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List of works by Claudia Haferlach

A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia

scientific article published on May 2007

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms

scientific article

A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases

A novel hierarchical prognostic model of AML solely based on molecular mutations

scientific article published on 20 August 2012

A novel recurrent AML1–ETO fusion: tight in vivo association with BCR–ABL1 ⬇️

scientific article published on February 21, 2013

A rare but specific subset of adult AML patients can be defined by the cytogenetically cryptic NUP98–NSD1 fusion gene ⬇️

scientific article published on August 14, 2012

AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients.

scientific article published on 16 December 2014

AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features

scientific article published on 8 May 2009

AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features.

scientific article

AML/MDS with 11q/MLL amplification show characteristic gene expression signature and interplay of DNA copy number changes

scientific article published in June 2009

ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome ⬇️

scientific article published on September 11, 2012

Accurate quantification of chromosomal lesions via short tandem repeat analysis using minimal amounts of DNA

scientific article published on 9 June 2017

Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics ⬇️

scientific article published on May 7, 2013

Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%.

scientific article published on 11 March 2014

Acute myeloid leukemias with ring sideroblasts show a unique molecular signature straddling secondary acute myeloid leukemia and de novo acute myeloid leukemia

scientific article published on 5 January 2017

Additional mutations in SRSF2, ASXL1 and/or RUNX1 identify a high-risk group of patients with KIT D816V(+) advanced systemic mastocytosis

scientific article published on 14 October 2015

Advanced age and high initial WBC influence the outcome of inv(3) (q21q26)/t(3;3) (q21;q26) positive AML.

scientific article published in November 2007

Age, not therapy intensity, determines outcomes of adults with acute myeloid leukemia

scientific article published on 11 March 2016

Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group

scientific article

Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV.

scientific article published on 18 November 2009

Amount of bone marrow blasts is strongly correlated to NPM1 and FLT3-ITD mutation rate in AML with normal karyotype ⬇️

scientific article published on May 31, 2011

Amplification of EVI1 on cytogenetically cryptic double minutes as new mechanism for increased expression of EVI1.

scientific article published on 28 February 2014

An accumulation of cytogenetic and molecular genetic events characterizes the progression from MDS to secondary AML: an analysis of 38 paired samples analyzed by cytogenetics, molecular mutation analysis and SNP microarray profiling ⬇️

scientific article published on January 14, 2011

Analysis for loss of heterozygosity on chromosome arm 13q by STR analysis or SNP sequencing can replace analysis of FLT3-ITD to detect patients with prognostically adverse AML.

scientific article published on 3 September 2014

Another piece of the AML puzzle

scientific article

Application of an NGS-based 28-gene panel in myeloproliferative neoplasms reveals distinct mutation patterns in essential thrombocythaemia, primary myelofibrosis and polycythaemia vera.

scientific article

Array-based comparative genomic hybridization detects copy number variations with prognostic relevance in 80% of ALL with normal karyotype or failed chromosome analysis

scientific article

Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants

scientific article published on 14 August 2017

Associations between imatinib resistance conferring mutations and Philadelphia positive clonal cytogenetic evolution in CML.

scientific article published on October 2010

Atypical mRNA fusions in PML-RARA positive, RARA-PML negative acute promyelocytic leukemia.

scientific article published in May 2010

BAALC expression: a suitable marker for prognostic risk stratification and detection of residual disease in cytogenetically normal acute myeloid leukemia

scientific article published on 10 January 2014

BCR-ABL1-positive and JAK2 V617F-positive clones in 23 patients with both aberrations reveal biologic and clinical importance.

scientific article

BRAF mutations in hairy-cell leukemia

scientific article

BRCC3 mutations in myeloid neoplasms

scientific article published on 22 May 2015

CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia ⬇️

scientific article published on March 21, 2011

Centrosome aberrations and G1 phase arrest after in vitro and in vivo treatment with the SRC/ABL inhibitor dasatinib

scientific article

Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups

scientific article

Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis

scientific article published on 23 November 2008

Characterization of NPM1-mutated AML with a history of myelodysplastic syndromes or myeloproliferative neoplasms ⬇️

scientific article published on January 14, 2011

Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene

scientific article published in February 2007

Clinical features and course of refractory anemia with ring sideroblasts associated with marked thrombocytosis

scientific article

Clinical impact of FLT3 mutation load in acute promyelocytic leukemia with t(15;17)/PML-RARA ⬇️

scientific article published on August 22, 2011

Clinical utility of multiparameter flow cytometry in the diagnosis of 1013 patients with suspected myelodysplastic syndrome: correlation to cytomorphology, cytogenetics, and clinical data

scientific article

Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

scientific article published on 18 June 2015

Comparison of cytogenetic clonal evolution patterns following allogeneic hematopoietic transplantation versus conventional treatment in patients at relapse of AML.

