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List of works by Laurie Glimcher

1,25-Dihydroxyvitamin D3 inhibits antigen-induced T cell activation ⬇️

scientific article published on 01 October 1984

A DNA binding protein regulated by IL-4 and by differentiation in B cells

scientific article published in December 1988

A biochemical analysis of Ak molecules from mutant antigen presenting cell lines

scientific article published on 01 January 1986

A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain

scientific article

A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB

scientific article published in March 1996

A common factor regulates both Th1- and Th2-specific cytokine gene expression

scientific article published on February 1994

A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding

scientific article

A functional role for signal transduction via the cytoplasmic domains of MHC class II proteins

scientific article published on 01 August 1989

A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B.

scientific article published on August 1989

A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo

scientific article

A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2

scientific article (publication date: 2002)

A minimal level of MHC class II expression is sufficient to abrogate autoreactivity

scientific article published on 01 August 1999

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

scientific article published on 09 September 2012

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter

scientific journal article

A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells

scientific journal article

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

scientific article published on December 2008

A novel transcription factor, T-bet, directs Th1 lineage commitment

scientific article

A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis

scientific article

A role for the immunological synapse in lineage commitment of CD4 lymphocytes

scientific article published on 22 September 2004

A single base mutation in an I-A alpha-chain gene alters T-cell recognition

scientific article

A tissue-specific DNase I-hypersensitive site in a class II A alpha gene is under trans-regulatory control

scientific article

Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy

scientific article published on 01 August 1994

Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice

scientific article published in November 2003

Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development ⬇️

scientific article published on October 1, 2003

Activation of T cells by superantigen in class II-negative mice.

scientific article published on December 1994

Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice

scientific article published on December 2011

Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome?like skeletal defects induced by Pdk1 or Cbp mutations in mice

scientific article published in May 2012

After GWAS: mice to the rescue? ⬇️

scientific article published on September 29, 2012

Alteration of a non-polymorphic residue in a class II E beta gene eliminates an antibody-defined epitope without affecting T cell recognition

scientific article published on 01 June 1987

Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.

scientific article

An HLA-DR? promoter DNA-binding protein is expressed ubiquitously and maps to human chromosomes 22 and 5 ⬇️

scientific article published on January 1, 1991

An Ia-positive mouse T-cell clone is functional in presenting antigen to other T cells.

scientific article published in January 1985

An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain ⬇️

scientific article published on June 12, 1992

An essential role in liver development for transcription factor XBP-1

scientific journal article

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

scientific article published on August 2015

An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells

scientific article

An intronic 10-base-pair deletion in a class II A beta gene affects RNA processing

scientific article published on October 1989

An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator

scientific article

Analysis of responder cell-cell interactions in the syngeneic mixed leukocyte response

scientific article published on June 1985

Antigen presentation abrogated in cells expressing truncated Ia molecules

scientific article published on 01 March 1989

Antigen-driven effector CD8 T cell function regulated by T-bet

scientific article

Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes

scientific article

Asthmatic changes in mice lacking T-bet are mediated by IL-13.

scientific article published on 6 July 2005

Author Correction: XBP-1 and the unfolded protein response (UPR)

scientific article published on 12 November 2020

Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice

scientific article

B lymphocyte development and activation independent of MHC class II expression

scientific article published on 01 February 1993

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes

scientific article published on 01 April 1994

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

scientific article published on March 1995

B7-2 (CD86) is essential for the development of IL-4-producing T cells

article

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

scientific article

BanI polymorphism at the XBP1 locus

scientific article published on September 1990

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

scientific article published on 01 June 1994

Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes

scientific article

Binding of toxic shock syndrome toxin-1 to murine major histocompatibility complex class II molecules

scientific article published in September 1990

Biochemical characterization of I-Ak proteins from mutant antigen-presenting B-cell--B-lymphoma hybridomas

scientific article published on 01 May 1985

Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response

scientific article published on 01 December 1996

Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self

scientific article

Breaking down barriers to clinical translation: an interview with Laurie Glimcher. Interview by Sarah Allan

scientific article published in January 2012

CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts

scientific article published on 01 April 1997

CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant

scientific article published on May 1997

Calcineurin regulates innate antifungal immunity in neutrophils

scientific article

Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization

scientific article published on 17 January 2015

Casein expression in cytotoxic T lymphocytes

scientific article

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

scientific article published on December 2011

Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice

scientific article (publication date: 18 January 1996)

Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease

scientific article

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice

scientific article

Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase

scientific article

Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells

scientific article published on September 2009

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system

scientific article

Complex regulation of class II gene expression: analysis with class II mutant cell lines

scientific article published on 01 November 1985

Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules ⬇️

scientific article published on June 15, 1993

Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus

scientific article published on 19 April 2007

Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse

scientific article published on 06 April 2009

Control of bone resorption in mice by Schnurri-3.

scientific article

Control of immunoglobulin heavy chain constant region gene expression

scientific article published on January 1991

Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3.

scientific article

Control of transcription at the murine A alpha locus

scientific article published on January 1990

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

scientific article published on May 1995

Corticosteroid induction of Ig+Ia- B cells in vitro is mediated via interaction with the glucocorticoid cytoplasmic receptor

scientific article published on 01 April 1988

Critical roles for transcription factor GATA-3 in thymocyte development

scientific journal article

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites

scientific article published on 10 October 2016

Cutting Edge: STAT1 and T-bet Play Distinct Roles in Determining Outcome of Visceral Leishmaniasis Caused by Leishmania donovani

scientific article published on 01 July 2006

Cytoplasmic domain affects membrane expression and function of an Ia molecule

scientific article

DNA-mediated transfer of major histocompatibility class II I-Ab and I-Abm12 genes into B lymphoma cells: molecular and functional analysis of introduced antigens.

scientific article published in August 1985

Dampening of death pathways by schnurri-2 is essential for T-cell development ⬇️

scientific article published on April 7, 2011

Decreased immediate inflammatory gene induction in activating transcription factor-2 mutant mice

scientific article

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc ⬇️

scientific article published on 01 January 1998

Delayed rejection of soluble tumor necrosis factor receptor-secreting tumor allografts ⬇️

scientific article published on January 15, 1998

Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.

scientific article

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice

scientific article published in September 1991

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet ⬇️

scientific article published on January 11, 2002

Developmental and cytokine-mediated regulation of MHC class II gene promoter occupancy in vivo

scientific article

Differences in DNA sequence specificity among MHC class II X box binding proteins

scientific article published on February 1989

Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.

scientific article published on February 2012

Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomas

scientific article published in December 2003

Differential induction of class II gene expression in murine pre-B-cell lines by B-cell stimulatory factor-1 and by antibodies to B-cell surface antigens

scientific article published in January 1988

Differing regulation and function of ICAM-1 and class II antigens on renal tubular cells

scientific article published on September 1990

Direct evidence that a class II molecule and a simple globular protein generate multiple determinants

scientific article

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

scientific article published on 28 November 2011

Distal regions of the human IFNG locus direct cell type-specific expression

scientific article

Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells ⬇️

scientific article published on January 11, 2002

Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element

scientific article published on 01 October 1988

Dominant negative mutants of transcription factor mXBP (CRE-BP1, ATF-2)

scientific article published on 01 April 1992

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

scientific article

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

scientific article

Early murine Lyme carditis has a macrophage predominance and is independent of major histocompatibility complex class II-CD4+ T cell interactions

scientific article published on 01 February 1995

Editorial overview

scientific article published on 23 December 2010

Ek beta mutant antigen-presenting cell lines expressing altered Ak alpha molecules

scientific article published on 01 May 1986

Endoplasmic reticulum stress in immunity

scientific article published on 10 December 2014

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

scientific journal article

Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis

scientific article published in January 1989

Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis

scientific article

Evidence that a "four-cell cluster" may prime cytotoxic T-cells during graft rejection

scientific article published on 01 February 1993

Evidence that autoreactive T hybridomas recognize multiple epitopes on the I-Ak molecule

scientific article published in March 1985

Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia

scientific article published on December 2011

Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection.

