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List of works by Johannes-Peter Stasch

A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway.

scientific article

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Activation of heme-free soluble guanylate cyclase with cinaciguat has beneficial cardiorenal actions when added to furosemide in experimental heart failure.

scientific article published in August 2011

Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling

scientific article published on 3 January 2006

Acute hemodynamic response to single oral doses of BAY 60-4552, a soluble guanylate cyclase stimulator, in patients with biventricular heart failure

scientific article published on 11 August 2009

Additional lack of iNOS attenuates diastolic dysfunction in aged ET-1 transgenic miceThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin

Additional stimulation of sGC on top of standard treatment with ARB`s may offer a new therapeutic approach for the treatment of diabetic nephropathy resistant to ARB treatment alone.

scientific article published in August 2011

Analysis of erectile responses to BAY 41-8543 and muscarinic receptor stimulation in the rat

scientific article published on 18 September 2012

Antihypertrophic actions of NO-independent soluble guanylyl cyclase (sGC) ligands BAY 41-2272 and BAY 58-2667 in vitro

scientific article published on 11 August 2009

Attenuated response of L-type calcium current to nitric oxide in atrial fibrillation

scientific article

BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase

scientific article published on April 2002

BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats ⬇️

scientific article published on September 7, 2010

BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts.

scientific article published on 30 April 2009

Biomarkers in two different animal models of pulmonary arterial hypertension (PAH) under treatment with a cGMP enhancing substance.

scientific article published in August 2011

Cardioprotective effects in aged spontaneously hypertensive rats due to chronic stimulation/activation of sGC without hypotension.

scientific article published on 11 August 2009

Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure

scientific article

Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies

scientific article

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

scientific article

Chronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats

scientific article

Chronic activation of heme free soluble guanylate cyclase leads to cardio-renal protection in experimental hypertension.

scientific article published on 29 August 2013

Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension

scientific article published on 31 March 2017

Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension

scientific article published on 19 August 2011

Comparison of different vasodilators, endothelin antagonist, PDE5 inhibitior and sGC stimulators, in an animal model of secondary pulmonary hypertension: effects on “desaturation”.

scientific article published in August 2011

Correction: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice.

scientific article published on 14 September 2011

Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors

scientific article published in December 2008

Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure

scientific article published on 22 February 2006

Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo

scientific article published on 22 August 2007

Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction

scientific article published on 9 July 2013

Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension

scientific article

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

scientific article published on 30 May 2017

Early Urinary and Plasma Biomarkers for Experimental Diabetic Nephropathy

Early urinary and plasma biomarkers for experimental diabetic nephropathy

scientific article published on January 1, 2012

Effects of different pulmonary vasodilators on arterial saturation in a model of pulmonary hypertension

scientific article

Effects of riociguat in severe experimental pulmonary hypertension.

scientific article published in August 2011

Effects of stimulation of soluble guanylate cyclase on diabetic nephropathy in diabetic eNOS knockout mice on top of angiotensin II receptor blockade

scientific article

Effects of the sGC stimulator BAY 41-2272 are not mediated by phosphodiesterase 5 inhibition

scientific article published in September 2004

Elevated plasma human urotensin-II-like immunoreactivity in ischemic cardiomyopathy

scientific article published in March 2004

Endothelin-1 Overexpression Improves Renal Function in eNOS Knockout Mice.

scientific article published on 29 October 2015

Endothelin-1 overexpression restores diastolic function in eNOS knockout mice

scientific article published in May 2011

Evidence for two catalytic centers and Mn2+ as physiological cofactor of soluble guanylyl cyclase.

scientific article published in August 2011

Fluorescence Dequenching Makes Haem-Free Soluble Guanylate Cyclase Detectable in Living Cells ⬇️

scientific article published on August 17, 2011

Gender-dependent impact of risk factors for cardiovascular and non-cardiovascular mortality in end-stage renal disease patients on haemodialysis

scientific article published on 20 November 2008

Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease

scientific article

Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators

scientific article published on 16 January 2013

Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase

scientific article published on 21 October 2003

Improvement of right heart structure and function by BAY 41-8543 in pulmonary artery banded mice.

scientific article published in August 2011

Increased levels of laminin and collagen type VI may reflect early remodelling in patients with acute myocardial infarction

scientific article

Increased serum levels of tissue inhibitor of metalloproteinase-1 in patients with acute myocardial infarction.

scientific article published in July 2009

Increases survival by apo-sGC activation via post-stroke blood brain barrier stabilisation and anti-inflammation.

