Search filters

List of works by Linda Partridge

1-Methyl-4-phenylpridinium (MPP+)-induced functional run-down of GABA(A) receptor-mediated currents in acutely dissociated dopaminergic neurons.

scientific article published in October 2002

2nd interventions in aging conference

scientific article

A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster

scientific article published on 01 March 2019

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

scientific article

A Drosophila insulin-like peptide promotes growth during nonfeeding states

scientific article

A case of mistaken identity in swordtail fish

scientific article published in Nature

A comparison of the genetic basis of wing size divergence in three parallel body size clines of Drosophila melanogaster.

scientific article

A cost of mating in female fruitflies

scientific article published in Nature

A crash course in survival

scientific article published in Nature

A delayed wave of death from reproduction in Drosophila.

scientific article published in December 1999

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice ⬇️

scientific article published on January 1, 2012

A functioning ovary is not required for sex peptide to reduce receptivity to mating in D. melanogaster

scientific article published on 10 January 2007

A holidic medium for Drosophila melanogaster

scientific article

A human monoclonal antiendothelial cell autoantibody uses a VH gene associated with an anti-DNA autoantibody

scientific article published on 01 May 1997

A longer and healthier life with TOR down-regulation: genetics and drugs

scientific article published on April 2011

A mortality cost of virginity at older ages in female Mediterranean fruit flies.

scientific article

A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data

scientific article published on 26 October 2020

A nutritional memory effect counteracts benefits of dietary restriction in old mice

scientific article published on 21 October 2019

A paradox for biology

scientific article published on 01 May 1991

A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.

scientific article published on 15 September 2017

A singular view of ageing

scientific article published in Nature

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

scientific article published on 30 September 2019

AN INTERACTION BETWEEN ENVIRONMENTAL TEMPERATURE AND GENETIC VARIATION FOR BODY SIZE FOR THE FITNESS OF ADULT FEMALE DROSOPHILA MELANOGASTER.

scientific article published in August 1997

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

scientific article

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

scientific article published on 4 March 2016

Action of diphenylamine carboxylate derivatives, a family of non-steroidal anti-inflammatory drugs, on [Ca2+]i and Ca(2+)-activated channels in neurons

scientific article published on 01 May 1995

Activation and modulation of calcium-activated non-selective cation channels from embryonic chick sensory neurons ⬇️

scientific article published on October 1, 1993

Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

scientific article

Adaptation and constraint in the evolution of Drosophila melanogaster wing shape.

scientific article published in March 2000

Ageing as a Risk Factor for Disease ⬇️

scientific article published on September 11, 2012

Ageing as a risk factor for ALS/FTD.

scientific article published in October 2017

Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network

scientific article

Ageing increases vulnerability to aβ42 toxicity in Drosophila

scientific article (publication date: 2012)

Ageing: A lethal side-effect

scientific article published in Nature

Ageing: levelling of the grim reaper.

scientific article published on July 1997

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

scientific article

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

scientific article published on 19 June 2020

An in vitro system for the study of tracheal epithelial cells

scientific article published on 01 January 1987

Antagonizing Methuselah to extend life span

scientific article published in 2007

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

scientific article published on 16 December 2015

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo

scientific article published on 11 April 2015

BERGMANN'S RULE IN ECTOTHERMS: IS IT ADAPTIVE?

scientific article

Behavioural genetics: Molecular genetics meets feeding ecology ⬇️

scientific article published on January 1, 1998

Benchmarks for ageing studies

scientific article published in Nature

Beyond the evolutionary theory of ageing, from functional genomics to evo-gero

scientific article published on 10 March 2006

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

scientific article

Biological mechanisms of aging predict age-related disease co-occurrence in patients

scientific article published on 08 March 2022

Biomarkers of aging in Drosophila

scientific article published on 29 March 2010

Block of hippocampal CAN channels by flufenamate

Body size and cell size in Drosophila: the developmental response to temperature.