scientific article published on 14 June 2010

Comparison of genetic and clinical aspects in patients with acute myeloid leukemia and myelodysplastic syndromes all with more than 50% of bone marrow erythropoietic cells ⬇️

scientific article published on May 23, 2011

Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes

scientific article published on 3 December 2010

Comprehensive study on ERG gene expression in normal karyotype acute myeloid leukemia: ERG expression is of limited prognostic value, whereas the accumulation of adverse prognostic markers stepwise worsens the prognosis

scientific article published on 09 December 2016

Correction: MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences

Correlation of flow cytometrically determined expression of ZAP-70 using the SBZAP antibody with IgVH mutation status and cytogenetics in 1,229 patients with chronic lymphocytic leukemia

scientific article published in November 2009

Cyclin D1 (CCND1) messenger RNA expression as assessed by real-time PCR contributes to diagnosis and follow-up control in patients with mantle cell lymphoma

scientific article published on 20 September 2013

Cytogenetic methods in chronic lymphocytic leukemia

scientific article published in January 2011

Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV.

scientific article

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

scientific article published on 29 July 2009

Detection and characterization of homozygosity of mutated by copy neutral loss of heterozygosity in myeloproliferative neoplasms among cases with high mutation loads or with progressive disease

scholarly article by Anna Stengel et al published 8 November 2018 in Haematologica

Detection of JAK2 exon 12 mutations in 15 patients with JAK2V617F negative polycythemia vera

scientific article published on March 2009

Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia

scientific article published in July 2010

Detection of centrosome aberrations in disease-unrelated cells from patients with tumor treated with tyrosine kinase inhibitors

scientific article published on 16 April 2010

Detection of recurrent and of novel fusion transcripts in myeloid malignancies by targeted RNA sequencing

scientific article published on 26 February 2018

Development and validation of a real-time quantification assay to detect and monitor BRAFV600E mutations in hairy cell leukemia ⬇️

scientific article published on February 13, 2012

Diagnostic pathways in acute leukemias: a proposal for a multimodal approach

scientific article published on 14 February 2007

Diagnostic tools in the indications for allogeneic stem cell transplantation in myelodysplastic syndromes

scientific article published on 30 September 2009

Discussion of the applicability of microarrays: profiling of leukemias

scientific article published on January 2009

Distinct characteristics of e13a2 versus e14a2 BCR-ABL1 driven chronic myeloid leukemia under first-line therapy with imatinib

scientific article

Distribution of cytogenetic abnormalities in myelodysplastic syndromes, Philadelphia negative myeloproliferative neoplasms, and the overlap MDS/MPN category

scientific article published on 5 May 2009

Diversity of the juxtamembrane and TKD1 mutations (Exons 13–15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data ⬇️

scientific article published on June 4, 2012

Dynamics of clonal evolution in myelodysplastic syndromes

scientific article

EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia

Early allo-SCT for AML with a complex aberrant karyotype—results from a prospective pilot study ⬇️

scientific article published on February 28, 2011

Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML).

scientific article

Equivalence of BCR-ABL transcript levels with complete cytogenetic remission in patients with chronic myeloid leukemia in chronic phase

scientific article published on 22 June 2014

Evaluation of IDH1G105 polymorphism as prognostic marker in intermediate-risk AML.

scientific article published on 9 September 2015

Expression of CEBPA is reduced in RUNX1-mutated acute myeloid leukemia ⬇️

scientific article published on August 31, 2012

Feasibility of BAALC gene expression for detection of minimal residual disease and risk stratification in normal karyotype acute myeloid leukaemia

scientific article published on 23 September 2016

Flow cytometric identification of 76 patients with biclonal disease among 5523 patients with chronic lymphocytic leukaemia (B-CLL) and its genetic characterization.

