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List of works by Leif Hertz

5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'.

scientific article published on May 2010

Additional mechanisms for brain activation failure due to reduced glucose metabolism-a commentary on Zilberter and Zilberter: The vicious circle of hypometabolism in neurodegenerative diseases

scientific article published on 2 November 2017

Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i

scientific article published on 7 April 2010

Alpha-adrenergic stimulation of ERK phosphorylation in astrocytes is alpha(2)-specific and may be mediated by transactivation

scientific article published in July 2003

Ammonia effects on pyruvate/lactate production in astrocytes--interaction with glutamate

scientific article published in July 2005

Ammonia, like K(+), stimulates the Na(+), K(+), 2 Cl(-) cotransporter NKCC1 and the Na(+),K(+)-ATPase and interacts with endogenous ouabain in astrocytes

scientific article

Ammonia-induced Na,K-ATPase/ouabain-mediated EGF receptor transactivation, MAPK/ERK and PI3K/AKT signaling and ROS formation cause astrocyte swelling

scientific article published on 14 September 2013

Amobarbital inhibits K(+)-stimulated glucose oxidation in cerebellar granule neurons by two mechanisms

scientific article published in June 2002

Antagonists of the Vasopressin V1 Receptor and of the β(1)-Adrenoceptor Inhibit Cytotoxic Brain Edema in Stroke by Effects on Astrocytes - but the Mechanisms Differ

scientific article

Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes ⬇️

scientific article published on September 24, 2012

Astrocyte Cultures Mimicking Brain Astrocytes in Gene Expression, Signaling, Metabolism and K+ Uptake and Showing Astrocytic Gene Expression Overlooked by Immunohistochemistry and In Situ Hybridization

scientific article published on 28 January 2016

Astrocyte ERK phosphorylation precedes K+-induced swelling but follows hypotonicity-induced swelling ⬇️

scientific article published on December 1, 2010

Astrocytic alkalinization by therapeutically relevant lithium concentrations: implications for myo-inositol depletion

scientific article published on 28 May 2008

Astrocytic amino acid metabolism under control conditions and during oxygen and/or glucose deprivation

scientific article published in February 2003

Astrocytic and neuronal accumulation of elevated extracellular K(+) with a 2/3 K(+)/Na(+) flux ratio-consequences for energy metabolism, osmolarity and higher brain function

scientific article

Astrocytic contributions to bioenergetics of cerebral ischemia

scientific article

Astrocytic control of glutamatergic activity: astrocytes as stars of the show

scientific article

Astrocytic energy metabolism and glutamate formation — relevance for 13C-NMR spectroscopy and importance of cytosolic/mitochondrial trafficking ⬇️

scientific article published on August 5, 2011

Astrocytic glycogenolysis: mechanisms and functions

scientific article published on 18 April 2014

Astrocytic involvement in learning and memory consolidation

scientific article published on 27 March 2008

Astrocytic-Neuronal-Astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA

scientific article published on 03 April 2014

Basic mechanism leading to stimulation of glycogenolysis by isoproterenol, EGF, elevated extracellular K+ concentrations, or GABA.

scientific article published on 6 February 2014

Bioenergetics of cerebral ischemia: a cellular perspective

scientific article published on 03 June 2008

Book review: “Glial physiology and pathophysiology” by Alexei Verkhratsky and Arthur Butt, Wiley-Blackwell, 2013.

scientific article published on 11 February 2014

Brain Glutamine Synthesis Requires Neuronal Aspartate: A Commentary ⬇️

scientific article published on November 10, 2010

Brain glycogenolysis, adrenoceptors, pyruvate carboxylase, Na+,K+-ATPase and Marie E. Gibbs' pioneering learning studies ⬇️

scientific article published on April 3, 2013

Cataplerotic TCA cycle flux determined as glutamate-sustained oxygen consumption in primary cultures of astrocytes ⬇️

scientific article published on September 1, 2003

Cell-Specific mRNA Alterations in Na+, K+-ATPase α and β Isoforms and FXYD in Mice Treated Chronically with Carbamazepine, an Anti-Bipolar Drug ⬇️

scientific article published on February 10, 2013

Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

scientific article

Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation

scientific article published on 7 August 2009

Comparison between drug-induced and K⁺-induced changes in molar acid extrusion fluxes (JH⁺) and in energy consumption rates in astrocytes

scientific article

Complexity of depolarization-mediated ERK phosphorylation in cerebellar granule cells in primary cultures

scientific article

Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH

scientific article published on April 27, 2012

Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons

scientific article

Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function? ⬇️

scientific article published on 02 April 2011

Down-regulation of GluK2 kainate receptor expression by chronic treatment with mood-stabilizing anti-convulsants or lithium in cultured astrocytes and brain, but not in neurons.

