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List of works by William T. Cefalu

"New twist" in Diabetes Care for HbA(1c) reporting: "it takes two to tango"!

scientific article published in December 2012

"Prediabetes": Are There Problems With This Label? No, We Need Heightened Awareness of This Condition!

scientific article published on August 2016

20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model

scientific article published on 06 January 2009

A "spoonful of sugar" and the realities of diabetes prevention!

scientific article published on April 2014

A natural history of botanical therapeutics

scientific article

A synthetic anti‐inflammatory sterol improves insulin sensitivity in insulin‐resistant obese impaired glucose tolerance subjects ⬇️

scientific article published on May 13, 2013

Adipocyte iron regulates adiponectin and insulin sensitivity

scientific article

Adipocyte iron regulates leptin and food intake

scientific article

Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors' Expert Forum

scientific article

Aggressive Blood Pressure Control Increases Coronary Heart Disease Risk Among Diabetic Patients ⬇️

scientific article published on May 20, 2013

American Diabetes Association's Standards of Care: A Paradigm Shift in the Dissemination of Information

scientific article published in March 2018

American Diabetes Association–European Association for the Study of Diabetes Position Statement: Due Diligence Was Conducted ⬇️

scientific article published on June 1, 2012

An Extract of Artemisia dracunculus L. Inhibits Ubiquitin-Proteasome Activity and Preserves Skeletal Muscle Mass in a Murine Model of Diabetes ⬇️

scientific article published on February 20, 2013

An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation

scientific article published on 23 February 2018

An ethanolic extract of Artemisia dracunculus L. regulates gene expression of ubiquitin-proteasome system enzymes in skeletal muscle: potential role in the treatment of sarcopenic obesity

scientific article

An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice

scientific article

An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A).

scientific article published on 26 February 2016

An update on sodium-glucose co-transporter-2 inhibitors for the treatment of diabetes mellitus

scientific article published on 24 November 2016

Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition

scientific article published on January 2006

Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice

scientific article

Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway ⬇️

scientific article published on May 21, 2013

Artemisia supplementation differentially affects the mucosal and luminal ileal microbiota of diet-induced obese mice

scientific article

Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys

scientific article

Author reply: Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus ⬇️

scientific article published on November 1, 2010

Beyond metformin: safety considerations in the decision-making process for selecting a second medication for type 2 diabetes management: reflections from a diabetes care editors' expert forum

scientific article published on September 2014

Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation

scientific article

Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women1–4 ⬇️

scientific article published on August 19, 2010

Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture

scientific article

Bioactives of Artemisia dracunculus L. Mitigate the Role of Ceramides in Attenuating Insulin Signaling in Rat Skeletal Muscle Cells ⬇️

scientific article published on February 7, 2012

Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells

scientific article

Blood pressure and heart failure risk among diabetic patients

scientific article

Blood pressure and stroke risk among diabetic patients

scientific article

Blueberries improve endothelial function, but not blood pressure, in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial

scientific article published on 27 May 2015

Body mass index and the risk of all-cause mortality among patients with type 2 diabetes mellitus

scientific article

Botanicals and cardiometabolic risk: positioning science to address the hype

scientific article published on July 2008

Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome

scientific article published on July 2008

Building Momentum: Taking on the Real “Issues” of Diabetes Care!

scientific article published on January 2016

Butyrate improves insulin sensitivity and increases energy expenditure in mice

scientific article published on 14 April 2009

Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial

scientific article published in October 2004

Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus

scientific article

Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats

scientific article

Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes

scientific article

Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques

scientific article

Clinical Assessment of Individualized Glycemic Goals in Patients With Type 2 Diabetes: Formulation of an Algorithm Based on a Survey Among Leading Worldwide Diabetologists

scientific article

Clinical Considerations for Use of Initial Combination Therapy in Type 2 Diabetes

scientific article published on August 2016

Clinical effect of chromium supplements on human health

article

Clinical management strategies for type 2 diabetes.

scientific article published on December 2007

Clinical research observations with use of exubera in patients with type 1 and 2 diabetes

scientific article published in June 2007

Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice ⬇️

scientific article published on June 18, 2012

Complications of type 1 diabetes

scientific article published on September 2010

Concept, strategies, and feasibility of noninvasive insulin delivery

scientific article published on January 2004

Considerations in the Management of Gestational Diabetes Mellitus: "You Are What Your Mother Ate!".

