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List of works by Brendan W Wren

"Pathotyping" Multiplex PCR Assay for Haemophilus parasuis: a Tool for Prediction of Virulence

scientific article published on 14 June 2017

'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution

scientific article published on February 2016

A Phylogenetic and Phenotypic Analysis of Salmonella enterica Serovar Weltevreden, an Emerging Agent of Diarrheal Disease in Tropical Regions

scientific article published on 11 February 2016

A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni

scientific article published on 23 May 2007

A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni

scientific article published in October 2007

A novel paralogous gene family involved in phase-variable flagella-mediated motility in Campylobacter jejuni

scientific article published on February 2002

A plasmid immunization construct encoding urease B of Helicobacter pylori induces an antigen-specific antibody response and upregulates the expression of beta-defensins and IL-10 in the stomachs of immunized mice

scientific article published in June 2004

Adaptation of Campylobacter jejuni NCTC11168 to high-level colonization of the avian gastrointestinal tract

scientific article published on July 2004

Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1

scientific article

All Yersinia enterocolitica are pathogenic: virulence of phylogroup 1 Y. enterocolitica in a Galleria mellonella infection model

scientific article published on 24 May 2016

Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses

scientific article published on January 2005

Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts

scientific article published on 29 June 2009

Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis

scientific article

Application of comparative phylogenomics to study the evolution of Yersinia enterocolitica and to identify genetic differences relating to pathogenicity

scientific article published on May 2006

Assessing the role of p-cresol tolerance in Clostridium difficile

scientific article published on June 2008

Bacteria like sharing their sweets

scientific article published on 25 July 2013

Bacterial epidemiology and biology - lessons from genome sequencing

scientific article

Bacterial pathogenomics

scientific article

Biofilm development on Caenorhabditis elegans by Yersinia is facilitated by quorum sensing-dependent repression of type III secretion

scientific article

Biological roles of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni

scientific article published on 30 January 2014

Burkholderia pseudomallei: animal models of infection

scientific article

BμG@Sbase--a microbial gene expression and comparative genomic database

scientific article published on 24 September 2011

Campylobacter jejuni glycosylation island important in cell charge, legionaminic acid biosynthesis, and colonization of chickens

scientific article published on 23 March 2009

Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation, and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation

scientific article

Campylobacter jejuni outer membrane vesicle-associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E-cadherin and occludin

scientific article

Campylobacter jejuni-mediated disease pathogenesis: an update

scientific article

Campylobacter--a tale of two protein glycosylation systems

scientific article

Cellular Response of Campylobacter jejuni to Trisodium Phosphate ⬇️

scientific article published on December 22, 2011

Characterisation of Clostridium difficile Biofilm Formation, a Role for Spo0A ⬇️

scientific article published on December 7, 2012

Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae

scientific article

Characterization of N-linked protein glycosylation in Helicobacter pullorum

scientific article

Characterization of New Virulence Factors Involved in the Intracellular Growth and Survival of Burkholderia pseudomallei

scientific article published on 28 December 2015

Characterization of enteropathogenic Escherichia coli of clinical origin from the pediatric population in Pakistan

scientific article published on July 2016

Characterization of the Burkholderia pseudomallei K96243 Capsular Polysaccharide I Coding Region ⬇️

scientific article published on January 17, 2012

Characterization of the structurally diverse N-linked glycans of Campylobacter species

scientific article

Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays

scientific article

Chromosomal integration vectors allowing flexible expression of foreign genes in Campylobacter jejuni

scientific article published on 24 October 2015

Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors

scientific article

Clostridium difficile using DNA microarrays

scientific article

Clostridium difficile--a continually evolving and problematic pathogen

scientific article published on 16 June 2009

Commonality and biosynthesis of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni

scientific article

Comparative analysis of BI/NAP1/027 hypervirulent strains reveals novel toxin B-encoding gene (tcdB) sequences

scientific article

Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium

scientific article

Comparative phylogenomics of Streptococcus pneumoniae isolated from invasive disease and nasopharyngeal carriage from West Africans

scientific article

Comparative phylogenomics of pathogenic bacteria by microarray analysis

scientific article

Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source

scientific article

Comparative sequence analysis of the capsular polysaccharide loci of Actinobacillus pleuropneumoniae serovars 1-18, and development of two multiplex PCRs for comprehensive capsule typing.

scientific article

Comprehensive Longitudinal Microbiome Analysis of the Chicken Cecum Reveals a Shift From Competitive to Environmental Drivers and a Window of Opportunity for

scientific article published in 2018

Comprehensive longitudinal microbiome analysis of the chicken cecum reveals a shift from competitive to environmental drivers and a window of opportunity forCampylobacter

