List of works by Eugene R Bleecker

116 Genome-Wide Association Studies of Asthma Indicate Opposite Immunopathogenesis Direction From Autoimmune Diseases.

scientific article published on 17 February 2012

123 Serum IL6 and Soluble IL6R Are Correlated With Lung Function in Non-Hispanic Whites with Asthma.

scientific article published on 17 February 2012

24-h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids

scientific article

24 Common and Rare Variation in the T Helper 2 Gene Pathway Predicts Allergic Asthma Phenotypes

A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography

scientific article published on 01 September 2019

A Roadmap to functional genomics

scientific article published on 27 February 2007

A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease. Dutch Chronic Non-Specific Lung Disease Study Group

scientific article published on November 12, 1992

A comparison of histamine, methacholine, and exercise airway reactivity in normal and asthmatic subjects.

scientific article

A comparison of short-term treatment with inhaled fluticasone propionate and zafirlukast for patients with persistent asthma

scientific article

A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study

scientific article published on 01 October 2006

A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects

scientific article published in July 2004

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

scientific article published on 11 October 2016

A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma

scientific article published on 12 September 2018

A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma

scientific article published on October 25, 2003

A genome-wide search for quantitative trait loci contributing to variation in seasonal pollen reactivity

scientific article published on 01 January 2006

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations

scientific article published on 10 November 2012

A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors

scientific article published on August 2008

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma

scientific article published on 08 January 2009

A shift from central and mixed sleep apnea to obstructive sleep apnea resulting from low-flow oxygen

scientific article published in August 1985

A trial of clarithromycin for the treatment of suboptimally controlled asthma

scientific article published on October 1, 2010

AB012. Current burden of uncontrolled asthma in the general population: the OPCRD asthma state of the Union study.

scientific article published in July 2016

ADRB2 p.Thr164Ile association with hospitalization depends upon asthma severity

scientific article published on 23 January 2019

ADRB2 polymorphisms and budesonide/formoterol responses in COPD.

scientific article

ALX receptor ligands define a biochemical endotype for severe asthma

scientific article

ALX receptor ligands define a biochemical endotype for severe asthma

scientific article published on 22 March 2018

ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts

scientific article

Acute upper airway injury in burn patients. Serial changes of flow-volume curves and nasopharyngoscopy

scientific article published on 01 February 1987

Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers

scientific article published on 12 March 2009

Adult patients may outgrow their asthma: a 25-year follow-up study

scientific article published in April 1997

Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.

scientific article published on 26 August 2016

Airway Mucin Concentration as a Marker of Chronic Bronchitis

scientific article published on September 2017

Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma

scientific article

Airways reactivity and asthma: significance and treatment.

scientific article

Alterations of the arginine metabolome in asthma

scientific article

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

scientific article

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos

scientific article published on 07 September 2018

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup

article

An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma

scientific article

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype

scientific article

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

scientific article

Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics

scientific article

Approaches to fine mapping in asthma

scientific article published on 01 April 1998

Approaches to mapping genes for allergy and asthma

scientific article published on July 1, 1995

Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma

scientific article (publication date: November 2005)

Assembly of a pan-genome from deep sequencing of 910 humans of African descent

Assessing productivity loss and activity impairment in severe or difficult-to-treat asthma.

scientific article published in March 2008

Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort

scientific article

Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels.

scientific article

Association of HLA-DRB1∗09:01 with tIgE levels among African-ancestry individuals with asthma

scientific article published on 22 January 2020

Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy

scientific article published on 01 September 2008

Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations

scientific article (publication date: October 2003)

