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List of works by Christopher S. Chen

"Stamp-off" to micropattern sparse, multicomponent features

scientific article published in January 2014

3D culture models of tissues under tension

scientific article published on December 2016

A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix

scientific article published on 01 April 2019

A DNA-based molecular probe for optically reporting cellular traction forces

scientific article

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

scientific article published on 28 August 2019

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A hitchhiker's guide to mechanobiology

scientific article published on July 2011

A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues

scientific article published on 4 January 2012

A multi-organ chip with matured tissue niches linked by vascular flow

scientific article published in 2022

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

scientific article published on 13 November 2017

A pilot study to examine the correlation between cognition and blood biomarkers in a Singapore Chinese male cohort with type 2 diabetes mellitus

scientific article (publication date: 2014)

A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

scientific article published on 31 October 2015

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

scientific article

Abnormalities of cortical thickness, subcortical shapes, and white matter integrity in subcortical vascular cognitive impairment

scientific article

Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension

scientific article

Activation of beta 1 but not beta 3 integrin increases cell traction forces

scientific article

Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin

scientific article published on 09 January 2014

Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch

scientific article published on 11 October 2012

An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling

scientific article

Ankle brachial index, MRI markers and cognition: The Epidemiology of Dementia in Singapore study

scientific article published on 05 July 2017

Ankle-Brachial Index, Cognitive Impairment and Cerebrovascular Disease in a Chinese Population

article

Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial

scientific article

ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model

scientific article published on 18 May 2016

Assembly of multicellular constructs and microarrays of cells using magnetic nanowires

scientific article published on 13 May 2005

Association Between Subclinical Cardiac Biomarkers and Clinically Manifest Cardiac Diseases With Cortical Cerebral Microinfarcts

scientific article published on 6 February 2017

Association of common genetic variants with brain microbleeds: A Genome-wide Association Study

scientific article published on 10 September 2020

Association of silent lacunar infarct with brain atrophy and cognitive impairment

scientific article published on 9 August 2013

B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the VITAmins TO Prevent Stroke (VITATOPS) MRI-substudy

scientific article published on 23 October 2012

Beyond Screening: Can the Mini-Mental State Examination be Used as an Exclusion Tool in a Memory Clinic?

scientific article published on 4 November 2015

Bioactive hydrogels made from step-growth derived PEG-peptide macromers

scientific article

Bioengineering Methods for Analysis of Cells In Vitro ⬇️

scientific article published on January 1, 2012

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

scientific article

Bioresponsive mesoporous silica nanoparticles for triggered drug release

scientific article published on 18 November 2011

Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension

scientific article

Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells

scientific article published on 21 August 2007

Cdc42 regulates branching in angiogenic sprouting in vitro

scientific article published on 4 April 2017

Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation ⬇️

scientific article published on May 15, 2013

Cell polarity triggered by cell-cell adhesion via E-cadherin

scientific article

Cell shape and substrate rigidity both regulate cell stiffness

scientific article

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment

scientific article

Cell traction forces direct fibronectin matrix assembly

scientific article published on January 2009

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

scientific article

Cellular control lies in the balance of forces ⬇️

scientific article published on April 1, 1998

Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study

scientific article

Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: a pilot study

scientific article published on 28 July 2012

Characterization of the nuclear deformation caused by changes in endothelial cell shape

scientific article published in October 2004

Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial

scientific article

Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial

scientific article published on 4 February 2016

Control of Cyclin D1, p27Kip1, and Cell Cycle Progression in Human Capillary Endothelial Cells by Cell Shape and Cytoskeletal Tension ⬇️

scientific article published on November 1, 1998

Control of surface chemistry, substrate stiffness, and cell function in a novel terpolymer methacrylate library

scientific article

Coronal CT is Comparable to MR Imaging in Aiding Diagnosis of Dementia in a Memory Clinic in Singapore

scientific article published in December 2017

Cortical cerebral microinfarcts on 3T MRI: A novel marker of cerebrovascular disease

scientific article published on 2 September 2016

Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients

scientific article

Cytoskeleton-based forecasting of stem cell lineage fates

scientific article

Danqi Piantan Jiaonang does not modify hemostasis, hematology, and biochemistry in normal subjects and stroke patients

scientific article

Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in poststroke recovery

scientific article

Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers

scientific article published on 28 January 2013

Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis

scientific article

Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner

scientific journal article

Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering

scientific article published on 07 April 2015

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

scientific article published on 24 March 2013

Detection, risk factors, and functional consequences of cerebral microinfarcts

scientific article

Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle

scientific article published on 2 November 2012

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement

scientific article

Dielectrophoretic registration of living cells to a microelectrode array

scientific article published on July 2004

Dielectrophoretic registration of living cells to a microelectrode array

scientific article published in February 2004

Differential Binding of Human ApoE Isoforms to Insulin Receptor is Associated with Aberrant Insulin Signaling in AD Brain Samples

