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List of works by Harihara M. Mehendale

A review of the role of tissue repair as an adaptive strategy: why low doses are often non-toxic and why high doses can be fatal

scientific article published on March 1996

Absence of diamine oxidase activity from rabbit and rat lungs

scientific article published on March 1986

Absence of metabolism of morphine during accumulation by isolated perfused rabbit lung

scientific article published on November 1, 1979

Absence of potentiation of bromoform hepatotoxicity and lethality by chlordecone

scientific article published on February 1, 1983

Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity

scientific article published on 18 July 2003

Acute hepatotoxicity and lethality of CCl4 in chlordecone-pretreated rats

scientific article published on August 1, 1983

Adaptive tolerance in mice upon subchronic exposure to chloroform: Increased exhalation and target tissue regeneration

scientific article

Adenosine triphosphate protection of chlordecone-amplified CCl4 hepatotoxicity and lethality

scientific article published on February 1994

Age-related differences in TGF-alpha and proto-oncogenes expression in rat liver after a low dose of carbon tetrachloride

scientific article published on October 1995

Age-related susceptibility to chlordecone-potentiated carbon tetrachloride hepatotoxicity and lethality is due to hepatic quiescence

scientific article published in August 1995

Aldrin epoxidase activity in developing rabbit lung.

scientific article published in April 1980

Altered hepatic energy status in chlordecone (kepone®)-potentiated ccl4 hepatotoxicity

scientific article published on August 15, 1990

Amplification of CCl4 toxicity by chlordecone: destruction of rat hepatic microsomal cytochrome P-450 subpopulation

scientific article published in March 1991

Amplified interactive toxicity of chemicals at nontoxic levels: mechanistic considerations and implications to public health

scientific article

Antimitotic intervention with colchicine alters the outcome of o-DCB-induced hepatotoxicity in Fischer 344 rats

scientific article published on June 1997

Assessment of neurotoxicity induced by oral administration of chlordecone (Kepone) in the mouse.

scientific article published in January 1981

Assessment of photomirex toxicity in the mouse

scientific article published in July 1980

Autoprotection: stimulated tissue repair permits recovery from injury

scientific article published on June 1994

Biliary excretory dysfunction following exposure to photomirex and photomirex/carbon tetrachloride combination

scientific article published on June 1, 1979

Biochemical assessment of the genotoxicity of thein vitro interaction between chlordecone and carbon tetrachloride in rat hepatocytes

scientific article published on August 1, 1991

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

scientific article published on 7 March 2007

Bromotrichloromethane Hepatotoxicity. The Role of Stimulated Hepatocellular Regeneration in Recovery: Biochemical and Histopathological Studies in Control and Chlordecone Pretreated Male Rats

scientific article published on January 1, 1990

Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants

scientific article published in September 2003

Calpain: a death protein that mediates progression of liver injury

scientific article

Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes

scientific article

Carbon tetrachloride metabolism in partially hepatectomized and sham-operated rats pre-exposed to chlordecone (Kepone).

scientific article

Carbon tetrachloride-induced alterations of hepatic calmodulin and free calcium levels in rats pretreated with chlordecone

scientific article published in February 1991

Cationic amphiphilic drugs and phospholipid storage disorder.

scientific article published on December 1990

Chemical reactivity-absorption, retention, metabolism, and elimination of hexachlorocyclopentadiene

scientific article published on December 1, 1977

Chlordecone (Kepone)-potentiated carbon tetrachloride hepatotoxicity in partially hepatectomized rats--a histomorphometric study

scientific article

Chlordecone potentiation of CCl4 hepatotoxicity in ovariectomized rats

scientific article published on February 1, 1984

Chlordecone‐induced fat depletion in the male rat

scientific article published on July 1, 1982

Chlordecone‐induced hepatic dysfunction

scientific article published on November 1, 1981

Chlorphentermine uptake by rabbit lung slices

scientific article published on January 1980

Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation

scientific article published on February 2006

Colchicine Antimitosis Abolishes CCl4 Autoprotection

scientific article published on January 1, 1991

Colchicine antimitosis abolishes resiliency of postnatally developing rats to chlordecone-amplified carbon tetrachloride hepatotoxicity and lethality

scientific article published on September 1, 1998

Colchicine antimitosis causes progression of S-(1,2-dichlorovinyl)-L-cysteine-induced injury leading to acute renal failure and death in mice