scientific article published in October 2005

Expression of metalloproteinases in pigmented villonodular synovitis

scientific article published on 01 August 1994

Expression of the T-cell-specific gamma gene is unnecessary in T cells recognizing class II MHC determinants

scientific article

Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice

scientific article published on 24 June 2011

Fine specificity of cloned insulin-specific T cell hybridomas: evidence supporting a role for tertiary conformation ⬇️

scientific article published on 01 December 1983

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

scientific article published on September 2009

From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis

scientific article published on September 2009

Functional Activity of a Transformed Thymic Epithelial Cell Line ⬇️

scientific article published on January 1, 1983

Functional Th1 cells are required for surgical adhesion formation in a murine model

scientific article published on May 2008

Functional and molecular characterization of I-A kappa beta mutants is consistent with the predicted three dimensional structure of class II MHC molecules

scientific article published on July 1990

Functional expression of a cloned I-A beta k gene in B-lymphoma cells

scientific article published on 01 February 1984

Genes that regulate interleukin-4 expression in T cells ⬇️

scientific article published on December 1, 1997

Genetic evidence for a new type of major histocompatibility complex class II combined immunodeficiency characterized by a dyscoordinate regulation of HLA-D alpha and beta chains

scientific article

Gout: new insights into an old disease.

scientific article

HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function

scientific article

Harvard's women four years later

scientific article published in June 2009

Homeostasis and inflammation in the intestine

scientific article

How we can help the next generation of scientists: introducing The "Hands-On" Primary Caregiver's Support Program

scientific article published on 01 September 2004

Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency

scientific article published on May 1995

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria

scientific article published on 03 December 2020

Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos

scientific article

Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products

scientific article published on March 2005

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

scientific article

I region-restricted antigen presentation by B cell–B lymphoma hybridomas ⬇️

scientific article published on July 15, 1982

IA mutant functional antigen-presenting cell lines ⬇️

scientific article published on May 1, 1983

IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508.

scientific article

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection

scientific article published on 25 June 2015

IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections

scientific article

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

scientific article published on 30 January 2012

IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

scientific article published in Nature

IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

scientific article published on 01 July 2019

Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells

scientific article

Identification of a cell-surface antigen selectively expressed on the natural killer cell ⬇️

scientific article published on January 1, 1977

Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts

scientific article

Identification of an IL-4-inducible gene expressed in differentiating lymphocytes and male germ cells

scientific article published on January 1990

Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells

scientific article published on July 1999

Identification of functional regions on the I-Ab molecule by site-directed mutagenesis

scientific article published on February 1986

Immune responses in MHC class II-deficient mice

scientific article

Immunogenetic Analysis of "Natural Killer" Activity in the Mouse ⬇️

scientific article published on January 1, 1979

Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products

scientific article

In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium

scientific article published on 01 September 1991

In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesis ⬇️

scientific article published on June 1, 1993

In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome

scientific article published on May 1991

Increased bone mass and bone matrix mineralization in schnurri-3 null mice

Increased bone matrix mineralization in Schnurri-3 null mice

article published in 2009

Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production

scientific article published in October 2005

Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo

scientific article

Influence of accessory cell and T cell surface antigens on mitogen-induced IL 2 receptor expression

scientific article published on 01 September 1985

Inhibition of IFN-gamma induction of class II MHC genes by cAMP and prostaglandins

scientific article published on January 1994

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

scientific article published in November 1998

Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis

scientific article published on February 1990

Interferon gamma regulates binding of two nuclear protein complexes in a macrophage cell line

scientific article published on February 1990

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression

scientific article

Intersection of the unfolded protein response and hepatic lipid metabolism

scientific article

Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets

scientific article

Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo

scientific article

It's a Good Year for Blimp-1 (and Plasma Cells) ⬇️

scientific article published on 01 October 2003

Laurie Glimcher: merging cell biology and immune function. Interview by Sedwick Caitlin

scientific article published on April 2010

Lentivirus delivery of shRNA constructs into osteoblasts

scientific article published on January 2008

Lineage commitment in lymphocytes: controlling the immune response ⬇️

scientific article published on October 1, 2001

Lineage commitment in the immune system: the T helper lymphocyte grows up.

scientific article published in July 2000

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

scientific article

Loss of a DNA-protein complex correlates with extinguished major histocompatibility complex class II expression in a human B cell

scientific article

MEKK2 mediates an alternative β-catenin pathway that promotes bone formation

scientific article published on 16 February 2016

MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells

scientific article published on February 1990

MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice

scientific article

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules ⬇️

scientific article published on October 1, 1983

Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin

scientific article published in November 2004

Major histocompatibility complex class II+B7-1+ tumor cells are potent vaccines for stimulating tumor rejection in tumor-bearing mice

scientific article

Marking IL-4-producing cells by knock-in of the IL-4 gene

scientific article published on 01 February 1999

Mice lacking major histocompatibility complex class I and class II molecules

scientific article

Mitogen-activated protein kinase pathways in osteoblasts

scientific article published on 31 May 2013

Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment

scientific article

Molecular cloning of mouse cathepsin D.