scientific article published in November 1998

Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control

scientific article published on 29 April 2019

Branched-Chain Amino Acids Have Equivalent Effects to Other Essential Amino Acids on Lifespan and Aging-Related Traits in Drosophila

scientific article published on 01 January 2020

Brief carbon dioxide exposure blocks heat hardening but not cold acclimation in Drosophila melanogaster

scientific article published on 10 August 2007

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A

article

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

scientific article published on 07 August 2014

CANARY ISLAND BLUE TITS AND ENGLISH COAL TITS: CONVERGENT EVOLUTION?

scientific article published in September 1977

Ca2+ store-dependent potentiation of Ca2+-activated non-selective cation channels in rat hippocampal neurones in vitro

scientific article published on 01 December 1999

Calcium buffering in bursting Helix pacemaker neurons.

scientific article published on December 1993

Calcium-activated non-selective channels in the nervous system

scientific article published on 01 August 1994

Calories do not explain extension of life span by dietary restriction in Drosophila

scientific article published on 31 May 2005

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

scientific article

Celebrating 350 years of Philosophical Transactions: life sciences papers

scientific article

Cell-mediated immunity in calves experimentally infected with BHV-1

scientific article published on 01 November 1990

Cell-nonautonomous effects of dFOXO/DAF-16 in aging

scientific article published on 06 February 2014

Cellular basis and developmental timing in a size cline of Drosophila melanogaster.

scientific article

Cellular basis of wing size variation in Drosophila melanogaster: a comparison of latitudinal clines on two continents.

scientific article published in March 2000

Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

scientific article published on 12 July 2017

Characterization of a complement-fragment-C5a-stimulated calcium-influx mechanism in U937 monocytic cells.

scientific article published on November 1993

Characterization of a monoclonal antibody recognizing a novel leucocyte adhesion molecule

scientific article published on 01 April 1990

Chemical Complexity and the Genetics of Aging

scientific article

Chemical changes in aging Drosophila melanogaster.

scientific article

Cloning and Characterisation of TPO Autoantibodies Using Combinatorial Phage Display Libraries ⬇️

scientific article published on January 1, 1994

Cocaine inhibits 5-HT3 receptor function in neurons from transgenic mice overexpressing the receptor.

scientific article

Combined whole-cell and single-channel current measurement with quantitative Ca2+ injection or Fura-2 measurement of Ca2+

scientific article published on 01 January 1998

Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting calories in Drosophila dietary restriction"Exp. Gerontology, doi:10.1016/j.exger.2006.10.009.

scientific article published on 17 January 2007

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

scientific article published on 01 May 2008

Comments from the departing Editor

scientific article published on February 2016

Comments from the new Editor

scientific article published in January 2011

Comparison of human monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation/activation states

scientific article published on 01 March 1988

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

scientific article published on 10 November 2015

Complex roles of myoglianin in regulating adult performance and lifespan.

scientific article published on 24 August 2017

Computational analysis of alpha-helical membrane protein structure: implications for the prediction of 3D structural models.

scientific article

Contributions of SERCA pump and ryanodine-sensitive stores to presynaptic residual Ca2+.

scientific article

Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.

scientific article

Correcting for sequence biases in present/absent calls

scientific article published on January 2007

Correction: Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

scientific article

Correlated responses to selection on body size in Drosophila melanogaster

scientific article published on 01 August 1999

Could cancer drugs provide ammunition against aging?

scientific article published on 20 November 2015

Counting the calories: the role of specific nutrients in extension of life span by food restriction

scientific article

Current developments at Philosophical Transactions of the Royal Society B.

scientific article published on January 2012

Cytochemical localization of adenyl cyclase in isoproterenol stimulated hepatoma ascites cells

scientific article published on 01 January 1984

Cytoplasmic Ca2+ activity regulation as measured by a calcium-activated current.

