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List of works by Michel Mittelbronn

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A 4-miRNA signature predicts the therapeutic outcome of glioblastoma

scientific article published on 11 June 2016

A 63-year-old man with dementia, ataxia and VI nerve palsy

scientific article

A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models

scientific article published on 6 March 2018

A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes

scientific article

ACTH- and prolactin-producing pituitary gland microadenoma with biphasic features of atypia and intermediate filament expression

scientific article published in February 2006

AI-26OVERCOMING RESISTANCE TO VEGF-BLOCKADE BY TARGETING THE ANGIOPOIETIN/TIE2 AXIS.

scientific article published in November 2014

AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry

scientific article published on 6 October 2013

ANGI-14. A GSK-3/b-CATENIN/ARHGAP AXIS REGULATES GLIOBLASTOMA INVASION ⬇️

APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria

scientific article

ASA404, a vascular disrupting agent, as an experimental treatment approach for brain tumors

scientific article published on 28 August 2017

ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment

scientific article published on 13 October 2015

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

scientific article published on 27 November 2014

Activated leukocyte cell adhesion molecule is expressed in neuroepithelial neoplasms and decreases with tumor malignancy, matrix metalloproteinase 2 expression, and absence of IDH1R132H mutation

scientific article published on 2 February 2012

Addition of Anti-Angiogenetic Therapy with Bevacizumab to Chemo- and Radiotherapy for Leptomeningeal Metastases in Primary Brain Tumors

scientific article

Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages - a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

scientific article published on 16 August 2016

Adora2b signaling on bone marrow derived cells dampens myocardial ischemia-reperfusion injury

scientific article

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

scientific article

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

scientific article published on 19 June 2015

Albumin in immunohistochemistry: Foe and friend

scientific article published in December 2006

Alterations in the NF2/LATS1/LATS2/YAP Pathway in Schwannomas

scientific article

Alterations in the RB1 Pathway in Low‐grade Diffuse Gliomas Lacking Common Genetic Alterations ⬇️

scientific article published on May 30, 2011

Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas

scientific article

Alternative generation of CNS neural stem cells and PNS derivatives from neural crest-derived peripheral stem cells

scientific article published in February 2015

Amplification of the STOML3, FREM2, and LHFP Genes Is Associated with Mesenchymal Differentiation in Gliosarcoma ⬇️

scientific article published on May 1, 2012

Analysis of cerebral angiogenesis in human glioblastomas.

scientific article

Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

scientific article

Anti-tissue factor (TF9-10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model

scientific article published on 5 February 2013

Atypical pituitary adenoma exhibiting densely secretory granules and basophilia without hormone production.

scientific article published in February 2006

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway

scientific article published in November 2017

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis

scientific article published in June 2008

BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease

scientific article published on 13 October 2015

BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family

scientific article (publication date: 2013)

BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression

scientific article

Bevacizumab and radiotherapy for the treatment of glioblastoma: brothers in arms or unholy alliance?

scientific article

Biopsies of pediatric brainstem lesions display low morbidity but strong impact on further treatment decisions

scientific article published on 12 July 2017

Brain invasion in otherwise benign meningiomas does not predict tumor recurrence

scientific article published on 27 July 2016

Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis

scientific article published on May 27, 2013

C5b-9 deposits on endomysial capillaries in non-dermatomyositis cases

scientific article published on 3 March 2016

CASP9 germline mutation in a family with multiple brain tumors

scientific article

CD133 expression is associated with small round blue cell tumour morphology in human central nervous system neoplasms

scientific article published on 25 March 2011

CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury

scientific article published in October 2007

CD8(+)/perforin/granzyme B(+) effector cells infiltrating cerebellum and inferior olives in gluten ataxia

scientific article published on 19 July 2009

Cardiac period 2 in myocardial ischemia: clinical implications of a light dependent protein

