List of works by Brian R. Murphy

A 36 nucleotide deletion mutation in the coding region of the NS1 gene of an influenza A virus RNA segment 8 specifies a temperature-dependent host range phenotype

scientific article published in January 1990

A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice

scientific article published on April 2004

A Live Human Parainfluenza Type 3 Virus Vaccine Is Attenuated and Immunogenic in Healthy Infants and Children ⬇️

scientific article published on December 1, 1995

A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3' Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys

scientific article (publication date: 2003)

A chimeric human-bovine parainfluenza virus type 3 expressing measles virus hemagglutinin is attenuated for replication but is still immunogenic in rhesus monkeys

scientific article

A cold-adapted mutant of parainfluenza virus type 3 is attenuated and protective in chimpanzees

scientific article published in April 1993

A cold-passaged, attenuated strain of human respiratory syncytial virus contains mutations in the F and L genes

scientific article

A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV.

scientific article published in November 1993

A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees

scientific article published on July 1994

A hexavalent human rotavirus-bovine rotavirus (UK) reassortant vaccine designed for use in developing countries and delivered in a schedule with the potential to eliminate the risk of intussusception

scientific article

A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults.

scientific article

A live attenuated H9N2 influenza vaccine is well tolerated and immunogenic in healthy adults.

scientific article

A live attenuated chimeric recombinant parainfluenza virus (PIV) encoding the internal proteins of PIV type 3 and the surface glycoproteins of PIV type 1 induces complete resistance to PIV1 challenge and partial resistance to PIV3 challenge

scientific article published on March 1999

A live attenuated recombinant chimeric parainfluenza virus (PIV) candidate vaccine containing the hemagglutinin-neuraminidase and fusion glycoproteins of PIV1 and the remaining proteins from PIV3 induces resistance to PIV1 even in animals immune to

scientific article published on 01 January 2000

A live attenuated recombinant dengue-4 virus vaccine candidate with restricted capacity for dissemination in mosquitoes and lack of transmission from vaccinees to mosquitoes.

scientific article published on November 2001

A live human parainfluenza type 3 virus vaccine is attenuated and immunogenic in young infants

scientific article published in May 2003

A novel human parainfluenza virus type 1 (HPIV1) with separated P and C genes is useful for generating C gene mutants for evaluation as live-attenuated virus vaccine candidates

scientific article published on 24 October 2009

A paramyxovirus-vectored intranasal vaccine against Ebola virus is immunogenic in vector-immune animals

scientific article published on August 2008

A recombinant chimeric La Crosse virus expressing the surface glycoproteins of Jamestown Canyon virus is immunogenic and protective against challenge with either parental virus in mice or monkeys.

scientific article

A recombinant human parainfluenza virus type 3 (PIV3) in which the nucleocapsid N protein has been replaced by that of bovine PIV3 is attenuated in primates

scientific article

A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.

scientific article published on April 1993

A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trial

scientific article published on 17 January 2013

A single dose of the DENV-1 candidate vaccine rDEN1Δ30 is strongly immunogenic and induces resistance to a second dose in a randomized trial

scientific article

A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal-dose Ebola virus challenge

scientific article

A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major determinant of the temperature-sensitive and attenuation phenotypes

scientific article published on August 1998

A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice

scientific article

A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4.

scientific article published on July 2003

Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene

scientific article published in January 1996

Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity.

scientific article

Advantage of live attenuated cold-adapted influenza A virus over inactivated vaccine for A/Washington/80 (H3N2) wild-type virus infection ⬇️

scientific article published on March 31, 1984

African green monkeys provide a useful nonhuman primate model for the study of human parainfluenza virus types-1, -2, and -3 infection

scientific article published in May 2000

Altered tissue tropism of human-avian reassortant influenza viruses

scientific article

An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

scientific article published on 11 July 2004

An evaluation of influenza A/Victoria/3/75-ts-1 [E] recombinant viruses for attenuation and immunogenicity in adult seronegative volunteers

scientific article published on 01 June 1977

An improved method for the recovery of recombinant paramyxovirus vaccine candidates suitable for use in human clinical trials

scientific article published on 8 January 2007

An influenza A live attenuated reassortant virus possessing three temperature-sensitive mutations in the PB2 polymerase gene rapidly loses temperature sensitivity following replication in hamsters

scientific article published in August 1997

An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines

scientific article published on April 1994

Analysis of immunoglobulin G antibody responses after administration of live and inactivated influenza A vaccine indicates that nasal wash immunoglobulin G is a transudate from serum

scientific article published on March 1987

Analysis of virus and host factors in a study of A/Peking/2/79 (H3N2) cold-adapted vaccine recombinant in which vaccine-associated illness occurred in normal volunteers

scientific article

Antibody responses of humans and nonhuman primates to individual antigenic sites of the hemagglutinin-neuraminidase and fusion glycoproteins after primary infection or reinfection with parainfluenza type 3 virus ⬇️

scientific article published on August 1, 1990

Antigenic and structural properties of the hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3: sequence analysis of variants selected with monoclonal antibodies which inhibit infectivity, hemagglutination, and neuraminidase

scientific article published on May 1987

Antigenic characterization of influenza A virus matrix protein with monoclonal antibodies

scientific article published on January 1984

Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunity

scientific article published on October 1987

Antigenic variation in the hemagglutinin-neuraminidase protein of human parainfluenza type 3 virus

scientific article

Are there alternative avian influenza viruses for generation of stable attenuated avian-human influenza A reassortant viruses?

scientific article published on December 1995

Arguments for live flavivirus vaccines

scientific article published in August 2004

Association of serum anti-neuraminidase antibody with resistance to influenza in man.

scientific article published in June 1972

Assurance of neuroattenuation of a live vaccine against West Nile virus: a comprehensive study of neuropathogenesis after infection with chimeric WN/DEN4Δ30 vaccine in comparison to two parental viruses and a surrogate flavivirus reference vaccine.

scientific article

Attenuated influenza virus in normal adults: role of pulmonary function studies in vaccine trials

scientific article published on February 1, 1976

Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1.