scientific article published on 29 August 2013

Influence of cinaciguat on gastrointestinal motility in apo-sGC mice

scientific article published on 8 September 2014

Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation

scientific article

Inhibition of the TGFβ signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis

scientific article published on March 2017

Insights into BAY 60-2770 Activation and S -Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes

scientific article

Is kynurenine a novel and important vasodilator in human septic shock?

scientific article published on 11 August 2009

Kynurenine is a novel endothelium-derived vascular relaxing factor produced during inflammation

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

scientific article

Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC

article

Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase ⬇️

scientific article published on May 16, 2003

NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

scientific article

NO- and haem-independent soluble guanylate cyclase activators

scientific article published on January 2009

NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy

scientific article published on 12 June 2006

NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size

scientific article published on 20 November 2013

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

scientific article

NO-independent, haem-dependent soluble guanylate cyclase stimulators

scientific article

NO-insensitive sGCbeta1 H105F knockin mice: if NO has no place to go.

scientific article published on 11 August 2009

New antithrombotics with an indazole structure

scientific article

Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease

scientific article published on 21 December 2017

Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis

scientific article

Nitric oxide-independent stimulation of soluble guanylate cyclase attenuates pulmonary fibrosis.

scientific article published in August 2011

Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models

scientific article published on August 2010

Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation

scientific article

Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury

scientific article

Novel, selective indole-based ECE inhibitors: lead optimization via solid-phase and classical synthesis

scientific article published in October 2005

Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells

scientific article published on 28 December 2013

Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1

scientific journal article

Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies

scientific article

Pharmacological preconditioning with the guanylate cyclase activator cinaciguat (BAY 58-2667) protects against reperfusion injury after cardiopulmonary bypass

scientific article published on 11 August 2009

Phenotypes of sGC mutant mice in basic conditions, disease and shock

scientific article published on 11 August 2009

Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart.

scientific article published on 8 May 2009

Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme

scientific article

Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production

scientific article published in April 2002

Receptor binding assay for NO-independent activators of soluble guanylate cyclase

scientific article published in January 2013

Receptor binding assay for nitric oxide- and heme-independent activators of soluble guanylate cyclase

scientific article published in March 2003

Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice.

scientific article published in August 2011

Relaxin is an independent risk factor predicting death in male patients with end-stage kidney disease

scientific article

Renal effects of soluble guanylate cyclase stimulators and activators: a review of the preclinical evidence

scientific article

Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase

scientific article published on 8 April 2005

Riociguat and cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats

scientific article

Riociguat prevents fibrotic tissue remodelling and improves survival in salt-sensitive Dahl rats.

scientific article published in August 2011

Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging

scientific article

Role of soluble guanylate cyclase in renal hemodynamics and autoregulation in the rat.

scientific article published on 10 September 2014

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

scientific article published on 13 February 2019

Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor

scientific article

Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma

scientific article published on 11 April 2016

Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease

scientific article

Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats

scientific article (publication date: 2011)

Soluble guanylate cyclase stimulator riociguat and phosphodiesterase 5 inhibitor sildenafil ameliorate pulmonary hypertension due to left heart disease in mice.

scientific article

Soluble guanylate cyclase stimulators in pulmonary hypertension

scientific article published on January 2013

Soluble guanylate cyclase: a potential therapeutic target for heart failure

scientific article published on March 2013

Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema

scientific article published in June 2014

Stimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis

scientific article published on 23 November 2004

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

scientific article

Structural insights into sGC activation by different activators.

scientific article published in August 2011

Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase

scientific article

Structure/activity relationships of (M)ANT- and TNP-nucleotides for inhibition of rat soluble guanylyl cyclase α1β1.

scientific article

Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure

scientific article

Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels

scientific article

The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat.

scientific article

The chemistry and biology of soluble guanylate cyclase stimulators and activators

scientific article published on 20 August 2013

The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat.

scientific article published in February 2013

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

scientific article

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats

scientific article

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.

scientific article

The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats

scientific article published on 22 September 2015

The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy

scientific article published on 7 November 2012

The uremic retention solute p-cresyl sulfate alters NO signal transduction by alteration of the soluble guanylate cyclase redox state

scientific article

Translational In Vivo Models for Cardiovascular Diseases

scientific article published on 10 November 2015

Urinary cGMP concentrations after exposure to radio-contrast media in patient at risk for contrast media induced nephropathy (CIN) predicts 90-day morbidity and mortality.

scientific article published on 29 August 2013

Urinary cGMP predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus before exposure to contrast medium.

scientific article published on 12 April 2018

sGC activators and stimulators attenuate ischemia/reperfusion injury of the lung.

scientific article

sGC redox regulation and asthma.

scientific article

α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders

scientific article published on 4 November 2014

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