scientific article published in May 1994

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

scientific article published on 12 February 2010

DIRECT AND CORRELATED RESPONSES TO SELECTION ON AGE AT REPRODUCTION IN DROSOPHILA MELANOGASTER

scientific article published on 01 February 1992

Death and dessert: nutrient signalling pathways and ageing

scientific article published on 09 August 2011

Deletion of endogenous Tau proteins is not detrimental in Drosophila

scientific article published on 15 March 2016

Demography of dietary restriction and death in Drosophila

scientific article

Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies

scientific article

Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission

scientific journal article

Dibutyryl cyclic AMP stimulation of a monocyte-like cell line, U937: a model for monocyte chemotaxis and Fc receptor-related functions

scientific article published on 01 March 1988

Diet and healthy aging

scientific article published on 01 December 2012

Diet, metabolism and lifespan in Drosophila

scientific article

Dietary Protein, Metabolism, and Aging

scientific article published on 29 April 2016

Dietary restriction and aging: a unifying perspective

scientific article published on August 2011

Dietary restriction extends lifespan in wild-derived populations of Drosophila melanogaster

scientific article

Dietary restriction in Drosophila.

scientific article

Dietary restriction in Drosophila: delayed aging or experimental artefact?

scientific article (publication date: 27 April 2007)

Dietary restriction in long-lived dwarf flies

scientific article published in April 2002

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

scientific article published on 28 March 2017

Dietary restriction, mortality trajectories, risk and damage

scientific article

Different cell size and cell number contribution in two newly established and one ancient body size cline of Drosophila subobscura

scientific article published in March 2003

Different routes to similar ends

scientific article published in Nature

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

scientific article

Dissociated dopaminergic neurons from substantia nigra zona compacta in young rats lack functional NMDA receptors ⬇️

scientific article published on April 1, 1998

Does the CDR3 of the heavy chain determine the specificity of autoantibodies in systemic lupus erythematosus?

scientific article published on 01 October 1998

Drosophila as a model for ageing.

scientific article published on 27 September 2017

Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation

scientific article

Drug repurposing for ageing research using model organisms

Drug repurposing for aging research using model organisms

scientific article published on 16 June 2017

Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila

scientific article published on 28 October 2020

Dynamics of the action of dFOXO on adult mortality in Drosophila

scientific article published on 26 April 2007

EVOLUTION AND DEVELOPMENT OF BODY SIZE AND CELL SIZE IN DROSOPHILA MELANOGASTER IN RESPONSE TO TEMPERATURE.

scientific article published on August 1994

EVOLUTIONARY EFFECTS OF SELECTION ON AGE AT REPRODUCTION IN LARVAL AND ADULT: DROSOPHILA MELANOGASTER.

scientific article

Editorial 2014.

scientific article

Editorial 2015

scientific article (publication date: 24 November 2014)

Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster.

scientific article

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

scientific article

Electrophysiological recordings from the giant fiber pathway of D. melanogaster

scientific article published on 14 January 2011

Endocrine regulation of aging and reproduction in Drosophila

scientific article published on 17 July 2008

Erratum to "Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease." [Neurobiol. Aging 32 (2011) 1977-1989].

scientific article published on 29 May 2015

Estimation and correction of non-specific binding in a large-scale spike-in experiment

scientific article

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

scientific article

Evolution of aging: testing the theory using Drosophila.

scientific article published on January 1993

Evolution: Contentious issues in sexual selection

scientific article published in Nature

Evolutionary biology. What the sperm count costs

scientific article published on December 3, 1992

Evolutionary biology: Costs of reproduction

scientific article published in Nature

Evolutionary biology: Group selection and the sex ratio

scholarly article by Paul H. Harvey et al published January 1985 in Nature

Evolutionary conservation of regulated longevity assurance mechanisms

scientific article published on January 2007

Evolving evolvability

scientific article published in Nature

Experimental analysis of risk factors for ulcerative dermatitis in mice

scientific article published on 01 September 2012

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

scientific article published on May 2009

Extending healthy life span--from yeast to humans

scientific article

Facing up to the global challenges of ageing

scientific article published in Nature

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

scientific article published on 18 June 2015

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

scientific article published on 10 November 2015

Feeding, fecundity and lifespan in female Drosophila melanogaster

scientific article published in July 2008

Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males.