scientific article

Flow cytometric identification of acute myeloid leukemia with limited differentiation and NPM1 type A mutation: a new biologically defined entity

scientific article published on 16 April 2009

Frequency and Prognostic Impact of CEBPA Proximal, Distal and Core Promoter Methylation in Normal Karyotype AML: A Study on 623 Cases ⬇️

scientific article published on January 1, 2013

Frequency and prognostic impact of casein kinase 1A1 mutations in MDS patients with deletion of chromosome 5q.

scientific article published on 24 February 2015

Frequency and prognostic impact of the aberrant CD8 expression in 5,523 patients with chronic lymphocytic leukemia ⬇️

scientific article published on December 5, 2011

Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype

scientific article published on 14 January 2009

Frontline therapy of acute promyelocytic leukemia: Randomized comparison of ATRA and intensified chemotherapy versus ATRA and anthracyclines

scientific article published on 7 November 2017

Fusion of PDGFRB to MPRIP, CPSF6, and GOLGB1 in three patients with eosinophilia-associated myeloproliferative neoplasms

scientific article

Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia ⬇️

scientific article published on November 10, 2011

Gene expression profiling for the diagnosis of acute leukaemia

scientific article published on 5 December 2006

Gene expression profiling in acute myeloid leukaemia (AML).

scientific article published on June 2009

Genes break barrier between MDS and AML.

scientific article published in January 2015

Genetic characterization of MYD88-mutated lymphoplasmacytic lymphoma in comparison with MYD88-mutated chronic lymphocytic leukemia

scientific article published on 14 November 2016

Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker

scientific article published on 23 October 2015

Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia

scientific article

Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 ⬇️

scientific article published on February 12, 2013

Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia

High dose ara-C in the treatment of newly diagnosed acute promyelocytic leukemia: long-term results of the German AMLCG.

scientific article published on 10 September 2009

High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms ⬇️

scientific article published on August 28, 2012

High incidence of RAS signalling pathway mutations in MLL-rearranged acute myeloid leukemia ⬇️

scientific article published on March 28, 2013

IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status

scientific article

IDH1R132, IDH2R140 and IDH2R172 in AML: different genetic landscapes correlate with outcome and may influence targeted treatment strategies.

scientific article published on 30 January 2018

Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms

scientific article published in May 2014

Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2).

scientific article published on February 2009

Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV

article

Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase

scientific article

Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV.

scientific article published on 28 October 2011

Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML.

scientific article published on 18 September 2015

Incidence and prognostic impact of cytogenetic aberrations in patients with systemic mastocytosis

scientific article published on 17 January 2018

Increasing intensity of therapies assigned at diagnosis does not improve survival of adults with acute myeloid leukemia

scientific article published on 9 February 2016

Insight into the molecular pathogenesis of myeloid malignancies

scientific article published on March 2007

Integrated analysis of copy number alterations and gene expression: a bivariate assessment of equally directed abnormalities

scientific article published on 14 October 2009

Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia

scientific article published on 6 July 2016

Interactive diagnostics in the indication to allogeneic SCT in AML.

scientific article published on 13 April 2009

Involvement of the MLL gene in adult T-lymphoblastic leukemia

scientific article published on 25 August 2012

Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia

scientific article published on 20 August 2015

Landmark analysis of DNMT3A mutations in hematological malignancies ⬇️

scientific article published on March 1, 2013

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

scientific article

Leukemia diagnosis: today and tomorrow

scientific article published on 25 June 2015

Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes

scientific article published on 27 September 2014

Long-term follow-up of treatment with imatinib in eosinophilia-associated myeloid/lymphoid neoplasms with PDGFR rearrangements in blast phase

scientific article published on 25 April 2013

Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment

scientific article published on 14 October 2015

MDS with deletions in the long arm of chromosome 11 are associated with a high frequency of SF3B1 mutations

scientific article published on 8 June 2017

MYC rearranged B-cell neoplasms: Impact of genetics on classification

scientific article published on 14 September 2016

MYC-containing amplicons in acute myeloid leukemia: Genomic structures, evolution, and transcriptional consequences

scientific article published on 28 November 2017

Microarrays and gene expression profiling for the diagnosis in leukemia. From research studies to routine application

scientific article

Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.