Association of a promoter polymorphism of the CD14 gene and atopy

scientific article published on March 2001

Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics

scientific article published on 24 September 2008

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort

scientific article published on 13 November 2017

Association studies of serum prostate-specific antigen levels and the genetic polymorphisms at the androgen receptor and prostate-specific antigen genes

scientific article published on 01 July 2002

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

scientific article published on 20 February 2019

Associations between hOGG1 sequence variants and prostate cancer susceptibility

scientific article published in April 2002

Asthma Is More Severe in Older Adults

scientific article

Asthma and endotoxin: lipopolysaccharide-binding protein and soluble CD14 in bronchoalveolar compartment

scientific article published on 01 May 1996

Asthma and gender impact accumulation of T cell subtypes

scientific article published on July 28, 2010

Asthma exacerbations and formoterol

scientific article published in April 2004

Asthma genetics and personalised medicine

scientific article published on 2 May 2014

Asthma heterogeneity and severity

scientific article

Asthma heterogeneity and severity-why is comprehensive phenotyping important?

scientific article

Asthma pharmacogenetics and the development of genetic profiles for personalized medicine

scientific article

Asthma pharmacogenomics

scientific article published on November 2005

Asthma training in third-year medical students

scientific article published in January 1997

Author Correction: Assembly of a pan-genome from deep sequencing of 910 humans of African descent

scientific article published on 01 February 2019

Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

scientific article published on 04 September 2019

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

scientific article published on 01 September 2018

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 01 June 2019

BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications

scientific article published on 01 October 2019

Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.

scientific article published on 30 August 2017

Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma

article published in 2018

Baseline sputum eosinophil + neutrophil subgroups' clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort

scientific article published on 05 February 2020

Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study

scientific article published on 07 September 2014

Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial

scientific article published on 22 May 2017

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

scientific article published on 8 October 2014

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

scientific article published on 5 September 2016

Beta agonists and asthma: how do new developments affect traditional therapy?

scientific article published in January 1993

Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate

scientific article published on 12 November 2009

Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects

scientific article published on 21 May 2013

Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.

scientific article

Biomarkers for severe eosinophilic asthma

scientific article published in December 2017

Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study

scientific article published on 19 October 2015

Bronchoalveolar macrophage CD14 expression: shift between membrane-associated and soluble pools

scientific article published on 01 May 1997

Bronchoconstriction induced by distilled water. Sensitivity in asthmatics and relationship to exercise-induced bronchospasm

scientific article published on 01 August 1986

Bronchodilator efficacy and safety of indacaterol 150 μg once daily in patients with COPD: an analysis of pooled data

scientific article

CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity

scientific article

COPD is associated with a macrophage scavenger receptor-1 gene sequence variation

scientific article

COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease

scientific article published on 01 November 2019

COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids

scientific article published on 29 April 2020

COVID-19, asthma, and biologic therapies: What we need to know

scientific article published on 16 May 2020

Changing patterns in asbestos-induced lung disease

scientific article published on February 2004

Characterisation of asthma subgroups associated with circulating YKL-40 levels

scientific article

Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program

scientific article

Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program

scientific article

Characterization of obstructive airway disease in family members of probands with asthma. An algorithm for the diagnosis of asthma.

scientific article published in June 1998

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

scientific article

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

scientific article published on 01 July 2020

Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma

scientific article

Clinical Issues in Severe Asthma: Consensus and Controversies on the Road to Precision Medicine

scientific article published on 01 October 2018

Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function

scientific article published on May 2016

Clinical consequences of ADRbeta2 polymorphisms

scientific article published on March 2008

Clinical effects of nedocromil sodium on allergen-related mechanisms.

scientific article published on November 1996

Clinical heterogeneity in the severe asthma research program

scientific article published on December 2013

Clinical significance of the bronchodilator response in children with severe asthma

scientific article published on 19 August 2019

Clinical trials in asthma and chronic airflow obstruction

scientific article published on January 1990

Collaborative studies on the genetics of asthma--National Heart, Lung and Blood Institute.

scientific article published in November 1995

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

scientific article

Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein

scientific article

Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

scientific article

Comparison of Ipratropium Bromide and Albuterol Sulfate Chlorofluorocarbon Metered-Dose Inhaler and Albuterol Hydrofluoroalkane Metered-Dose Inhaler in a Crossover Trial in Patients with Moderate-to-Severe Asthma

scholarly article by E.R. Bleecker et al published February 2011 in The Journal of Allergy and Clinical Immunology

Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial

scientific article published on September 2012

Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study

scientific article published on 08 January 2014

Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)

scientific article

Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids

scientific article

Complex association patterns for inflammatory mediators in induced sputum from subjects with asthma.

scientific article published on 9 March 2018

Computerized tomography in obstructive sleep apnea. Correlation of airway size with physiology during sleep and wakefulness

scientific article published in February 1983

Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment

scientific article published on 07 October 2009

Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma

scientific article published on 05 May 2005

Corrigendum to “Efficacy and safety of fluticasone furoate 100 μg once-daily in patients with persistent asthma: A 24-week placebo and active-controlled randomised trial” [Res Med 108 (2014) 41–49]

article

Cumulative association of five genetic variants with prostate cancer

scientific article published on 16 January 2008

Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma

scientific article

Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study

scientific article published on 18 May 2017

Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).

scientific article

Determinants of exhaled breath condensate pH in a large population with asthma

scientific article

Detrimental effects of environmental tobacco smoke in relation to asthma severity

scientific article

Development and initial validation of the Asthma Severity Scoring System (ASSESS)

scientific article published on 08 October 2019

Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial

scientific article published in April 2004

Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes

scientific article published on 05 May 2005

Differentiation of quantitative CT imaging phenotypes in asthma versus COPD.

scientific article published on 9 November 2017

Direct assessment of small airways reactivity in human subjects.

scientific article

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma

scientific article published on 31 October 2013

Disease Burden and Long-Term Risk of Persistent Very Poorly Controlled Asthma: TENOR II

scientific article published on 12 March 2020

Do symptoms predict COPD in smokers?

scientific article

Dose effect of once-daily fluticasone furoate in persistent asthma: A randomized trial

article

Dutch approach to the study of the genetics of asthma

scientific article published on 01 November 1995

Early Life Influences and Interventions in Asthma. Introduction

scientific article published on 01 February 2000

Ease of use of the ELLIPTA dry powder inhaler: data from three randomised controlled trials in patients with asthma

scientific article published on 26 June 2014

Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies

scientific article published on December 2007

Effect of Environmental Antigen on Cholinergic Hyperreactivity

scientific article published on February 1, 1979

Effect of alpha-adrenergic blockade on exercise-induced asthma and conditioned cold air

scientific article published on September 1, 1984

Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial

scientific article

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study

scientific article

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial

scientific article

Effect of β2-adrenergic receptor gene (ADRB2) 3' untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response

scientific article

Effectiveness of fevipiprant in reducing exacerbations in patients with severe asthma (LUSTER-1 and LUSTER-2): two phase 3 randomised controlled trials

scientific article published on 24 September 2020

Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma

scientific article

Effects of airway pressure on bronchial blood flow.

scientific article

Effects of antihistamines on the cardiopulmonary changes due to canine anaphylaxis

scientific article published on 01 January 1988

Effects of beta2-agonists on airway tone and bronchial responsiveness

scientific article

Effects of bronchoscopy on lung function in asthmatics

scientific article published on 5 January 2017

Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.

scientific article

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

scientific article published on 2 September 2016

Efficacy and safety of budesonide/formoterol pressurized metered-dose inhaler: randomized controlled trial comparing once- and twice-daily dosing in patients with asthma

scientific article published in January 2010

Efficacy and safety of fluticasone furoate 100 μg once-daily in patients with persistent asthma: A 24-week placebo and active-controlled randomised trial

article

Efficacy and safety of fluticasone furoate/vilanterol compared with fluticasone propionate/salmeterol combination in adult and adolescent patients with persistent asthma: a randomized trial

scientific article published on October 2013

Efficacy and safety of ipratropium bromide/albuterol compared with albuterol in patients with moderate-to-severe asthma: a randomized controlled trial

scientific article

Efficacy and safety of once-daily fluticasone furoate 50 mcg in adults with persistent asthma: a 12-week randomized trial

scientific article

Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial

scientific article published on 6 October 2011

Efficacy of once-daily tiotropium Respimat in adults with asthma at GINA Steps 2-5

scientific article published on 23 December 2019

Erratum

scholarly article published in European Respiratory Journal

Erratum: Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers

scientific article published on 01 January 2020

Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort

scientific article published on 12 September 2019

Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma

scientific article published on 15 February 2006

Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease

scientific article published in March 2002

Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma

scientific article published on 01 September 2001

Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study.