scientific article published on 5 June 2006

Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes

scientific article published on 2 July 2007

Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.

scientific article published on November 2001

Attenuation and immunogenicity in primates of vaccinia virus recombinants expressing human interleukin-2.

scientific article published in February 1990

Attenuation and phenotypic stability of influenza B/Texas/1/84 cold-adapted reassortant virus: studies in hamsters and chimpanzees

scientific article

Attenuation of bovine parainfluenza virus type 3 in nonhuman primates and its ability to confer immunity to human parainfluenza virus type 3 challenge

scientific article published in April 1988

Attenuation of the recombinant human parainfluenza virus type 3 cp45 candidate vaccine virus is augmented by importation of the respiratory syncytial virus cpts530 L polymerase mutation

scientific article published in July 1999

Attenuation of wild-type human influenza A virus by acquisition of the PA polymerase and matrix protein genes of influenza A/Ann Arbor/6/60 cold-adapted donor virus

scientific article

Avian-human reassortant influenza A viruses derived by mating avian and human influenza A viruses

scientific article published in December 1984

Beta 2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase.

scientific article published in June 1993

Biological, genetic and biochemical characterization of a cold-adapted recombinant A/Victoria/3/75 virus and its evaluation in volunteers

scientific article published on June 1, 1977

Bovine parainfluenza virus type 3 (BPIV3) fusion and hemagglutinin-neuraminidase glycoproteins make an important contribution to the restricted replication of BPIV3 in primates

scientific article

Bronchial reactivity in experimental infections with influenza virus

scientific article

Cell-Mediated Immune Responses in Humans after Induced Infection with Influenza A Virus ⬇️

scientific article published on May 1, 1977

Cellular Inflammatory Response to Flaviviruses in the Central Nervous System of a Primate Host

scientific article

Characterization of a gene coding for M proteins which is involved in host range restriction of an avian influenza A virus in monkeys

scientific article published on February 1986

Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys

scientific article

Characterization of the attenuating M and NP gene segments of the avian influenza A/Mallard/78 virus during in vitro production of avian-human reassortant vaccine viruses and after replication in humans and primates

scientific article published in July 1991

Characterization of the genotype and level of attenuation of an influenza A reassortant virus produced by mating the Xia-ts donor virus with A/Beijing/70 (H1N1) wild type virus

scientific article published in September 1984

Characterization of the temperature sensitive phenotype of the A/Ann Arbor/6/60 cold-adapted virus and its recombinants

scientific article published in May 1981

Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in vero cells or human liver cells and attenuated in mice

scientific article

Chimeric West Nile/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity.

scientific article

Chimeric bovine respiratory syncytial virus with glycoprotein gene substitutions from human respiratory syncytial virus (HRSV): effects on host range and evaluation as a live-attenuated HRSV vaccine

scientific article

Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge

scientific article

Chimeric recombinant human metapneumoviruses with the nucleoprotein or phosphoprotein open reading frame replaced by that of avian metapneumovirus exhibit improved growth in vitro and attenuation in vivo

scientific article

Codon stabilization analysis of the "248" temperature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates

scientific article published on 29 July 2009

Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro

scientific article published on February 2004

Cold adapted variants of influenza A. II. Comparison of the genetic and biological properties of ts mutants and recombinants of the cold adapted A/AA/6/60 strain

scientific article published on 01 January 1977

Cold-Adapted Variants of Influenza A Virus: Evaluation in Adult Seronegative Volunteers of A/Scotland/840/74 and A/Victoria/3/75 Cold-Adapted Recombinants Derived from the Cold-Adapted A/Ann Arbor/6/60 Strain ⬇️

scientific article published on February 1, 1979

Cold-adapted variants of influenza virus A. I. Comparison of the genetic properties of ts mutants and five cold-adapted variants of influenza virus A

scientific article published on March 1, 1977

Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys ⬇️

scientific article published on March 1, 1992

Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immunogenic, and protective in seronegative chimpanzees, even when RSV antibodies are infused shortly before immunization

scientific article published on June 1995

Comparative Neuropathogenesis and Neurovirulence of Attenuated Flaviviruses in Nonhuman Primates

scientific article (publication date: June 2008)

Comparative studies of wild-type and 'cold-mutant' (temperature sensitive) influenza viruses: geneology of the matrix (M) and non-structural (NS) proteins in recombinant cold-adapted H3N2 viruses

scientific article published on 01 October 1977

Comparison by studies in squirrel monkeys, chimpanzees, and adult humans of avian-human influenza A virus reassortants derived from different avian influenza virus donors.

scientific article published on September 1986

Comparison of different approaches to measuring influenza A virus-specific hemagglutination inhibition antibodies in the presence of serum inhibitors ⬇️

scientific article published on April 1, 1992

Comparison of live and inactivated tick-borne encephalitis virus vaccines for safety, immunogenicity and efficacy in rhesus monkeys

scientific article

Comparison of live attenuated cold-adapted and avian-human influenza A/Bethesda/85 (H3N2) reassortant virus vaccines in infants and children

scientific article published in August 1990

Comparison of live, attenuated H1N1 and H3N2 cold-adapted and avian-human influenza A reassortant viruses and inactivated virus vaccine in adults

scientific article

Comparison of the immunogenicity and efficacy of a replication-defective vaccinia virus expressing antigens of human parainfluenza virus type 3 (HPIV3) with those of a live attenuated HPIV3 vaccine candidate in rhesus monkeys passively immunized wit

scientific article published in June 1999

Comparison of the relative roles of the F and HN surface glycoproteins of the paramyxovirus simian virus 5 in inducing protective immunity

scientific article published on June 1987

Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors

scientific article published on January 1989

Conserved epitopes on the hemagglutinin-neuraminidase proteins of human and bovine parainfluenza type 3 viruses: nucleotide sequence analysis of variants selected with monoclonal antibodies

scientific article published on October 1986

Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters

scientific article published on December 1983

Construction of a live-attenuated bivalent vaccine virus against human parainfluenza virus (PIV) types 1 and 2 using a recombinant PIV3 backbone

scientific article

Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity

scholarly article

Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia--RSV recombinants or RSV.