scientific article published on July 1990

Molecular mechanisms regulating Th1 immune responses

scientific article

Most gamma delta T cells develop normally in the absence of MHC class II molecules

scientific article published on 01 November 1993

Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome

scientific article published on 01 June 1999

Murine class II (Ia) molecules associate with human invariant chain

scientific article published on 01 March 1987

Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules ⬇️

scientific article published on November 1, 1981

Mutations of class II MHC molecules

scientific article

Mycobacterium tuberculosis Rv2224c modulates innate immune responses

scientific journal article

NF-AT-Driven interleukin-4 transcription potentiated by NIP45

scientific article

NFATc1 and NFATc2 repress spontaneous osteoarthritis

scientific article

NFATc1 and NFATc2 together control both T and B cell activation and differentiation

scientific article published on 01 January 2001

NFATc1 balances quiescence and proliferation of skin stem cells

scientific journal article

NFATc1 in inflammatory and musculoskeletal conditions

scientific article published on January 2010

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

scientific article

NFATc2 and NFATc3 regulate TH2 differentiation and modulate TCR-responsiveness of naïve TH cells ⬇️

scientific article published on December 10, 2001

NIP45 controls the magnitude of the type 2 T helper cell response.

scientific article

Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice.

scientific article

Non-consensus DNA sequences function in a cell-type-specific enhancer of the mouse class II MHC gene A alpha

scientific article

Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation

scientific article

Novel roles for XBP1 in hematopoietic development

scientific article published on 8 April 2016

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

scientific article

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection ⬇️

scientific article published on July 1, 2011

Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.

scientific article published on 09 April 2006

Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system

scientific article

Peripheral lymphoid development and function in TCR mutant mice

scientific article published on 01 July 1994

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice

scientific article

Pillars article: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000. 100: 655-669.

scientific article published in April 2015

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

scientific journal article

Plasma cell differentiation requires the transcription factor XBP-1

scientific article

Polyclonal B-cell activation by a B-cell differentiation factor B151-TRF2. IV. B151-TRF2-responsive F1 B cells consist of two separate populations capable of recognizing only one of the parental I-A products expressed on B cells

scientific article published on 01 January 1987

Post-translational control of T cell development by the ESCRT protein CHMP5.

scientific article published on 29 May 2017

Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice

scientific article

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

scientific article

Production of autoreactive I region-restricted T cell hybridomas ⬇️

scientific article published on August 1, 1982

Promoter accessibility within the environment of the MHC is affected in class II-deficient combined immunodeficiency.

scientific article published on January 1993

Prostaglandin E2 inhibits the activation of cloned T cell hybridomas

scientific article published on 01 April 1985

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

scientific article (publication date: 19 August 2003)

Protective role of major histocompatibility complex class II Ebd transgene on collagen-induced arthritis

scientific article

Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy model

scientific article published on 10 March 2008

Protein folding stress in neurodegenerative diseases: a glimpse into the ER ⬇️

scientific article published on January 31, 2011

Protein homeostasis networks in physiology and disease ⬇️

scientific article published on April 1, 2011

RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling

retracted scientific article published on May 2013

Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response

scientific journal article

Recent developments in the transcriptional regulation of cytolytic effector cells

scientific article

Reflections on health care

scientific article published on October 2009

Regulation of MHC class II gene transcription

scientific article published on February 1991

Regulation of Memory Formation by the Transcription Factor XBP1.

scientific article

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

scientific article

Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.

scientific article published on May 2006

Regulation of bone formation and immune cell development by Schnurri proteins

scientific article published on January 2010

Regulation of class II gene expression in a murine pre-B cell line.

scientific article

Regulation of class II gene expression: analysis in B cell stimulatory factor 1-inducible murine pre-B cell lines

scientific article published on 01 November 1986

Regulation of cytokine gene expression in T helper cell subsets.

scientific article published on January 1994

Regulation of hepatic lipogenesis by the transcription factor XBP1

scientific journal article

Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum ⬇️

scientific article published on November 18, 2010

Regulation of the E beta gene in vivo: lessons from E beta d transgenic mice

scientific article published on February 1996

Rejection of MHC class II-transfected tumor cells requires induction of tumor-encoded B7-1 and/or B7-2 costimulatory molecules

scientific article published on 01 May 1996

Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney transplant model.