scientific article

Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer

scientific article published on June 15, 2003

Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer

scientific article

Evaluation of sleep-disordered breathing. Is polysomnography necessary?

scientific article

Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency

scientific article published on 01 June 2020

Evidence for a locus regulating total serum IgE levels mapping to chromosome 5

scientific article published on 01 September 1994

Evidence for a prostate cancer linkage to chromosome 20 in 159 hereditary prostate cancer families

scientific article published on 01 May 2001

Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma

scientific article

Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure

scientific article published on April 2003

Evidence for linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q: a major regulatory locus important in asthma

scientific article published on 01 November 1995

Evidence for multiple genetic susceptibility loci for asthma

scientific article published on October 1997

Evidence for two unlinked loci regulating total serum IgE levels

scientific article published on August 1995

Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials

scientific article published on 11 September 2019

Exclusion of chromosome 11q and the FcepsilonRI-beta gene as aetiological factors in allergy and asthma in a population of Dutch asthmatic families

scientific article published in April 1998

Exercise-induced asthma. Physiologic and clinical considerations.

scientific article published in March 1984

Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma: A Delphi Study

scientific article published on 28 October 2020

Exploring pleiotropy using principal components

scientific article

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort

scientific article published on 6 April 2016

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

scientific article published on 01 May 2019

Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21

scientific article

Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28

article

Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial

scientific article published on 09 August 2011

Fluticasone furoate-vilanterol 100-25 mcg compared with fluticasone furoate 100 mcg in asthma: a randomized trial.

scientific article published on 24 April 2014

Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma

scientific article published on 21 December 2011

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

scientific article

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans

scientific article published on 4 October 2012

GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma

scientific article published on 13 October 2013

Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease

scientific article published on 16 December 2016

Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways

scientific article

Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma

scientific article

Genetic Susceptibility to Asthma in a Changing Environment

scientific article published on January 1, 1997

Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy

scientific article published on October 5, 1995

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

scientific article published on 11 August 2020

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

scientific article published on 21 April 2021

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

scientific article

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.

scientific article published on 13 January 2015

Genetics of allergy and bronchial hyperresponsiveness

scientific article

Genetics of asthma

scientific article

Genetics of asthma susceptibility and severity

scientific article

Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA)

scientific article published on 01 May 2004

Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure

scientific article published in June 2005

Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects

scientific article

Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene

scientific article

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

scholarly article by Johannes Waage et al published August 2018 in Nature Genetics

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases

scientific article published on 12 June 2012

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos

scientific article published on 6 December 2014

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients

scientific article published on 28 March 2013

Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions

scientific article

Genome-wide association study of lung function and clinical implication in heavy smokers

Genome-wide interaction studies reveal sex-specific asthma risk alleles

scientific article

Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families

scientific article

Genome-wide search for atopy susceptibility genes in Dutch families with asthma

scientific article published on 01 March 2002

Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma

scientific article

Genomewide screen for pulmonary function in 200 families ascertained for asthma

scientific article published on 18 May 2005

Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

scientific article (publication date: October 2002)

Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk

scientific article

Guidelines for the methodology of exercise challenge testing of asthmatics. Study Group on Exercise Challenge, Bronchoprovocation Committee, American Academy of Allergy.