scientific article published in January 1992

Current approaches to the development of vaccines effective against parainfluenza and respiratory syncytial viruses

scientific article

Current research on respiratory viral infections: Third International Symposium

scientific article

Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus

scientific article published in February 1995

Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity

scientific article

Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans

scientific article published on 23 January 2009

Demonstration of a non-temperature-sensitive growth-restricting mutation in a ts mutant of influenza A virus: implications for live virus vaccine development

scientific article published on December 1, 1977

Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4

scientific article (publication date: 6 February 2008)

Detection of respiratory syncytial virus (RSV) infected cells by in situ hybridization in the lungs of cotton rats immunized with formalin-inactivated virus or purified RSV F and G glycoprotein subunit vaccine and challenged with RSV.

scientific article published in June 1990

Determinants of the host range restriction of replication of bovine parainfluenza virus type 3 in rhesus monkeys are polygenic

scientific article

Determination of antibody response to influenza virus surface glycoproteins by kinetic enzyme-linked immunosorbent assay.

scientific article published on October 1988

Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine.

scientific article published on January 1986

Development of a live attenuated dengue virus vaccine using reverse genetics

scientific article

Development of a replication-deficient recombinant vaccinia virus vaccine effective against parainfluenza virus 3 infection in an animal model

scientific article published in October 1996

Development of effective vaccines against pandemic influenza.

scientific article

Development of subtype-specific and heterosubtypic antibodies to the influenza A virus hemagglutinin after primary infection in children

scientific article published on May 1985

Differential immunoglobulin G subclass antibody titers to respiratory syncytial virus F and G glycoproteins in adults

scientific article published on April 1987

Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine

scientific article published on August 1986

Dose response of A/Alaska/6/77 (H3N2) cold-adapted reassortant vaccine virus in adult volunteers: role of local antibody in resistance to infection with vaccine virus

scientific article

Dose response of cold-adapted, reassortant influenza A/California/10/78 virus (H1N1) in adult volunteers

scientific article

Dose response of influenza A/Washington/897/80 (H3N2) avian-human reassortant virus in adult volunteers

scientific article published in July 1985

Dose response of influenza A/Washington/897/80 (H3N2) cold-adapted reassortant virus in adult volunteers

scientific article

Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection

scientific article

Effect of coexpression of interleukin-2 by recombinant respiratory syncytial virus on virus replication, immunogenicity, and production of other cytokines

scientific article

Effect of heterosubtypic immunity on infection with attenuated influenza A virus vaccines in young children

scientific article published on April 1993

Effect of passive antibody on the immune response of cotton rats to purified F and G glycoproteins of respiratory syncytial virus (RSV).

scientific article published in March 1991

Effective immunization with live attenuated influenza A virus can be achieved in early infancy. Pediatric Care Center

scientific article published in January 1996

Effectiveness of enteric immunization in the development of secretory immunoglobulin A response and the outcome of infection with respiratory syncytial virus

scientific article published on February 1991

Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10.

scientific article published on August 1994

Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization

scientific article published in October 1990

Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus

scientific article published on March 1986

Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex.

scientific article published in October 1973

Escape of a highly defective influenza A virus mutant from its temperature sensitive phenotype by extragenic suppression and other types of mutation

scientific article

Evaluation in chimpanzees of vaccinia virus recombinants that express the surface glycoproteins of human respiratory syncytial virus

scientific article published in April 1990

Evaluation in non-human primates of the safety, immunogenicity and efficacy of recombinant vaccinia viruses expressing the F or G glycoprotein of respiratory syncytial virus

scientific article

Evaluation of A/Alaska/6/77 (H3N2) cold-adapted recombinant viruses derived from A/Ann Arbor/6/60 cold-adapted donor virus in adult seronegative volunteers

scientific article

Evaluation of St. Louis encephalitis virus/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeys

scientific article (publication date: 5 August 2008)

Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children

scientific article

Evaluation of a live attenuated bovine parainfluenza type 3 vaccine in two- to six-month-old infants

scientific article published on 01 August 1996

Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy

scientific article published on 22 September 2000

Evaluation of a phenotypic revertant of the A/Alaska/77-ts-1A2 reassortant virus in hamsters and in seronegative adult volunteers: further evidence that the temperature-sensitive phenotype is responsible for attenuation of ts-1A2 reassortant viruses

scientific article

Evaluation of a temperature-sensitive influenza virus in elderly and chronically ill subjects

scientific article published on March 1, 1976

Evaluation of avian-human reassortant influenza A/Washington/897/80 x A/Pintail/119/79 virus in monkeys and adult volunteers.

scientific article published on July 1986

Evaluation of bovine, cold-adapted human, and wild-type human parainfluenza type 3 viruses in adult volunteers and in chimpanzees.

scientific article published on June 1991

Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children

scientific article published on 8 November 2004

Evaluation of influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and cold-adapted recombinant viruses in seronegative adult volunteers

scientific article

Evaluation of live avian-human reassortant influenza A H3N2 and H1N1 virus vaccines in seronegative adult volunteers

scientific article published on May 1986

Evaluation of the A/Seal/Mass/1/80 virus in squirrel monkeys

scientific article published on October 1983

Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers

scientific article

Evaluation of the genetic stability of the temperature-sensitive PB2 gene mutation of the influenza A/Ann Arbor/6/60 cold-adapted vaccine virus.

scientific article published on December 1994

Evaluation of the infectivity, immunogenicity, and efficacy of live cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in adult volunteers

scientific article published in May 1990

Evaluation of the live attenuated cpts 248/404 RSV vaccine in combination with a subunit RSV vaccine (PFP-2) in healthy young and older adults

scientific article published in March 2000

Evaluation of the replication and immunogenicity of recombinant human parainfluenza virus type 3 vectors expressing up to three foreign glycoproteins

scientific article published on May 2002

Evaluation of three strains of influenza A virus in humans and in owl, cebus, and squirrel monkeys

scientific article

Evaluation of two chimeric bovine-human parainfluenza virus type 3 vaccines in infants and young children

scientific article

Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults.

