article

Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype

scientific article

Distinct sequences on 11q13.5 and 11q23-24 are frequently coamplified with MLL in complexly organized 11q amplicons in AML/MDS patients

scientific article published on April 2004

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin

scientific article

Distribution of cytogenetic abnormalities in myelodysplastic syndromes, Philadelphia negative myeloproliferative neoplasms, and the overlap MDS/MPN category

scientific article published on 5 May 2009

Diversity of the juxtamembrane and TKD1 mutations (Exons 13–15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data ⬇️

scientific article published on June 4, 2012

Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia

scientific article published on 24 March 2015

EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia

Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients ⬇️

scientific article published on May 3, 2011

Equivalence of BCR-ABL transcript levels with complete cytogenetic remission in patients with chronic myeloid leukemia in chronic phase

scientific article published on 22 June 2014

Evaluation of IDH1G105 polymorphism as prognostic marker in intermediate-risk AML.

scientific article published on 9 September 2015

Expression of CEBPA is reduced in RUNX1-mutated acute myeloid leukemia ⬇️

scientific article published on August 31, 2012

FLT3 length mutations as marker for follow-up studies in acute myeloid leukaemia

scientific article published on January 2004

Feasibility of BAALC gene expression for detection of minimal residual disease and risk stratification in normal karyotype acute myeloid leukaemia

scientific article published on 23 September 2016

Flow cytometric identification of 76 patients with biclonal disease among 5523 patients with chronic lymphocytic leukaemia (B-CLL) and its genetic characterization.

scientific article

Flow cytometric identification of acute myeloid leukemia with limited differentiation and NPM1 type A mutation: a new biologically defined entity

scientific article published on 16 April 2009

Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases

scientific article

Frequency and prognostic impact of the aberrant CD8 expression in 5,523 patients with chronic lymphocytic leukemia ⬇️

scientific article published on December 5, 2011

Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype

scientific article published on 14 January 2009

Frontline therapy of acute promyelocytic leukemia: Randomized comparison of ATRA and intensified chemotherapy versus ATRA and anthracyclines

scientific article published on 7 November 2017

Further correlations of morphology according to FAB and WHO classification to cytogenetics in de novo acute myeloid leukemia: a study on 2,235 patients.

scientific article

Fusion of PDGFRB to MPRIP, CPSF6, and GOLGB1 in three patients with eosinophilia-associated myeloproliferative neoplasms.

scientific article

Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia ⬇️

scientific article published on November 10, 2011

Gene expression profiling as a diagnostic tool in acute myeloid leukemia

scientific article published in January 2004

Gene expression profiling as a tool for the diagnosis of acute leukemias ⬇️

scientific article published on October 1, 2003

Gene expression profiling for the diagnosis of acute leukaemia

scientific article published on 5 December 2006

Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways.

scientific article published on 29 April 2010

Genetic basis of congenital erythrocytosis: mutation update and online databases

scientific article published on 22 October 2013

Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker

scientific article published on 23 October 2015

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

scientific article

Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1.

scientific article

High dose ara-C in the treatment of newly diagnosed acute promyelocytic leukemia: long-term results of the German AMLCG.

scientific article published on 10 September 2009

High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms ⬇️

scientific article published on August 28, 2012

High incidence of RAS signalling pathway mutations in MLL-rearranged acute myeloid leukemia

scientific article

IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status

scientific article

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor

scientific article

Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia.

scientific article

Implications of NRAS mutations in AML: a study of 2502 patients

scientific article

Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1.

scientific article published in March 2002

Increasing intensity of therapies assigned at diagnosis does not improve survival of adults with acute myeloid leukemia

scientific article published on 9 February 2016

Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse

scientific article published on 14 September 2012

Insight into the molecular pathogenesis of myeloid malignancies

scientific article published on March 2007

Interactive diagnostics in the indication to allogeneic SCT in AML.

scientific article published on 13 April 2009

Isolated epidural chloroma with translocation t(15; 17) successfully treated with chemotherapy and all-trans-retinoic acid

scientific article published in August 2003

KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance

scientific article

KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.