scientific article published in December 1979

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

scientific article published on 13 January 2020

Hemodynamic mechanisms in anaphylaxis

scientific article published on 01 January 1983

Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program

scientific article

Heterogeneous burden of lung disease in smokers with borderline airflow obstruction

scientific article published on 20 November 2018

How cytokines co-occur across asthma patients: from bipartite network analysis to a molecular-based classification

journal article published in 2011

Human airway branch variation and chronic obstructive pulmonary disease

scientific article published on 16 January 2018

IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist

scientific article published on 26 April 2012

IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist

scientific article published on October 1, 2010

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle

scientific article published on 22 May 2015

IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function

scientific article published on 05 July 2007

IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression

scientific article

Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population

scientific article published on 01 September 2001

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness

scientific article published on 3 September 2009

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

scientific article

Identification of coding polymorphisms in human circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS in a multi-ethnic screening panel.

scientific article

Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel

scientific article published on 01 June 2004

Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

scientific article published on 18 September 2018

Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS)

scientific article published on 15 July 2019

Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes

scientific article published on 01 July 1991

Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012

scientific article published on 13 June 2016

Importance of hedgehog interacting protein and other lung function genes in asthma

scientific article

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations

scientific article

Influences of suggestion on airway reactivity in asthmatic subjects

scientific article published on 01 November 1968

Inhibitability and enhanceability of basophil histamine release in asthmatic and normal subjects.

scientific article

Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor

scientific article published on 01 March 1996

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis

scientific article

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene

scientific article (publication date: 2013)

Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma

scientific article published on 19 May 2010

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

scientific article published on 12 December 2013

Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control

scientific article published on 25 October 2017

Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma

scientific article published on 09 September 2019

Investigative bronchoscopy in subjects with asthma and other obstructive pulmonary diseases. Whether and when

scientific article published on 01 February 1992

Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility

scientific article published on 01 March 2002

Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study

scientific article

Latent traits of lung tissue patterns in former smokers derived by dual channel deep learning in computed tomography images

scientific article published in 2021

Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer

scientific article published on 01 November 2001

Linkage and association studies of prostate cancer susceptibility: evidence for linkage at 8p22-23

scholarly article by J Xu et al published 6 July 2001 in American Journal of Human Genetics

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

scientific article published on 08 November 2018

Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers

scientific article published in 2022

Low-dose inhaled fluticasone propionate versus oral zafirlukast in the treatment of persistent asthma

scientific article published on 01 June 2000

Lung function and symptom improvement with fluticasone propionate/salmeterol and ipratropium bromide/albuterol in COPD: response by beta-agonist reversibility

scientific article published in May 2008

Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation

scientific article

Lung function, airway and peripheral basophils and eosinophils are associated with molecular pharmacogenomic endotypes of steroid response in severe asthma

scientific article published on 27 September 2021

Major genes regulating total serum immunoglobulin E levels in families with asthma

scientific article

Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12.

scientific article published on 15 July 2002

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

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Mapping susceptibility genes for allergic diseases

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Mapping susceptibility genes for asthma and allergy

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Mapping susceptibility genes for asthma and allergy

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Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program

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Mechanisms of asthma

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Meeting the obligation to balance bioethics and clinical trial design in asthma

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Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

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Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma

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Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

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Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines

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Montelukast added to fluticasone propionate does not alter inflammation or outcomes

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More Than a Decade Follow-up in Severe or Difficult-to-Treat Asthma: TENOR II.

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Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers

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Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.

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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

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Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma

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Mutational analysis of PINX1 in hereditary prostate cancer.

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Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

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Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma

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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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No genetic association detected with mepolizumab efficacy in severe asthma

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Once-daily fluticasone furoate is efficacious in patients with symptomatic asthma on low-dose inhaled corticosteroids

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Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report

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Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis

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P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy

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PHENOTYPIC CHARACTERISTICS AND RISK FACTORS ASSOCIATED WITH EXACERBATOR-PRONE ASTHMA IN OLDER ADULTS

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Peripheral airways resistance in smokers.

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Peripheral circulatory alterations in canine anaphylactic shock

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Peripheral lung resistance in normal and asthmatic subjects.

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Pharmacogenetics of asthma: where are we now?

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Pharmacogenetics of the beta 2-adrenergic receptor gene

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Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity

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Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma

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Physiologic effects of inhaled histamine in asthma: Reversible changes in pulmonary mechanics and total lung capacity

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Physiologic manifestations of human anaphylaxis

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Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts

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Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk

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Polymorphisms in SPINK5 are not associated with asthma in a Dutch population

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Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk

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Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma

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Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?