scientific article

Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children

scientific article

Evidence for intrasegmental complementation between two influenza A viruses having ts mutations on their P1 genes

scientific article published on 01 March 1982

Experimental production of respiratory tract disease in cebus monkeys after intratracheal or intranasal infection with influenza A/Victoria/3/75 or influenza A/New Jersey/76 virus ⬇️

scientific article published on July 1, 1978

Expression of biologically active and antigenically authentic parainfluenza type 3 virus hemagglutinin-neuraminidase glycoprotein by a recombinant baculovirus

scientific article

Expression of the F and HN glycoproteins of human parainfluenza virus type 3 by recombinant vaccinia viruses: contributions of the individual proteins to host immunity

scientific article published on November 1987

Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity

scientific article published on October 1986

Failure of attenuated temperature-sensitive influenza A (H3N2) virus to induce heterologous interference in humans to parainfluenza type 1 virus ⬇️

scientific article published on July 1, 1975

Formalin-inactivated respiratory syncytial virus vaccine induces antibodies to the fusion glycoprotein that are deficient in fusion-inhibiting activity.

scientific article published on August 1988

Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines

scientific article published on February 1988

Frequent frameshift and point mutations in the SH gene of human metapneumovirus passaged in vitro

scientific article published on 21 March 2007

Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza virus vaccine candidate.

scientific article

Generation and characterization of an H9N2 cold-adapted reassortant as a vaccine candidate.

scientific article

Generation of a parainfluenza virus type 1 vaccine candidate by replacing the HN and F glycoproteins of the live-attenuated PIV3 cp45 vaccine virus with their PIV1 counterparts

scientific article published in October 1999

Generation of recombinant human parainfluenza virus type 1 vaccine candidates by importation of temperature-sensitive and attenuating mutations from heterologous paramyxoviruses

scientific article published on February 2004

Genetic approaches to attenuation of influenza A viruses for man ⬇️

scientific article published on February 25, 1980

Genetic approaches to control of influenza

scientific article published on January 1979

Genetic approaches to control of influenza

scientific article published on 01 January 1979

Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cells

scientific article published on August 2002

Genetic diversity between human metapneumovirus subgroups ⬇️

scientific article published on October 10, 2003

Genetic factors associated with loss of the temperature-sensitive phenotype of the influenza A/Alaska/77-ts-1A2 recombinant during growth in vivo

scientific article published on 01 July 1981

Genetically modified, live attenuated dengue virus type 3 vaccine candidates

scientific article

Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes

scientific article (publication date: 8 May 2007)

Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells

scientific article

Group-specific serum antibody responses in children with primary and recurrent respiratory syncytial virus infections

scientific article published in July 1991

Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys

scientific article

Hemagglutinin-specific antibody responses in immunoglobulin G, A, and M isotypes as measured by enzyme-linked immunosorbent assay after primary or secondary infection of humans with influenza A virus

scientific article published on August 1983

Hemagglutinin-specific enzyme-linked immunosorbent assay for antibodies to influenza A and B viruses ⬇️

scientific article published on March 1, 1981

Heterotypic dengue infection with live attenuated monotypic dengue virus vaccines: implications for vaccination of populations in areas where dengue is endemic

scientific article

High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence ⬇️

scientific article published on August 3, 2010

Human immune responses to influenza virus vaccines administered by systemic or mucosal routes

scientific article published in August 1995

Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity ⬇️

scientific article published on November 1, 1992

Human monoclonal antibody Fab fragments cloned from combinatorial libraries: potential usefulness in prevention and/or treatment of major human viral diseases

scientific article published on June 1993

Human parainfluenza virus type 1 C proteins are nonessential proteins that inhibit the host interferon and apoptotic responses and are required for efficient replication in nonhuman primates

scientific article published on 9 July 2008

Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates

scientific article

Human parainfluenza virus type 3 (PIV3) expressing the hemagglutinin protein of measles virus provides a potential method for immunization against measles virus and PIV3 in early infancy

scientific article

Human parainfluenza virus type I (HPIV1) vaccine candidates designed by reverse genetics are attenuated and efficacious in African green monkeys

scientific article published in September 2005

Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants

scientific article published in March 2005

Identification of human parainfluenza virus type 2 (HPIV-2) V protein amino acid residues that reduce binding of V to MDA5 and attenuate HPIV-2 replication in nonhuman primates

scientific article

Identification of mutations contributing to the temperature-sensitive, cold-adapted, and attenuation phenotypes of the live-attenuated cold-passage 45 (cp45) human parainfluenza virus 3 candidate vaccine.

scientific article

Immune response to dengue virus and prospects for a vaccine

scientific article published on January 2011

Immunization of cotton rats with the fusion (F) and large (G) glycoproteins of respiratory syncytial virus (RSV) protects against RSV challenge without potentiating RSV disease

scientific article

Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cells ⬇️

scientific article published on July 1, 1993

Immunization of primates with a Newcastle disease virus-vectored vaccine via the respiratory tract induces a high titer of serum neutralizing antibodies against highly pathogenic avian influenza virus.

scientific article

Immunization with vaccinia virus recombinants that express the surface glycoproteins of human parainfluenza virus type 3 (PIV3) protects patas monkeys against PIV3 infection

scientific article published on April 1988

Immunogenicity of recombinant adenovirus-respiratory syncytial virus vaccines with adenovirus types 4, 5, and 7 vectors in dogs and a chimpanzee

scientific article published on October 1, 1992

Immunosuppression of the antibody response to respiratory syncytial virus (RSV) by pre-existing serum antibodies: partial prevention by topical infection of the respiratory tract with vaccinia virus-RSV recombinants

scientific article

Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection

scientific article published on 24 September 2008

In elderly persons live attenuated influenza A virus vaccines do not offer an advantage over inactivated virus vaccine in inducing serum or secretory antibodies or local immunologic memory

scientific article published on March 1991

In vitro production of anti-influenza virus antibody after intranasal inoculation with cold-adapted influenza virus ⬇️

scientific article published on November 1, 1981

Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity.