scientific article

Repression of Constitutive and Interferon-gamma-Induced Class II Major Histocompatibility Complex Genes by Cyclic AMP and Prostaglandins

scientific article published on 01 September 1995

Repression of class II major histocompatibility complex genes by cyclic AMP is mediated by conserved promoter elements

scientific article published on December 1991

Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development

scientific article

Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma.

scientific article

Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

scientific article published in April 2018

Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene

scientific article

SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

scientific article published on 20 February 2017

Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells

scientific article

Schnurri-3 is an essential regulator of osteoblast function and adult bone mass

scientific article published on November 2007

Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

scientific article published on 15 August 2013

Schnurri-3: A Key Regulator of Postnatal Skeletal Remodeling

scientific article published on 01 January 2007

Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo.

scientific article

Sequences and factors: a guide to MHC class-II transcription

scientific article published on January 1, 1992

Sequential involvement of NFAT and Egr transcription factors in FasL regulation

scientific journal article

Serologic and functional characterization of a panel of antigen-presenting cell lines expressing mutant I-A class II molecules ⬇️

scientific article published on November 1, 1983

Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus

scientific article

Signaling pathways in Th2 development

scientific article

Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression

scientific article published on November 19, 1992

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

scientific article

Single amino acid mutations in the murine MHC class II A beta cytoplasmic domain abrogate antigen presentation ⬇️

scientific article published on December 15, 1997

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

scientific article published on 01 October 1993

Stimulated kidney tubular epithelial cells express membrane associated and secreted TNF alpha

scientific article published on 01 August 1991

Structural mutation affecting intracellular transport and cell surface expression of murine class II molecules

scientific article

Structure and function of murine class II major histocompatibility complex genes.

scientific article published in March 1986

Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities

scientific article

Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities☆

article

T cell abnormalities in NZB mice occur independently of autoantibody production

scientific article

T cell clones and hybridomas as probes for the analysis of the syngeneic mixed leukocyte reaction

scientific article published on May 1, 1983

T cell directives for transcriptional regulation in asthma

scientific article published on 12 November 2003

T cell receptor gene segment usage in a panel of hen-egg white lysozyme specific, I-Ak-restricted T helper hybridomas

scientific article

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

scientific article

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

scientific article published on 10 June 2002

T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells

scientific article published on 01 February 2002

T-bet Runs INTERFERence

scientific article published on 20 June 2017

T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes

scientific article

T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity

scientific article published in November 2006

T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses

scientific article

T-bet in disease.

scientific article published on 20 June 2011

T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells

scientific article

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.

scientific article published on 12 July 2005

T-bet plays a key role in NK-mediated control of melanoma metastatic disease

scientific article published on June 2008

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness

scientific article

T-bet regulates IgG class switching and pathogenic autoantibody production

scientific journal article

T-bet regulates metastasis rate in a murine model of primary prostate cancer

scientific article published on 01 January 2004

T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells

scientific article

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

scientific journal article

T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma

scientific article (publication date: 2005)

T-bet, a T-cell-associated transcription factor, is expressed in a subset of B-cell lymphoproliferative disorders

scientific article published on 01 August 2004

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

scientific article

T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships

scientific article published on 08 August 2009

T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function

scientific article published on 17 June 2009

T-bet-dependent expression of osteopontin contributes to T cell polarization

scientific article

T-bet: a bridge between innate and adaptive immunity.

scientific article published on 11 October 2013

T-cell sets that control B-cell secretion of antigen-specific immunoglobulin also control secretion of nonspecific immunoglobulin

scientific article published on 01 July 1982

TAK1 is an essential regulator of BMP signalling in cartilage

scientific journal article

TAK1 mediates BMP signaling in cartilage

scientific article

TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids

scientific article

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

scientific article

TNF-alpha is expressed on the surface of kidney proximal tubular cells

scientific article published on February 1991

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.

