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List of works by Shane Crotty

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates

scientific article published on 01 June 2020

A Blueprint for HIV Vaccine Discovery

scientific article

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.

scientific article published on 24 June 2016

A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.

scientific article published on 02 May 2016

A brief history of T cell help to B cells

scientific article

A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers

scientific article published on 11 July 2017

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

scientific article published on 31 October 2019

AI-guided discovery of the invariant host response to viral pandemics

scientific article published on 22 September 2020

AI-guided discovery of the invariant host response to viral pandemics

scientific article

Activin A programs the differentiation of human TFH cells

scientific article

Adaptive immunity to SARS-CoV-2 and COVID-19

scientific article

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

scientific article

Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells

scientific article published on 12 May 2017

An epitope conserved in orthopoxvirus A13 envelope protein is the target of neutralizing and protective antibodies ⬇️

scientific article published on August 2, 2011

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

scientific article published on 16 September 2020

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.

scientific article published on 15 March 2018

Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity

scientific article published on 01 May 2020

Author Correction: Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

scientific article published on 17 August 2020

B Cell-Specific Expression of B7-2 Is Required for Follicular Th Cell Function in Response to Vaccinia Virus ⬇️

scientific article published on March 25, 2011

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

scientific article published on 01 September 2020

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

scientific article published on 20 March 2018

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms

scientific article

Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits

scientific article published on 22 June 2020

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

scientific article

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation ⬇️

scientific article published on March 16, 2012

Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory

scientific article

Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.

scientific article

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

scientific article published on 14 January 2016

CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects

scientific article

CXCL13 is a plasma biomarker of germinal center activity

scientific article published on 23 February 2016

Characterization of murine antibody responses to vaccinia virus envelope protein A14 reveals an immunodominant antigen lacking of effective neutralization targets

scientific article published on 17 March 2018

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes

scientific article published on July 2007

Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model

scientific article

Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells

scientific article

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

scientific article published on 09 December 2020

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

scientific article

Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses.

scientific article published on 20 February 2018

Cross-reactive memory T cells and herd immunity to SARS-CoV-2

scientific article published on 06 October 2020

Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination ⬇️

scientific article published on November 15, 2003

Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection

scientific article published on 05 February 2016

Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation

scientific article

Cutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function

scientific article published on 8 May 2015

Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique

scientific article published on 22 June 2016

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

scientific article

Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells.

scientific article published in September 2016

Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses

scientific article

Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens

scientific article

Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity

scientific article published on 20 July 2015

Development of an animal model of progressive vaccinia in nu/nu mice and the use of bioluminescence imaging for assessment of the efficacy of monoclonal antibodies against vaccinial B5 and L1 proteins

scientific article published on 8 May 2017

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

scientific article published in Nature Communications

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

scientific article

Diversity of neutralizing antibody responses in human smallpox vaccinees

scientific article published on 21 June 2021

Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells

scientific article published on 21 April 2017

Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells ⬇️

scientific article published on May 18, 2013

Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection

scientific article

Editorial overview: Vaccine immunology: what is seen and not seen

scientific article published on 21 June 2019

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

scientific article

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

scientific article

Engineered immunogen binding to alum adjuvant enhances humoral immunity

scientific article published on 17 February 2020

Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.

scientific article published on 13 March 2017

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

scientific article published on 23 February 2018

Erratum: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.

scientific article

Erratum: Activin A programs the differentiation of human TFH cells

scientific article

Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation

scientific article published on 01 May 2017

Erratum: Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

scientific article published on 10 January 2018

Evidence that recurrent Group A streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant Tfh cells

Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.

scientific article published on 07 October 2013

Ezh2 programs T differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

scientific article published in Nature Communications

Factors in B cell competition and immunodominance

scientific article published on 01 June 2020

From structure to sequence: Antibody discovery using cryoEM

scientific article published on 19 January 2022

Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

scientific article

Germinal center enhancement by extended antigen availability

scientific article

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

scientific article

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

scientific article published on 16 June 2020

Harnessing CD4+ T cell responses in HIV vaccine development ⬇️

scientific article published on February 6, 2013

Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5.

scientific article published on 30 September 2009

Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer

scientific article published on 01 March 2022

Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses

scientific article published on 12 September 2013

Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease

scientific article

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6 ⬇️

scientific article published on June 24, 2011

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation ⬇️

scientific article published on March 14, 2011

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.

scientific article published on 23 May 2016

Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax

scientific article published on 30 August 2004

Immunity and immunological memory following smallpox vaccination

scientific article published on June 2006

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

scientific article

Immunological memory in humans

scientific article published in June 2004

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

scientific article published on 06 January 2021

Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin

scientific article

In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation

scientific article

In vivo RNAi screens: concepts and applications

scientific article published on 27 April 2015

In vivo regulation of Bcl6 and T follicular helper cell development

scientific article

Inadequate T follicular cell help impairs B cell immunity during HIV infection.

scientific article published on 10 March 2013

Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum

scientific article published on 25 May 2009

Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials

article

LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

scientific article

Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox

scientific article published on 17 February 2016

Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice.

