Search filters

List of works by Laurence D. Hurst

A Novel Gene Controls a New Structure: PiggyBac Transposable Element-Derived 1, Unique to Mammals, Controls Mammal-Specific Neuronal Paraspeckles

scientific article published in 2022

A RCT for assessment of active human-centred learning finds teacher-centric non-human teaching of evolution optimal

scientific article published on 04 December 2020

A mixture of "cheats" and "co-operators" can enable maximal group benefit

scientific article

A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

scientific article

A test of the null model for 5' UTR evolution based on GC content

scientific article

A unification of mosaic structures in the human genome

scientific article published on 29 July 2003

Active and repressed biosynthetic gene clusters have spatially distinct chromosome states

scientific article published on 03 June 2020

Atypical at skew in Firmicute genomes results from selection and not from mutation

scientific article

Biased codon usage near intron-exon junctions: selection on splicing enhancers, splice-site recognition or something else?

scientific article published in May 2005

Birt Hogg-Dubé syndrome-associated FLCN mutations disrupt protein stability

scientific article published on 12 July 2011

Both Maintenance and Avoidance of RNA-Binding Protein Interactions Constrain Coding Sequence Evolution

scientific article

Can codon usage bias explain intron phase distributions and exon symmetry?

scientific article

Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee.

scientific article

Chance and necessity in the evolution of minimal metabolic networks

scientific article

Chromatin remodelling is a major source of coexpression of linked genes in yeast

scientific article published on 5 September 2007

Clustering of Tissue-Specific Genes Underlies Much of the Similarity in Rates of Protein Evolution of Linked Genes

article

Clustering of housekeeping genes provides a unified model of gene order in the human genome

scientific article

Co-expressed yeast genes cluster over a long range but are not regularly spaced

scientific article published on 06 April 2006

Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes

scientific article

Comparative Analyses of Selection Operating on Nontranslated Intergenic Regions of Diverse Bacterial Species.

scientific article

Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights

scientific article

Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos

scientific article published on 14 April 2010

Comparisons of dN/dS are time dependent for closely related bacterial genomes

scientific article

Competition between transposable elements and mutator genes in bacteria

scientific article published on 23 April 2012

Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance

scientific article

Conditional expression explains molecular evolution of social genes in a microbe

scientific article published on 23 July 2019

Covert sex ⬇️

scientific article published on May 1, 1992

Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs

scientific article published on 5 November 2015

Direct Determination of the Mutation Rate in the Bumblebee Reveals Evidence for Weak Recombination-Associated Mutation and an Approximate Rate Constancy in Insects

scientific article published on 20 October 2016

Direct and indirect consequences of meiotic recombination: implications for genome evolution ⬇️

scientific article published on December 7, 2011

Dissecting dispensability

scientific article published on 01 March 2005

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

scientific article

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

scientific article published on 13 September 2017

Do Alu repeats drive the evolution of the primate transcriptome?

scientific article published on February 2008

Do Wolbachia-associated incompatibilities promote polyandry?

scientific article

Does negative auto-regulation increase gene duplicability?

scientific article

Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals

scientific article published on 13 July 2009

Dosage sensitivity and the evolution of gene families in yeast

scientific article

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses

scientific article

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

scientific article published on 10 February 2017

Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations

scientific article

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA ⬇️

scientific article published on 18 July 2018

Error prevention and mitigation as forces in the evolution of genes and genomes

article

Estimating the prevalence of functional exonic splice regulatory information

scientific article published on 12 April 2017

Evidence against the selfish operon theory

scientific article

Evidence for Purifying Selection Against Synonymous Mutations in Mammalian Exonic Splicing Enhancers

article

Evidence for a preferential targeting of 3'-UTRs by cis-encoded natural antisense transcripts

scientific article

Evidence for a priming effect on maternal resource allocation: implications for interbrood competition.

scientific article published in August 2003

Evidence for a trade-off between translational efficiency and splicing regulation in determining synonymous codon usage in Drosophila melanogaster

scientific article

Evidence for co-evolution of gene order and recombination rate

scientific article

Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes

scientific article published on 02 December 2008

Evidence for deep phylogenetic conservation of exonic splice-related constraints: splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans.

scientific article published on January 2013

Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals

scientific article

Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design

scientific article published on 12 May 2020

Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptionand organismic complexity

scientific article

Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates

scientific article

Evidence that the human X chromosome is enriched for male-specific but not female-specific genes

scientific article published on 30 May 2003

Evolutionary Genetics: The silence of the genes ⬇️

scientific article published on May 1, 1995

Evolutionary and physiological importance of hub proteins

scientific article published on 5 June 2006

Evolutionary genomics and the reach of selection

scientific article published on 23 February 2009

Evolutionary genomics: A positive becomes a negative

scientific article

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients

scientific article published on 12 August 2014

Exonic Splicing Regulatory Elements Skew Synonymous Codon Usage near Intron-exon Boundaries in Mammals

scientific article published on 24 May 2007

Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

scientific article published on 7 February 2008

Fundamental concepts in genetics: Genetics and the understanding of selection

scientific article

Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction

scientific article

Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving.

scientific article published on 10 September 2013

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

scientific article published on 8 December 2014

Genomic function (communication arising): Rate of evolution and gene dispensability

scientific article published in Nature

Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile

scientific article

Great majority of recombination events in Arabidopsis are gene conversion events

scientific article

GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution

scientific article

Growth effects of uniparental disomies and the conflict theory of genomic imprinting ⬇️

scientific article published on November 1, 1997

Hearing silence: non-neutral evolution at synonymous sites in mammals

scientific article

How Common Are Intragene Windows with K A > K S Owing to Purifying Selection on Synonymous Mutations?