scientific article published on 7 February 2006

Comparative changes in hepatic DNA, RNA, protein, lipid, and glycogen induced by a subtoxic dose of CCl4 in chlordecone, mirex, and phenobarbital pretreated rats

scientific article published in February 1987

Comparative evaluation of sequestration of polyamines by perfused rabbit and rat lungs

scientific article published on December 1990

Comparison of brain discrete area distributions of chlordecone and mirex in the mouse

scientific article published on October 1, 1982

Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats

scientific article published in August 2001

Destruction of hepatic mixed-function oxygenase parameters by CCl4 in rats following acute treatment with chlordecone, mirex, and phenobarbital

scientific article published on December 5, 1983

Diabetic mice are protected from normally lethal nephrotoxicity of S-1,2-dichlorovinyl-L-cysteine (DCVC): role of nephrogenic tissue repair

scientific article published on 25 August 2005

Diallyl sulfide inhibition of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality

scientific article

Diet Restriction Enhances Compensatory Liver Tissue Repair and Survival Following Administration of Lethal Dose of Thioacetamide

scientific article published on May 1, 1998

Differential protooncogene expression in Sprague Dawley and Fischer 344 rats during 1,2-dichlorobenzene-induced hepatocellular regeneration

scientific article

Disrupted G1 to S phase clearance via cyclin signaling impairs liver tissue repair in thioacetamide-treated type 1 diabetic rats

scientific article published in September 2005

Dose-dependent liver regeneration in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity in rats

scientific article published on 7 June 2005

Dose-dependent liver tissue repair in chloroform plus thioacetamide acute hepatotoxicity

scientific article published on November 1, 2004

Effect of adrenalectomy on chlordecone potentiation of carbontetrachloride hepatotoxicity

scientific article published on November 1, 1983

Effect of amiodarone on Na+-, K+-ATPase and Mg2+-ATPase activities in rat brain synaptosomes

scientific article published in April 1986

Effect of an antimitotic agent colchicine on thioacetamide hepatotoxicity

scientific article published on July 1996

Effect of chlordecone on carbon tetrachloride-induced increase in calcium uptake in isolated perfused rat liver

scientific article published in April 1986

Effect of cytochrome P-450 and flavin-containing monooxygenase modifying factors on the in vitro metabolism of amiodarone by rat and rabbit

scientific article published on July 1987

Effect of endrin and endrin derivatives on hepatobiliary function and carbon tetrachloride-induced hepatotoxicity in male and female rats

scientific article published in August 1986

Effect of mirex on the activities of various rat hepatic mixed-function oxidases

scientific article published in October 1973

Effect of phenobarbital and mirex pretreatments on CCl4 autoprotection

scientific article published on May 1994

Effect of preexposure to kepone on hepatic mixed-function oxidases in the female rat.

scientific article

Effect of preexposure to kepone on the biliary excretion of imipramine and sulfobromophthalein

scientific article

Effect of two isomeric tetrachlorobiphenyls on rats and their hepatic enzymes.

scientific article

Effects of drug-induced pulmonary phospholipidosis on lung mechanics in rats

scientific article published in May 1989

Effects of hexachlorobutadiene (HCBD) on renal function and renal organic ion transport in the rat

scientific article published on September 1, 1979

Effects of kepone and mirex on mitochondrial Mg2+-ATPase activity in rat liver

scientific article

Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice

scientific article published on October 1, 1982

Efficient tissue repair underlies the resiliency of postnatally developing rats to chlordecone + CCl4 hepatotoxicity

scientific article published on July 1996

Evidence for stimulated glutathione synthesis by phenobarbital pretreatment during an oxidative challenge in isolated hepatocytes

scientific article published on January 1991

Excessive hepatic accumulation of intracellular Ca2+ in chlordecone potentiated CCl4 toxicity

scientific article published on February 14, 1984

Extent and timeliness of tissue repair determines the dose-related hepatotoxicity of chloroform

scientific article published on January 2003

Fate of mirex-14C in the rat and plants

scientific article published on October 1, 1972

Fluorescence studies on binding of amphiphilic drugs to isolated lamellar bodies: relevance to phospholipidosis

scientific article published on August 1989

Functional and biochemical correlates of chlordecone exposure and its enhancement of CCl4 hepatotoxicity