scientific article published on January 2016

Controlling hypoglycemia in type 2 diabetes: which agent for which patient?

scientific article

Creatine ( methyl-d3) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA.

scientific article published on 31 August 2017

Current concepts about chromium supplementation in type 2 diabetes and insulin resistance

scientific article published on April 2010

Dapagliflozin's Effects on Glycemia and Cardiovascular Risk Factors in High-Risk Patients With Type 2 Diabetes: A 24-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study With a 28-Week Extension

scientific article published on 7 April 2015

Defining insulin resistance from hyperinsulinemic-euglycemic clamps

scientific article

Diabetes Care to Date: “The Hits Just Keep on Coming!”.

scientific article

Diabetes Care: "Lagniappe" and "Seeing Is Believing"!

scientific article published on 9 June 2016

Diabetes Care: "Taking It to the Limit One More Time".

scientific article published in January 2017

Diabetes Care: Change Is Constant

scientific article published on 9 December 2011

Diabetes Care: “State of the Union” ⬇️

scientific article published on January 1, 2013

Diabetes and Aging: Unique Considerations and Goals of Care

scientific article published on April 2017

Diabetes, the metabolic syndrome, and angiographic progression of coronary arterial disease in postmenopausal women

scientific article published on 20 October 2005

Diabetes: HOME reveals new data on a cornerstone of treatment

scientific article published in September 2009

Dietary Methionine Restriction Increases Fat Oxidation in Obese Adults with Metabolic Syndrome ⬇️

scientific article published on February 23, 2011

Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating

scientific article published on 27 March 2015

Disrupted anabolic and catabolic processes may contribute to alcohol-accentuated SAIDS-associated wasting

scientific article

Does Body Mass Index Adequately Convey a Patient's Mortality Risk? ⬇️

scientific article published on January 2, 2013

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

scholarly article by Elizabeth F Sutton et al published 5 June 2018 in Cell Metabolism

Economics of diabetes-cost impact of not treating diabetes early and intensively

scientific article

Effect of Shilianhua extract and its fractions on body weight of obese mice

scientific article published on July 2008

Effect of combination glipizide GITS/metformin on fibrinolytic and metabolic parameters in poorly controlled type 2 diabetic subjects

scientific article published in December 2002

Effects of Artemisia species on de novo lipogenesis in vivo

scientific article

Effects of canagliflozin on body weight and relationship to HbA1c and blood pressure changes in patients with type 2 diabetes

scientific article published on 27 March 2015

Effects of chromium picolinate on food intake and satiety

scientific article

Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet

scientific article

Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels

scientific article

Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial ⬇️

scientific article published on July 12, 2013

Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans

scientific article published on June 2008

Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial

scientific article published in August 2005

Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancy: evidence for a protective adaptation in diabetes

scientific article published in May 2005

Erratum. George A. Bray, MD: Progress in Obesity-Multidisciplinary Research, Multidimensional Man. Diabetes Care 2016;39:1481-1485.

scientific article published on 27 December 2016

Evaluation of alternative strategies for optimizing glycemia: progress to date

scientific article published in October 2002

Evolving Treatment Strategies for the Management of Type 2 Diabetes ⬇️

scientific article published on January 1, 2012

Evolving strategies for insulin delivery and therapy

scientific article published on January 2004

Exubera. Inhale therapeutic systems

scientific article published in May 2002

Feasibility of intravenous glucose tolerance testing prior to puberty

scientific article

Fractalkine: A Cellular Link Between Adipose Tissue Inflammation and Vascular Pathologies ⬇️

scientific article published on May 1, 2011

George A. Bray, MD: Progress in Obesity-Multidisciplinary Research, Multidimensional Man.

scientific article published on September 2016

Getting to the "Heart" of the Matter on Diabetic Cardiovascular Disease: "Thanks for the Memory".