scientific article

KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival

scientific article published on 27 October 2005

Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia

scientific article published on 20 August 2015

Landmark analysis of DNMT3A mutations in hematological malignancies

scientific article published in March 2013

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

scientific article

Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: a detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH.

scientific article published on September 2002

Minimal residual disease diagnostics and chimerism in the post-transplant period in acute myeloid leukemia.

scientific article published on 3 February 2011

Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.

scientific article

Modern diagnostics in acute leukemias

scientific article

Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow ⬇️

scientific article published on April 17, 2012

Molecular analysis of RAS-RAF tyrosine-kinase signaling pathway alterations in patients with plasma cell myeloma ⬇️

scientific article published on August 31, 2012

Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations

scientific article published on 11 January 2011

Molecular characterization of acute leukemias by use of microarray technology

scientific article published on August 2003

Molecular diagnostics in acute leukemias

scientific article

Molecular diagnostics, targeted therapy, and the indication for allogeneic stem cell transplantation in acute lymphoblastic leukemia

scientific article published on 10 November 2011

Molecular genetics in acute myeloid leukemia

scientific article

Molecular mutations are prognostically relevant in AML with intermediate risk cytogenetics and aberrant karyotype ⬇️

scientific article published on July 17, 2012

Molecular subtypes of NPM1 mutations have different clinical profiles, specific patterns of accompanying molecular mutations and varying outcomes in intermediate risk acute myeloid leukemia

scientific article published on 15 October 2015

Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status

scientific article

Monitoring of minimal residual disease in acute myeloid leukemia

scientific article

Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease

scientific article

Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as "AML not oth

Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity ⬇️

scientific article published on March 22, 2012

Multiparameter Flow Cytometry Provides Independent Prognostic Information in Patients with Suspected Myelodysplastic Syndromes: A Study on 804 Patients.

scientific article

Multiparameter flow cytometry provides independent prognostic information in patients with suspected myelodysplastic syndromes: A study on 804 patients

scientific article published on 24 March 2015

Multiparameter flow cytometry reveals myelodysplasia-related aberrant antigen expression in myelodysplastic/myeloproliferative neoplasms

scientific article published on 2 January 2013

Mutation analysis of the Nijmegen breakage syndrome gene (NBS1) in nineteen patients with acute myeloid leukemia with complex karyotypes.

scientific article published in November 2003

Mutations in the JAK2 and MPL genes and their correlation to clinical parameters in patients with chronic myeloproliferative disease

scientific article published on 13 March 2009

Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD–transformed hematopoietic cells ⬇️

scientific article published on November 6, 2003

Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis

scientific article published on 10 November 2009

Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies

scientific article published on 02 March 2010

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia.

scientific article

New score predicting for prognosis in PML-RARA+, AML1-ETO+, or CBFBMYH11+ acute myeloid leukemia based on quantification of fusion transcripts.

scientific article

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

article

Next-generation deep-sequencing detects multiple clones of CALR mutations in patients with BCR-ABL1 negative MPN.

scientific article

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

scientific article

Outcome of elderly patients with acute promyelocytic leukemia: results of the German Acute Myeloid Leukemia Cooperative Group

scientific article published on 23 October 2012

Patients with therapy-related myelodysplastic syndromes and acute myeloid leukemia share genetic features but can be separated by blast counts and cytogenetic risk profiles into prognostically relevant subgroups

scientific article published on 21 August 2012

Perspective on how to approach molecular diagnostics in acute myeloid leukemia and myelodysplastic syndromes in the era of next-generation sequencing

scientific article published on 14 February 2014

Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.

scientific article published on 12 January 2006

Prognosis in patients with MDS or AML and bone marrow blasts between 10% and 30% is not associated with blast counts but depends on cytogenetic and molecular genetic characteristics

article published in 2011

Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients

scientific article

Prognostic impact of FLT3-ITD load in NPM1 mutated acute myeloid leukemia ⬇️

scientific article published on May 3, 2011

Prognostic impact of early response to induction therapy as assessed by multiparameter flow cytometry in acute myeloid leukemia.

scientific article

Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

scientific article

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia ⬇️

scientific article published on August 9, 2011

Quantification of rare NPM1 mutation subtypes by digital PCR.