Construction of a Yersinia pestis microarray

scientific article published on January 2003

Corrigendum to ‘Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae’ [Veterinary Microbiology 178 (2015) 279–282].

scientific article published in September 2015

Cyclic diGMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage

scientific article published on 17 August 2015

Cytoplasmic glycoengineering of Apx toxin fragments in the development of Actinobacillus pleuropneumoniae glycoconjugate vaccines

article

Deciphering tsetse's secret partner

scientific article published on 01 November 2002

Deletion of a previously uncharacterized flagellar-hook-length control gene fliK modulates the sigma54-dependent regulon in Campylobacter jejuni

scientific article published in September 2007

Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux

scientific article

Development of a Multiplex PCR Assay for Rapid Molecular Serotyping of Haemophilus parasuis

scientific article

Development of a self-replicating plasmid system for Mycoplasma hyopneumoniae

scientific article published on 29 July 2013

Draft Genome Sequence of Campylobacter jejuni 11168H

scientific article published on 2 February 2017

Draft Genome Sequence of Robinsoniella peoriensis 6600698, a Confounder of Clostridium difficile Diagnosis

scientific article published on 17 November 2016

Draft Genome Sequence of the Enteropathogenic Bacterium Campylobacter jejuni Strain cj255

scientific article

Effect of chicken meat environment on gene expression of Campylobacter jejuni and its relevance to survival in food.

scientific article published on 7 September 2010

Emergence and global spread of epidemic healthcare-associated Clostridium difficile

scientific article published on 9 December 2012

Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage ⬇️

scientific article published on September 8, 2011

Enteric bacterial invasion of intestinal epithelial cells in vitro is dramatically enhanced using a vertical diffusion chamber model

scientific article published on 22 October 2013

Erratum: Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

scientific article published on 12 May 2015

Escherichia coli Pathotypes in Pakistan from Consecutive Floods in 2010 and 2011 ⬇️

scientific article published on January 28, 2013

Evidence of Yersinia pestis DNA from fleas in an endemic plague area of Zambia ⬇️

scientific article published on January 26, 2012

Evolutionary dynamics of Clostridium difficile over short and long time scales

scientific article published on 20 April 2010

Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis

scientific article

Explorative multifactor approach for investigating global survival mechanisms of Campylobacter jejuni under environmental conditions

scientific article

Functional analysis of N-linking oligosaccharyl transferase enzymes encoded by deep-sea vent proteobacteria

scientific article

Functional analysis of the Campylobacter jejuni N-linked protein glycosylation pathway

scientific article published on March 2005

Functional analysis of the Helicobacter pullorum N-linked protein glycosylation system

scientific article published on 11 January 2018

Further strategies for signature-tagged mutagenesis and the application of oligonucleotide microarrays for the quantification of DNA-tagged strains

Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis

scientific article published on 21 April 2009

Galleria mellonella is an effective model to study Actinobacillus pleuropneumoniae infection

scientific article published on 20 November 2014

Galleria mellonella is low cost and suitable surrogate host for studying virulence of human pathogenic Vibrio cholerae

scientific article

Gene content and diversity of the loci encoding biosynthesis of capsular polysaccharides of the 15 serovar reference strains of Haemophilus parasuis

scientific article published on 19 July 2013

Gene function hypotheses for the Campylobacter jejuni glycome generated by a logic-based approach

scientific article published on 24 October 2012

Generation of a Tn5 transposon library in Haemophilus parasuis and analysis by transposon-directed insertion-site sequencing (TraDIS).

scientific article

Genes to genetic immunization: identification of bacterial vaccine candidates ⬇️

scientific article published on November 1, 2003

Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence

scientific article published on 18 December 2015

Genome-wide evaluation of the interplay between Caenorhabditis elegans and Yersinia pseudotuberculosis during in vivo biofilm formation

scientific article

Genomic epidemiology of Vibrio cholerae O1 associated with floods, Pakistan, 2010.

scientific article

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

scientific article

Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes

scientific article published on 21 March 2011

Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system

scientific article

Glycoproteomics: a powerful tool for characterizing the diverse glycoforms of bacterial pilins and flagellins ⬇️

scientific article published on October 1, 2010

Helicobacter pylori adherence to gastric epithelial cells: a role for non-adhesin virulence genes

scientific article

Hijacking bacterial glycosylation for the production of glycoconjugates, from vaccines to humanised glycoproteins

scientific article

Host immunity to Clostridium difficile PCR ribotype 017 strains

scientific article

Hypervirulent Clostridium difficile PCR-ribotypes exhibit resistance to widely used disinfectants

scientific article

ICEApl1, an Integrative Conjugative Element Related to ICEHin1056, Identified in the Pig Pathogen Actinobacillus pleuropneumoniae