scholarly article

Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy

scientific article

Targeting skeletal endothelium to ameliorate bone loss

scientific article published on 21 May 2018

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

scientific article published on 14 February 2012

Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties

scientific article

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

scientific article

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc

scientific article published on 13 May 2019

The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex

scientific article

The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells ⬇️

scientific article published on September 1, 1998

The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response

scientific article

The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells

scientific article

The autologous mixed lymphocyte reaction in strains of mice with autoimmune disease

scientific article published on 01 October 1980

The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core

scientific article

The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens ⬇️

scientific article published on November 1, 1978

The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology

scientific article published on January 2008

The endoplasmic reticulum stress response in immunity and autoimmunity

scientific article published on September 2008

The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells

scientific article published on 25 January 2009

The isolation and functional characterization of autoimmune clones expressing inappropriate Ia

scientific article published on 01 August 1984

The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2

scientific article

The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis

scientific article

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

scientific article

The presence of a DNA binding complex correlates with E beta class II MHC gene expression

scientific article

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis

scientific article published on 18 May 2007

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

scientific article published on June 1996

The proximal promoter of the IL-4 gene is composed of multiple essential regulatory sites that bind at least two distinct factors

scientific article published on 01 June 1995

The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes

scientific article

The ripple effect: why promoting female leadership in global health matters.

scientific article

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice

scientific article

The role of Th1/Th2 polarization in mucosal immunity

scientific article

The specificity of the syngeneic mixed leukocyte response, a primary anti-I region T cell proliferative response, is determined intrathymically

scientific article published on 01 September 1982

The structure-function relationship of I-A molecules: correlation of serologic and functional phenotypes of four I-Ak mutant cell lines ⬇️

scientific article published on 01 December 1984

The transcription T-bet is required for optimal proinflammatory trafficking of CD4+ T cells.

scientific article published on 17 February 2005

The transcription factor NF-ATc is essential for cardiac valve formation ⬇️

scientific article published on March 12, 1998

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

scientific article

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

scientific journal article

The transcription factor XBP1 is selectively required for eosinophil differentiation

scientific article

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

scientific journal article

The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism

scientific article published on 12 June 2011

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

scientific article

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

scientific article

Three distinct signals can induce class II gene expression in a murine pre-B-cell line

scientific article published on July 1986

Three in vivo promoter phenotypes in MHC class II deficient combined immunodeficiency

scientific article published on 01 January 1993

Thymic stromal cell specialization and the T-cell receptor repertoire

scientific article published on February 1997

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages

scientific article published on November 1993

Tissue-specific regulation of cytokine gene expression

scientific article

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

scientific article

Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells

scientific article

Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13

scholarly article

Transcription factors in lymphocyte development--T and B cells get together

scientific article published on 01 January 1999

Transcription of the interleukin 4 gene is regulated by multiple promoter elements

scientific article

Transcription: tantalizing times for T cells

scientific article

Transcriptional regulation of Th1/Th2 polarization

scientific article

Transforming growth factor beta 1 repression of the HLA-DR alpha gene is mediated by conserved proximal promoter elements.

scientific article published on October 1993

Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation

scientific article published on 01 April 1995

Transgenic tubular cell expression of class II is insufficient to initiate immune renal injury

scientific article published on 01 June 1993

Translating Research into Therapies ⬇️

scientific article published on March 16, 2012

Trawling for treasure: tales of T-bet

scientific article published on May 2007

Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes

scientific article

Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease

Tumor cells expressing major histocompatibility complex class II and B7 activation molecules stimulate potent tumor-specific immunity

scientific article published on 01 October 1993

Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45).

scientific article

Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer

scientific article (publication date: 9 February 2017)

Turning down the system: counter-regulatory mechanisms in bone and adaptive immunity

scientific article

Two levels of help for B cell alloantibody production

scientific article published on February 1996

Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3

scientific article

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

scholarly article

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

scientific article published in Nature

Upstream elements of the MHC class II E beta gene active in B cells

scientific article

Using thymus anatomy to dissect T cell repertoire selection

scientific article published on 01 February 1999

Variable effects of transgenic c-Maf on autoimmune diabetes.

scientific article

William Erwin Paul (1936-2015).

scientific article published on October 2015

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response ⬇️

scientific article published on November 1, 2003

XBP-1 and the unfolded protein response (UPR)

scientific article published on 02 July 2020

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

scientific article

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy

scientific article published on 06 November 2009

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

scientific journal article

XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells

scientific article

XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum ⬇️

scientific article published on October 14, 2010

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

scientific article published on 14 September 2009

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

scientific article published on September 2004

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

scientific article

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

scientific article

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

scientific article

XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease

scientific article published in September 2015

XBP1: the last two decades

scientific article published on January 2010

c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms

scientific article

mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element

scientific article

p38α MAPK is required for tooth morphogenesis and enamel secretion

scientific article

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