scientific article

Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow ⬇️

scientific article published on April 17, 2012

Molecular analysis of RAS-RAF tyrosine-kinase signaling pathway alterations in patients with plasma cell myeloma ⬇️

scientific article published on August 31, 2012

Molecular analysis of myelodysplastic syndrome with isolated deletion of the long arm of chromosome 5 reveals a specific spectrum of molecular mutations with prognostic impact: a study on 123 patients and 27 genes

scientific article published on 22 June 2017

Molecular characterization of EZH2 mutant patients with myelodysplastic/myeloproliferative neoplasms

scientific article

Molecular diagnostics in acute leukemias

scientific article

Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2.

scientific article published on 22 March 2018

Molecular landscape of acute promyelocytic leukemia at diagnosis and relapse

scientific article published on 24 March 2017

Molecular mutations are prognostically relevant in AML with intermediate risk cytogenetics and aberrant karyotype ⬇️

scientific article published on July 17, 2012

Molecular subtypes of NPM1 mutations have different clinical profiles, specific patterns of accompanying molecular mutations and varying outcomes in intermediate risk acute myeloid leukemia

scientific article published on 15 October 2015

Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status

scientific article

Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease ⬇️

scientific article published on August 20, 2013

Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as "AML not oth

Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity ⬇️

scientific article published on March 22, 2012

Multiparameter Flow Cytometry Provides Independent Prognostic Information in Patients with Suspected Myelodysplastic Syndromes: A Study on 804 Patients

scientific article

Multiparameter flow cytometry provides independent prognostic information in patients with suspected myelodysplastic syndromes: A study on 804 patients

scientific article published on 24 March 2015

Multiparameter flow cytometry reveals myelodysplasia‐related aberrant antigen expression in myelodysplastic/myeloproliferative neoplasms ⬇️

scientific article published on January 2, 2013

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

scientific article

Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis

scientific article published on 10 November 2009

Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies

scientific article published on 02 March 2010

Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit

scientific article published on 3 April 2014

Myelodysplastic syndromes with del(5q): indications and strategies for cytogenetic testing

scientific article published on December 2008

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia.

scientific article

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

article

Next-generation deep-sequencing detects multiple clones of CALR mutations in patients with BCR-ABL1 negative MPN.

scientific article

Occurrence of AML in cells of donor origin after treatment of CML in relapse with imatinib and donor stem cell boost 16 years after the original allogeneic BMT.

scientific article published on 23 February 2009

Outcome of elderly patients with acute promyelocytic leukemia: results of the German Acute Myeloid Leukemia Cooperative Group

scientific article published on 23 October 2012

Patients with therapy-related myelodysplastic syndromes and acute myeloid leukemia share genetic features but can be separated by blast counts and cytogenetic risk profiles into prognostically relevant subgroups

scientific article published on 21 August 2012

Prognosis in patients with MDS or AML and bone marrow blasts between 10% and 30% is not associated with blast counts but depends on cytogenetic and molecular genetic characteristics

article published in 2011

Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients

scientific article

Prognostic impact of FLT3-ITD load in NPM1 mutated acute myeloid leukemia ⬇️

scientific article published on May 3, 2011

Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

scientific article

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia ⬇️

scientific article published on August 9, 2011

Quantification of rare NPM1 mutation subtypes by digital PCR.

scientific article published on 18 July 2014

RQ-PCR based WT1 expression in comparison to BCR-ABL quantification can predict Philadelphia negative clonal evolution in patients with imatinib-treated chronic myeloid leukaemia.

scientific article published on 16 July 2009

Rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases

scientific article published on February 2014

Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma

article

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

scientific article

Refractory anemia with ring sideroblasts and marked thrombocytosis cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations

scientific article published on 19 December 2014

Response of ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3.

scientific article

Robustness of Amplicon Deep Sequencing Underlines Its Utility in Clinical Applications

scholarly article by Vera Grossmann et al published July 2013 in The Journal of Molecular Diagnostics

Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements ⬇️

scientific article published on August 8, 2012

SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations

scientific article published on 30 April 2013

SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients

scientific article published on 12 September 2013

SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3.