scientific article published on 21 November 2005

Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates

scientific article

Infectivity and antigenicity of live avian-human influenza A reassortant virus: comparison of intranasal and aerosol routes in squirrel monkeys

scientific article published in October 1986

Infectivity of West Nile/dengue chimeric viruses for West Nile and dengue mosquito vectors

scientific article published on January 2005

Interactions of a nonneutralizing IgM antibody and complement in parainfluenza virus neutralization

scientific article

Interferon gamma expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity

scientific article published on March 1999

Introducing point and deletion mutations into the P/C gene of human parainfluenza virus type 1 (HPIV1) by reverse genetics generates attenuated and efficacious vaccine candidates

scientific article published on 15 November 2005

Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunity

scientific article published on September 2004

Isolation and characterization of a chimpanzee monoclonal antibody to the G glycoprotein of human respiratory syncytial virus

scientific article published on November 1994

Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus

scientific article

Isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (Fab RSVF2-5) that exhibits therapeutic efficacy in vivo

scientific article

La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys

scientific article published on 11 February 2008

Live Victoria/75- ts -1[E] Influenza A Virus Vaccines in Adult Volunteers: Role of Hemagglutinin Immunity in Protection Against Illness and Infection Caused by Influenza A Virus ⬇️

scientific article published on October 1, 1979

Live subgroup B respiratory syncytial virus vaccines that are attenuated, genetically stable, and immunogenic in rodents and nonhuman primates

scientific article published in April 1996

Live vaccines for human metapneumovirus designed by reverse genetics

scientific article published on October 2006

Live viral vaccines for respiratory and enteric tract diseases

scientific article published on April 1988

Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets

scientific article

Live-attenuated intranasal parainfluenza virus type 2 vaccine candidates developed by reverse genetics containing L polymerase protein mutations imported from heterologous paramyxoviruses

scientific article published on September 2005

Live-attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: applications of reverse genetics

scientific article

Long nucleotide insertions between the HN and L protein coding regions of human parainfluenza virus type 3 yield viruses with temperature-sensitive and attenuation phenotypes

scientific article published on June 2000

Measles virus infection in rhesus macaques: altered immune responses and comparison of the virulence of six different virus strains

scientific article published in October 1999

Mechanism of antibody-mediated viral clearance in immunotherapy of respiratory syncytial virus infection of cotton rats

scientific article published on June 1990

Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice

scientific article published in September 2004

Minimum Protein Requirements for Transcription and RNA Replication of a Minigenome of Human Parainfluenza Virus Type 3 and Evaluation of the Rule of Six ⬇️

scientific article published on July 21, 1997

Modification of the trypsin-dependent cleavage activation site of the human metapneumovirus fusion protein to be trypsin independent does not increase replication or spread in rodents or nonhuman primates

scientific article

Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virus ⬇️

scientific article published on September 15, 2003

Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein

scientific article published on December 1998

More antibody with less antigen: can immunogenicity of attenuated live virus vaccines be improved?

scientific article

Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS.

scientific article published in June 2004

Mucosal immunization of rhesus monkeys against respiratory syncytial virus subgroups A and B and human parainfluenza virus type 3 by using a live cDNA-derived vaccine based on a host range-attenuated bovine parainfluenza virus type 3 vector backbone

scientific article

Mucosal parainfluenza virus-vectored vaccine against Ebola virus replicates in the respiratory tract of vector-immune monkeys and is immunogenic

scientific article

Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates

scientific article published in September 1999

Mutations which enhance the replication of dengue virus type 4 and an antigenic chimeric dengue virus type 2/4 vaccine candidate in Vero cells ⬇️

scientific article published on October 1, 2003

New enzyme immunoassays for measurement of influenza A/Victoria/3/75 virus in nasal washes ⬇️

scientific article published on April 19, 1980

New generation live vaccines against human respiratory syncytial virus designed by reverse genetics

scientific article

Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens

scholarly article

Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys.

scientific article

Nonsegmented negative-strand viruses as vaccine vectors

scientific article

Nucleoprotein and membrane protein genes are associated with restriction of replication of influenza A/Mallard/NY/78 virus and its reassortants in squirrel monkey respiratory tract

scientific article published on March 1985

Nucleoprotein and membrane protein genes responsible for restriction of replication of influenza A/Mallard/NY/78 virus and its reassortants in the respiratory tract of squirrel monkeys

scientific article published in February 1986

Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983.

scientific article

Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins

scientific article published in December 1986

Nucleotide sequence analysis of the respiratory syncytial virus subgroup A cold-passaged (cp) temperature sensitive (ts) cpts-248/404 live attenuated virus vaccine candidate

scientific article published in November 1996

Nucleotide sequence changes in the polymerase basic protein 2 gene of temperature-sensitive mutants of influenza A virus

scientific article published on November 1, 1992

Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes

scientific article

Passive transfer of respiratory syncytial virus (RSV) antiserum suppresses the immune response to the RSV fusion (F) and large (G) glycoproteins expressed by recombinant vaccinia viruses

scientific article published on October 1988

Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines

scientific article

Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice

scientific article published on March 1990

Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult Volunteers

scientific article (publication date: November 2009)

Phase 2 evaluation of parainfluenza type 3 cold passage mutant 45 live attenuated vaccine in healthy children 6-18 months old.

scientific article published on 20 January 2004

Phase I clinical evaluation of rDEN4Delta30-200,201: a live attenuated dengue 4 vaccine candidate designed for decreased hepatotoxicity

scientific article

Present status of live influenza A virus vaccine

scientific article published on January 1, 1979

Priming and boosting immunity to respiratory syncytial virus by recombinant replication-defective vaccinia virus MVA.

