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List of works by Linda Griffith

"Menstruation: Science and Society"

scientific article published on 06 June 2020

A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties

scientific article published on 2 December 2016

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

scientific article published on 13 September 2021

A microfabricated array bioreactor for perfused 3D liver culture

scientific article published on 01 May 2002

A microphysiological system model of therapy for liver micrometastases

scientific article

A model of dormant-emergent metastatic breast cancer progression enabling exploration of biomarker signatures.

scientific article published on 20 January 2018

A modular polymer microbead angiogenesis scaffold to characterize the effects of adhesion ligand density on angiogenic sprouting

scientific article published on 16 July 2020

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

scientific article published on January 2016

A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes

scientific article published on January 2009

A process engineering approach to increase organoid yield

scientific article published on 7 February 2017

A three-dimensional osteochondral composite scaffold for articular cartilage repair

scientific article published in December 2002

ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling

scientific article published on 14 May 2013

ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker

scientific article published on 23 June 2018

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

scientific article published on 28 September 2011

Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis

scientific article published on 29 August 2006

All-human microphysical model of metastasis therapy

scientific article

Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development

scientific article

An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential.

scientific article published on 11 June 2013

An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha

scientific article

Analysis of an Integrated Human Multiorgan Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics

scientific article published on 21 June 2019

Application of a gut-immune co-culture system for the study of N-glycan-dependent host-pathogen interactions of Campylobacter jejuni

scientific article published on 15 January 2020

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

scientific article published on 02 May 2014

Author Correction: Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron

scientific article published on 01 August 2020

Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays.

scientific article

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

scientific article

Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

scientific article published on 28 February 2020

Bioreactor technologies to support liver function in vitro.

scientific article

CD26/DPPIV down-regulation in endometrial stromal cell migration in endometriosis

scientific article published on 10 May 2014

Capturing complex 3D tissue physiology in vitro

scientific article

Carbon dioxide extraction of residual chloroform from biodegradable polymers

scientific article published in January 2002

Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling

scientific article

Cellular strategies for enhancement of fracture repair

scientific article published on February 2008

Chain Conformations at the Surface of a Polydisperse Amphiphilic Comb Copolymer Film

scientific article published on July 2006

Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1

scientific article

Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis

scientific article published on 23 May 2018

Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK).

scientific article published on September 2003

Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

scientific article published on 13 February 2018

Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

Clostridioides difficile-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms

scientific article published on 24 March 2020

Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus.

scientific article published on April 2002

Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix

scientific article published on 31 January 2014

Comparison of cytokines in the peritoneal fluid and conditioned medium of adolescents and adults with and without endometriosis

scientific article published on 18 September 2020

Comparison of tethered star and linear poly(ethylene oxide) for control of biomaterials surface properties ⬇️

scientific article published on 01 June 1998

Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling

scientific article

Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation.

scientific article

Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation

scientific article published on April 2010

Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold Interactions

scientific article

Development and Application of the Metalloprotease Activity Multiplexed Bead-Based Immunoassay (MAMBI)

scientific article published on 09 September 2019

Driving the future of dental research

scientific article published in June 2006

Dual responsiveness of a tunable thermo-sensitive polypeptide

scientific article

Dysregulated sphingolipid metabolism in endometriosis

scientific article

Education for careers in tissue engineering and regenerative medicine

scientific article published in February 2006

Effect of Pore Size and Void Fraction on Cellular Adhesion, Proliferation, and Matrix Deposition ⬇️

scientific article published on October 1, 2001

Emerging design principles in biomaterials and scaffolds for tissue engineering

scientific article

Endometrioma, the follicular fluid inflammatory network and its association with oocyte and embryo characteristics

scientific article published on 23 December 2019

Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes.

scientific article

Engineering Helical Modular Polypeptide-Based Hydrogels as Synthetic Extracellular Matrices for Cell Culture

scientific article published on 02 January 2020

Engineering PEG-based hydrogels to foster efficient endothelial network formation in free-swelling and confined microenvironments ⬇️

scientific article published on 06 March 2020

Engineering liver

scientific article

Engineering principles of clinical cell-based tissue engineering.

scientific article published in July 2004

Enhanced ex vivo expansion of adult mesenchymal stem cells by fetal mesenchymal stem cell ECM.

scientific article

Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator

scientific article

Epidermal Growth Factor Tethered to β-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. ⬇️

scientific article published on 08 July 2016

Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells

scientific article published on 8 September 2005

Equilibrium and dynamic design principles for binding molecules engineered for reagentless biosensors.

scientific article published on 9 May 2014

Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies.

scientific article

Evaluation of osteoconductive scaffolds in the canine femoral multi-defect model.

scientific article

Extracellular matrix signaling through growth factor receptors during wound healing

scientific article published in May 2004

Folding artificial mucosa with cell-laden hydrogels guided by mechanics models

article published in the Proceedings of the National Academy of Sciences of the United States of America

Formation of osteogenic colonies on well-defined adhesion peptides by freshly isolated human marrow cells

scientific article published on 11 January 2007

Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids

scientific article published on 25 May 2020

Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor

scientific article published in July 2002

Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro.

scientific article published on September 2009

Gene delivery properties of end-modified poly(beta-amino ester)s

scientific article

Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron

scientific article published on 30 March 2020

Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.

scientific article

Growth factor regulation of proliferation and survival of multipotential stromal cells ⬇️

scientific article published on October 26, 2010

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

scientific article published on 18 March 2020

Helix versus coil polypeptide macromers: gel networks with decoupled stiffness and permeability

scientific article published on November 2012

Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation

scientific article published on 17 December 2014

Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells.