scientific article published on 18 July 2014

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis

scientific article

RQ-PCR based WT1 expression in comparison to BCR-ABL quantification can predict Philadelphia negative clonal evolution in patients with imatinib-treated chronic myeloid leukaemia.

scientific article published on 16 July 2009

Rapid diagnostic approach to PML-RARalpha-positive acute promyelocytic leukemia

scientific article published in January 2002

Rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases

scientific article published on February 2014

Re: Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia.

scientific article

Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study.

scientific article

Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia ⬇️

scientific article published on March 9, 2011

Recurrent SETBP1 mutations in atypical chronic myeloid leukemia

scientific article

Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma

article

Refractory anemia with ring sideroblasts and marked thrombocytosis cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations

scientific article published on 19 December 2014

Reverse transcriptase-polymerase chain reaction based quantification of the combined MDS-EVI1/EVI1 gene in acute myeloid leukemia.

scientific article

Risk assessment by monitoring expression levels of partial tandem duplications in the MLL gene in acute myeloid leukemia during therapy.

scientific article

Robustness of Amplicon Deep Sequencing Underlines Its Utility in Clinical Applications

scholarly article by Vera Grossmann et al published July 2013 in The Journal of Molecular Diagnostics

Role of gene expression profiling for diagnosing acute leukemias.

scientific article

SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations

scientific article published on 30 April 2013

SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients

scientific article published on 12 September 2013

SOX11 overexpression is a specific marker for mantle cell lymphoma and correlates with t(11;14) translocation, CCND1 expression and an adverse prognosis

scientific article

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

scientific article

STAT3 mutations are highly specific for large granular lymphocytic leukemia ⬇️

scientific article published on December 4, 2012

Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study

scientific article

Serial assessment of suspected myelodysplastic syndromes: significance of flow cytometric findings validated by cytomorphology, cytogenetics, and molecular genetics ⬇️

scientific article published on August 28, 2012

Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatment

scientific article published on 29 October 2009

Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia

scientific article published on 19 September 2014

Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology

scientific article

Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias

scientific article published on 9 November 2009

Subclones with the t(9;22)/BCR-ABL1 rearrangement occur in AML and seem to cooperate with distinct genetic alterations.

scientific article published on 31 January 2011

Subtype-specific patterns of molecular mutations in acute myeloid leukemia.

scientific article published on 10 June 2016

TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis

scientific article

Targeted next-generation sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure

article

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

scientific article

The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype

scientific article

The diagnosis of BCR/ABL-negative chronic myeloproliferative diseases (CMPD): a comprehensive approach based on morphology, cytogenetics, and molecular markers

scientific article

The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner

scientific article

The impact of cytomorphology, cytogenetics, molecular genetics, and immunophenotyping in a comprehensive diagnostic workup of myelodysplastic syndromes

scientific article published in October 2009

The influence of age on prognosis of de novo acute myeloid leukemia differs according to cytogenetic subgroups.

scientific article published in September 2004

The kinetics of relapse in DEK-NUP214-positive acute myeloid leukemia patients

scientific article published on 21 January 2015

The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.

scientific article

The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3.

scientific article published on 24 October 2002

The role of different genetic subtypes of CEBPA mutated AML.

scientific article published on 23 September 2013

The role of multiparameter flow cytometry for disease monitoring in AML.

scientific article published on 12 August 2010

Toward a comprehensive prognostic scoring system in chronic lymphocytic leukemia based on a combination of genetic parameters

scientific article

Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia

scientific article published on 23 August 2013

Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene

scientific article published in October 2006

Translocations as a mechanism for homozygous deletion of 13q14 and loss of the ATM gene in a patient with B-cell chronic lymphocytic leukemia

scientific article published on April 2007

Treatment of AML in biological subgroups

scientific article

Treatment of older patients with AML.

scientific article

Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases

scientific article published on 24 June 2012

WT1 mutations are secondary events in AML, show varying frequencies and impact on prognosis between genetic subgroups.

scientific article published on 11 August 2014

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

scientific article

Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.

scientific article published on 27 October 2013

[Microarrays and gene expression profiling for the diagnosis in leukemia. From research studies to routine application].

scientific article

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