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List of works by Arne Klungland

5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism

scientific article

8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells

scholarly article

A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage

scientific journal article

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

scientific article published on 18 August 2016

A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation

scientific article

A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.

scientific article published on 7 February 2011

A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome

scientific article

A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies

scientific article published on 24 October 2018

ALKBH1 is a histone H2A dioxygenase involved in neural differentiation

scientific article published on December 2012

ALKBH1-Mediated tRNA Demethylation Regulates Translation

scientific journal article

ALKBH1-Mediated tRNA Demethylation Regulates Translation

scientific article published on 01 December 2016

ALKBH4 depletion in mice leads to spermatogenic defects

scientific article

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.

scientific article

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

scientific article

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells

scientific article published on 26 December 2017

ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage

scientific article

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

scientific article

ALKBHs-facilitated RNA modifications and de-modifications

scientific article published on 17 May 2016

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

scientific article

AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.

scientific article

Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes

scientific article published on 10 September 2012

Base excision repair of oxidative DNA damage activated by XPG protein

scientific article published on 01 January 1999

Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA.

scientific article

Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015.

scientific article published on 16 December 2015

Better late than never for repair of miscoding lesions within a transcribed template

scientific article published on October 2003

Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism

scientific article published on 2 March 2016

Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria

scientific article

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

scientific article published on 14 September 2016

Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells

scientific article published on 31 May 2016

Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells

scientific article published in June 2003

Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice

scientific article

Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes

scientific article published on February 2017

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

scientific article

DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates

scientific article published on 22 February 2016

DNA metabolism: bases of DNA repair and regulation

scientific article

DNA repair in mammalian cells: Base excision repair: the long and short of it.

scientific article published on March 2009

DNA repair is indispensable for survival after acute inflammation

scientific article

Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse

scientific article published in October 2006

Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice

scientific journal article

Deletion of mouse Alkbh7 leads to obesity

scientific article

Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine

scientific article published in November 2004

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

scientific article published on 06 September 2018

Dynamic RNA modifications in disease

scientific article published on June 2014

Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.

scientific article

Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice

scientific article

Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015.

scientific article published on 12 December 2015

Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination

scientific article

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10).

scientific article

Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins

scientific article published in June 2018

Excision of uracil from DNA by hSMUG1 includes strand incision and processing

scientific article published on 01 January 2019

Excision of uracil from DNA by the hyperthermophilic Afung protein is dependent on the opposite base and stimulated by heat-induced transition to a more open structure.

scientific article published on December 2001

Expression of the E.coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents ⬇️

scientific article published on December 1, 1992

Gene expression profiles in preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia

scientific article published on 08 February 2017

Genome instability and DNA damage accumulation in gene-targeted mice.

scientific article published on 9 January 2007

Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation

scientific article

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

scientific article

Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos

scientific article

Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone

scientific article published on 25 October 2019

Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure

scientific article

Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V

scientific journal article

Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients.

scientific article published on 29 June 2018

Increased removal of 3-alkyladenine reduces the frequencies of hprt mutations induced by methyl- and ethylmethanesulfonate in Chinese hamster fibroblast cells.

scientific article published on May 1994

KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes

scientific article published on 30 March 2020

Kinetics of endogenous mouse FEN1 in base excision repair.

scientific article

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice

scientific article

Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding

scientific article

Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA.

scientific article published on 8 September 2017

Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus

scientific article published on October 2002

Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects

scientific article

Micro chromatin immunoprecipitation (μChIP) from early mammalian embryos

scientific article published in January 2015

Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses

scientific article published on 07 May 2011

Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior

scientific article

Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond

scientific article published on 25 February 2011

Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

scientific journal article

Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol

scientific article published on 16 May 2007

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

scientific article published on 16 December 2019

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

scientific article published on January 2017

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice

scientific article published on 21 August 2012

No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice

scientific article

Nobel Prize for genetic modification

scientific article published in November 2007

Non-homologous functions of the AlkB homologs

scientific article published on 23 May 2015

Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy

scientific article

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

scientific article published on 22 April 2007

Organ and cell specificity of base excision repair mutants in mice

scientific article published on January 2007

Oxidative damage to purines in DNA: role of mammalian Ogg1.

scientific article published on 28 November 2006

Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells

scientific article published on 27 August 2013

Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine

scientific article published on 24 November 2016

Positioning Europe for the EPITRANSCRIPTOMICS challenge.

scientific article published on 19 April 2018

Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage

scientific journal article

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities

scientific article

Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads.

scientific article

Purification and properties of the alkylation repair DNA glycosylase encoded the MAG gene from Saccharomyces cerevisiae.

scientific article published in April 1995

RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum.

scientific article published on 31 May 2018

Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein

scientific article

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

scientific article published on 14 October 2016

Repair and Processing Events at DNA Ends ⬇️

scientific article published on January 1, 1997

Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice.

scientific article published in April 2006

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

scientific article

Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice

scientific article

Reversible RNA modifications in meiosis and pluripotency

scientific article

Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide

scientific article

Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells

scientific article published on 15 January 2016

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes.

scientific article published on 12 August 2017

STIM1 R304W causes muscle degeneration and impaired platelet activation in mice

scientific article published on 05 October 2018

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

scientific article

Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations.

scientific article published on 25 January 2016

Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol

scientific article published on 9 November 2010

Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.

scientific article published on 17 April 2013

Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA

scientific article

Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice

scientific article

Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes

scientific article published on 23 March 2015

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

scientific article published on 16 December 2015

TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.

scientific article published on 17 January 2017

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage

scientific article

The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement

scientific article published on 7 May 2010

The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.

scientific article

Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo

scientific article

Transcription activities at 8-oxoG lesions in DNA.

scientific article published in November 2004

Tzfp represses the androgen receptor in mouse testis

scientific article

Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair

scientific article

Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species.

scientific article

Waves of sumoylation support transcription dynamics during adipocyte differentiation

scientific article published on 01 February 2022

X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction.

scientific article published on 29 September 2011

Ythdf2-mediated m6A mRNA clearance modulates neural development in mice.

scientific article published on 31 May 2018

[Life without DNA repair]

scientific article published on 01 January 2001

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