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List of works by Tamara Alpermann

AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients.

scientific article published on 16 December 2014

Amount of bone marrow blasts is strongly correlated to NPM1 and FLT3-ITD mutation rate in AML with normal karyotype ⬇️

scientific article published on May 31, 2011

Associations between imatinib resistance conferring mutations and Philadelphia positive clonal cytogenetic evolution in CML.

scientific article published on October 2010

BRCC3 mutations in myeloid neoplasms

scientific article published on 22 May 2015

CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia ⬇️

scientific article published on March 21, 2011

Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups

scientific article

Clinical impact of FLT3 mutation load in acute promyelocytic leukemia with t(15;17)/PML-RARA ⬇️

scientific article published on August 22, 2011

Comparison of cytogenetic clonal evolution patterns following allogeneic hematopoietic transplantation versus conventional treatment in patients at relapse of AML.

scientific article published on 14 June 2010

Comparison of genetic and clinical aspects in patients with acute myeloid leukemia and myelodysplastic syndromes all with more than 50% of bone marrow erythropoietic cells ⬇️

scientific article published on May 23, 2011

Cyclin D1 (CCND1) messenger RNA expression as assessed by real-time PCR contributes to diagnosis and follow-up control in patients with mantle cell lymphoma

scientific article published on 20 September 2013

Diversity of the juxtamembrane and TKD1 mutations (Exons 13–15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data ⬇️

scientific article published on June 4, 2012

EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia

Evaluation of IDH1G105 polymorphism as prognostic marker in intermediate-risk AML.

scientific article published on 9 September 2015

Feasibility of BAALC gene expression for detection of minimal residual disease and risk stratification in normal karyotype acute myeloid leukaemia

scientific article published on 23 September 2016

Flow cytometric identification of 76 patients with biclonal disease among 5523 patients with chronic lymphocytic leukaemia (B-CLL) and its genetic characterization.

scientific article

Frequency and Prognostic Impact of CEBPA Proximal, Distal and Core Promoter Methylation in Normal Karyotype AML: A Study on 623 Cases ⬇️

scientific article published on January 1, 2013

Frequency and prognostic impact of the aberrant CD8 expression in 5,523 patients with chronic lymphocytic leukemia ⬇️

scientific article published on December 5, 2011

Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia ⬇️

scientific article published on November 10, 2011

High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms ⬇️

scientific article published on August 28, 2012

IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status

scientific article

Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia

scientific article published on 20 August 2015

Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow ⬇️

scientific article published on April 17, 2012

Molecular subtypes of NPM1 mutations have different clinical profiles, specific patterns of accompanying molecular mutations and varying outcomes in intermediate risk acute myeloid leukemia

scientific article published on 15 October 2015

Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity ⬇️

scientific article published on March 22, 2012

Multiparameter Flow Cytometry Provides Independent Prognostic Information in Patients with Suspected Myelodysplastic Syndromes: A Study on 804 Patients

scientific article

Multiparameter flow cytometry provides independent prognostic information in patients with suspected myelodysplastic syndromes: A study on 804 patients

scientific article published on 24 March 2015

Multiparameter flow cytometry reveals myelodysplasia‐related aberrant antigen expression in myelodysplastic/myeloproliferative neoplasms ⬇️

scientific article published on January 2, 2013

Patients with therapy-related myelodysplastic syndromes and acute myeloid leukemia share genetic features but can be separated by blast counts and cytogenetic risk profiles into prognostically relevant subgroups

scientific article published on 21 August 2012

Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse

scientific article

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia ⬇️

scientific article published on August 9, 2011

Quantification of rare NPM1 mutation subtypes by digital PCR.

scientific article published on 18 July 2014

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

scientific article

Refractory anemia with ring sideroblasts and marked thrombocytosis cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations

scientific article published on 19 December 2014

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

scientific article

Serial assessment of suspected myelodysplastic syndromes: significance of flow cytometric findings validated by cytomorphology, cytogenetics, and molecular genetics ⬇️

scientific article published on August 28, 2012

Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia

scientific article published on 19 September 2014

Subclones with the t(9;22)/BCR-ABL1 rearrangement occur in AML and seem to cooperate with distinct genetic alterations.

scientific article published on 31 January 2011

Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases

scientific article published on 24 June 2012

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