scientific article published on 03 January 2013

Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors

scientific article published on 12 March 2007

Coincidence of semilobar holoprosencephaly and Chiari II malformation: correlation of prenatal diagnostics and neuropathologic findings

scientific article published in May 2006

Common polymorphisms in the MDM2 and TP53 genes and the relationship between TP53 mutations and patient outcomes in glioblastomas

scientific article published on 6 May 2008

Comparative transcriptomics reveals similarities and differences between astrocytoma grades

scientific article published on 16 December 2015

Comprehensive diagnostics in a case of hereditary diffuse leukodystrophy with spheroids

scientific article published on 4 July 2015

Confirmation of R132H mutation of isocitrate dehydrogenase 1 as an independent prognostic factor in anaplastic astrocytoma

scientific article published on 8 October 2011

Confounding factors in diagnostics of MGMT promoter methylation status in glioblastomas in stereotactic biopsies.

scientific article

DMBT1 homozygous deletion in diffuse astrocytomas is associated with unfavorable clinical outcome

scientific article published on August 2012

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

scientific article published on 14 March 2017

DNA methylation-based classification of central nervous system tumours

scientific article published on 14 March 2018

Death receptor-mediated apoptosis in human malignant glioma cells: modulation by the CD40/CD40L system

scientific article

Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas

scientific article

Differential Tissue-Specific Function of Adora2b in Cardioprotection

scientific article

Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation

scientific article published in October 2013

Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription

scientific article published on January 2007

Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy.

scientific article published in July 2005

Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases

scientific article published on 16 October 2015

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

scientific article published on 24 October 2013

Down-regulation of tumor suppressor A kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms

scientific article

Downstream effects of plectin mutations in epidermolysis bullosa simplex with muscular dystrophy

scientific article published on 27 April 2016

EGFL7 ligates αvβ3 integrin to enhance vessel formation

scientific article published on 5 February 2013

EGR-1 is regulated by N-methyl-D-aspartate-receptor stimulation and associated with patient survival in human high grade astrocytomas

scientific article

Effect of focal cerebral infarctions on lesional RhoA and RhoB expression

scientific article

Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells.

scientific article

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

scientific article

ErbB2/Her2-specific NK cells for adoptive immunotherapy of glioblastoma

scientific article published on 6 November 2014

Expression Profile of Sonic Hedgehog Pathway Members in the Developing Human Fetal Brain

scientific article published on 21 July 2015

Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium

scientific article published on 13 March 2009

Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma.

scientific article

Expression of integrins αvβ3 and αvβ5 and their ligands in primary and secondary central nervous system neoplasms

scientific article

Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain

scientific article

Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity

scientific article published on 25 August 2005

Expression of the water channel protein aquaporin-9 in malignant brain tumors

scientific article

Expression of vascular endothelial growth factor (VEGF) and its receptors VEGFR1 and VEGFR2 in primary and recurrent WHO grade III meningiomas

scientific article published on March 11, 2013

Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival

scientific article published in May 2007

FTY720 Treatment in the Convalescence Period Improves Functional Recovery and Reduces Reactive Astrogliosis in Photothrombotic Stroke ⬇️

scientific article published on July 31, 2013

Femtosecond Laser-Assisted Capsulotomy: Histological Comparison of Four Different Laser Platforms

scientific article

Fermented Mistletoe Extract as a Multimodal Antitumoral Agent in Gliomas ⬇️

scientific article published on October 22, 2012

Frequent BRAF gain in low-grade diffuse gliomas with 1p/19q loss

scientific article published in June 2012

Functional genomics suggest neurogenesis in the adult human olfactory bulb

scientific article published on 09 August 2013

GDF-15 contributes to proliferation and immune escape of malignant gliomas

scientific article published on 9 June 2010

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

scientific article published on 20 December 2016

Genetic Alterations in Gliosarcoma and Giant Cell Glioblastoma

scientific article published on 7 October 2015

Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype

article published in 2019

Gliosarcoma with chondroid and osseous differentiation

scientific article published in February 2007

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium

scientific article

HLA-E protects glioma cells from NKG2D-mediated immune responses in vitro: implications for immune escape in vivo