scientific article published on January 1, 1980

G2 Subpopulation in Rat Liver Induced into Mitosis by Low-Level Exposure to Carbon Tetrachloride: An Adaptive Response

scientific article published on July 1, 1993

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling

scientific article

Halomethane-chlordecone (CD) interactive hepatotoxicity--current concepts on the mechanism

scientific article published on August 1993

Hepatic Overexpression of Annexin A1 and A2 in Thioacetamide-Primed Mice Protects Them Against Acetaminophen-Induced Liver Failure and Death

scientific article published on 22 July 2016

Hepatic cell division and tissue repair: a key to survival after liver injury

scientific article published on February 1996

Hepatic failure leads to lethality of chlordecone-amplified hepatotoxicity of carbon tetrachloride

scientific article published in November 1993

Hepatic microsomal metabolism of CCL4 after pretreatment with chlordecone, mirex, or phenobarbital in male rats

scientific article published on July 1, 1983

Hepatic polyamines and related enzymes following chlordecone-potentiated carbon tetrachloride toxicity in rats

scientific article published in January 1989

Hepatobiliary dysfunction and inhibition of adenosine triphosphatase activity of bile canaliculi-enriched fractions following in vivo mirex, photomirex, and chlordecone exposures*1

scientific article published on December 1, 1981

Hepatoprotective agent (+)-cyanidanol increases the synthetic phase of hepatocellular regeneration

scientific article published on January 1, 1991

Hepatotoxicity and lethality of halomethanes in Mongolian gerbils pretreated with chlordecone, phenobarbital or mirex

scientific article published on January 1, 1991

High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity

scientific article

In vivo and in vitro synthesis, release, and uptake of [3-H]-dopamine in mouse striatal slices after in vivo exposure to chlordecone

scientific article published in December 1986

In vivo metabolism of CCl4 by rats pretreated with chlordecone, mirex, or phenobarbital

scientific article published in April 1988

Induction of hepatic mixed function oxidases by photomirex

scientific article published on November 1, 1979

Inhibition of cell division in hepatoma cell cultures by chlordecone and carbon tetrachloride combination

scientific article published on January 1, 1990

Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury

scientific article published on 4 January 2008

Inhibition of mitochondrial Mg2+ ATPase activity in isolated perfused rat liver by kepone

scientific article published on June 15, 1977

Injury and repair as opposing forces in risk assessment

scientific article published on December 1995

Kepone induction of hepatic mixed function oxidases in the male rat

scientific article published on March 15, 1977

Lack of effects of chlordecone on synthesis rates, steady state levels and metabolites of catecholamines in rat brain.

scientific article published in January 1984

Lethal effects of CCl4 and its metabolism by mongolian gerbils pretreated with chlordecone, phenobarbital, or mirex

scientific article published on July 1, 1990

Liver Regeneration and Tissue Repair

Liver regeneration: a critical toxicodynamic response in predictive toxicology

scientific article

Loss of Calcium Homeostasis Leads to Progressive Phase of Chlordecone-Potentiated Carbon Tetrachloride Hepatotoxicity

scientific article published on September 1, 1993

Mechanism of protection of moderately diet restricted rats against doxorubicin-induced acute cardiotoxicity

scientific article published on 21 August 2007

Mechanism of the lethal interaction of chlordecone and CCl4 at non-toxic doses

scientific article published on December 1989

Mechanisms and outcomes of drug- and toxicant-induced liver toxicity in diabetes

scientific article published on June 2007

Mechanisms of increased liver tissue repair and survival in diet-restricted rats treated with equitoxic doses of thioacetamide

scientific article published on 7 March 2003

Mechanisms of inhibited liver tissue repair in toxicant challenged type 2 diabetic rats

scientific article published on 14 January 2007

Metabolism of aldicarb pesticide in laying hens

scientific article published on January 1, 1972

Microarray analysis of thioacetamide-treated type 1 diabetic rats

scientific article published on 17 November 2005

Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors

scientific article

Mirex-induced impairment of hepatobiliary function. Suppressed biliary excretion of imipramine and sulfobromophthalein

scientific article published on January 1, 1977

Mirex-induced suppression of biliary excretion of polychlorinated biphenyl compounds

scientific article published on May 1, 1976

Modification of hepatobiliary function by toxic chemicals

scientific article published on July 1, 1979

Molecular mechanisms of enhanced renal cell division in protection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death

scientific article published in March 2005

Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway

scientific article published in November 2003

NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea

scientific article

Neurotoxicity in rats following subchronic amiodarone treatment.

