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List of works by Mark Frederick McCarty

"Nutritional insurance" supplementation and corticosteroid toxicity

scientific article published on August 1982

A "mini-fast with exercise" protocol for fat loss

scientific article

A diet rich in taurine, cysteine, folate, B12 and betaine may lessen risk for Alzheimer's disease by boosting brain synthesis of hydrogen sulfide

scientific article published on 12 August 2019

A general strategy for the use of allogeneic lymphocyte infusions in the treatment of disorders characterized by impaired helper or suppressor T cell function: autoimmune diseases and the acquired immunodeficiency syndrome (AIDS).

scientific article published on March 1985

A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas

scientific article published on 30 October 2014

A moderately low phosphate intake may provide health benefits analogous to those conferred by UV light – a further advantage of vegan diets ⬇️

scientific article published on November 1, 2003

A note on "orthomolecular aids for dieting"--myasthenic syndrome due to dl-carnitine

scientific article published on December 1982

A practical prescription for cancer prevention--synergistic use of chemopreventive agents

scientific article published on July 1984

A preliminary fast may potentiate response to a subsequent low-salt, low-fat vegan diet in the management of hypertension - fasting as a strategy for breaking metabolic vicious cycles

scientific article published in May 2003

A role for cAMP-driven transactivation of EGFR in cancer aggressiveness - therapeutic implications.

scientific article

A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets

scientific article

A two-phase strategy for treatment of oxidant-dependent cancers

scientific article published on 14 May 2007

A wholly nutritional 'multifocal angiostatic therapy' for control of disseminated cancer

scientific article

ACE inhibition may decrease diabetes risk by boosting the impact of bradykinin on adipocytes

scientific article published in June 2003

AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues

scientific article published on 31 January 2009

Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1.

scientific article

Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease.

scientific article published on 30 June 2009

Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic acid

scientific article

Aldosterone and the Gerson diet — A speculation ⬇️

scientific article published on May 1, 1981

An antithrombotic role for nutritional antioxidants: implications for tumor metastasis and other pathologies

scientific article published on April 1986

An expanded concept of “insurance” supplementation — Broad-spectrum protection from cardiovascular disease ⬇️

scientific article published on October 1, 1981

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

scientific article published on 11 September 2015

Anabolic effects of insulin on bone suggest a role for chromium picolinate in preservation of bone density.

scientific article

Androgenic progestins amplify the breast cancer risk associated with hormone replacement therapy by boosting IGF-I activity

scientific article

Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complications

article

Association of moderately elevated trimethylamine N-oxide with cardiovascular risk: is TMAO serving as a marker for hepatic insulin resistance

scholarly article by James J DiNicolantonio et al published 2019 in Open heart

Astaxanthin plus berberine: a nutraceutical strategy for replicating the benefits of a metformin/fibrate regimen in metabolic syndrome

scientific article published on 05 August 2019

Autophagy-induced degradation of Notch1, achieved through intermittent fasting, may promote beta cell neogenesis: implications for reversal of type 2 diabetes

scientific article published on 22 May 2019

Azithromycin and Glucosamine May Amplify the Type 1 Interferon Response to RNA Viruses in a Complementary Fashion

scientific article published on 28 September 2020

Bioavailable dietary phosphate, a mediator of cardiovascular disease, may be decreased with plant-based diets, phosphate binders, niacin, and avoidance of phosphate additives

scientific article published on 15 December 2013

Boosting endogenous production of vasoprotective hydrogen sulfide via supplementation with taurine and N-acetylcysteine: a novel way to promote cardiovascular health

scientific article published on 22 May 2017

Can moderate elevations of parathyroid hormone acutely increase risk for ischemic cardiac arrhythmias?

scientific article published in February 2009

Capsaicin may have important potential for promoting vascular and metabolic health

scientific article published on 17 June 2015

Carvedilol and spirulina may provide important health protection to smokers and other nicotine addicts: a call for pertinent research.

scientific article published in January 2015

Chromium and other insulin sensitizers may enhance glucagon secretion: implications for hypoglycemia and weight control

scientific article

Cimetidine as an adjuvant for allogeneic lymphocyte immunotherapy of cancer

scientific article published on June 1985

Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy

scientific article published in September 2000

Coenzyme Q versus hypertension: does CoQ decrease endothelial superoxide generation?

scientific article

Coenzyme Q10 for the treatment of heart failure: a review of the literature

scientific article

Complementary measures for promoting insulin sensitivity in skeletal muscle.