scientific article published on June 2005

High GDF-15 Serum Levels Independently Correlate with Poorer Overall Survival of Patients with Tumor-Free Stage III and Unresectable Stage IV Melanoma

scientific article published on 22 July 2016

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

scientific article published on 19 October 2015

Holocord pilocytic astrocytoma--case report and review of the literature

scientific article

Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid

scientific article

Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen

scientific article

Identification of intestinal ganglioneuromatosis leads to early diagnosis of MEN2B: role of rectal biopsy

scientific article published on 17 November 2016

Identification of transcriptional targets of GSK3 involved in glioblastoma invasion

Immature teratoma of the tectum mesencephali with histopathological detection of rudimentary eye anlage in a 3-year-old boy: Report of a rare case

scientific article published on 25 April 2016

Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors

scientific article published on 19 May 2015

Increased mitotic and proliferative activity are associated with worse prognosis in papillary tumors of the pineal region

scientific article published in January 2014

Increased tumor vascularization is associated with the amount of immune competent PD-1 positive cells in testicular germ cell tumors.

scientific article published on 27 April 2018

Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke

scientific article published on 14 September 2008

Inflammatory myofibroblastic tumor of the ulnar nerve. Case report and review of the literature

scientific article published on June 2007

Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis

scientific article published on 24 October 2016

Intramedullary Solitary Fibrous Tumor--A Benign Form of Hemangiopericytoma? Case Report and Review of the Literature

scientific article

IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis

scientific article published on 14 September 2015

Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus

scientific article

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

scientific article published on 28 March 2017

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

scientific article

Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components

scientific article published in October 2007

MET gain in diffuse astrocytomas is associated with poorer outcome

scientific article

MIF Receptor CD74 is Restricted to Microglia/Macrophages, Associated with a M1-Polarized Immune Milieu and Prolonged Patient Survival in Gliomas

scientific article published on 20 November 2014

Macrophage migration inhibitory factor (MIF) expression in human malignant gliomas contributes to immune escape and tumour progression

scientific article

Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1.

scientific article published on April 2007

Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death

scientific article

Mature cerebellar teratoma in adulthood

scientific article published on 9 July 2008

Melanoma brain metastasis is independent of lactate dehydrogenase A expression

scientific article

Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles

scientific article published on 15 December 2014

Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups

scientific article published on 28 January 2016

Methylation-based classification of benign and malignant peripheral nerve sheath tumors

scientific article published on 8 February 2016

Microglia in Health and Disease: A Unique Immune Cell Population

article

Modulation of TGF-beta activity by latent TGF-beta-binding protein 1 in human malignant glioma cells

scientific article

Molecular Classification of Low-Grade Diffuse Gliomas ⬇️

scientific article published on November 12, 2010

Moving beyond VEGF: inhibing glioma angiogenesis by targeting the tie2/angiopoietin signaling pathway

scientific article published in July 2014

Multifactorial modulation of susceptibility to l-lysine in an animal model of glutaric aciduria type I.

scientific article published on 2 January 2015

Multiple thromboembolic events in fetofetal transfusion syndrome in triplets contributing to the understanding of pathogenesis of hydranencephaly in combination with polymicrogyria

scientific article published on 25 September 2006

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

scientific journal article

Mutational inactivation of the nijmegen breakage syndrome gene (NBS1) in glioblastomas is associated with multiple TP53 mutations

scientific article published on February 2009

Myofiber degeneration in autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD) (LGMD1B).

scientific article published in October 2006

OPA1, associated with autosomal dominant optic atrophy, is widely expressed in the human brain

scientific article published on 8 February 2005

Oncomodulation by human cytomegalovirus: novel clinical findings open new roads

scientific article

PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells ⬇️

scientific article published on August 18, 2011

PDGFRA gain in low-grade diffuse gliomas

scientific article published in January 2013

Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas

scientific article published in February 2015

Papillary Tumor of the Pineal Region: A Distinct Molecular Entity

scientific article

Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma.