scientific article

SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations

scientific article

SOX11 overexpression is a specific marker for mantle cell lymphoma and correlates with t(11;14) translocation, CCND1 expression and an adverse prognosis ⬇️

scientific article published on May 7, 2013

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

scientific article

STAT3 mutations are highly specific for large granular lymphocytic leukemia ⬇️

scientific article published on December 4, 2012

Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study

scientific article

Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis

scientific article

Serial assessment of suspected myelodysplastic syndromes: significance of flow cytometric findings validated by cytomorphology, cytogenetics, and molecular genetics ⬇️

scientific article published on August 28, 2012

Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatment

scientific article published on 29 October 2009

Smoldering Development of Acute Megakaryoblastic Leukemia with Clonal Evolution in an Infant without Down Syndrome

scientific article published on 13 November 2017

Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia

scientific article published on 19 September 2014

Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology

scientific article

Subclones with the t(9;22)/BCR-ABL1 rearrangement occur in AML and seem to cooperate with distinct genetic alterations.

scientific article published on 31 January 2011

Subtype-specific patterns of molecular mutations in acute myeloid leukemia

scientific article published on 10 June 2016

Successful allogeneic stem cell transplantation in second chronic-phase CML induced by the tyrosine kinase inhibitor nilotinib (AMN107) after blast crisis under imatinib

article by H Menzel et al published 23 April 2007 in Bone Marrow Transplantation

TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis

scientific article

Targeted next-generation sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure

article

The 5q deletion size in myeloid malignancies is correlated to additional chromosomal aberrations and to TP53 mutations

scientific article published on 24 May 2016

The European LeukemiaNet: achievements and perspectives

scientific article

The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype

scientific article

The diagnosis of BCR/ABL-negative chronic myeloproliferative diseases (CMPD): a comprehensive approach based on morphology, cytogenetics, and molecular markers

scientific article

The idic(X)(q13) in myeloid malignancies: breakpoint clustering in segmental duplications and association with TET2 mutations

scientific article published on 21 January 2010

The impact of TP53 mutations and TP53 deletions on survival varies between AML, ALL, MDS and CLL: an analysis of 3307 cases

scientific article published on 29 September 2016

The impact of cytomorphology, cytogenetics, molecular genetics, and immunophenotyping in a comprehensive diagnostic workup of myelodysplastic syndromes

scientific article published in October 2009

The kinetics of relapse in DEK-NUP214-positive acute myeloid leukemia patients

scientific article published on 21 January 2015

The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia

scientific article published on 20 June 2017

The molecular profile of adult T‐cell acute lymphoblastic leukemia: Mutations in RUNX1 and DNMT3A are associated with poor prognosis in T‐ALL ⬇️

scientific article published on January 23, 2013

The mutational landscape of 18 investigated genes clearly separates four subtypes of myelodysplastic/myeloproliferative neoplasms.

scientific article published in May 2018

The new provisional WHO entity 'RUNX1 mutated AML' shows specific genetics but no prognostic influence of dysplasia

scientific article published on 23 May 2016

The role of different genetic subtypes of CEBPA mutated AML.

scientific article published on 23 September 2013

The role of multiparameter flow cytometry for disease monitoring in AML.

scientific article published on 12 August 2010

The role of the RAS pathway in iAMP21-ALL.

scientific article published on 10 May 2016

Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-α in newly diagnosed chronic myeloid leukemia

scientific article published on 21 March 2011

Toward a comprehensive prognostic scoring system in chronic lymphocytic leukemia based on a combination of genetic parameters

scientific article

Transfusion Independency and Histological Remission in a Patient with Advanced Primary Myelofibrosis Receiving Iron-Chelation Therapy with Deferasirox

scientific article

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus

scientific article published on 29 August 2016

Translocations as a mechanism for homozygous deletion of 13q14 and loss of the ATM gene in a patient with B-cell chronic lymphocytic leukemia

scientific article published on April 2007

Ultra-deep sequencing leads to earlier and more sensitive detection of the tyrosine kinase inhibitor resistance mutation T315I in chronic myeloid leukemia

scientific article published on 21 April 2016

Update on developments in the diagnosis and prognostic evaluation of patients with myelodysplastic syndromes (MDS): Consensus statements and report from an expert workshop ⬇️

scientific article published on 03 December 2011

Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases

scientific article published on 24 June 2012

WT1 mutations are secondary events in AML, show varying frequencies and impact on prognosis between genetic subgroups

scientific article published on 11 August 2014

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

scientific article

Will a peripheral blood (PB) sample yield the same diagnostic and prognostic cytogenetic data as the concomitant bone marrow (BM) in myelodysplasia? ⬇️

scientific article published on April 25, 2012

mutated AML can relapse with wild-type : persistent clonal hematopoiesis can drive relapse

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