List of works - Amira Klip

A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis

scientific article

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation

scientific article

A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle

scientific article

Activation of the glucose transporter GLUT4 by insulin

scientific article

Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors

scientific article published on January 2003

Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

scientific article

Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation

scientific article published on 10 July 2008

Arp2/3- and Cofilin-coordinated Actin Dynamics Is Required for Insulin-mediated GLUT4 Translocation to the Surface of Muscle Cells ⬇️

scientific article published on August 25, 2010

Bone marrow adipose cells - cellular interactions and changes with obesity

scientific article published on 06 March 2020

Cellular location of insulin-triggered signals and implications for glucose uptake

scientific article

Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells

scientific article

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

scientific article published in March 2017

Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling

scientific journal article

Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant

scientific article

Contracting C2C12 myotubes release CCL2 in an NF-κB-dependent manner to induce monocyte chemoattraction

scientific article published on 10 November 2015

Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells

scientific article

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

scientific article published on 31 December 2012

Deconstructing metabolic inflammation using cellular systems

scientific article published on 14 February 2017

Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation

scientific article published on 12 September 2019

Desperately seeking sugar: glial cells as hypoglycemia sensors

scientific article published on December 2005

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

scientific article

Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells

scientific article published on October 2009

Dissecting GLUT4 traffic components in L6 myocytes by fluorescence-based, single-cell assays

scientific article published on January 2008

Dissecting signalling by individual Akt/PKB isoforms, three steps at once

scientific article published on September 2015

Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers

scientific article published in March 2010

Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide

scientific article published on 4 April 2014

Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14.

scientific article

Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kγ-Akt-AS160 in skeletal muscle cells

scientific article published on 28 December 2012

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4 ⬇️

scientific article published on March 25, 2011

Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

scientific article

Exercise- and insulin-stimulated muscle glucose transport: distinct mechanisms of regulation.

scientific article

Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells

scientific article published on 16 August 2007

GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity

scientific article

GLUT4 Translocation in Single Muscle Cells in Culture: Epitope Detection by Immunofluorescence

scientific article published in January 2018

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells

scientific article published on 23 July 2008

GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice

scientific article published on 13 October 2021

Glucose transporter 4: cycling, compartments and controversies

scientific article

Health care crisis in Gaza

scientific article published in June 2009

Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis.

scientific article published on 24 February 2018

Insulin action on glucose transporters through molecular switches, tracks and tethers

scientific article published on July 2008

Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP.

scientific article published on 06 October 2004

Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts

scientific article

Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides

scientific article published on 13 June 2005

Insulin uptake and action in microvascular endothelial cells of lymphatic and blood origin

scientific article published on 6 March 2018

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)

scientific article

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

scientific article published on 17 October 2017

Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

scientific article published on 04 May 2020

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake

scientific article published on 27 May 2004

Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells

scientific article

Intracellular traffic and activation of the muscle glucose transporter.

scientific article published in January 2004

Kei on GSK: a contribution by the 2007 recipient of the Young Scientist Award

scientific article published on 27 November 2007

Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet-Induced Hyperglycemia.

scientific article

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis

scientific article published on 11 March 2003

Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners

scientific article

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.

scientific article published on 17 January 2006

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

scientific article published on 19 October 2012

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

scientific journal article

Muscle insulin resistance: assault by lipids, cytokines and local macrophages

scientific article published on July 2010

Muscle-specific Pten deletion protects against insulin resistance and diabetes

scientific article

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

scientific journal article

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

scientific journal article

NOD1 Activators Link Innate Immunity to Insulin Resistance ⬇️

scientific article published on June 29, 2011

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance ⬇️

scientific article published on October 6, 2010

NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells

scientific article

Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice

scientific article published in September 2002

Nucleotides released from palmitate-activated murine macrophages attract neutrophils

scientific article published on 04 March 2020

Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance

scientific journal article

PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells.

scientific article

Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells

scientific article published on 7 October 2008

Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε

scientific article (publication date: 2011)