scientific article published on May 1986

Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate

scientific article published on 20 March 2008

Novel mechanisms in chemically induced hepatotoxicity.

scientific article published on December 1994

Once initiated, how does toxic tissue injury expand?

scientific article published on March 21, 2012

Onset and recovery from chlordecone- and mirex-induced hepatobiliary dysfunction

scientific article published on March 30, 1981

PB-PK derived metabolic constants, hepatotoxicity, and lethality of BrCCl3 in rats pretreated with chlordecone, phenobarbital, or mirex

scientific article published in July 1991

PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate

scientific article

Perturbation of calcium homeostasis by CCl4 in rats pretreated with chlordecone and phenobarbital

scientific article published on August 1, 1984

Perturbations in polyamines and related enzymes following chlordecone-potentiated bromotrichloromethane hepatotoxicity

scientific article published on January 1, 1990

Pesticide-induced modification of hepatobiliary function: Hexachlorobenzene, DDT and toxaphene

scientific article published on February 1, 1978

Phenobarbital-induced cytoprotective mechanisms in menadione metabolism: The role of glutathione reductase and DT-diaphorase

scientific article published on January 1, 1990

Phenobarbital-induced cytosolic cytoprotective mechanisms that offset increases in NADPH cytochrome P450 reductase activity in menadione-mediated cytotoxicity

scientific article published on June 1989

Phosphatidyl Carnitine: a Possible Intermediate in the Biosynthesis of Phosphatidyl β-Methylcholine in Phormia regina (Meigen)

scientific article published in August 1966

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone

scientific article published in January 1996

Pivotal Role of Hepatocellular Regeneration in the Ultimate Hepatotoxicity of CCl 4 in Chlordecone-, Mirex-, or Phenobarbital-Pretreated Rats

scientific article published on January 1, 1992

Possible molecular mechanism of mirex-induced hepatobiliary dysfunction

scientific article published on January 1, 1979

Possible nephrotoxic effect of carbon tetrabromide and its interaction with chlordecone

scientific article published on June 1, 1983

Potentiation of BrCCl3 hepatotoxicity by chlordecone: Biochemical and ultrastructural study

scientific article published on September 1, 1991

Potentiation of CCl4 hepatotoxicity and lethality by chlordecone in female rats

scientific article published on March 1, 1983

Potentiation of CCl4 lethality by chlordecone

scientific article published in April 1982

Potentiation of brominated halomethane hepatotoxicity by chlordecone in the male rat*1, *2

scientific article published on December 1, 1981

Potentiation of bromotrichloromethane hepatotoxicity and lethality by chlordecone preexposure in the rat.

scientific article published in July 1982

Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats

scientific article published on 10 November 2003

Potentiation of halomethane hepatotoxicity by chlordecone: A hypothesis for the mechanism

scientific article published on December 1, 1990

Potentiation of halomethane hepatotoxicity: Chlordecone and carbon tetrachloride*1

scientific article published on June 1, 1984

Potentiation of the hepatotoxicity of carbon tetrachloride following preexposure to chlordecone (Kepone) in the male rat

scientific article published on November 1, 1979

Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.

scientific article

Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice

scientific article published on 21 February 2006

Priming dose of phenylhydrazine protects against hemolytic and lethal effects of 2-butoxyethanol

scientific article published on 30 June 2007

Pristane-induced effects on cytochrome P-4501A, ornithine decarboxylase and putrescine in rats

scientific article published on August 16, 1995

Protection from CCI4 toxicity by prestimulation of hepatocellular regeneration in partially hepatectomized gerbils

scientific article published on July 15, 1991

Protection from chlordecone (Kepone)-potentiated CCl4 hepatotoxicity in rats by fructose 1,6-diphosphate

scientific article published in January 1989

Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: Biochemical and histological studies

scientific article published on March 15, 1991

Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: Regeneration studies

scientific article published on March 15, 1991

Protection of chlordecone-potentiated carbon tetrachloride hepatotoxicity and lethality by partial hepatectomy

scientific article

Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss-Webster mice

scientific article

Protective role of fructose 1,6-bisphosphate during CCl4 hepatotoxicity in rats

scientific article published on September 1989

Pulmonary sequestration of amiodarone and desethylamiodarone.

