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List of works by Justin Hanes

A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue

scientific article

A diaCEST MRI approach for monitoring liposomal accumulation in tumors

scientific article published on 15 February 2014

A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles

scientific article published on 3 September 2011

Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier

scientific article published on January 2008

Altering mucus rheology to"solidify" human mucus at the nanoscale

scientific article

Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain

scientific article published on 17 December 2015

Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus ⬇️

scientific article published on February 18, 2011

Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors

scientific article published on 07 July 2017

Biodegradable mucus-penetrating nanoparticles composed of diblock copolymers of polyethylene glycol and poly(lactic-co-glycolic acid)

scientific article published on April 2012

Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles

scientific article

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

scientific article published on 24 August 2016

Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy

scientific article published on 11 March 2016

Common Gene Therapy Viral Vectors Do Not Efficiently Penetrate Sputum from Cystic Fibrosis Patients ⬇️

scientific article published on May 27, 2011

Constitutive model development and micro-structural topology optimisation for nafion hydrogel membranes with ionic clustering

scientific article published in January 2003

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats

scientific article published on 6 March 2017

Development of Absorbable, Antibiotic-Eluting Sutures for Ophthalmic Surgery

scientific article published on 03 January 2017

Directed evolution for drug and nucleic acid delivery

scientific article published on 28 August 2007

Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus

scientific article

Efficient active transport of gene nanocarriers to the cell nucleus

scientific article

Enhanced adhesion of ligand-conjugated biodegradable particles to colitic venules

scientific article

Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo

scientific article published on 30 September 2009

Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport

scientific article published on 17 September 2003

Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-l-lysine ⬇️

scientific article published on December 17, 2011

Enhancing Intracranial Delivery of Clinically Relevant Non-viral Gene Vectors

scientific article published on 19 April 2016

Ex Vivo Characterization of Particle Transport in Mucus Secretions Coating Freshly Excised Mucosal Tissues ⬇️

scientific article published on May 23, 2013

Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation

scientific article published on 13 December 2017

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

scientific article published on 19 February 2013

Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles

scientific article published on October 2006

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

scientific article

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

scientific article

Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus

scientific article

Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection

scientific article published on 30 October 2017

Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina

scientific article

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

scientific article published on 24 August 2015

Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies

scientific article published on 27 April 2002

Large porous particle impingement on lung epithelial cell monolayers--toward improved particle characterization in the lung

scientific article published on May 2003

Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma

scientific article published in April 2003

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

scientific article published on 14 January 2014

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound

scientific article

Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles ⬇️

scientific article published on July 16, 2012

Micro- and macrorheology of mucus

scientific article

Microstructural alterations of sputum in cystic fibrosis lung disease

scientific article

Model development and numerical simulation of electric-stimulus-responsive hydrogels subject to an externally applied electric field.

scientific article

Mucoadhesive Nanoparticles May Disrupt the Protective Human Mucus Barrier by Altering Its Microstructure ⬇️

scientific article published on June 29, 2011

Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces

scientific article published on 26 September 2016

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

scientific article published on 13 December 2008

Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus

scientific article published on June 2012

Nanoparticle diffusion in respiratory mucus from humans without lung disease

scientific article published on 4 February 2013

Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo

scientific article published on 28 January 2013

Nanoparticle-based drug delivery to the vagina: a review

scientific article

Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo

scientific article published on 12 May 2016

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

scientific article

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

scientific article

New technology and clinical applications of nanomedicine: highlights of the second annual meeting of the American Academy of Nanomedicine (Part I).

scientific article

Non-degradative intracellular trafficking of highly compacted polymeric DNA nanoparticles ⬇️

scientific article published on October 30, 2011

Novel Approaches to Vaginal Delivery and Safety of Microbicides: Biopharmaceuticals, Nanoparticles, and Vaccines ⬇️

scientific article published on December 1, 2010

Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model

scientific article

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers ⬇️

scientific article published on December 24, 2011

Overcoming the cystic fibrosis sputum barrier to leading adeno-associated virus gene therapy vectors

scientific article

PEGylation of nanoparticles improves their cytoplasmic transport

scientific article published on January 2007

Particle tracking in drug and gene delivery research: State-of-the-art applications and methods

scientific article

Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography

scientific article

Photoactivatable fluorescent probes reveal heterogeneous nanoparticle permeation through biological gels at multiple scales

scientific article published on 31 May 2017

Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs

scientific article

Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective, avid, and focal adhesion to sites of atherosclerosis

scientific article published in October 2008

Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway

scientific article published on 27 February 2007

Protein nanocages that penetrate airway mucus and tumor tissue

scientific article published on 24 July 2017

Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons

scientific article published in March 2007

Rapid Transport of Muco-Inert Nanoparticles in Cystic Fibrosis Sputum Treated with N -Acetyl Cysteine ⬇️

scientific article published on February 1, 2011

Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

scientific article

Real-time intracellular transport of gene nanocarriers studied by multiple particle tracking

scientific article published in March 2004

Real-time multiple-particle tracking: applications to drug and gene delivery

scientific article

Real‐time gene delivery vector tracking in the endo‐lysosomal pathway of live cells ⬇️

scientific article published on November 17, 2011

Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus

scientific article published on 07 June 2013

Scleral permeability varies by mouse strain and is decreased by chronic experimental glaucoma

scientific article

Strategies to enhance the distribution of nanotherapeutics in the brain

scientific article

Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits

scientific article published on 23 June 2016

Sustained delivery of a HIF-1 antagonist for ocular neovascularization

scientific article

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

scientific article published on 28 December 2015

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound

scientific article

The Mucus Barrier to Inhaled Gene Therapy

scientific article published on 20 September 2016

The microstructure and bulk rheology of human cervicovaginal mucus are remarkably resistant to changes in pH

scientific article

Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus ⬇️

scientific article published on July 29, 2011

Transport of polymeric nanoparticle gene carriers in gastric mucus

scientific article

Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers

scientific article

Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth

scientific article

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