scientific article published on 15 February 2018

Dual antiplatelets reduce microembolic signals in patients with transient ischemic attack and minor stroke: subgroup analysis of CLAIR study

scientific article

Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and meta-analysis of randomized controlled trials

scientific article published on 26 January 2012

E-cadherin engagement stimulates proliferation via Rac1

scientific article

Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis

scientific article published on 13 June 2013

Efficacy and safety of MLC601 (NeuroAiD®), a traditional Chinese medicine, in poststroke recovery: a systematic review

scientific article

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

scientific article

Emergence of patterned stem cell differentiation within multicellular structures

scientific article published on 14 August 2008

Emergent patterns of growth controlled by multicellular form and mechanics

scientific article

Endothelial cell sensing of flow direction

scientific article

Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering ⬇️

scientific article published on October 20, 2010

Engineering a living cardiac pump on a chip using high-precision fabrication

scientific article published on 22 April 2022

Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton

scientific article

Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies

Epidemiology of dementia in Asia: insights on prevalence, trends and novel risk factors

scientific article published on 09 August 2012

Evaluation of an fMRI USPIO-based assay in healthy human volunteers

scientific article published on 24 October 2016

Evaluation of the Post Stroke Checklist: a pilot study in the United Kingdom and Singapore

scientific article published on 4 August 2014

Fabrication and Mechanical Properties Measurements of 3D Microtissues for the Study of Cell-Matrix Interactions

scientific article published in January 2018

Fabrication of aligned microstructures with a single elastomeric stamp

scientific article

Fibrous hyaluronic acid hydrogels that direct MSC chondrogenesis through mechanical and adhesive cues

scientific article published on 24 April 2013

Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model

scientific article published on August 2005

Fluid shear stress threshold regulates angiogenic sprouting

scientific article

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions

scientific article published on 8 January 2018

Force measurement tools to explore cadherin mechanotransduction

scientific article published on 23 April 2014

Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

scientific article published on 21 April 2021

Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening

scientific article

Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis

scientific article published on October 2012

Formation and optogenetic control of engineered 3D skeletal muscle bioactuators

scientific article

Frequency of microemboli signal in stroke patients treated with low molecular weight heparin or aspirin

scientific article published on 16 December 2008

Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis

scientific article (publication date: 2016)

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

scholarly article published 28 August 2017

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Genetic architecture of subcortical brain structures in 38,851 individuals

scientific article published on 21 October 2019

Geometric control of vascular networks to enhance engineered tissue integration and function

scientific article published on 22 April 2013

Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis

scientific article published on 08 December 2015

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

scientific article

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

scientific article published on 16 July 2006

Heterotypic cell pair co-culturing on patterned microarrays

scientific article

Homocysteine and Cerebral Atrophy: The Epidemiology of Dementia in Singapore Study

scientific article published in January 2018

How cells sense extracellular matrix stiffness: a material's perspective

scientific article

How vinculin regulates force transmission

scientific article published on 28 May 2013

Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation

scientific article

Imaging retina to study dementia and stroke

scientific article

In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.

scientific article

Inflammatory markers and their association with post stroke cognitive decline

scientific article published on 12 March 2013

Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

scientific article published on 6 January 2017

Intracranial stenosis in cognitive impairment and dementia

scientific article published on 3 August 2016

Intracranial stenosis, cerebrovascular diseases, and cognitive impairment in chinese

scientific article published in January 2015

Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' trial

scientific article published in February 2009

Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers

scientific article

Low-molecular-weight heparin and early neurologic deterioration in acute stroke caused by large artery occlusive disease

scientific article

Low-molecular-weight heparin versus aspirin for acute ischemic stroke with large artery occlusive disease: subgroup analyses from the Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) study

scientific article

Magnetic microposts as an approach to apply forces to living cells

scientific article

Magnetic microposts for mechanical stimulation of biological cells: fabrication, characterization, and analysis

scientific article

Manipulation of 3D Cluster Size and Geometry by Release from 2D Micropatterns ⬇️

scientific article published on September 1, 2012

Manipulation of cell-cell adhesion using bowtie-shaped microwells

scientific article published in January 2007

Markers of cardiac dysfunction in cognitive impairment and dementia

scientific article

Matrix degradability controls multicellularity of 3D cell migration

scientific article

Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition

scientific article published on 11 January 2012

Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling

scientific article

Measurement and analysis of traction force dynamics in response to vasoactive agonists

scientific article

Measurement of mechanical tractions exerted by cells in three-dimensional matrices.