scientific article published in June 1996

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

scientific article published on 30 November 2020

Flight activity, mortality rates, and lipoxidative damage in Drosophila

scientific article published in February 2006

Forever young

scholarly article

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

scientific article published on 7 November 2017

Gender and longevity: why do men die earlier than women? Comparative and experimental evidence

scientific article published on 22 June 2013

Gene Expression-Based Drug Repurposing to Target Ageing

article

Gene expression-based drug repurposing to target aging

article

Gene-environment interaction for body size and larval density in Drosophila melanogaster: an investigation of effects on development time, thorax length and adult sex ratio.

scientific article published in May 1994

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

scientific journal article

Genetic and environmental responses to temperature of Drosophila melanogaster from a latitudinal cline.

scientific article

Genetic models of C9orf72: what is toxic?

scientific article published on 29 March 2017

Genetic variation for total fitness in Drosophila melanogaster: complex yet replicable patterns

scientific article

Genetics of longevity in model organisms: debates and paradigm shifts

scientific article

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

scientific article

Genome-wide gene expression in response to parasitoid attack in Drosophila

scientific article

Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster

scientific article published on April 2002

Genome-wide transcription analysis of clinal genetic variation in Drosophila

scientific article

Geographic variation in competitive ability in Drosophila melanogaster

scientific article published on 01 June 1998

Gerontology: Extending the healthspan

journal article; published in Nature on 2016-01-13

Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

scientific article published on 16 December 2019

Good Ol' Fat: Links between Lipid Signaling and Longevity.

scientific article published on 9 August 2017

Growing old gracefully

scientific article published in Nature

Guidance on clinical research involving infants, children and young people: an update for researchers and research ethics committees.

scientific article published on 9 June 2014

Haldane's rule and the hazards of heterogamety

scientific article published on 01 January 1993

Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity

article

Heritability of pre-adult viability differences can explain apparent heritability of sperm displacement ability in Drosophila melanogaster.

scientific article published in September 1997

High-performance liquid chromatographic determination of lombricine and N-phosphoryl lombricine in the earthworm by pre-column fluorescence derivatisation with o-phthaldialdehyde-ethanethiol

scientific article published on 01 July 1988

Horizons in the evolution of aging

Hydroxylamine blocks adenosine A1 receptor-mediated inhibition of synaptic transmission in rat hippocampus.

scientific article published in January 1999

Identifying Potential Ageing-Modulating Drugs In Silico

scientific article published on 20 December 2018

Immunocytochemical localization of tubulin with colloidal gold in cilia of rabbit tracheal epithelial cultures.

scientific article published on January 1983

Immunogenic and antigenic epitopes of immunoglobulins. II. Antigenic differences between secreted and membrane IgG demonstrated using monoclonal antibodies

scientific article published on 01 January 1982

Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

scientific article published on 6 March 2018

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

scientific article published on 09 August 2016

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

scientific article published on September 2016

Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling

scientific article published on 14 September 2020

Influence of female reproductive anatomy on the outcome of sperm competition in Drosophila melanogaster.

scientific article published in March 2003

Influence of temperature and activity on the metabolic rate of adult Drosophila melanogaster.

scientific article

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

scientific article

Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system

scientific article published in 2024

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing

scientific article

Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary

scientific article published in April 2005

Insulin signalling regulates remating in female Drosophila

scientific article published on 25 August 2010

Insulin/IGF-like signalling, the central nervous system and aging

scientific article

Interactions of mating, egg production and death rates in females of the Mediterranean fruit fly, Ceratitis capitata.