scientific article published in October 1999

Principles underlying the development and use of live attenuated cold-adapted influenza A and B virus vaccines

scientific article

Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice

scientific article published on April 2004

Probable association of plaque size with neuraminidase subtype among H3N2 influenza A viruses ⬇️

scientific article published on January 1, 1979

Processing, surface expression, and immunogenicity of carboxy-terminally truncated mutants of G protein of human respiratory syncytial virus

scientific article published on January 1989

Production and level of genetic stability of an influenza A virus temperature-sensitive mutant containing two genes with ts mutations

scientific article

Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5' proximal open reading frame of the M2 mRNA in gene expression and provides a capability for va

scientific article

Prospects for a dengue virus vaccine

scientific article (publication date: July 2007)

Protection of cotton rats by immunization with the human parainfluenza virus type 3 fusion (F) glycoprotein expressed on the surface of insect cells infected with a recombinant baculovirus

scientific article published in September 1991

Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of CD4+ T cells ⬇️

scientific article published on December 1, 1992

Rapid human metapneumovirus microneutralization assay based on green fluorescent protein expression

scientific article published on September 2005

Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics.

scientific article

Reappraisal of the Association of Intussusception with the Licensed Live Rotavirus Vaccine Challenges Initial Conclusions

article

Reassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeys

scientific article published in December 1982

Recombinant bovine/human parainfluenza virus type 3 (B/HPIV3) expressing the respiratory syncytial virus (RSV) G and F proteins can be used to achieve simultaneous mucosal immunization against RSV and HPIV3.

scientific article

Recombinant human Metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: deletion of G yields a promising vaccine candidate

scientific article published on December 2004

Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates.

scientific article

Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates.

scientific article

Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice

scientific article

Recombinant newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates

scientific article

Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees

scientific article

Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees.

scientific article

Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse

scientific article published on December 1997

Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees

scientific article

Recombinant respiratory syncytial virus with the G and F genes shifted to the promoter-proximal positions

scientific article

Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys

scientific article

Recovery of Infectious Human Parainfluenza Virus Type 3 from cDNA ⬇️

scientific article published on September 1, 1997

Recovery of a fully viable chimeric human parainfluenza virus (PIV) type 3 in which the hemagglutinin-neuraminidase and fusion glycoproteins have been replaced by those of PIV type 1.

scientific article

Recovery of human metapneumovirus from cDNA: optimization of growth in vitro and expression of additional genes

scientific article published on April 2004

Reduced Infectivity of Cold-Adapted Influenza A H1N1 Viruses in the Elderly: Correlation with Serum and Local Antibodies ⬇️

scientific article published on February 1, 1992

Relationship of genotype of recombinants of influenza A/Hong Kong/68-ts-1[E]virus used as live virus vaccines to virulence in humans ⬇️

scientific article published on October 1, 1979

Replacement of the F and G proteins of respiratory syncytial virus (RSV) subgroup A with those of subgroup B generates chimeric live attenuated RSV subgroup B vaccine candidates.

scientific article

Replacement of the ectodomains of the hemagglutinin-neuraminidase and fusion glycoproteins of recombinant parainfluenza virus type 3 (PIV3) with their counterparts from PIV2 yields attenuated PIV2 vaccine candidates

scientific article

Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys

scientific article published in December 2004

Resistance of adults to challenge with influenza A wild-type virus after receiving live or inactivated virus vaccine

scientific article published on January 1986

Resistance to challenge with influenza A/Hong Kong/123/77 (H1N1) wild-type virus induced by live attenuated A/Hong Kong/123/77 (H1N1) cold-adapted reassortant virus

scientific article published in April 1985

Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein

scientific article published on March 1986

Resistance to respiratory syncytial virus (RSV) challenge induced by infection with a vaccinia virus recombinant expressing the RSV M2 protein (Vac-M2) is mediated by CD8+ T cells, while that induced by Vac-F or Vac-G recombinants is mediated by ant ⬇️

scientific article published on February 1, 1992

Respiratory syncytial virus (RSV) F, G, M2 (22K), and N proteins each induce resistance to RSV challenge, but resistance induced by M2 and N proteins is relatively short-lived

scientific article published on March 1991

Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant

scientific article

Respiratory syncytial virus can tolerate an intergenic sequence of at least 160 nucleotides with little effect on transcription or replication in vitro and in vivo

scientific article

Respiratory syncytial virus-specific immunoglobulins in preterm infants

scientific article published in May 1993

Respiratory syncytial virus: reverse genetics and vaccine strategies

scientific article

Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response ⬇️

scientific article published on October 27, 2010

Response of seronegative and seropositive adult volunteers to live attenuated cold-adapted reassortant influenza A virus vaccine

scientific article published on June 1985

Restricted replication of a cold-adapted reassortant influenza A virus in the lower respiratory tract of chimpanzees

scientific article published in August 1986

Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epithelium

scientific article published on 4 June 2008

SARS vaccine protective in mice

scientific article published on August 2005

Safety and immunogenicity of a cold-adapted influenza A (H1N1) reassortant virus vaccine administered to infants less than six months of age.

scientific article

Safety and immunogenicity of live attenuated cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in infants and children

scientific article published in April 1991

Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine

scientific article

Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis

scientific article published on June 1994

Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines.

scientific article

Secretory immunological response after intranasal inactivated influenza A virus vaccinations: evidence for immunoglobulin A memory

scientific article

Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and lower respiratory tract of African green monkeys and chimpanzees

scientific article published in May 2002

Sequence analysis of the Washington/1964 strain of human parainfluenza virus type 1 (HPIV1) and recovery and characterization of wild-type recombinant HPIV1 produced by reverse genetics

scientific article published on January 2002

Sequence determination and molecular analysis of two strains of bovine parainfluenza virus type 3 that are attenuated for primates

scientific article published on January 2000

Sequential addition of temperature-sensitive missense mutations into the PB2 gene of influenza A transfectant viruses can effect an increase in temperature sensitivity and attenuation and permits the rational design of a genetically engineered live ⬇️

scientific article published on 01 October 1995

Serious respiratory tract disease caused by respiratory syncytial virus: prospects for improved therapy and effective immunization ⬇️

scientific article published on July 1, 1992

Serological diagnosis of influenza A/USSR/77 H1N1 infection: value of ELISA compared to other antibody techniques

Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus

scientific article published on July 1986

Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection.

scientific article published on June 1986

Serum immunoglobulin G antibody subclass response to respiratory syncytial virus F and G glycoproteins after first, second, and third infections

scientific article published on March 1989

Serum immunoglobulin G antibody subclass responses to respiratory syncytial virus F and G glycoproteins after primary infection.

scientific article published on August 1986

Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters

scientific article

Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice

scientific article

Specific anti-influenza virus antibody production in vitro by human peripheral blood mononuclear cells

scientific article

Specificity of the local secretory antibody to influenza A virus infection.

scientific article published in November 1974

Studies of passive immunotherapy for infections of respiratory syncytial virus in the respiratory tract of a primate model

scientific article published in November 1985

Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys ⬇️

scientific article published on October 1, 2003

Successful topical respiratory tract immunization of primates against Ebola virus

scientific article published on 11 April 2007

Successful vaccination with a polyvalent live vector despite existing immunity to an expressed antigen

scientific article published in Nature

Systemic and local antibody responses in elderly subjects given live or inactivated influenza A virus vaccines

scientific article published on December 1989

Tahyna virus genetics, infectivity, and immunogenicity in mice and monkeys

scientific article published on 24 March 2011

Targeted mutagenesis as a rational approach to dengue virus vaccine development

scientific article

Temperature sensitive mutants of influenza virus. IX. Genetic and biological characterization of TS-1[E] lesions when transferred to a 1972 (H3N2) influenza A virus

scientific article

Temperature sensitive mutations in the genes encoding the NS1, NS2A, NS3, and NS5 nonstructural proteins of dengue virus type 4 restrict replication in the brains of mice ⬇️

scientific article published on May 1, 2003

Temperature-Sensitive Mutants of Influenza Virus. III. Further Characterization of the ts-1[E] Influenza A Recombinant (H3N2) Virus in Man ⬇️

scientific article published on October 1, 1973

Temperature-Sensitive Mutants of Influenza Virus. IV. Induction of Interferon in the Nasopharynx by Wild-Type and a Temperature-Sensitive Recombinant Virus ⬇️

scientific article published on October 1, 1973

Temperature-Sensitive mutants of influenza virus. VII. Transfer of the TS-1[E] lesions to a wild-type influenza A virus with the HON1 surface antigens

scientific article published on August 1, 1975

Temperature-sensitive Mutants of Influenza A Virus: Response of Children to the Influenza A/Hong Kong/68-ts-1[E] (H3N2) and Influenza A/Udorn/72-ts-1[E] (H3N2) Candidate Vaccine Viruses and Significance of Immunity to Neuraminidase Antigen ⬇️

scientific article published on April 1, 1976

Temperature-sensitive mutants of influenza A virus. Transfer of the two ts-1A2 ts lesions present in the Udorn/72-ts-1A2 donor virus to the influenza A/Alaska/6/77 (H3N2) wild type virus

scientific article published in January 1980

Temperature-sensitive mutants of influenza A virus. XI. Transfer of ts lesions in the Hong Kong/68-ts-1 [a] virus to the influenza A/Udorn/72 wild type

scientific article published on December 1, 1976

Temperature-sensitive mutants of influenza A virus. XII. Safety, antigenicity, transmissibility, and efficacy of influenza A/Udorn/72-ts-1[E] recombinant viruses in human adults

scientific article published on December 1, 1976

Temperature-sensitive mutants of influenza A virus. XIV. Production and evaluation of influenza A/Georgia/74-ts-1[E] recombinant viruses in human adults

scientific article published on August 1, 1977

Temperature-sensitive mutants of influenza A virus: evaluation of A/Victoria/3/75-ts-1[E] recombinant viruses in volunteers

scientific article

Temperature-sensitive mutants of influenza A virus: evaluation of the A/Victoria/75-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers ⬇️

scientific article published on February 1, 1979

Temperature-sensitive mutants of influenza A virus: evaluation of the Alaska/77-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers

scientific article

Temperature-sensitive mutants of influenza A virus: production and characterization of A/Victoria/3/75-ts-1[E] recombinants ⬇️

scientific article published on June 1, 1978

Temperature-sensitive mutants of influenza A virus: transfer of the two temperature-sensitive lesions in the Udorn/72-ts-1A2 virus to the A2Hong Kong/123/77 (H1N1) wild-type virus

scientific article

Temperature-sensitive mutants of influenza A/Udorn/72 (H3N2) virus. I. Isolation of temperature-sensitive mutants some of which exhibit host-dependent temperature sensitivity

scientific article

Temperature-sensitive mutants of influenza A/Udorn/72 (H3N2) virus. II. Genetic analysis and demonstration of intrasegmental complementation

scientific article

Temperature-sensitive mutants of influenza A/Udorn/72 (H3N2) virus. III. Genetic analysis of temperature-dependent host range mutants

scientific article

Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man.