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Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial

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Predicting worsening asthma control following the common cold

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Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies

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Predictors of response to tiotropium versus salmeterol in asthmatic adults

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Proventil HFA provides bronchodilation comparable to ventolin over 12 weeks of regular use in asthmatics

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Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort

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Psychologic factors and bronchial asthma, laboratory model for investigation

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Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program

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Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

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Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS

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Recent advances in the genetics of asthma

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Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

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Regulatory haplotypes in ARG1 are associated with altered bronchodilator response

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Resequencing candidate genes implicates rare variants in asthma susceptibility

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Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort

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Response to mepolizumab treatment is sustained across 4-weekly dosing periods

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Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate to Severe Asthma

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Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation.

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Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study

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Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up

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Roentgenogram of the month. Persistent pleuritic pain in an asthmatic

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Rural Residence and COPD Exacerbations: Analysis of the SPIROMICS Cohort

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SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs.

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Safety and tolerability of the novel inhaled corticosteroid fluticasone furoate in combination with the β2 agonist vilanterol administered once daily for 52 weeks in patients >=12 years old with asthma: a randomised trial

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Safety of investigative bronchoscopy in the Severe Asthma Research Program

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Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma

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Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population

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Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk

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Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk

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Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study

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Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone.

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Severe asthma during childhood and adolescence: A longitudinal study

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Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program

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Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies

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Severity assessment in asthma: An evolving concept

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Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation

Sibling effect on atopy in children of patients with asthma

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Similarities and differences in asthma and COPD. The Dutch hypothesis

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Sleep quality and asthma control and quality of life in non-severe and severe asthma

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Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

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Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma

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Strength in numbers: The quest for asthma genes

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Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers

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Subacute lack of asthma control and acute asthma exacerbation history as predictors of subsequent acute asthma exacerbations: evidence from managed care data

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Subjects with mild and moderate asthma respond to segmental allergen challenge with similar, reproducible, allergen-specific inflammation

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Summary: the pharmacology of leukotrienes in asthma.

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Susceptibility loci regulating total serum IgE levels, bronchial hyperresponsiveness, and clinical asthma map to chromosome 5q

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Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management

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Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS

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T-Cell repertoire in the blood and lungs of atopic asthmatics before and after ragweed challenge

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The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients

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The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS

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The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma

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The Mechanism of Action of Suggestion in the Induction of Acute Asthma Attacks

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The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol

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The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.

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The effect of alpha adrenergic blockade on non-specific airways reactivity and exercise induced asthma.

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The effect of chronic nocturnal oxygen administration upon sleep apnea

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The effects of oxygen in patients with sleep apnea

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The effects of protriptyline in sleep-disordered breathing

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The genetics of asthma and atopy

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The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids

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The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations

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Therapeutic responses in asthma and COPD. Corticosteroids

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Tiotropium Respimat efficacy and safety in asthma: Relationship to age

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Tiotropium Respimat® add-on therapy to inhaled corticosteroids in patients with symptomatic asthma improves clinical outcomes regardless of baseline characteristics

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Tiotropium bromide step-up therapy for adults with uncontrolled asthma

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Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials

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Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study

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Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP

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Two locus segregation and linkage analysis for total serum IgE levels

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Two-Year Integrated Efficacy And Safety Analysis Of Benralizumab In Severe Asthma

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Two-year integrated steroid-sparing analysis and safety of benralizumab for severe asthma

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Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort

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Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

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Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

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Upper airway function in burn patients. Correlation of flow-volume curves and nasopharyngoscopy

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Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma

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Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine

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Variability in objective and subjective measures affects baseline values in studies of patients with COPD.

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Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation

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Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations

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Weight loss, not aerobic exercise, improves pulmonary function in older obese men.

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XXIV World Allergy Congress 2015

scientific article (publication date: April 2016)

XXIV World Allergy Congress 2015: Seoul, Korea. 14-17 October 2015

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eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes

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