scientific article

Identification and characterisation of a novel adhesin Ifp in Yersinia pseudotuberculosis ⬇️

scientific article published on April 28, 2011

Identification of N-acetylgalactosamine-containing glycoproteins PEB3 and CgpA in Campylobacter jejuni

scientific article published on January 2002

Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae

scientific article

Identification of immunogenic and virulence-associated Campylobacter jejuni proteins

scientific article

Identification of possible virulence marker from Campylobacter jejuni isolates

scientific article

Improved bacterial mutagenesis by high-frequency allele exchange, demonstrated in Clostridium difficile and Streptococcus suis

scientific article published on 31 May 2013

In-depth genetic analysis ofClostridiumdifficilePCR-ribotype 027 strains reveals high genome fluidity including point mutations and inversions ⬇️

scientific article published on March 16, 2010

Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences

scientific article published on 21 June 2016

Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity

scientific article published on March 2010

Intestinal innate immunity to Campylobacter jejuni results in induction of bactericidal human beta-defensins 2 and 3.

scientific article

Intracellular replication of the well-armed pathogen Burkholderia pseudomallei

scientific article

Invertebrates as a source of emerging human pathogens

scientific article published in October 2004

Liposomal delivery of p-ialB and p-omp25 DNA vaccines improves immunogenicity but fails to provide full protection against B. melitensis challenge

scientific article published on 16 July 2010

LsaA, an antigen involved in cell attachment and invasion, is expressed by Lawsonia intracellularis during infection in vitro and in vivo

scientific article

Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations

scientific article

Microarray analysis of campylobacter jejuni: to the guts of the problem!

scientific article

Microarray analysis of the transcriptional responses of Clostridium difficile to environmental and antibiotic stress

scientific article published in June 2008

Microarrays for bacterial pathogens - hope or hype? ⬇️

scientific article published on January 2002

Mucosal immunization with a urease B DNA vaccine induces innate and cellular immune responses against Helicobacter pylori.

scientific article

Multiplex PCR assay for unequivocal differentiation of Actinobacillus pleuropneumoniae serovars 1 to 3, 5 to 8, 10, and 12.

scientific article

N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli

scientific article

N-linked glycosylation in bacteria: an unexpected application

scientific article published on May 2009

Neutrophil extracellular traps exhibit antibacterial activity against burkholderia pseudomallei and are influenced by bacterial and host factors

scientific article

New levels of sophistication in the transcriptional landscape of bacteria

scientific article published on 03 August 2009

Numerical analysis of DNA microarray data of Campylobacter jejuni strains correlated with survival, cytolethal distending toxin and haemolysin analyses

scientific article

Parallel independent evolution of pathogenicity within the genus Yersinia

scientific article

Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014.

scientific article published on 13 June 2017

Phenotypic and genotypic characterization of enteroaggregative Escherichia coli isolates from pediatric population in Pakistan

scientific article published on 2 August 2016

Population Biology of Streptococcus pneumoniae in West Africa: Multilocus Sequence Typing of Serotypes That Exhibit Different Predisposition to Invasive Disease and Carriage ⬇️

scientific article published on January 16, 2013

Production and efficacy of a low-cost recombinant pneumococcal protein polysaccharide conjugate vaccine.

scientific article published on 25 May 2018

Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis

scientific article published on 16 February 2018

Protein glycosylation in bacterial mucosal pathogens

scientific article

Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction

scientific article

Quantitative Analyses Reveal Novel Roles for Glycosylation in a Major Enteric Bacterial Pathogen

scientific article published in 2019

Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence

scientific article

Recent advances in systems microbiology

scientific article published on 11 September 2009

Recent advances in the production of recombinant glycoconjugate vaccines

article

Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design ⬇️

scientific article published on April 19, 2012

Recombinant expression of Streptococcus pneumoniae capsular polysaccharides in Escherichia coli

scientific article

Revised nomenclature of Clostridium difficile toxins and associated genes

scientific article published in February 2005

Role of Glycosyltransferases Modifying Type B Flagellin of Emerging Hypervirulent Clostridium difficile Lineages and Their Impact on Motility and Biofilm Formation

scientific article published on 04 October 2016

Role of the Cj1371 periplasmic protein and the Cj0355c two-component regulator in the Campylobacter jejuni NCTC 11168 response to oxidative stress caused by paraquat

scientific article

Serotype differences and lack of biofilm formation characterize Yersinia pseudotuberculosis infection of the Xenopsylla cheopis flea vector of Yersinia pestis

scientific article

Shared characteristics between Mycobacterium tuberculosis and fungi contribute to virulence

scientific article published on January 2014

Signature-tagged mutagenesis of Yersinia pestis

scientific article

Simple sequence repeats in Helicobacter canadensis and their role in phase variable expression and C-terminal sequence switching

scientific article

Sodium Taurocholate Stimulates Campylobacter jejuni Outer Membrane Vesicle Production via Down-Regulation of the Maintenance of Lipid Asymmetry Pathway.