scientific article

Measuring cell-generated forces: a guide to the available tools

scientific article

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

scientific article

Measuring traction forces of motile dendritic cells on micropost arrays

scientific article published in December 2011

Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes

scientific article

Mechanical regulation of glycolysis via cytoskeleton architecture

scientific article published on 12 February 2020

Mechanical tugging force regulates the size of cell-cell junctions

scientific article

Microfabricated post-array-detectors (mPADs): an approach to isolate mechanical forces

scientific article

Microfabricated silicone elastomeric post arrays for measuring traction forces of adherent cells

scientific article published in January 2007

Microfabrication of a platform to measure and manipulate the mechanics of engineered microtissues

scientific article published on January 2014

Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients

scientific article

Micropatterned dynamically adhesive substrates for cell migration

scientific article published on October 2010

Microvascular network alterations in retina of subjects with cerebral small vessel disease

scientific article published on 14 June 2014

Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues

Multi-stage segmentation of white matter hyperintensity, cortical and lacunar infarcts

scientific article published on 22 February 2012

Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions

scientific article published on 31 December 2012

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

scientific article published on 7 February 2015

Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices

scientific article published on 3 May 2017

Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature

scientific article

N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells

scientific article published on 4 March 2015

Nanotechnology for cell-substrate interactions

scientific article

Necking and Failure of Constrained Contractile 3D Microtissues: Role of Geometry and Stiffness

scholarly article published 26 June 2013

Necking and failure of constrained 3D microtissues induced by cellular tension

scientific article published on 09 December 2013

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

scientific article

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

Ocular Fundus Photography as a Tool to Study Stroke and Dementia

scientific article published on 06 October 2015

Optimization of yield in magnetic cell separations using nickel nanowires of different lengths

scientific article

Patterning vascular networks in vivo for tissue engineering applications

scientific article published on 18 February 2015

Patterns of neuropsychological impairment in Alzheimer's disease and mixed dementia

scientific article published on 25 July 2013

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs

scientific article

Prevalence and Risk Factors of Acute Incidental Infarcts

scientific article published on 20 August 2015

Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study.

scientific article

Probing cellular traction forces with magnetic nanowires and microfabricated force sensor arrays

scientific article published on 20 January 2012

Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study

scientific article published on 19 October 2017

Protrusive and Contractile Forces of Spreading Human Neutrophils

scientific article

Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion

scientific article published on January 2008

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway

scientific article

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

scientific article

Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations

scientific article

Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus

scientific article published on September 2003

Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells

scientific article

Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

scientific article

Retinal microvasculature in Alzheimer's disease

scientific article

Retinal microvasculature in acute lacunar stroke: a cross-sectional study.

scientific article published on 28 May 2009

Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

scientific article published on 19 October 2014

Retinal vascular caliber and extracranial carotid disease in patients with acute ischemic stroke: the Multi-Centre Retinal Stroke (MCRS) study

scientific article

Retinal vascular fractals and cognitive impairment

scientific article

Risk Factors and Consequences of Cortical Thickness in an Asian Population

scientific article

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

scientific article

Safety profile of MLC601 (Neuroaid) in acute ischemic stroke patients: A Singaporean substudy of the Chinese medicine neuroaid efficacy on stroke recovery study

scientific article published on 16 April 2010

Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes

scientific article published on 06 October 2021

Serum erythrocyte sedimentation rate is higher among ethnic South Asian compared to ethnic Chinese ischemic stroke patients. Is this attributable to metabolic syndrome or central obesity?

scientific article

Silent stroke: not listened to rather than silent

scientific article published on 4 September 2012

Simple approach to micropattern cells on common culture substrates by tuning substrate wettability

scientific article published in May 2004

Stem cell differentiation: sticky mechanical memory

scientific article published in June 2014

Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces

scientific article published on 4 February 2011

Subcortical Atrophy in Cognitive Impairment and Dementia

scientific article

Substrates with engineered step changes in rigidity induce traction force polarity and durotaxis

scientific article published on 09 October 2013

The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation

scientific article published on 5 July 2017

The Cdc42 Guanine Nucleotide Exchange Factor FGD1 Regulates Osteogenesis in Human Mesenchymal Stem Cells ⬇️

scientific article published on March 1, 2011

The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke

scientific article published in December 2010

The Vascular Impairment of Cognition Classification Consensus Study

scientific article published on 10 December 2016

The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial

scientific article

The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions

scientific article published on 20 August 2013

The interaction between neuropsychological and motor deficits in patients after stroke

scientific article published on January 2013

Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function

scientific article published on August 2017

Tissue-engineered, hydrogel-based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function.

scientific article

Treatment With B Vitamins and Incidence of Cancer in Patients With Previous Stroke or Transient Ischemic Attack

article

Using Retinal Imaging to Study Dementia

scientific article published on 6 November 2017

VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension

scientific article published on 22 July 2003

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise

scientific article published in March 2018

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise

scientific article published in April 2018

Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA.

scientific article

World Wide Fingers will advance dementia prevention

scientific article published on 16 December 2017

miR-125b Is an adhesion-regulated microRNA that protects mesenchymal stem cells from anoikis

scientific article published in May 2012

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