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

scientific article published on 24 October 2019

Putting Rac1 on the path to glucose uptake

scientific article published on June 2013

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells ⬇️

scientific article published on November 16, 2010

Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells

scientific article published on 27 December 2006

Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance

scientific article published on 2 May 2013

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

scientific article

Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

scientific article

Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis

scientific article

Reciprocal regulation of endocytosis and metabolism

scientific article

Rho GTPases-Emerging Regulators of Glucose Homeostasis and Metabolic Health.

scientific article published on 9 May 2019

Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release

scientific article published on 13 September 2016

Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cells

scientific article

Shuttling glucose across brain microvessels, with a little help from GLUT1 and AMP kinase. Focus on “AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress” ⬇️

scientific article published on July 18, 2012

Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation

scientific article published on 05 March 2014

Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells

scientific article

Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling

scientific article published on 13 November 2003

Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose

scientific article published on 28 July 2017

Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity

scientific article published on July 2002

TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells

scientific article

The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle

scientific article (publication date: September 2003)

The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2

scientific journal article

The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic

scientific article published in February 2007

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

scientific article

The cell biology of systemic insulin function.

scientific article published on 5 April 2018

The many ways to regulate glucose transporter 4.

scientific article

The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation

scientific article

The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6.

scientific article published on 27 December 2007

Thirty sweet years of GLUT4

scientific article published on 07 June 2019

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

scientific article

Triiodothyronine acutely stimulates glucose transport into L6 muscle cells without increasing surface GLUT4, GLUT1, or GLUT3.

scientific article published on 4 June 2012

Turning signals on and off: GLUT4 traffic in the insulin-signaling highway

scientific article

Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention ⬇️

scientific article published on May 26, 2010

Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action

scientific article

List of works by Amira Klip

A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation

A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle

Activation of the glucose transporter GLUT4 by insulin

Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors

Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation

Arp2/3- and Cofilin-coordinated Actin Dynamics Is Required for Insulin-mediated GLUT4 Translocation to the Surface of Muscle Cells ⬇️

Bone marrow adipose cells - cellular interactions and changes with obesity

Cellular location of insulin-triggered signals and implications for glucose uptake

Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling

Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant

Contracting C2C12 myotubes release CCL2 in an NF-κB-dependent manner to induce monocyte chemoattraction

Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Deconstructing metabolic inflammation using cellular systems

Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation

Desperately seeking sugar: glial cells as hypoglycemia sensors

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells

Dissecting GLUT4 traffic components in L6 myocytes by fluorescence-based, single-cell assays

Dissecting signalling by individual Akt/PKB isoforms, three steps at once

Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers

Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide

Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14.

Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kγ-Akt-AS160 in skeletal muscle cells

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4 ⬇️

Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

Exercise- and insulin-stimulated muscle glucose transport: distinct mechanisms of regulation.

Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells

GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity

GLUT4 Translocation in Single Muscle Cells in Culture: Epitope Detection by Immunofluorescence

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells

GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice

Glucose transporter 4: cycling, compartments and controversies

Health care crisis in Gaza

Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis.

Insulin action on glucose transporters through molecular switches, tracks and tethers

Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP.

Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts

Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides

Insulin uptake and action in microvascular endothelial cells of lymphatic and blood origin

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake

Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells

Intracellular traffic and activation of the muscle glucose transporter.

Kei on GSK: a contribution by the 2007 recipient of the Young Scientist Award

Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet-Induced Hyperglycemia.

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis

Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

Muscle insulin resistance: assault by lipids, cytokines and local macrophages

Muscle-specific Pten deletion protects against insulin resistance and diabetes

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

NOD1 Activators Link Innate Immunity to Insulin Resistance ⬇️

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance ⬇️

NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells

Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice

Nucleotides released from palmitate-activated murine macrophages attract neutrophils

Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance

PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells.

Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells

Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

Putting Rac1 on the path to glucose uptake

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells ⬇️

Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells

Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis

Reciprocal regulation of endocytosis and metabolism