scientific article published in October 1998

Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster

scientific article

Interpreting interactions between treatments that slow aging

scientific article

Intervening in ageing to prevent the diseases of ageing

scientific article published on 29 August 2014

Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

scientific article published in October 2017

Intracellular calcium signaling induced by thapsigargin in excitable and inexcitable cells.

scientific article published on December 1994

Invertebrate models of age-related muscle degeneration

scientific article published on 27 June 2009

Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster.

scientific article published in April 2005

Isoprenaline-induced and constitutive members of a proline-rich protein sub-group from mouse parotid glands studied with monoclonal antibody NAL1

scientific article published on 01 July 1989

Joint regulation of cell size and cell number in the wing blade of Drosophila melanogaster

scientific article published on 01 February 1997

Kindred spirits

scientific article published in Nature

LATITUDINAL VARIATION OF WING:THORAX SIZE RATIO AND WING-ASPECT RATIO IN DROSOPHILA MELANOGASTER.

scientific article published in October 1998

Laboratory adaptation of life history in Drosophila

scientific article published on 01 December 2001

Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila

scientific article published in June 2004

Life history response of Mediterranean fruit flies to dietary restriction

scientific article published in December 2002

Life-history consequences of egg size in Drosophila melanogaster.

scientific article published in August 1997

Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity

scientific article published in July 2004

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor

scientific article

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

scientific article published on 7 April 2016

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease

scientific article (publication date: 30 July 2014)

Long-lived Drosophila with overexpressed dFOXO in adult fat body

scientific article published on 10 June 2004

Long-term in vivo imaging of Drosophila larvae

scientific article published on 10 February 2020

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

scientific article

Longevity GWAS Using the Drosophila Genetic Reference Panel

scientific article

Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production

scientific article published on 13 November 2019

Longevity of Indy mutant Drosophila not attributable to Indy mutation

scholarly article

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

scientific article

Loss of miR-210 leads to progressive retinal degeneration in

scientific article published on 22 January 2019

Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila

scientific article

MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals

scientific article

Male size and mating success in Drosophila melanogaster and D. pseudoobscura under field conditions

Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster

scientific article

Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan

scientific article published on May 2017

Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan.

scientific article published on March 2017

Mate choice increases a component of offspring fitness in fruit flies

scientific article published in Nature

Mating and hormonal triggers regulate accessory gland gene expression in male Drosophila

scientific article published on 01 November 1997

Mating-induced inhibition of remating in female Mediterranean fruit flies Ceratitis capitata.

scientific article published in November 1999

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix

scientific article published on March 2011

Measuring fitness by means of balancer chromosomes

scientific article published on 01 June 2000

Measuring reproductive costs.

scientific article

Mechanism of action of the non-steroidal anti-inflammatory drug flufenamate on [Ca2+]i and Ca(2+)-activated currents in neurons

scientific article published on 01 May 1996

Mechanisms of ageing: public or private?

scientific article

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

scientific article

Messages from mortality: the evolution of death rates in the old

scientific article published on 01 November 1999

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster

scientific article published in August 2004

Methuselah among nematodes

scientific article published in Nature

Mixed-Species Flocks of Birds in Hill Forest in Ceylon

scholarly article published in The Condor in January 1976

Modulation of calcium-activated non-specific cation currents by cyclic AMP-dependent phosphorylation in neurones of Helix

scientific article published on 01 October 1990

Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder.

scientific article published on 3 May 2007

Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence analyses of the Dca gene

scientific article published on 4 April 2011

Molecular evolution and functional characterization of Drosophila insulin-like peptides

scientific article

Molecular recognition of antibody (IgG) by cellular Fc receptor (FcRI)

scientific article published on 01 November 1988

Multiple signalling pathways in the C5a-induced expression of adhesion receptor Mac-1.

scientific article published on April 1994

Murderous mandibles and black holes in hymenopteran wasps

scientific article published in Nature

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

article published in the Proceedings of the National Academy of Sciences of the United States of America

