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List of works by Giampietro Viola

1-Thioangelicin: crystal structure, computer-aided studies and photobiological activity

scientific article published in February 2004

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

scientific article published on 5 December 2017

2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization

scientific article published on September 2009

3-Aryl/Heteroaryl-5-amino-1-(3′,4′,5′-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization

scholarly article by Romeo Romagnoli published in October 2018

9-(4-Dimethylaminophenyl)benzo[b]quinolizinium: a near-infrared fluorophore for the multicolor analysis of proteins and nucleic acids in living cells

scientific article published on 22 May 2013

A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents

scientific article

AKR1C enzymes sustain therapy resistance in paediatric T-ALL.

scientific article

BMP9 counteracts the tumorigenic and pro-angiogenic potential of glioblastoma

scientific article published on 05 July 2018

Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase

scientific article published on 12 October 2015

Central role of mitochondria and p53 in PUVA-induced apoptosis in human keratinocytes cell line NCTC-2544.

scientific article published on 11 October 2007

Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer

scientific article published on 22 October 2018

Comparative Studies on the DNA-Binding Properties of Linear and Angular Dibenzoquinolizinium Ions

article

Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues

scientific article published on 15 October 2015

Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents

scientific article

Control of the DNA-Binding and Antiproliferative Properties of Hydroxybenzo[b]quinolizinium Derivatives with pH and Light.

scientific article

Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents

scientific article

Cytotoxic compounds from Polygala vulgaris ⬇️

scientific article published on November 2002

Cytotoxic constituents of roots of Chaerophyllum hirsutum

scientific article published in September 2004

DNA cleavage induced by photoexcited antimalarial drugs: a photophysical and photobiological study

scientific article

Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3',4',5'-Trimethoxyphenyl)-2-Aryl-1H-Imidazole

scientific article published on 24 May 2016

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

scientific article published on 18 January 2019

Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents

scientific article

Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents.

scientific article

Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents

scientific article

Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

scientific article published on 01 August 2019

Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors

scientific article

Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

scientific article published on 31 March 2016

Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.

scientific article published on 26 March 2015

Diazoniapolycyclic ions inhibit the activity of topoisomerase I and the growth of certain tumor cell lines

scientific article published on November 2008

Differentiation and apoptosis in UVA-irradiated cells treated with furocoumarin derivatives.

scientific article published on August 2009

Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.

scientific article

EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells

scientific article published on 11 July 2018

Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones

scientific article published on 03 June 2019

Excited-state properties and in vitro phototoxicity studies of three phenothiazine derivatives

scientific article

FOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugs

scientific article

FOXO3a and Posttranslational Modifications Mediate Glucocorticoid Sensitivity in B-ALL.

scientific article published on 16 September 2015

Furocoumarins photolysis products induce differentiation of human erythroid cells

scientific article

Glioblastoma cancer stem cells: role of the microenvironment and therapeutic targeting

scientific article published on 11 October 2012

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation

scientific article

Human Medulloblastoma Cell Lines: Investigating on Cancer Stem Cell-Like Phenotype

scientific article published on 17 January 2020

Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation

scientific article published on 12 February 2009

Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma

scientific article published on 10 August 2010

Identification of novel indole derivatives acting as inhibitors of the Keap1-Nrf2 interaction.

scientific article

Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

scientific article published in Nature Communications

Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs

scientific article published on 25 September 2009

Indolo[2,3-b]-quinolizinium bromide: an efficient intercalator with DNA-photodamaging properties

scientific article published in June 2002

Induction of DNA-double-strand breaks by auger electrons from 99mTc complexes with DNA-binding ligands

scientific article published in February 2005

Induction of apoptosis by photoexcited tetracyclic compounds derivatives of benzo[b]thiophenes and pyridines

scientific article published on 2 November 2005

Interaction Between Nerve Growth Factor and Lysophosphatidylserine in rat Peritoneal Mast Cells ⬇️

scientific article published on 01 April 1990

Intercalation of organic dye molecules into double-stranded DNA. Part 2: the annelated quinolizinium ion as a structural motif in DNA intercalators

scientific article

Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I.

scientific article

Kinome expression profiling of human neuroblastoma tumors identifies potential drug targets for ultra high-risk patients

scientific article

Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors

scientific article published on 25 July 2018

MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells

scientific article published on 22 September 2011

NPM-ALK expression levels identify two distinct subtypes of paediatric anaplastic large cell lymphoma

scientific article published on 24 October 2016

Naphthoquinolizinium derivatives as a novel platform for DNA-binding and DNA-photodamaging chromophores

scientific article published in November 2002

Natural daucane esters induces apoptosis in leukaemic cells through ROS production

scientific article published on 4 October 2014

Natural daucane sesquiterpenes with antiproliferative and proapoptotic activity against human tumor cells.

scientific article

New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1.