scientific article published in December 1998

Complementary vascular-protective actions of magnesium and taurine: a rationale for magnesium taurate

scientific article

Concurrent administration of sustained-release bezafibrate may counteract the increased thrombotic risk associated with oral estrogen therapy

scientific article published in August 2001

Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs

scientific article

Cytostatic and reverse-transforming therapies of cancer — A brieff review and future prospects ⬇️

scientific article published on June 1, 1982

DL-phenylalanine markedly potentiates opiate analgesia - an example of nutrient/pharmaceutical up-regulation of the endogenous analgesia system

scientific article

Decreased magnesium status may mediate the increased cardiovascular risk associated with calcium supplementation

scientific article published on 22 May 2017

Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection.

scientific article

Do omega-3 fatty acids cause prostate cancer?

scientific article published on 01 July 2013

Does a vegan diet reduce risk for Parkinson's disease?

scientific article published in September 2001

Does elevated bilirubin aid weight control by preventing development of hypothalamic leptin resistance?

article

Does postprandial storage of triglycerides in endothelial cells contribute to the endothelial dysfunction associated with insulin resistance and fatty diets?

scientific article published in August 2003

Does regular ethanol consumption promote insulin sensitivity and leanness by stimulating AMP-activated protein kinase?

scientific article published in September 2001

Does supplemental creatine prevent herpes recurrences?

scientific article published in September 2001

Endothelial membrane potential regulates production of both nitric oxide and superoxide--a fundamental determinant of vascular health

scientific article

Enhanced synovial production of hyaluronic acid may explain rapid clinical response to high-dose glucosamine in osteoarthritis ⬇️

scientific article published on June 1, 1998

Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression--an adjuvant role for chromium picolinate?

scientific article

Fish oil may be an antidote for the cardiovascular risk of smoking

scientific article published in April 1996

GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets.

scientific article

Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells

scientific article

Glucosamine for the Treatment of Osteoarthritis: The Time Has Come for Higher-Dose Trials

scientific article published on 18 April 2018

Glucosamine may retard atherogenesis by promoting endothelial production of heparan sulfate proteoglycans

scientific article published on March 1997

Hemostatic concomitants of syndrome X ⬇️

scientific article published on March 1, 1995

Hepatothermic therapy of obesity: rationale and an inventory of resources

scientific article published in September 2001

High-dose biotin may down-regulate hepatic expression of acute phase reactants by mimicking the physiological role of nitric oxide

scientific article published in October 2003

High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes

scientific article published in May 1999

High-dose folate and dietary purines promote scavenging of peroxynitrite-derived radicals--clinical potential in inflammatory disorders.

scientific article published on 5 May 2009

High-dose pyridoxine as an 'anti-stress' strategy

scientific article published on May 2000

Homologous physiological effects of nutritional antioxidants and eicosapentaenoic acid

scientific article published on January 1987

Hormonal and nutritional enhancement of Na+-K+-ATPase activity may aid the prevention and treatment of essential hypertension ⬇️

scientific article published on April 1, 1984

IGF-I activity may be a key determinant of stroke risk--a cautionary lesson for vegans

scientific article published in September 2003

Iatrogenic lipodystrophy in HIV patients – the need for very-low-fat diets ⬇️

scientific article published on November 1, 2003

In type 1 diabetics, high-dose biotin may compensate for low hepatic insulin exposure, promoting a more normal expression of glycolytic and gluconeogenic enyzymes and thereby aiding glycemic control

scientific article published on 10 August 2016

Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol

scientific article

Insulin secretion as a determinant of pancreatic cancer risk

scientific article published in August 2001

Insulin secretion as a potential determinant of homocysteine levels

scientific article published in November 2000

Integration of allogeneic lymphocyte immunotherapy with short-course chemotherapy and hypoenergic hyperthermia: a "triple-threat" treatment for disseminated cancer

scientific article published on January 1985

Interleukin-1beta may act on hepatocytes to boost plasma homocysteine - The increased cardiovascular risk associated with elevated homocysteine may be mediated by this cytokine

scientific article published on 14 March 2017

Is interleukin-6 the link between low LDL cholesterol and increased non-cardiovascular mortality in the elderly?

scientific article

Ivermectin may be a clinically useful anti-inflammatory agent for late-stage COVID-19

scientific article published on 01 September 2020

Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1.

scientific article published on 10 August 2015

L-carnitine for the treatment of acute myocardial infarction

scientific article published on January 2014

Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity

scientific article

Longevity effect of chromium picolinate--'rejuvenation' of hypothalamic function?