scientific article published on May 2016

Global call for free academic movement for international dialogue

scientific article published in August 2012

Glucose control, macro- and microvascular disease, and the Food and Drug Administration: let's keep our eye on the ball

scientific article published on 2 September 2008

Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy

scientific article published on 11 September 2014

Guiding principles for diabetes care

scientific article published on October 2015

HbA1c and lower-extremity amputation risk in low-income patients with diabetes

scientific article published on 23 September 2013

Health policy and diabetes care: is it time to put politics aside?

scientific article published on 22 March 2015

How do we define cure of diabetes?

scientific article published on November 2009

Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling

scientific article published on 16 April 2008

Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children

scientific article

Improved absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia dracunculus L.

scientific article

Improved glucose control decreases the interaction of plasma low-density lipoproteins with arterial proteoglycans

scientific article published in October 2002

Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice

scientific journal article

Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age

scientific article published on 12 October 2006

Inflammation, insulin resistance, and type 2 diabetes: back to the future?

scientific article published on February 2009

Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial

scientific article published in October 2005

Inhaled insulin: a novel route for insulin delivery

scientific article

Innovative approaches to understanding and addressing health disparities in diabetes care and research

scientific article published on February 2015

Insulin physiology and therapy. Preface

scientific article

Insulin therapy in people with type 2 diabetes: opportunities and challenges?

scientific article published on June 2014

Insulin's Role in Diabetes Management: After 90 Years, Still Considered the Essential "Black Dress".

scientific article published in December 2015

Intensive glycemic control and cardiovascular disease observations from the ACCORD study: now what can a clinician possibly think?

scientific article published in May 2008

Introduction to the 5th World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)

scientific article published on August 2016

Is it time to change the way we report and discuss weight loss?

scientific article

Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice

scientific article published on 27 April 2015

Lipid in skeletal muscle myotubes is associated to the donors' insulin sensitivity and physical activity phenotypes

scientific article published on 10 September 2013

Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study

scientific article published on 28 October 2013

Long-term glycemic control measurements in diabetic patients receiving hemodialysis

scientific article published in February 2002

Maturation of CGM and Glycemic Measurements Beyond HbA1c-A Turning Point in Research and Clinical Decisions

scientific article published in December 2017

Metabolic Surgery for Type 2 Diabetes: Changing the Landscape of Diabetes Care

scientific article published on June 2016

Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.

scientific article published on 3 July 2008

Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination

scientific article

Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells ⬇️

scientific article published on March 6, 2013

Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol

scientific article published on July 2008

Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys

scientific article published on 31 March 2009

Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle

scientific article published on 5 March 2015

Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite ⬇️

scientific article published on October 27, 2010

Mortality and glycemic targets in the intensive care unit: another paradigm shift?

scientific article published in July 2009

Multidisciplinary interventions: mapping new horizons in diabetes care

scientific article published in July 2008

Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats

scientific article published in June 2002

Overcoming the barriers for achieving standards of diabetes care: the formation of CADRE.

scientific article

Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition

scientific article published on 27 January 2014

Patients' perceptions of subcutaneous insulin in the OPTIMIZE study: a multicenter follow-up study

scientific article published on February 2008

Perceptions community residents have about partner institutions and clinical research

scientific article published on 18 October 2013

Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum

scientific article published on June 2013

Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation

scientific article published on December 2007

Phytochemical composition and metabolic performance-enhancing activity of dietary berries traditionally used by Native North Americans

scientific article

Plant-derived therapeutics for the treatment of metabolic syndrome ⬇️

scientific article published on October 1, 2010

Potential adverse effects of botanical supplementation in high-fat-fed female mice

Primary prevention of type 2 diabetes: there are no simple solutions!

scientific article published on August 2009

Progress to date for Diabetes Care: going mobile and putting information at your fingertips!

scientific article published on July 2012

Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L ⬇️

scientific article published on March 26, 2012

Psychosocial Research and Care in Diabetes: Altering Lives by Understanding Attitudes.

scientific article published in December 2016

Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet

scientific article

Randomized study to characterize glycemic control and short-term pulmonary function in patients with type 1 diabetes receiving inhaled human insulin (exubera).

scientific article published on 26 September 2006

Redefining treatment success in type 2 diabetes mellitus: Comprehensive targeting of core defects

scientific article published on December 2009

Reducing the Glycemic Index or Carbohydrate Content of Mixed Meals Reduces Postprandial Glycemia and Insulinemia Over the Entire Day but Does Not Affect Satiety ⬇️

scientific article published on June 11, 2012

Reevaluation of CMS' Competitive Bidding Program

scientific article published on July 2016

Regulation of insulin action by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture: a proteomics approach

scientific article published in September 2010

Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.