scientific article published on January 2015

Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity

scientific article

Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation

scientific article

On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles

scientific article published on 14 January 2008

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent

scientific article published on 15 October 2011

Photophysical and photobiological behavior of antimalarial drugs in aqueous solutions

scientific article published in March 2004

Photophysical and phototoxic properties of the antibacterial fluoroquinolones levofloxacin and moxifloxacin

scientific article

Photophysical properties and photobiological behavior of amodiaquine, primaquine and chloroquine

scientific article

Photosensitization of DNA strand breaks by three phenothiazine derivatives

scientific article

Photosensitization of biomolecules by phenothiazine derivatives

scientific article published on September 2006

Photostability of pitavastatin--a novel HMG-CoA reductase inhibitor

scientific article published on 17 October 2008

Phytosterol and γ-Oryzanol Conjugates: Synthesis and Evaluation of their Antioxidant, Antiproliferative, and Anticholesterol Activities

scientific article published on 17 October 2018

Pyrano[2,3-e]isoindol-2-ones, new angelicin heteroanalogues

scientific article

Pyrazolyl-diamine ligands that bear anthracenyl moieties and their rhenium(I) tricarbonyl complexes: synthesis, characterisation and DNA-binding properties

scientific article published on January 2008

Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity

scientific article published in August 2003

Pyrrolo[3,4-h]quinolinones a new class of photochemotherapeutic agents

scientific article published on 18 February 2011

Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition

scientific article published on 11 April 2009

Recent advances in vascular disrupting agents in cancer therapy.

scientific article published on September 2014

Relationship between the structure and the DNA binding properties of diazoniapolycyclic duplex- and triplex-DNA binders: efficiency, selectivity, and binding mode

scientific article published on 16 October 2007

Results of a multicenter universal newborn screening program for sickle cell disease in Italy: A call to action

scientific article published on 05 February 2019

Ribociclib, A Cdk4/Cdk6 Kinase Inhibitor, Enhances Glucocorticoid Sensitivity In B-Acute Lymphoblastic Leukemia (B-All).

scientific article

Selective ratiometric detection of H2O2 in water and in living cells with boronobenzo[b]quinolizinium derivatives

scientific article published on 01 August 2014

Signalling mechanism in the lysophosphatidylserine-induced activation of mouse mast cells ⬇️

scientific article published on April 9, 1990

Structure and Biological Activity of Furocoumarins

Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.

scientific article

Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents

scientific article

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues

scientific article

Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity

scientific article published on March 2006

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.

scientific article

Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents

scientific article published on 18 March 2013

Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents

scientific article published on 12 October 2012

Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling.

scientific article

Synthesis and biological evaluation of new geiparvarin derivatives

scientific article published on May 2009

Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity

scientific article published on 21 December 2011

Synthesis and fluorosolvatochromism of 3-arylnaphtho[1,2-b]quinolizinium derivatives.

scientific article published on 2 May 2016

Synthesis and in vitro evaluation of 3h-pyrrolo[3,2-f]-quinolin-9-one derivatives that show potent and selective anti-leukemic activity

scientific article

Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones

scientific article

Synthesis, DNA binding and in vitro antiproliferative activity of purinoquinazoline, pyridopyrimidopurine and pyridopyrimidobenzimidazole derivatives as potential antitumor agents

Synthesis, DNA-binding and antiproliferative properties of diarylquinolizinium derivatives

scientific article published on 07 January 2021

Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles

scientific article

Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors

scientific article

Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues

scientific article

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents

scientific article published on 26 January 2019

Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents.

scientific article

TP-0903 inhibits neuroblastoma cell growth and enhances the sensitivity to conventional chemotherapy.

scientific article published on 14 November 2017

TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis

scientific article published on 2 March 2013

Targeting BAG-1: a novel strategy to increase drug efficacy in acute myeloid leukemia

scientific article published on 11 November 2014

Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs.

scientific article

The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation.

scientific article

The phototoxicity of fluvastatin, an HMG-CoA reductase inhibitor, is mediated by the formation of a benzocarbazole-like photoproduct.

scientific article published on 28 July 2010

The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma

scientific article published on 22 March 2017

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa

scientific article published on July 2013

Thiopyrano[2,3-e]indol-2-ones: angelicin heteroanalogues with potent photoantiproliferative activity

scientific article

Tricarbonyl M(I) (M = Re, (99m)Tc) complexes bearing acridine fluorophores: synthesis, characterization, DNA interaction studies and nuclear targeting

scientific article published on 20 July 2010

Two new sesquiterpene lactones from the leaves of Laurus nobilis ⬇️

scientific article

Vascular disrupting activity of combretastatin analogues

scientific article published on 25 May 2016

Vitamin K2 cannot substitute Coenzyme Q as electron carrier in the mitochondrial respiratory chain of mammalian cells

scientific article published on 25 April 2019

ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia.

scientific article published on 16 February 2017

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