scientific article

Magnesium taurate and fish oil for prevention of migraine

scientific article

Magnesium taurate for the prevention and treatment of pre-eclampsia/eclampsia

scientific article

Management of acute myocardial infarction with natural physiological agents

scientific article published on August 1983

Maturity-onset diabetes mellitus — Toward a physiologically appropriate management ⬇️

scientific article published on October 1, 1981

Minimizing Membrane Arachidonic Acid Content as a Strategy for Controlling Cancer: A Review

article

Modulation of adipocyte lipoprotein lipase expression as a strategy for preventing or treating visceral obesity

scientific article

Monoselenolipoic acid may be an outstanding pharmaceutical antioxidant with direct thioredoxin-like activity

scientific article published in September 2000

NADPH oxidase mediates glucolipotoxicity-induced beta cell dysfunction--clinical implications.

scientific article

Neuroprotective potential of high-dose biotin

scientific article published on 16 October 2017

Nitric oxide deficiency, leukocyte activation, and resultant ischemia are crucial to the pathogenesis of diabetic retinopathy/ neuropathy — preventive potential of antioxidants, essential fatty acids, chromium, ginkgolides, and pentoxifylline ⬇️

scientific article published on May 1, 1998

Non-toxic inhibition of extracellular tumor enzymes--potential in cancer therapy

scientific article published on March 1982

Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond

scientific article published on 25 December 2020

Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration

scientific article published in 2022

Nutritional modulation of mineralocorticoid and prostaglandin production: Potential role in prevention and treatment of gastric pathology ⬇️

scientific article published on August 1, 1983

Nutritional prevention of pre-eclampsia--a special role for 1 series prostaglandin precursors?

scientific article published on September 1982

Nutritional support of central catecholaminergic tone may aid smoking withdrawal

scientific article

Omega-3 and prostate cancer: examining the pertinent evidence

scientific article published on 06 March 2014

Omega-3s and cardiovascular health.

scientific article

Optimized mitochondrial function as a nutritional strategy in cancer immunotherapy

scientific article published on January 1981

Optimizing exercise for fat loss

scientific article published in May 1995

Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders.

scientific article

Orthomolecular aids for dieting

scientific article

Oxidative stress therapy for solid tumors - a proposal

scientific article published on 20 January 2010

PPAR gamma agonists can be expected to potentiate the efficacy of metronomic chemotherapy through CD36 up-regulation

scientific article published on 4 June 2007

PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight ⬇️

scientific article published on November 1, 2003

Pentoxifylline for vascular health: a brief review of the literature

scientific article

Peroxisome proliferators as adjuvants for the reverse-electron-transport therapy of obesity: an explanation for the large increase in metabolic rate of MEDICA 16-treated rats

scientific article published on October 1999

Plant-based diets relatively low in bioavailable phosphate and calcium may aid prevention and control of prostate cancer by lessening production of fibroblast growth factor 23.

scientific article published on 3 January 2017

Point of view--a role for "nutritional insurance" supplementation in preventive medicine

scientific article published on February 1981

Policosanol safely down-regulates HMG-CoA reductase - potential as a component of the Esselstyn regimen

scientific article

Potential complementarity of high-flavanol cocoa powder and spirulina for health protection.

scientific article

Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy

scientific article published on 20 January 2010

Practical strategies for targeting NF-kappaB and NADPH oxidase may improve survival during lethal influenza epidemics.

scientific article

Prenatal high-dose pyridoxine may prevent hypertension and syndrome X in-utero by protecting the fetus from excess glucocorticoid activity

scientific article published on May 2000

Prospects for glycerol-rescued hypoglycemia as a cancer therapy

scientific article published in March 2001

Prospects for nutritional control of hypertension

scientific article

Pyruvate and hydroxycitrate/carnitine may synergize to promote reverse electron transport in hepatocyte mitochondria, effectively 'uncoupling' the oxidation of fatty acids

scientific article published in May 1999

RE: Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial

scientific article

Rationale for a novel immunotherapy of cancer with allogeneic lymphocyte infusion

scientific article published on November 1984

Rationales for micronutrient supplementation in diabetes ⬇️

scientific article published on February 1, 1984

Red Yeast Rice Plus Berberine: Practical Strategy for Promoting Vascular and Metabolic Health.