scientific article

Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas

scientific article

Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach.

scientific article

Primary glioblastoma cultures: can profiling of stem cell markers predict radiotherapy sensitivity?

scientific article published on 18 July 2014

Problems in fast intraoperative diagnosis in Hirschsprung's disease

scientific article

Prognostic factors in recurrent glioblastoma patients treated with bevacizumab

scientific article

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

scientific article published on 2 August 2017

Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: a population-based study

scientific article published on 8 November 2008

Prospective evaluation of serum glial fibrillary acidic protein (GFAP) as a diagnostic marker for glioblastoma

scientific article published on 30 October 2015

Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis

scientific article published on 19 August 2013

Quantitative T2 mapping of recurrent glioblastoma under bevacizumab improves monitoring for non-enhancing tumor progression and predicts overall survival ⬇️

scientific article published on 07 August 2013

Radiologically typical pilocytic astrocytoma with histopathological signs of atypia

scientific article published on 21 June 2012

Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: proposal of an unusual pathogenetic event and review of the literature

scientific article

Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir4.1 differs in low- and high-grade human brain tumors

scientific article published on 19 February 2005

Reduced cortisol levels in cerebrospinal fluid and differential distribution of 11beta-hydroxysteroid dehydrogenases in multiple sclerosis: implications for lesion pathogenesis

scientific article published on 10 April 2010

Regeneration and tolerance factor: a novel mediator of glioblastoma-associated immunosuppression

scientific article published on April 2006

Risk of long-term anticoagulation under sustained severe arterial hypertension: A translational study comparing warfarin and the new oral anticoagulant apixaban

scientific article published on 11 April 2016

Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury

scientific article published on 19 March 2008

Severe hypoxia and multiple infarctions resembling Creutzfeldt-Jakob disease.

scientific article published in January 2008

Suppression of oxidative phosphorylation confers resistance against bevacizumab in experimental glioma

scientific article published on 27 November 2017

Survival according to BRAF-V600 tumor mutations--an analysis of 437 patients with primary melanoma

scientific article published on 24 January 2014

Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma.

scientific article

Sustained focal antitumor activity of bevacizumab in recurrent glioblastoma

scientific article published on 13 June 2014

TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations

scientific article published on 20 June 2011

TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

scientific article published on 3 August 2006

TP53, MSH4, and LATS1 germline mutations in a family with clustering of nervous system tumors

scientific article

The "go or grow" potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress

scientific article published on 15 January 2012

The angiogenic switch leads to a metabolic shift in human glioblastoma

scientific article published on 3 September 2016

The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas

scientific article

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

scientific article

The pro-migratory and pro-invasive role of the procoagulant tissue factor in malignant gliomas

scientific article published on October 2010

The striate sign: peritumoural perfusion pattern of infiltrative primary and recurrent gliomas

scientific article published on 2 March 2010

Therapeutic exploitation of apoptosis and autophagy for glioblastoma

scientific article published on July 2010

Thrombolysis with recombinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke ⬇️

scientific article published on March 23, 2012

Towards an unbiased, collaborative effort to reach evidence about the presence of human cytomegalovirus in glioblastoma (and other tumors).

scientific article published in July 2015

Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma

scientific article

Tumour necrosis factor receptor superfamily member 9 (TNFRSF9) is up-regulated in reactive astrocytes in human gliomas

scientific article published in February 2015

VEGF-dependent induction of CD62E on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells

scientific article

Viscumins functionally modulate cell motility-associated gene expression

scientific article published on 3 January 2017

WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism?

scientific article published on 31 May 2007

WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes.

scientific article

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells

scientific article published on 18 September 2013

[11C]PIB binding in Parkinson's disease dementia

scientific article published on 22 October 2007

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