scientific article published in August 1972

Temperature-sensitive mutants of influenza virus. Identification of the loci of the two ts lesions in the Udorn-ts-1A2 donor virus and the correlation of the presence of these two ts lesions with a predictable level of attenuation

scientific article

Temperature-sensitive mutants of influenza virus. V. Evaluation in man of an additional ts recombinant virus with a 39 C shutoff temperature

scientific article published in August 1974

Temperature-sensitive mutants of influenza virus. VI. Transfer of TS lesions from the Asian subtype of influenza A virus (H2N2) to the Hong Kong subtype (H3N2)

scientific article published on August 1, 1975

Temperature-sensitive mutants of influenza virus. XIII. Evaluation of influenza A/Hong Kong/68 and A/Udorn/72 ts and wild-type viruses in tracheal organ culture at permissive and restrictive temperatures

scientific article published on July 1, 1977

Temperature-sensitive mutants of influenza virus. XV. The genetic and biological characterization of a recombinant influenza virus containing two ts lesions produced by mating two complementing, single lesion ts mutants

scientific article published on July 15, 1978

Temperature-sensitive mutants of influenza virus. XVI. Transfer of the two ts lesions present in the Udorn/72-ts-1A2 donor virus to the Victoria/3/75 wild-type virus

scientific article published in July 1978

Temperature-sensitive mutants of influenza. VIII. Genetic and biological characterization of TS mutants of influenza virus A (H3N2) and their assignment to complementation groups

scientific article published on August 1, 1975

The A/Mallard/6750/78 avian-human, but not the A/Ann Arbor/6/60 cold-adapted, influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine retains partial virulence for infants and children

scientific article published on May 1991

The B allele of the NS gene of avian influenza viruses, but not the A allele, attenuates a human influenza A virus for squirrel monkeys

scientific article published on July 1989

The C proteins of human parainfluenza virus type 1 (HPIV1) control the transcription of a broad array of cellular genes that would otherwise respond to HPIV1 infection

scientific article published on 03 December 2008

The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R

scientific article

The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines

scientific article published on 28 August 2007

The association of the temperature-sensitive phenotype with viral attenuation in animals and humans: implications for the development and use of live virus vaccines

scientific article published on May 1979

The attenuation phenotype conferred by the M gene of the influenza A/Ann Arbor/6/60 cold-adapted virus (H2N2) on the A/Korea/82 (H3N2) reassortant virus results from a gene constellation effect

scientific article published in September 1992

The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/Pintail/79 reassortant viruses for monkeys

scientific article published on September 1987

The cDNA-derived investigational human parainfluenza virus type 3 vaccine rcp45 is well tolerated, infectious, and immunogenic in infants and young children

scientific article

The complete nucleotide sequence of the JS strain of human parainfluenza virus type 3: comparison with the Wash/47885/57 prototype strain

scientific article published on September 1, 1992

The complete nucleotide sequence of two cold-adapted, temperature-sensitive attenuated mutant vaccine viruses (cp12 and cp45) derived from the JS strain of human parainfluenza virus type 3 (PIV3).

scientific article

The cytolytic activity of pulmonary CD8+ lymphocytes, induced by infection with a vaccinia virus recombinant expressing the M2 protein of respiratory syncytial virus (RSV), correlates with resistance to RSV infection in mice.

scientific article published on February 1993

The full genome sequence of three strains of Jamestown Canyon virus and their pathogenesis in mice or monkeys

scientific article published in 2011

The genome length of human parainfluenza virus type 2 follows the rule of six, and recombinant viruses recovered from non-polyhexameric-length antigenomic cDNAs contain a biased distribution of correcting mutations

scientific article

The immunogenicity and efficacy of intranasally or parenterally administered replication-deficient vaccinia-parainfluenza virus type 3 recombinants in rhesus monkeys

scientific article published in August 1998

The interferon antagonist NS2 protein of respiratory syncytial virus is an important virulence determinant for humans

scientific article

The live attenuated dengue serotype 1 vaccine rDEN1Delta30 is safe and highly immunogenic in healthy adult volunteers.

scientific article published on 24 July 2006

The live attenuated subgroup B respiratory syncytial virus vaccine candidate RSV 2B33F is attenuated and immunogenic in chimpanzees, but exhibits partial loss of the ts phenotype following replication in vivo

scientific article published in January 1999

The major attenuating mutations of the respiratory syncytial virus vaccine candidate cpts530/1009 specify temperature-sensitive defects in transcription and replication and a non-temperature-sensitive alteration in mRNA termination

scientific article

The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome

scientific article

The recombinant chimeric human parainfluenza virus type 1 vaccine candidate, rHPIV3-1cp45, is attenuated, immunogenic, and protective in African green monkeys

scientific article published in March 2002

The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes

scientific article published on 08 October 2008

The systemic and mucosal immune response of humans to influenza A virus

scientific article published on January 1989

The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein ⬇️

scientific article published on August 1, 1997

The two amino acid substitutions in the L protein of cpts530/1009, a live-attenuated respiratory syncytial virus candidate vaccine, are independent temperature-sensitive and attenuation mutations

scientific article published in March 1999

The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness

scientific article

Three amino acid substitutions in the L protein of the human parainfluenza virus type 3 cp45 live attenuated vaccine candidate contribute to its temperature-sensitive and attenuation phenotypes

scientific article

Three strains of influenza A virus (H3N2): interferon sensitivity in vitro and interferon production in volunteers ⬇️

scientific article published on March 1, 1976

Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlers

scientific article

Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers ⬇️

scientific article published on March 1, 1992

Use of temperature-sensitive and cold-adapted mutant viruses in immunoprophylaxis of acute respiratory tract disease

scientific article

Use of temperature-sensitive mutants of influenza A virus as live virus vaccine strains. Evaluation in laboratory animals, adults and children

scientific article published on June 1976

Use of the enzyme-linked immunosorbent assay to detect serum antibody responses of volunteers who received attenuated influenza A virus vaccines

scientific article

Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2

scientific article

Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Delta30 with those of DEN1

scientific article (publication date: 28 February 2007)

Virulence of avian influenza A viruses for squirrel monkeys.

scientific article

What are the risks--hypothetical and observed--of recombination involving live vaccines and vaccine vectors based on nonsegmented negative-strain RNA viruses?

scientific article published on October 2008

rDEN2/4Delta30(ME), a live attenuated chimeric dengue serotype 2 vaccine is safe and highly immunogenic in healthy dengue-naïve adults.

scientific article published on 5 November 2006

rDEN4delta30, a live attenuated dengue virus type 4 vaccine candidate, is safe, immunogenic, and highly infectious in healthy adult volunteers

scientific article published on 27 January 2005

ts P1 and P3 genes are responsible for satisfactory level of attenuation of ts-1A2 recombinants bearing H1N1 or H3N2 surface antigens of influenza A virus

scientific article

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