scientific article published on 07 June 2007

How do synonymous mutations affect fitness?

scientific article

Human antisense genes have unusually short introns: evidence for selection for rapid transcription

article

Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro.

scientific article

Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2.

scientific article published on 10 October 2006

Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study

scientific article

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons

scientific article published on 17 September 2019

Intronic AT Skew is a Defendable Proxy for Germline Transcription but does not Predict Crossing-Over or Protein Evolution Rates in Drosophila melanogaster ⬇️

scientific article published on October 12, 2010

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

scientific article published on 21 January 2016

It's easier to get along with the quiet neighbours

scientific article published on 26 September 2017

Late replicating domains are highly recombining in females but have low male recombination rates: implications for isochore evolution

scientific article

Late-replicating domains have higher divergence and diversity in Drosophila melanogaster

scientific article published on 31 October 2011

Leukocyte tyrosine kinase functions in pigment cell development

scientific article published in March 2008

Maternally-inherited Grb10 reduces placental size and efficiency

scientific article published on 13 October 2009

Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast

scientific article published in June 2004

Metabolic trade-offs and the maintenance of the fittest and the flattest

scientific article

Monoallelic expression and tissue specificity are associated with high crossover rates

scientific article published on 21 October 2009

Mutation rate analysis via parent-progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids.

scientific article published in October 2016

Mutation rate analysis via parent-progeny sequencing of the perennial peach. II. No evidence for recombination-associated mutation.

scientific article

Mystery of the mutagenic male

scientific article published in Nature

Neighboring Genes Show Correlated Evolution in Gene Expression

scientific article published on 4 March 2015

Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

scientific article

Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation

scientific article

Open questions: A logic (or lack thereof) of genome organization ⬇️

scientific article published on May 28, 2013

Parent-progeny sequencing indicates higher mutation rates in heterozygotes.

scientific article published on 15 July 2015

Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?

scientific article

Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp

scientific article published on 28 September 2013

Positively charged residues are the major determinants of ribosomal velocity

scientific article

Predicting the virulence of MRSA from its genome sequence

scientific article

Preliminary Assessment of the Impact of MicroRNA-Mediated Regulation on Coding Sequence Evolution in Mammals

scientific article published on 16 June 2006

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

scientific article

Protein evolution: causes of trends in amino-acid gain and loss

scientific article published in August 2006

Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates

scientific article

Purifying Selection on Exonic Splice Enhancers in Intronless Genes

scientific article published on 23 January 2016

Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs

scientific article

Recent advances in understanding of the evolution and maintenance of sex ⬇️

scientific article published on February 1, 1996

Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life

scientific article published on 16 June 2020

SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity.

scientific article

Scientific aptitude better explains poor responses to teaching of evolution than psychological conflicts

article

Sensitivity of Patterns of Molecular Evolution to Alterations in Methodology: A Critique of Hughes and Yeager ⬇️

scientific article published on 01 October 1998

Sex-ratio adjustment in solitary and social spiders ⬇️

scientific article published on 01 October 1992

Similar rates but different modes of sequence evolution in introns and at exonic silent sites in rodents: evidence for selectively driven codon usage

scientific article published on 10 March 2004

Splicing and the evolution of proteins in mammals

scientific article published in February 2007

Still stratus not altocumulus: further evidence against the date/party hub distinction

scientific article

Stochasticity in protein levels drives colinearity of gene order in metabolic operons of Escherichia coli

scientific article

Stratus not altocumulus: a new view of the yeast protein interaction network

scientific article published in October 2006

Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation ⬇️

scientific article published on March 17, 2011

Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance.

scientific article

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias.

scientific article published on 20 November 2017

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

scientific article published on 18 December 2015

The architecture of intra-organism mutation rate variation in plants

article

The determinants of gene order conservation in yeasts

scientific article

The evolution, impact and properties of exonic splice enhancers

scientific article

The evolutionary dynamics of eukaryotic gene order

scientific article

The form of a trade-off determines the response to competition

scientific article published on 31 July 2013

The impact of the nucleosome code on protein-coding sequence evolution in yeast

scientific article

The proteins of linked genes evolve at similar rates

scientific article published in Nature

The signature of selection mediated by expression on human genes

scientific article

The small introns of antisense genes are better explained by selection for rapid transcription than by "genomic design"

scientific article

The sound of silence

scientific article published in Nature

Timing of Replication Is a Determinant of Neutral Substitution Rates but Does Not Explain Slow Y Chromosome Evolution in Rodents

article

Transcriptional coupling of neighboring genes and gene expression noise: evidence that gene orientation and noncoding transcripts are modulators of noise

scientific article published on 14 March 2011

Understanding the limits to generalizability of experimental evolutionary models

scientific article published in September 2008

Unique cost dynamics elucidate the role of frameshifting errors in promoting translational robustness

scientific article

Unusual linkage patterns of ligands and their cognate receptors indicate a novel reason for non-random gene order in the human genome

scientific article

Why Selection Might Be Stronger When Populations Are Small: Intron Size and Density Predict within and between-Species Usage of Exonic Splice Associated cis-Motifs

scientific article published on 13 March 2015

Why there is more to protein evolution than protein function: splicing, nucleosomes and dual-coding sequence

scientific article published on August 2009

Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution

scientific article

Paulina is supported by:

About Paulina

Help