Myc mouse and anti-ageing therapy

scientific article

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

scientific article published on 30 October 2015

Myostatin-like proteins regulate synaptic function and neuronal morphology

scientific article published on 22 May 2017

Neurosteroid modulation of glutamate release in hippocampal neurons: lack of an effect of a chronic prenatal ethanol exposure paradigm.

scientific article published on July 2003

Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells.

scientific article

Neurosteroid-induced enhancement of short-term facilitation involves a component downstream from presynaptic calcium in hippocampal slices.

scientific article published on 24 August 2006

Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors.

scientific article published in March 2005

Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.

scientific article published on 31 May 2002

New model of health promotion and disease prevention for the 21st century

scientific article published on 8 July 2008

No extension of lifespan by ablation of germ line in Drosophila

scientific article published in April 2006

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects

scientific article

No reduction in the cost of mating for Drosophila melanogaster females mating with spermless males.

scientific article published in September 1993

Normal development of embryonic thalamocortical connectivity in the absence of evoked synaptic activity.

scientific article

Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila

scientific article published on 19 January 2016

Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging

scientific article published on 18 September 2015

Of cuckoo clocks and cowbirds

scientific article published in Nature

On the use of tester stocks to predict the competitive ability of genotypes.

scientific article published in December 1992

Optimization of dietary restriction protocols in Drosophila

scientific article

PICALM rescues glutamatergic neurotransmission, behavioural function, and survival in a Drosophila model of Aβ42 toxicity

scientific article published on 27 June 2020

Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button

scientific article published on 01 June 2018

Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation

scientific article

Pervasive effects of P element mutagenesis on body size in Drosophila melanogaster

scientific article published on 01 August 1998

Phenobarbital: a locus of action on spike broadening and potassium inactivation

scientific article published on 01 January 1987

Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster

scientific article published in March 2008

Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster

scientific article

Pregnenolone sulfate acts through a G-protein-coupled sigma1-like receptor to enhance short term facilitation in adult hippocampal neurons.

scientific article published on July 2005

Promoting health and longevity through diet: from model organisms to humans

scientific article

Protocols to Study Aging in Drosophila.

scientific article published on January 2016

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity

scientific article published on 30 August 2017

QTL mapping reveals a striking coincidence in the positions of genomic regions associated with adaptive variation in body size in parallel clines of Drosophila melanogaster on different continents

scientific article published on November 2003

Quantification of food intake in Drosophila

scientific article

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.

scientific article

RAPID LABORATORY EVOLUTION OF ADULT LIFE-HISTORY TRAITS IN DROSOPHILA MELANOGASTER IN RESPONSE TO TEMPERATURE

scientific article published on 01 June 1995

RAPID LOSS OF STRESS RESISTANCE IN DROSOPHILA MELANOGASTER UNDER ADAPTATION TO LABORATORY CULTURE

article

RESISTANCE OF GENETIC CORRELATION STRUCTURE TO DIRECTIONAL SELECTION IN DROSOPHILA MELANOGASTER.

scientific article published in December 1990

RESPONSES AND CORRELATED RESPONSES TO ARTIFICIAL SELECTION ON THORAX LENGTH IN DROSOPHILA MELANOGASTER.

scientific article published in February 1993

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats

scientific article published on 29 July 2019

Rapid laboratory evolution of adult wing area in Drosophila melanogaster in response to humidity

scientific article published in April 2003

Rapid loss of stress resistance in Drosophila melanogaster under adaptation to laboratory culture.

scientific article published in February 2001

Ras inhibition by trametinib treatment in Drosophila attenuates gut pathology in females and extends lifespan in both sexes

Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice

scientific article published on 25 July 2016

Reduced molecular expression of K(+) channel proteins in vascular smooth muscle from rats made hypertensive with N{omega}-nitro-L-arginine.

