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List of works by Leonard P. Guarente

3-Ketoacyl thiolase delays aging ofCaenorhabditis elegansand is required for lifespan extension mediated bysir-2.1 ⬇️

scientific article published on October 18, 2010

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

scientific article published in November 2005

AGING INSACCHAROMYCES CEREVISIAE

scientific article published in 1998

Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants ⬇️

scientific article published on August 29, 1997

Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers.

scientific article published on 5 July 2016

Aging and disease: connections to sirtuins

scientific article published on April 2010

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

scientific article

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span

scientific article published in June 2006

Calorie restriction extends yeast life span by lowering the level of NADH.

scientific article

Cassette for the generation of sequential gene disruptions in the yeast Schizosaccharomyces pombe.

scientific article published in June 1997

Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging

scientific article published on August 1996

Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington’s Disease Phenotypes In Vivo

scientific article published on 25 March 2021

Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells.

scientific article

Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

scientific article published on 29 December 2015

DIVERGENT REGULATION OF SIRT1 MEDIATES THE ENDOCRINE RESPONSE TO CALORIE RESTRICTION

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span

scientific article

Deviation of innate circadian period from 24 h reduces longevity in mice.

scientific article

Dietary restriction: standing up for sirtuins

scientific article published on August 2010

Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

scientific article published on 22 January 2019

Erratum: Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

scholarly article published in NPJ aging and mechanisms of disease

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

scientific journal article

Extrachromosomal rDNA circles--a cause of aging in yeast

scientific article (publication date: 26 December 1997)

Genetic links between diet and lifespan: shared mechanisms from yeast to humans

scientific article

Genetic pathways that regulate ageing in model organisms

scientific article (publication date: 9 November 2000)

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

scientific journal article

IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

scientific article published in March 2018

Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging

scientific article published on 01 February 2019

Increase in activity during calorie restriction requires Sirt1

scientific article published on 01 December 2005

Increased life span due to calorie restriction in respiratory-deficient yeast

Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota

scientific article

Life-span extension in yeast.

scientific article

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

scientific article (publication date: 28 May 1999)

Mammalian SIRT1 represses forkhead transcription factors

scientific article (publication date: 20 February 2004)

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

scientific journal article

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

scientific article

Model organisms as a guide to mammalian aging

scientific article

Molecular Biology of Aging

scientific article published on 01 January 1999

Molecular mechanisms of yeast aging

scientific article published on 01 April 1998

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

scientific journal article

Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy

scientific article

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

scientific article (publication date: February 1995)

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

scientific article

Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection

scientific article

NAD+ supplementation rejuvenates aged gut adult stem cells.

scientific article

Neurogenesis directed by Sirt1.

scientific article published on April 2008

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction

scientific article

Nucleolar localization of the Werner syndrome protein in human cells ⬇️

scientific article published on June 9, 1998

Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae

scientific article published on August 1999

Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer's disease

scientific article published on 27 May 2019

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

scientific article

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes ⬇️

scientific article published on September 21, 2011

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

scientific article published on 24 November 2017

Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10.

scientific article published on 14 August 2014

SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones ⬇️

scientific article published on January 4, 2012

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive

scientific article

SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis

scientific article published on 8 October 2018

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

scientific article

SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

scientific journal article

SIRT1 promotes differentiation of normal human keratinocytes.

scientific article published on 19 June 2008

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

scientific article published on 30 January 2013

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

scientific article published on 5 March 2013

SIRT1 shows no substrate specificity in vitro

scientific article published on 6 January 2005

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

scientific article

SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis

scientific article published on 11 April 2013

SIRT1 transgenic mice show phenotypes resembling calorie restriction

scientific article (publication date: 13 August 2007)

SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo

scientific article

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

scientific article

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

scientific journal article

Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm

scientific article published on 01 July 2020

Science fact and the SENS agenda. What can we reasonably expect from ageing research?

scientific article

SirT1 is required in the male germ cell for differentiation and fecundity in mice

scientific article

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway ⬇️

scientific article published on December 18, 2011

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

scientific article

Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency.

scientific article published on October 2016

Sirtuins at a glance.

scientific article

Sirtuins in aging and disease

scientific article

Small-molecule allosteric activators of sirtuins

scientific article

SnapShot: sirtuins, NAD, and aging.

scientific article published in July 2014

Superoxide dismutase 1 knock-down induces senescence in human fibroblasts

scientific article

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

scientific journal article

Telomeres, the nucleolus and aging ⬇️

scientific article published on 01 June 1998

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

scientific article

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

scientific article

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

scientific article

The Saccharomyces cerevisiae Hap5p Homolog from Fission Yeast Reveals Two Conserved Domains That Are Essential for Assembly of Heterotetrameric CCAAT-Binding Factor ⬇️

scientific article published on December 1, 1997

The brain, sirtuins, and ageing

scientific article

The place of genetics in ageing research.

scientific article published on 10 July 2012

The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration

scientific article published on 30 August 2008

Tissue-specific regulation of SIRT1 by calorie restriction

scientific article

Urea cycle regulation by mitochondrial sirtuin, SIRT5.

scientific article published on 29 June 2009

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

scientific article published on 22 June 2016

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