scientific article published on June 1986

Pulmonary synthesis of 5-hydroxytryptamine in isolated perfused rabbit and rat lung preparations

scientific article published in January 1986

Relationship of hepatotoxicity and lethality with metabolic constants of BrCCl3 in rats pretreated with chlordecone, phenobarbital and mirex

Renal and hepatic transporter expression in type 2 diabetic rats

scientific article

Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice

scientific article published in April 2003

Resiliency to Amplification of Carbon Tetrachloride Hepatotoxicity by Chlordecone during Postnatal Development in Rats

scientific article published on March 1, 1993

Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury. A two-stage model of toxicity

scientific article published on August 1991

Role of hepatocellular regeneration in CCl4 autoprotection

scientific article published in January 1991

Role of hepatocellular regeneration in chlordecone potentiated hepatotoxicity of carbon tetrachloride

scientific article

Role of tissue repair in survival from s-(1,2-dichlorovinyl)-L-cysteine-induced acute renal tubular necrosis in the mouse

scientific article published on 2 May 2003

Role of tissue repair in toxicologic interactions among hepatotoxic organics

scientific article

Saturation toxicokinetics of thioacetamide: role in initiation of liver injury

scientific article published on 23 September 2005

Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2.

scientific article published on 3 January 2008

Secretory phospholipase A2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2

scientific article published on January 26, 2011

Stimulated pulmonary cell hyperplasia underlies resistance to alpha-naphthylthiourea

scientific article

Strain differences in tissue repair response to 1,2-dichlorobenzene

scientific article published in January 1996

Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity

scientific article published in April 2003

Studies on the age-dependent effects of galactosamine in primary rat hepatocyte cultures.

scientific article

Suppression of cellular immune responses in BALB/c mice following oral exposure to permethrin

scientific article published in May 1995

The effect of dietary exposure to a mirex plus chlordecone combination on CCl4 hepatotoxicity

scientific article published in August 1985

The effects of Kepone pretreatment on biliary excretion of xenobiotics in the male rat

scientific article published on February 1, 1979

The isolated perfused lung — A critical evaluation

scientific article published on January 1, 1981

The rat red blood cell proteome is altered by priming with 2-butoxyethanol

scientific article published on 15 March 2008

The role of NF-kappaB signaling in impaired liver tissue repair in thioacetamide-treated type 1 diabetic rats

scientific article published on 24 October 2005

The time course of liver injury and [3H]thymidine incorporation in chlordecone-potentiated CHCl3 hepatotoxicity

scientific article published in August 1989

Tissue Repair Response as a Function of Dose during Trichloroethylene Hepatotoxicity

scientific article published on April 1, 1998

Tissue repair plays pivotal role in final outcome of liver injury following chloroform and allyl alcohol binary mixture

scientific article published on August 2003

Tissue repair response as a function of dose in thioacetamide hepatotoxicity

scientific article published on March 1995

Tissue repair: an important determinant of final outcome of toxicant-induced injury

scientific article

Tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity

scientific article

Topical exposure to chlordane reduces the contact hypersensitivity response to oxazolone in BALB/c mice

scientific article published in November 1995

Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology

scientific article published in April 1999

Toxicodynamics of low level toxicant interactions of biological significance: inhibition of tissue repair

scientific article published on December 1995

Type 1 diabetic mice are protected from acetaminophen hepatotoxicity

scientific article published on 15 April 2003

Type 2 diabetic rats are sensitive to thioacetamide hepatotoxicity

scientific article

Types of interaction of amphiphilic drugs with phospholipid vesicles

scientific article published on July 1988

Ultrastructural and biochemical correlates of the specificity of chlordecone‐potentiated carbon tetrachloride hepatotoxicity

scientific article published on March 1, 1981

Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon toxic challenge

scientific article published in October 2002

Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity

scientific journal article

Uptake and accumulation of chlorpromazine in the isolated perfused rabbit lung

scientific article published on November 1, 1979

Uptake and disposition of aldrin and dieldrin by isolated perfused rabbit lung

scientific article published on November 1, 1975

Uptake and disposition of chlorinated biphenyls by isolated perfused rat liver

scientific article published on March 1, 1976

Wnt/β-Catenin Signaling Drives Thioacetamide-Mediated Heteroprotection Against Acetaminophen-Induced Lethal Liver Injury

scientific article published on 30 January 2017