scientific article published on August 2015

Reduction of free fatty acids may ameliorate risk factors associated with abdominal obesity ⬇️

scientific article published on April 1, 1995

Regular thermal therapy may promote insulin sensitivity while boosting expression of endothelial nitric oxide synthase--effects comparable to those of exercise training

scientific article published on 8 February 2009

Role of dietary histidine in the prevention of obesity and metabolic syndrome.

scientific article published in July 2018

Selenium, calcium channel blockers, and cancer risk— the Yin and Yang of apoptosis? ⬇️

scientific article published on May 1, 1998

Sulfated glycosaminoglycans and glucosamine may synergize in promoting synovial hyaluronic acid synthesis

scientific article

Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1β signalling: a potential strategy for preventing cardiovascular events?

scientific article published on 28 July 2017

Supplemental creatine may decrease serum homocysteine and abolish the homocysteine 'gender gap' by suppressing endogenous creatine synthesis

scientific article

Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases

scientific article

Suppression of dolichol synthesis with isoprenoids and statins may potentiate the cancer-retardant efficacy of IGF-I down-regulation

scientific article

Synergistic denaturant therapy--a general strategy for treatment of solid malignancies

scientific article published on October 1980

Targeting Casein kinase 2 with quercetin or enzymatically modified isoquercitrin as a strategy for boosting the type 1 interferon response to viruses and promoting cardiovascular health

scientific article published on 04 May 2020

Targeting aspirin resistance with nutraceuticals: a possible strategy for reducing cardiovascular morbidity and mortality

scientific article published on 2 September 2017

Thalidomide for autoimmune disease

scientific article published on April 1983

The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha

scientific article published on 11 September 2008

The cardiometabolic benefits of glycine: Is glycine an 'antidote' to dietary fructose?

scientific article published on 28 May 2014

The chlorophyll metabolite phytanic acid is a natural rexinoid--potential for treatment and prevention of diabetes

scientific article

The hyperpolarizing impact of glycine on endothelial cells may be anti-atherogenic

scientific article published on 18 February 2009

The insulin-sensitizing activity of moderate alcohol consumption may promote leanness in women

scientific article

The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy

scientific article

The molecular biology and pathophysiology of vascular calcification

scientific article

The neglect of glucosamine as a treatment for osteoarthritis--a personal perspective

scientific article published in May 1994

The origins of western obesity: a role for animal protein?

scientific article

The protection conferred by chelation therapy in post-MI diabetics might be replicated by high-dose zinc supplementation

scientific article published on 31 January 2015

The putative therapeutic value of high-dose selenium in proliferative retinopathies may reflect down-regulation of VEGF production by the hypoxic retina

scientific article published in January 2005

The therapeutic potential of glucose tolerance factor

scientific article

The unique merits of a low-fat diet for weight control

scientific article published on June 1986

Thrombotic complications of COVID-19 may reflect an upregulation of endothelial tissue factor expression that is contingent on activation of endosomal NADPH oxidase

scientific article published on 01 June 2020

Toward a "bio-energy supplement" -- a prototype for functional orthomolecular supplementation

scientific article published on April 1981

Toward a wholly nutritional therapy for type 2 diabetes

scientific article

Toward practical prevention of type 2 diabetes

scientific article

Turning an 'Achilles' Heel' into an asset--activation of HIF-1alpha during angiostatic therapy will increase tumor sensitivity to iron-catalyzed oxidative damage

scientific article published in October 2003

Up-regulation of IGF binding protein-1 as an anticarcinogenic strategy: relevance to caloric restriction, exercise, and insulin sensitivity

scientific article published in April 1997

Up-regulation of endothelial nitric oxide activity as a central strategy for prevention of ischemic stroke - just say NO to stroke!

scientific article

Up-regulation of hepatic IGFBP-1 production as a strategy for preventing benign prostatic hyperplasia

scientific article

Upregulation of lymphocyte apoptosis as a strategy for preventing and treating autoimmune disorders: a role for whole-food vegan diets, fish oil and dopamine agonists

scientific article published in August 2001

Vascular heparan sulfates may limit the ability of leukocytes to penetrate the endothelial barrier--implications for use of glucosamine in inflammatory disorders

scientific article published on July 1998

Vascular nitric oxide may lessen Alzheimer's risk

scientific article published in December 1998

Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity

scientific article

Versatile cytoprotective activity of lipoic acid may reflect its ability to activate signalling intermediates that trigger the heat-shock and phase II responses

scientific article published in September 2001

natural antimutagenic agents may prolong efficacy of human immunodeficiency virus drug therapy

scientific article published in March 1997

β-Alanine and orotate as supplements for cardiac protection

scientific article

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