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List of works by Laurence Pearl

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

scientific article

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer

scientific article

A combinatorial method to enable detailed investigation of protein-protein interactions

scientific article published on March 2011

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

scientific article published on 20 November 2008

A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus

scientific article

A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli

scientific article

A structural model for the retroviral proteases.

scientific article

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX.

scientific article published on 24 November 2015

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

scientific article

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

scientific article

Activation segment exchange: a common mechanism of kinase autophosphorylation?

scientific article published on 12 July 2007

An iron-sulfur cluster in the family 4 uracil-DNA glycosylases

scientific article published on 27 February 2002

Assays for HSP90 and inhibitors.

scientific article

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

scientific article published in Nature Communications

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

scientific article published on 08 October 2018

Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody

scientific article published in January 2005

CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors ⬇️

scientific article published on January 15, 2011

Chaperone ligand-discrimination by the TPR-domain protein Tah1.

scientific article

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

scientific article

Cloning and expression of the uracil-DNA glycosylase inhibitor (UGI) from bacteriophage PBS-1 and crystallization of a uracil-DNA glycosylase-UGI complex

scientific article published on 01 July 1995

Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle

scientific article published on 2 October 2004

Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications

scientific article published in October 2006

Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism.

scientific article published on 20 June 2016

Crystal Structure of the Retinoblastoma Protein N Domain Provides Insight into Tumor Suppression, Ligand Interaction, and Holoprotein Architecture

scientific article

Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex.

scientific article

Crystal structure of a thwarted mismatch glycosylase DNA repair complex

scientific article

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

scientific article (publication date: 20 April 2006)

Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability

scientific article

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

scientific article

Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2.

scientific article

Crystal structure of the proximal BAH domain of the polybromo protein.

scientific article published on August 2005

Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation

scientific article

Crystallization and preliminary X-ray analysis of the beta-galactosidase from the extreme thermophilic archaebacterium Sulfolobus solfataricus

scientific article published in January 1993

Crystallization and preliminary X-ray analysis of the uracil-DNA glycosylase DNA repair enzyme from herpes simplex virus type 1.

scientific article published in December 1993

Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition

scientific article published on 13 January 2011

DNA repair, genome stability and cancer: a historical perspective

scientific article published on 15 December 2015

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

article

Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.

scientific article published on 10 February 2010

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

scientific article

Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex.

scientific article published in December 2009

Electron microscopy studies on DNA recognition by DNA-PK.

scientific article

Elimination of twinning in crystals of Sulfolobus sofataricus alcohol dehydrogenase holo-enzyme by growth in agarose gels

scientific article published on 01 July 1994

Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting

scientific article

Erratum: Corrigendum: The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

scientific article published on 01 August 2015

Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies

scientific article

Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase

scientific article published on September 2006

Expression and crystallization of the yeast Hsp82 chaperone, and preliminary x-ray diffraction studies of the amino-terminal domain

scientific article published on 01 August 1996

Expression of the Fabs of human auto-antibodies in Escherichia coli: optimization and determination of their fine binding characteristics and cross-reactivity

scientific article published in May 2001

Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90

scientific article

Fine binding characteristics of human autoantibodies-partial molecular characterization

scientific article

Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites

scientific article published in January 2002

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

scientific article published in April 2004

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

scientific article

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

scientific article published on September 2008

Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

scientific article published on 30 May 2016

Identification of the Axin and Frat binding region of glycogen synthase kinase-3.

scientific article

In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies

scientific article

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol

scientific article published on November 2006

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

scientific article

Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV.

scientific article

Molecular Recognition of Transcriptional Repressor Motifs by the WD Domain of the Groucho/TLE Corepressor

scientific article published on 01 June 2006

Molecular characterization of macbecin as an Hsp90 inhibitor

scientific article

Molecular cloning and expression of the Fabs of human autoantibodies in Escherichia coli. Determination of the heavy or light chain contribution to the anti-DNA/-cardiolipin activity of the Fab.

scientific article

Oligomerization of the amide sensor protein AmiC by x-ray and neutron scattering and molecular modeling

scientific article published in July 1997

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

scientific article

Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1

scientific article

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

scientific article published on 28 May 2019

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

scientific article published on 16 April 2018

Recurrence of a binding motif?

scientific article published in March 1993

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans

scientific article published on 23 June 2011

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

scientific article

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

scientific article published on 2 December 2013

Retroviral proteinases. A second front against AIDS.

scientific article published in February 1989

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

scientific article

Sequence specificity of retroviral proteases

scientific article published in Nature

Shared structural motif in proteins

scientific article published in Nature

Similarity of active-site structures.

scientific article

Specialized interfaces of Smc5/6 control hinge stability and DNA association.

scientific article published on 30 January 2017

Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors

scientific article

Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1

scientific article

Structural and mechanistic insights into ras association domains of phospholipase C epsilon

scientific article

Structural basis for recruitment of BRCA2 by PALB2

scientific article

Structural basis for recruitment of BRCA2 by PALB2.

scientific article published on July 2017

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

scientific article

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

scientific article published in March 2004

Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the -clamp

scientific article

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

scientific article published in February 2004

Structural basis for uracil recognition by archaeal family B DNA polymerases

scientific article published in December 2002

Structural basis of the radicicol resistance displayed by a fungal hsp90

scientific article

Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2

scientific article

Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs

scientific article

Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.

scientific article published on 21 July 2009

Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct

scientific article published on August 1, 1998

Structure of an Hsp90-Cdc37-Cdk4 complex.

scientific article published in September 2006

Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity

scientific article published on 31 August 2006

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response ⬇️

scientific article published on February 11, 2011

Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes

scientific article published on 25 April 2015

Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies

scientific article

The BAH domain of Rsc2 is a histone H3 binding domain ⬇️

scientific article published on July 31, 2013

The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections

article

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

scientific article published on 11 April 2016

The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ Phosphatase

scientific article

The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins

scientific article

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

scientific article published on July 2005

The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues

scientific article published in October 2000

The structural basis of specific base-excision repair by uracil-DNA glycosylase

scientific article

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

scientific article

Therapeutic opportunities within the DNA damage response

scientific article

Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

scientific article published on February 2005

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

scientific article

TopBP1 utilises a bipartite GINS binding mode to support genome replication

scientific article published in 2024

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

scientific article

Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs

scientific article published on November 2003

Visualization of a DNA-PK/PARP1 complex.

scientific article published on 5 January 2012

p185, an immunodominant epitope, is an autoantigen mimotope.

scientific article

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