scientific article published on 25 March 2005

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

scientific article published on 13 September 2017

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs

scientific article

Regulation of gene expression is preserved in aging Drosophila melanogaster ⬇️

scientific article published on April 9, 1998

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk

scientific article

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1 ⬇️

scientific article published on January 25, 2011

Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications

scientific article

Resistance of Genetic Correlation Structure to Directional Selection in Drosophila melanogaster

Resolution of neuroactive non-protein amino acid enantiomers by high-performance liquid chromatography utilising pre-column derivatisation with o-phthaldialdehyde-chiral thiols. Application to 2-amino-omega-phosphonoalkanoic acid homologues and alph

scientific article published on 01 May 1989

Resolution of neuroexcitatory non-protein amino acid enantiomers by high-performance liquid chromatography utilising pre-column derivatisation with o-phthaldialdehyde chiral thiols. Application to omega-N-oxalyl diamino acids

scientific article published on 01 April 1989

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

scientific article published on 30 January 2008

Role of insulin-like signalling in Drosophila lifespan

scientific article published on 6 April 2007

Role of the mitochondrial protein LRPPRC2 in Drosophila melanogaster

Science fact and the SENS agenda. What can we reasonably expect from ageing research?

scientific article

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

scientific article

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?

scientific article published on February 2008

Sex and conflict

scientific article

Sex and death: what is the connection?

scientific article

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction.

scientific article published on 16 February 2016

Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster

scientific article published in January 2004

Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females.

scientific article published on 12 September 2012

Sex-specific selection on time to remate in Drosophila melanogaster.

scientific article published in November 1998

Sexual activity reduces lifespan of male fruitflies

scientific article published in Nature

Sexual conflict and speciation.

scientific article

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension.

scientific article

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

scientific article

Small nucleoli are a cellular hallmark of longevity

scientific article published on 30 August 2016

Some highlights of research on aging with invertebrates, 2006-2007.

scientific article published on 24 August 2007

Some highlights of research on aging with invertebrates, 2008.

scientific article published on 31 July 2008

Some highlights of research on aging with invertebrates, 2009.

scientific article published on 22 July 2009

Some highlights of research on aging with invertebrates, 2010 ⬇️

scientific article published on December 7, 2010

Stage debut for the elusive Drosophila insulin-like growth factor binding protein

scientific article published on 07 July 2008

Starvation resistance and adult body composition in a latitudinal cline of Drosophila melanogaster.

scientific article published in October 2000

Stress-response hormesis and aging: "that which does not kill us makes us stronger".

scientific article

Subclasses of IgG on the surface of human lymphocytes: a study with monoclonal antibodies

scientific article published on 01 April 1984

Superoxide and hydrogen peroxide production by Drosophila mitochondria

scientific article published in October 2003

Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution

scientific article published on 14 November 2006

SurvCurv database and online survival analysis platform update

scientific article

THERMAL EVOLUTION OF EGG SIZE IN DROSOPHILA MELANOGASTER.

scientific article

THERMAL SENSITIVITY OF DROSOPHILA MELANOGASTER RESPONDS RAPIDLY TO LABORATORY NATURAL SELECTION

scientific article published on 01 May 1991

Temperature and clinal variation in larval growth efficiency in Drosophila melanogaster

scientific article published in January 2001

Testing for asymmetrical gene flow in a Drosophila melanogaster body-size cline

scientific article

Tetraspanins in viral infections: a fundamental role in viral biology?

scientific article

The Acp26Aa seminal fluid protein is a modulator of early egg hatchability in Drosophila melanogaster.

scientific article published in August 2001

The Insulin Signaling Pathway and Aging in Drosophila

scientific article published on 01 May 2001

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

scientific article published on 25 June 2015

The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster

scientific article

The development of ciliated and mucus cells from basal cells in hamster tracheal epithelial cell cultures.