scientific article published on June 2015

In vitro models for liver toxicity testing

scientific article published on 23 November 2012

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System

scientific article

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

scientific article published on 27 July 2017

Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk.

scientific article

Integration of surface modification and 3D fabrication techniques to prepare patterned poly(L-lactide) substrates allowing regionally selective cell adhesion ⬇️

scientific article published on January 1, 1998

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.

scientific article published on 14 March 2018

Interplay between PEO tether length and ligand spacing governs cell spreading on RGD-modified PMMA-g-PEO comb copolymers

scientific article published on 18 September 2007

Interrogating signaling nodes involved in cellular transformations using kinase activity probes

scientific article

Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging

scientific article

Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro

scientific article published on 10 November 2011

Liver 'organ on a chip'.

scientific article published on 29 December 2017

Liver metastases: Microenvironments and ex-vivo models.

scientific article

Liver tissue engineering in the evaluation of drug safety

scientific article

Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function

scientific article published on 20 March 2017

Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness

scientific article

Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor

scientific article published on 29 April 2015

Microdistribution of substratum-bound ligands affects cell function: hepatocyte spreading on PEO-tethered galactose ⬇️

scientific article published on June 1, 1998

Microfluidic shear devices for quantitative analysis of cell adhesion

scientific article

Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform.

scientific article

Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates

scientific article published on 23 October 2017

Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation

scientific article

Motility signaled from the EGF receptor and related systems

scientific article published on 01 January 2006

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS).

scientific article

Multilayer thin film coatings capable of extended programmable drug release: application to human mesenchymal stem cell differentiation

scientific article

Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells

scientific article published on November 2009

Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis

scientific article

Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 1. Synthesis and Characterization of Comb Thin Films ⬇️

scientific article published on January 1, 2001

Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 2. Surface Segregation of Comb Polymers in Polylactide ⬇️

scientific article published on January 1, 2001

Novel Technology to Capture Objective Data from Patients' Recovery from Laparoscopic Endometriosis Surgery

scientific article published on 29 June 2020

Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression

scientific article published on January 2007

On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks.

scientific article published on 23 March 2017

OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks

scientific article published on 28 August 2019

Osteoblast response to PLGA tissue engineering scaffolds with PEO modified surface chemistries and demonstration of patterned cell response

scientific article published on June 2004

PCLN-07. A 3D HYDROGEL CULTURE SYSTEM FACILITATES STUDY OF PRIMARY PEDIATRIC LOW-GRADE GLIOMA CELLS IN VITRO

scientific article published on 22 June 2018

Perfused multiwell plate for 3D liver tissue engineering

scientific article published on 22 October 2009

Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility

scientific article

Perspective: The promise of multi-cellular engineered living systems

scientific article published on 11 October 2018

Photopatterning of hydrogel scaffolds coupled to filter materials using stereolithography for perfused 3D culture of hepatocytes

scientific article

Physiomimetic Models of Adenomyosis

scientific article published on 09 November 2020

PiFlow: A Biocompatible Low-Cost Programmable Dynamic Flow Pumping System Utilizing a Raspberry Pi Zero and Commercial Piezoelectric Pumps

PiFlow: A biocompatible low-cost programmable dynamic flow pumping system utilizing a Raspberry Pi Zero and commercial piezoelectric pumps

scientific article published in October 2018

Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand.

scientific article published on 17 April 2012

Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities

scientific article published on 23 December 2010

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

scientific article published on 19 October 2016

Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels

scientific article published on 19 December 2018

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration

scientific article published on 5 October 2015

Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes.

scientific article published on 10 April 2007

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

scientific article published on 16 March 2016

Regenerating the cell resistance of micromolded PEG hydrogels

scientific article published in May 2015

Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment ⬇️

scientific article published on April 14, 1998

Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands

scientific article

Staying Professional on Social Media

scientific article published in December 2017

Surface tethered epidermal growth factor protects proliferating and differentiating multipotential stromal cells from FasL-induced apoptosis.

scientific article

Survival and Function of Hepatocytes on a Novel Three-Dimensional Synthetic Biodegradable Polymer Scaffold With an Intrinsic Network of Channels ⬇️

scientific article published on July 1, 1998

Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells

scientific article

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

scientific article

Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels.

scientific article

Tailoring chimeric ligands for studying and biasing ErbB receptor family interactions

scientific article

Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

scientific article

Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy

scientific article

Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells

scientific article published on 18 January 2007

Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (βTCP) via Fusion to a High Affinity, Multimeric βTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors

scientific article published on 29 June 2015

The Vaginal Microbiome as a Tool to Predict rASRM Stage of Disease in Endometriosis: a Pilot Study

scientific article published on 06 January 2020

The dormancy dilemma: quiescence versus balanced proliferation

scientific article published on 21 June 2013

The influence of tethered epidermal growth factor on connective tissue progenitor colony formation.

scientific article

The matrikine tenascin-C protects multipotential stromal cells/mesenchymal stem cells from death cytokines such as FasL.

scientific article published on May 2013

Three dimensional human small intestine models for ADME-Tox studies.

scientific article published on 20 May 2014

Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death

scientific article

Tissue engineering--current challenges and expanding opportunities

scientific article

Transport and shear in a microfluidic membrane bilayer device for cell culture

scientific article

Transport-mediated angiogenesis in 3D epithelial coculture

scientific article

Uncharged Helical Modular Polypeptide Hydrogels for Cellular Scaffolds

scientific article

α4β1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development

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