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List of works by Millie M. Georgiadis

"Skinny" and "Fat" DNA: Two New Double Helices

scientific article published on 10 September 2018

A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a "highly twisted" benzimidazole-diamidine

scientific article published on June 2006

A host-guest approach for determining drug-DNA interactions: an example using netropsin

scientific article

APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.

scientific article published in January 2012

Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii ⬇️

scientific article published on February 24, 2011

Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity

scientific article

Building better DNA polymerases: Engineering the replication of expanded genetic alphabets

scientific article published on 01 October 2020

Building better enzymes: Molecular basis of improved non-natural nucleobase incorporation by an evolved DNA polymerase

scientific article published on 14 November 2019

Characterization of critical interactions between Ndt80 and MSE DNA defining a novel family of Ig-fold transcription factors

scientific article

Characterization of the Redox Activity and Disulfide Bond Formation in Apurinic/Apyrimidinic Endonuclease ⬇️

scientific article published on January 4, 2012

Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations

scientific article

Crystal Structure of a Trypanocidal 4,4′-Bis(imidazolinylamino)diphenylamine Bound to DNA ,

scientific article

Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals

scientific article

Crystal structure of DNA-bound Co(III)·bleomycin B2: Insights on intercalation and minor groove binding

scientific article

Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast

scientific article

Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase

scientific article

Crystal structures of oligonucleotides including the integrase processing site of the Moloney murine leukemia virus

scientific article

Crystallization of and selenomethionine phasing strategy for a SETMAR-DNA complex

scientific article

Crystallographic studies of a novel DNA-binding domain from the yeast transcriptional activator Ndt80

scientific article published on 23 November 2002

Differential multimerization of Moloney murine leukemia virus integrase purified under nondenaturing conditions.

scientific article published in November 2003

Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1

scientific article published on 06 February 2019

Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

scientific article published on 25 October 2020

Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1 ⬇️

scientific article published on January 4, 2011

Hachimoji DNA and RNA: A genetic system with eight building blocks

scientific article published in Science

High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.

scientific article

Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited

scientific article published on 18 April 2013

Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme

scientific article

Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells

scientific article

Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription

scientific article published on November 2006

Redox regulation of DNA repair: implications for human health and cancer therapeutic development

scientific article

Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1

scientific article published on November 2008

S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.

scientific article

Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library

scientific article

Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons

scientific article

Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide

article published in 2018

Staying straight with A-tracts: a DNA analog of the HIV-1 polypurine tract

scientific article

Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase.

scientific article

Structural basis for a six nucleotide genetic alphabet

scientific article

Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (X) and 2,4-Diaminopyrimidine (K).

scientific article published on 28 July 2017

Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression

scientific article

Targeting the OB‐Folds of Replication Protein A with Small Molecules ⬇️

scientific article published on December 6, 2010

The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart

scientific article

The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor

scientific article

The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli

scientific article

The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus

scientific article published in May 2004

The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family

scientific article published on 01 December 2006

The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition

scientific article

The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition. Corrigendum

scholarly article published in Acta Crystallographica Section D: Biological Crystallography

Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information System

scientific article

Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: induced fit and bound water

scientific article published on 17 May 2007

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