Search filters

List of works by Geir Christensen

A mouse model of reverse cardiac remodelling following banding‐debanding of the ascending aorta ⬇️

scientific article published on October 28, 2011

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice

scientific article published on 12 June 2015

Alterations in circulating activin A, GDF-15, TGF-beta3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis

scientific article

Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice

scientific article published on 31 March 2006

Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes ⬇️

scientific article published on April 7, 2011

Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5.

scientific article published on 26 August 2014

Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice

scientific article published on 19 March 2013

Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content

scientific article published on 17 January 2011

Calcium dynamics in the ventricular myocytes of SERCA2 knockout mice: A modeling study

scientific article

Calcium release units in heart failure: that's about the size of it ⬇️

scientific article published on July 24, 2012

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis ⬇️

scientific article published on October 20, 2010

Chromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardium

scientific article published on 2 June 2010

Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study

scientific article

Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload

scientific article published on 5 June 2010

Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice

scientific article published on 27 August 2010

Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure

scientific article published on 28 May 2008

Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice

scientific article published on 8 April 2005

Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse

scientific article published on 14 February 2013

Diagnostic accuracy for heart failure – data from the Akershus Cardiac Examination 2 Study

scientific article

Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study

scientific article published on 17 July 2018

Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A.

scientific article published on 3 July 2008

Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure

scientific article published on 09 May 2005

Effect of short- and long-term physical activities on circulating granin protein levels

scientific article

Electrical stimulation of adult rat cardiomyocytes in culture improves contractile properties and is associated with altered calcium handling ⬇️

scientific article published on October 1, 1997

Elevated levels of activin A in clinical and experimental pulmonary hypertension

scientific article published on 5 February 2009

Elevated levels of activin A in heart failure: potential role in myocardial remodeling

scientific article published in March 2004

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

scientific article

Endothelin-1 in the human myocardium and circulating plasma: evaluation before, during and after correction of aortic stenosis with aortic valve replacement

scientific article

Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice

scientific article published on 23 September 2010

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout ⬇️

scientific article published on February 21, 2012

Fibroblast growth factor 23 in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study

scientific article

Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis

scientific article published on February 2017

Glycosylated Chromogranin A: Potential Role in the Pathogenesis of Heart Failure

scientific article published on 3 October 2017

High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2.

scientific article published on 18 February 2010

Identifying pathogenic processes by integrating microarray data with prior knowledge

scientific article

Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2.

scientific article published on 31 January 2014

In memory of Guro Valen (1960-2014).

scientific article published on 7 December 2014

Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage

scientific article

Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling

scientific article published on 22 September 2009

Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling

scientific article published on 13 February 2004

Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure

scientific journal article

Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus Cardiac Examination 2 Study

scientific article

Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload

scientific article

Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice

scientific article published on 17 February 2015

Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes

scientific article published in December 2004

Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene

scientific article

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.

scientific article published on 2 April 2013

Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models

scientific article

Mid-regional pro-adrenomedullin in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study

scientific article

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene

scientific article

Multiple cytokine biomarkers in heart failure

scientific article published on March 2010

Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure

scientific article

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

scientific article published on January 2017

No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium

scientific article published on October 2012

Overexpression of integrin α11 induces cardiac fibrosis in mice

scientific article published on 3 August 2017

Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding

scientific article

Prognostic Value of Secretoneurin in Critically Ill Patients With Infections

scientific article published on 13 July 2016

Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study.

scientific article

Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study

scientific article

Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis

scientific article

Psychological distress and mortality in patients with acute dyspnea: data from the Akershus Cardiac Examination (ACE) 2 Study

scientific article

Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

scientific article published on 17 December 2009

Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity

scientific article published in February 2002

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression

article

SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium

scientific article published on September 2013

Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties

scientific article (publication date: 2012)

Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling.

scientific article published in February 2015

Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure

scientific article published on 23 December 2009

Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.

scientific article published on 5 October 2015

Sodium Accumulation in SERCA Knockout-Induced Heart Failure ⬇️

scientific article published on May 2, 2012

Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout

scientific article published on 14 December 2009

Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice

scientific article published on 13 October 2015

Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease

scientific article published on 11 January 2018

Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity

scientific article published on April 2013

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart

scientific article published on 12 January 2015

Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway

scientific article

Syndecans in heart fibrosis

scientific article published on 14 July 2016

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling

scientific article

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury

scientific article published on 10 April 2013

The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy

scientific article published on 4 May 2017

The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure

The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling

article published in 2018

The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure

scientific article

The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling

scientific article

The influence of heart failure co-morbidity on high-sensitivity troponin T levels in COPD exacerbation in a prospective cohort study: data from the Akershus cardiac examination (ACE) 2 study

scientific article published on 12 January 2016

The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.

scientific article published in August 2011

Thyroid hormone control of contraction and the Ca(2+)-ATPase/phospholamban complex in adult rat ventricular myocytes

scientific article

Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice

scientific article

Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy

scientific article

Wnt5a is elevated in heart failure and affects cardiac fibroblast function

scientific article published on 30 March 2017

Paulina is supported by:

About Paulina

Help