scientific article

Manganese-Dependent Polioviruses Caused by Mutations within the Viral Polymerase ⬇️

scientific article published on May 1, 2003

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

scientific article published on 01 February 2021

Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination

scientific article published on 03 June 2013

Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection

scientific article

Mucosal immunization of cynomolgus macaques with two serotypes of live poliovirus vectors expressing simian immunodeficiency virus antigens: stimulation of humoral, mucosal, and cellular immunity

scientific article

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

scientific article published on 21 August 2020

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors

scientific article published on 01 December 2020

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

scientific article

Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E

scientific article

NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi

scholarly article

Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations

scientific article published on 17 January 2020

OX40 Facilitates Control of a Persistent Virus Infection ⬇️

scientific article published on September 6, 2012

OX40 drives protective vaccinia virus-specific CD8 T cells

scientific article published on December 2008

Optimal replication of poliovirus within cells

scientific article published on 03 February 2005

Poliovirus RNA-dependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B

scientific article (publication date: 18 August 2000)

Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection

scientific article

Poliovirus vaccine strains as mucosal vaccine vectors and their potential use to develop an AIDS vaccine.

scientific article

Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage

scientific article

Potent Neutralization of Vaccinia Virus by Divergent Murine Antibodies Targeting a Common Site of Vulnerability in L1 Protein

scientific article

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

scientific article published on 07 July 2020

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

scientific article published on 26 December 2017

Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery

scientific article

Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors

scientific article

Protection of rabbits and immunodeficient mice against lethal poxvirus infections by human monoclonal antibodies

scientific article

Protective murine and human monoclonal antibodies against eczema vaccinatum

scientific article published on January 2011

Proteome-wide analysis of the serological response to vaccinia and smallpox

scientific article published on May 2007

Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo

scientific article published on 17 October 2007

RNA virus error catastrophe: direct molecular test by using ribavirin

scientific article

Raging evolution of a B cell response to a viral infection

scientific article published on 2 January 2018

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization ⬇️

scientific article published on 01 November 2019

Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells.

scientific article published in February 2019

Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine

scientific article

Reinvigorating NIH Grant Peer Review

scientific article published on 01 January 2020

Resolution of a chronic viral infection after interleukin-10 receptor blockade

scientific article

Response to Comment on "A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood".

scientific article published in October 2016

Retroviral vector expression in TCR transgenic CD4⁺ T cells

scientific article published on January 2015

Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.

scientific article

Ribavirin's antiviral mechanism of action: lethal mutagenesis?

scientific article

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.

scientific article published on 6 December 2017

SAP is required for generating long-term humoral immunity

scientific journal article

SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation

scientific article

SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.

scientific article published in January 2007

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

scientific article published on 19 November 2021

SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

scientific article published on 24 January 2022

STAT5 is a potent negative regulator of TFH cell differentiation

scientific article published on 23 January 2012

Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities

scientific article published on June 2008

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

scientific article

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

scientific article published on 09 May 2019

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

scientific article published on 01 January 2020

Structural and Biochemical Characterization of the Vaccinia Virus Envelope Protein D8 and Its Recognition by the Antibody LA5

scientific article

Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer

scientific article published on September 2015

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.

scientific article published on 21 November 2017

Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.

scientific article published on 9 November 2017

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

scientific article published on 04 October 2016

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults

scientific article published on 04 November 2020

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

scientific article published on 01 May 2019

T cells control the generation of nanomolar-affinity anti-glycan antibodies

scientific article published on 13 March 2017

T follicular helper cell differentiation, function, and roles in disease

scientific article published in October 2014

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

scientific article published on 05 August 2020

Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

scientific article published on 20 May 2020

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem

scientific article published on January 2017

Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunization in adolescence and adulthood

scientific article published on 14 May 2016

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters

scientific article published on 06 August 2018

The 1‐1‐1 fallacy ⬇️

scientific article published on May 1, 2012

The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells

scientific article

The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development ⬇️

scientific article published on June 7, 2012

The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.

scientific article published in April 2018

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

scientific article published in December 2000

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

article

The poliovirus replication machinery can escape inhibition by an antiviral drug that targets a host cell protein

scientific article published on April 2004

The smallpox vaccine induces an early neutralizing IgM response

scientific article published on 12 October 2009

The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells

scientific journal article

The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.

scientific article published on 10 February 2015

Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system

scientific article

Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

scientific article

Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine

scientific article published on 14 November 2012

Using a combined computational-experimental approach to predict antibody-specific B cell epitopes

scientific article published on 13 March 2014

Vaccination induces HIV broadly neutralizing antibody precursors in humans ⬇️

journal article published in 2022

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells

scientific article published on 06 September 2021

Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates

scientific article published in 2024

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

scholarly article by Matthias G Pauthner et al published 15 January 2019 in Immunity

Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.

scientific article

Vaccinia virus extracellular enveloped virion neutralization in vitro and protection in vivo depend on complement

scientific article

Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses

scientific article

When designing vaccines, consider the starting material: the human B cell repertoire

scholarly article by Colin Havenar-Daughton et al published 1 August 2018 in Current Opinion in Immunology

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