scientific article

Response to Comment on Cefalu et al. Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors' Expert Forum. Diabetes Care 2016;39:1186-1201.

scientific article published in February 2017

Response to comment on Cefalu et Al. The alarming and rising costs of diabetes and prediabetes: a call for action! Diabetes care 2014;37:3137-3138.

scientific article published on May 2015

Response to comment on Home et al. Insulin therapy in people with type 2 diabetes: opportunities and challenges? Diabetes care 2014;37:1499-1508.

scientific article published on November 2014

Role of chromium in human health and in diabetes

scientific article

SGLT2 inhibitors: the latest "new kids on the block"!

scientific article published on March 2015

Safety and efficacy of inhaled human insulin (exubera) during discontinuation and readministration of therapy in adults with type 2 diabetes: a 3-year randomized controlled trial

scientific article published in November 2009

Screening native botanicals for bioactivity: an interdisciplinary approach

scientific article

Signals and noise in drug safety analyses: the incretin therapy debate provides the rationale for revamping epidemiologic pharmacovigilance

scientific article published on 21 May 2013

Skeletal muscle ceramides and daily fat oxidation in obesity and diabetes

scientific article published on 4 January 2018

Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans

scientific article

Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes

scientific article published on 6 June 2015

Status of Diabetes Care: "It just doesn't get any better . . . or does it?".

scientific article published on July 2014

Status of Diabetes Care: New Challenges, New Concepts, New Measures--Focusing on the Future!

scientific article published on July 2015

Steps Toward the Meaningful Translation of Prevention Strategies for Type 2 Diabetes ⬇️

scientific article published on April 1, 2012

Stinging Nettle (Urtica dioica L.) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an Adiponectin Dependent Manner

scientific article

Study Design and Rationale of a Dose‐Ranging Trial of LX4211, a Dual Inhibitor of SGLT1 and SGLT2, in Type 2 Diabetes Inadequately Controlled on Metformin Monotherapy ⬇️

scientific article published on April 29, 2013

Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers

scientific article published on February 2008

The "Evidence" Is In! It Does Get Better!

scientific article published on January 2015

The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes

scientific article

The Hurricane Katrina aftermath and its impact on diabetes care: observations from "ground zero": lessons in disaster preparedness of people with diabetes

scientific article

The Impact of Precision Medicine in Diabetes: A Multidimensional Perspective

scientific article

The alarming and rising costs of diabetes and prediabetes: a call for action!

scientific article published on December 2014

The artificial pancreas: are we there yet?

scientific article published on January 2014

The contribution of race and diabetes status to metabolic flexibility in humans

scientific article

The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: the "gift" that keeps on giving!

scientific article published on January 2014

The importance of waist circumference and BMI for mortality risk in diabetic adults

scientific article published on 11 June 2013

The integral role of clinical research in clinical care

scientific article

The new diabetes inhalers: new tools for the clinician

scientific article published on June 2007

The physiologic role of incretin hormones: clinical applications.

scientific article published on March 2010

Titration of inhaled human insulin (Exubera) in a treat-to-target regimen for patients with type 2 diabetes

scientific article published in March 2010

Tools for the identification of bioactives impacting the metabolic syndrome: screening of a botanical extract library using subcutaneous and visceral human adipose-derived stem cell-based assays

scientific article

Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans

scientific article

Translating "Nondiabetic" A1C levels to clinical practice: the art of medicine

scientific article

Treatment satisfaction in type 2 diabetes: a comparison between an inhaled insulin regimen and a subcutaneous insulin regimen

scientific article published on April 2002

Two-year pulmonary safety and efficacy of inhaled human insulin (Exubera) in adult patients with type 2 diabetes

scientific article published on 5 June 2008

Type 1 diabetes at a crossroads!

scientific article published on June 2015

Unsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome

scientific article

Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors' Expert Forum

scientific article

“TODAY” Reflects on the Changing “Faces” of Type 2 Diabetes ⬇️

scientific article published on June 1, 2013

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