scientific article

The distribution of cationized ferritin receptors on ciliated epithelial cells of rat trachea

scientific article published on 01 January 1981

The ecological context of life history evolution.

scientific article

The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila

scientific article published in January 2006

The effect of pentylenetetrazol on inward currents of non-bursting neurons and its role in plateau formation ⬇️

scientific article published on June 18, 1984

The effect of pentylenetetrazol on spike broadening and potassium inactivation

scientific article published on 01 January 1984

The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster

scientific article published on 25 January 2006

The effects of reproduction on longevity and fertility in male Drosophila melanogaster

scientific article published on 01 June 1997

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila

scientific article published on 19 August 2009

The evolution of longevity

scientific article published on 01 August 2002

The genetic bases of divergence in desiccation and starvation resistance among tropical and temperate populations of Drosophila melanogaster.

scientific article published on September 2001

The good enough calculi of evolving control systems: evolution is not engineering

scientific article published on 01 March 1982

The hallmarks of aging

scientific article

The identification of endothelial cell autoantigens.

scientific article

The interaction between FOXO and SIRT1: tipping the balance towards survival

scientific article published in August 2004

The neuronal receptor tyrosine kinase Alk is a target for longevity

scientific article published on 15 April 2020

The new biology of ageing

scientific article

The new science of ageing

scientific article published on September 2015

The new science of ageing

scientific article published on January 2011

The place of genetics in ageing research.

scientific article published on 10 July 2012

The preparation and crystallization of Fab fragments of a family of mouse esterolytic catalytic antibodies and their complexes with a transition-state analogue

scientific article published on 23 July 2001

The production of monoclonal antibodies to membrane proteins

scientific article published on 01 January 1994

The quest to slow ageing through drug discovery

scientific article published on 28 May 2020

The role of somatic mutation in determining the affinity of anti-DNA antibodies.

scientific article

The sequential-interval state space: a means of displaying temporal information in neuron firing

scientific article published on 01 April 1989

The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference

scientific article published on 31 July 2003

The site of action for the convulsant effect of pentylenetetrazol

scientific article published on 01 January 1981

The use of anti-IgG monoclonal antibodies in mapping the monocyte receptor site on IgG

scientific article published on 01 December 1986

Thermal sensitivity of Drosophila melanogaster: evolutionary responses of adults and eggs to laboratory natural selection at different temperatures.

scientific article published in July 1997

Tissue rejection: the price of sexual acceptance?

scientific article published on 01 August 1983

Tissue-specific modulation of gene expression in response to lowered insulin signalling in <i>Drosophila</i>

scientific article published on 21 April 2021

Toward a control theory analysis of aging

scientific article published on January 2008

Tracking dynamic changes in Alzheimer's disease brain proteome reveals ageing-independent damage in Drosophila

scholarly article published 19 December 2018

Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice

scientific article published on 14 January 2021

Translational strategies in aging and age-related disease

scientific article

Two forms of death in ageing Caenorhabditis elegans

scientific article published on 23 May 2017

Unraveling the biological roles of reactive oxygen species

scientific article published on April 2011

Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing

scientific article

Using doubly-labeled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster.

scientific article

Using the drug-protein interactome to identify anti-ageing compounds for humans

Using the drug-protein interactome to identify anti-ageing compounds for humans

scientific article published on 09 January 2019

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

scientific article published on 19 April 2012

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

scientific article published on 04 April 2012

Vascular smooth muscle cell membrane depolarization after NOS inhibition hypertension.

scientific article published on May 2002

Water-independent effects of dietary restriction in Drosophila

scientific article published on 2 April 2010

When deviants are favoured: evolution of sex determination

scientific article published on 01 February 1984

Women in Metabolism: Part 3.

scientific article published in December 2015

dFOXO-independent effects of reduced insulin-like signaling in Drosophila

scientific article

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

scientific article published on 27 October 2016

pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity

scientific article published on 07 October 2016

Paulina is supported by:

About Paulina

Help