scientific article published on 29 May 2019

Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens

scientific article

Structural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system

scientific article published on June 2002

Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC.

scientific article published on 6 March 2018

Temporal changes in nasopharyngeal carriage of Streptococcus pneumoniae serotype 1 genotypes in healthy Gambians before and after the 7-valent pneumococcal conjugate vaccine

scientific article

The Campylobacter jejuni MarR-like transcriptional regulators RrpA and RrpB both influence bacterial responses to oxidative and aerobic stresses

scientific article published on 21 July 2015

The Campylobacter jejuni NCTC11168 capsule prevents excessive cytokine production by dendritic cells ⬇️

scientific article published on August 24, 2011

The Campylobacter jejuni glycome

scientific article

The Campylobacter jejuni transcriptional regulator Cj1556 plays a role in the oxidative and aerobic stress response and is important for bacterial survival in vivo

scientific article published on 3 June 2011

The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor ⬇️

scientific article published on May 21, 2012

The RovA regulons of Yersinia enterocolitica and Yersinia pestis are distinct: evidence that many RovA-regulated genes were acquired more recently than the core genome

scientific article published on 03 September 2007

The S-layer protein of a SLCT-11 strain displays a complex glycan required for normal cell growth and morphology

scientific article published in Journal of Biological Chemistry

The Streptococcos suis sortases SrtB and SrtF are essential for disease in pigs

scientific article published on 13 December 2018

The Type B Flagellin of Hypervirulent Clostridium difficile Is Modified with Novel Sulfonated Peptidylamido-glycans

scientific article published on 07 October 2016

The agr locus regulates virulence and colonization genes in Clostridium difficile 027.

scientific article

The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains

scientific article

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.

scientific article

The complete genome sequence of Francisella tularensis, the causative agent of tularemia

scientific article

The continually evolving Clostridium difficile species

scientific article published on August 2012

The generation of successive unmarked mutations and chromosomal insertion of heterologous genes in Actinobacillus pleuropneumoniae using natural transformation

scientific article

The importance of the Rcs phosphorelay in the survival and pathogenesis of the enteropathogenic yersiniae

scientific article published on April 2008

The importance of the glycosylation of antimicrobial peptides: natural and synthetic approaches

scientific article

The importance of the magnesium transporter MgtB for virulence of Yersinia pseudotuberculosis and Yersinia pestis

scientific article published on 18 September 2014

The induction and identification of novel Colistin resistance mutations in Acinetobacter baumannii and their implications

scientific article published on 22 June 2016

The insect toxin complex of Yersinia

scientific article published on January 2007

The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

scientific article

The post-translational modification of the Clostridium difficile flagellin affects motility, cell surface properties and virulence ⬇️

scientific article published on 15 September 2014

The second century of Campylobacter research: recent advances, new opportunities and old problems

scientific article published on October 2007

The sudden dominance of blaCTX-M harbouring plasmids in Shigella spp. Circulating in Southern Vietnam

scientific article

The twin arginine translocation system is essential for aerobic growth and full virulence of Burkholderia thailandensis

scientific article published on 8 November 2013

The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis

scientific article published on 24 December 2014

The yersiniae--a model genus to study the rapid evolution of bacterial pathogens

scientific article published on October 2003

Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores

scientific article

Transposon mutagenesis in Mycoplasma hyopneumoniae using a novel mariner-based system for generating random mutations

scientific article

Understanding and managing zoonotic risk in the new livestock industries

scientific article published on 10 May 2013

Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs

scientific article published on 4 December 2017

Vibrio cholerae accessory colonisation factor AcfC: a chemotactic protein with a role in hyperinfectivity.

scientific article published on 30 May 2018

Whole Genome Sequencing for Surveillance of Antimicrobial Resistance in Actinobacillus pleuropneumoniae

scientific article published on 06 March 2017

Whole genome investigation of a divergent clade of the pathogen Streptococcus suis

scientific article

YPTB3816 of Yersinia pseudotuberculosis strain IP32953 is a virulence-related metallo-oligopeptidase

scientific article

Yersinia enterocolitica provides the link between thyroid-stimulating antibodies and their germline counterparts in Graves' disease

scientific article published on 29 April 2013

Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1 ⬇️

scientific article published on December 23, 2010

YtxR acts as an overriding transcriptional off switch for the Yersinia enterocolitica Ysc-Yop type 3 secretion system

scientific article published on 14 November 2008

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