scientific article published on 9 July 2009

ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.

scientific article

Editorial: All 3 Types of Glial Cells Are Important for Memory Formation

scientific article published on 27 September 2016

Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

scientific article published on 23 April 2015

Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis

scientific article

Energy metabolism in brain cells: effects of elevated ammonia concentrations

scientific article published on December 2007

Energy metabolism in the brain

scientific article

Fluoxetine affects GluK2 editing, glutamate-evoked Ca(2+) influx and extracellular signal-regulated kinase phosphorylation in mouse astrocytes

scientific article

Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects

scientific article

Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation

scientific article published on 29 August 2008

Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline

scientific article

Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine-Glutamate/GABA Cycle

scientific article published in January 2016

Glutamate, a neurotransmitter--and so much more. A synopsis of Wierzba III.

scientific article

Glutamine as an energy substrate in cultured neurons during glucose deprivation

scientific article published in November 2007

Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase

scientific article

Glycogen is a preferred glutamate precursor during learning in 1-day-old chick: biochemical and behavioral evidence

scientific article

Glycogenolysis and purinergic signaling

scientific article published in January 2014

Glycogenolysis, an astrocyte-specific reaction, is essential for both astrocytic and neuronal activities involved in learning

scientific article published on 28 June 2017

Importance of astrocytes for potassium ion (K(+)) homeostasis in brain and glial effects of K(+) and its transporters on learning

scientific article

Importance of glutamate-generating metabolic pathways for memory consolidation in chicks

scientific article published in July 2005

Inhibition of astrocytic energy metabolism by D-lactate exposure impairs memory

scientific article published on 26 October 2007

Inhibition of brain swelling after ischemia-reperfusion by β-adrenergic antagonists: correlation with increased K+ and decreased Ca2+ concentrations in extracellular fluid.

scientific article

Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens

scientific article published in August 2006

Integration between Glycolysis and Glutamate-Glutamine Cycle Flux May Explain Preferential Glycolytic Increase during Brain Activation, Requiring Glutamate

scientific article

Intercellular metabolic compartmentation in the brain: past, present and future

scientific article

Lactate transport and transporters: general principles and functional roles in brain cells

scientific article

Mechanisms for L-channel-mediated increase in [Ca(2+)]i and its reduction by anti-bipolar drugs in cultured astrocytes combined with its mRNA expression in freshly isolated cells support the importance of astrocytic L-channels

scientific article published on 19 August 2013

Metabolic Studies in Brain Slices – Past, Present, and Future ⬇️

scientific article published on March 9, 2012

Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity

scientific article

Nucleoside transporter expression and function in cultured mouse astrocytes

scientific article published in October 2005

Ouabain binding kinetics and FXYD7 expression in astrocytes and neurons in primary cultures: implications for cellular contributions to extracellular K+ homeostasis?

scientific article

Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(-).

scientific article published on 20 October 2009

Reciprocal changes in forebrain contents of glycogen and of glutamate/glutamine during early memory consolidation in the day-old chick

scientific article

Regulatory volume increase in astrocytes exposed to hypertonic medium requires β1 -adrenergic Na(+) /K(+) -ATPase stimulation and glycogenolysis

scientific article published on 14 August 2014

Requirement of Glycogenolysis for Uptake of Increased Extracellular K+ in Astrocytes: Potential Implications for K+ Homeostasis and Glycogen Usage in Brain ⬇️

scientific article published on December 12, 2012

Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease.

scientific article published in May 2009

Response: Commentary: Chronic SSRI Stimulation of Astrocytic 5-HT2B Receptors Change Multiple Gene Expressions/Editings and Metabolism of Glutamate, Glucose and Glycogen: A Potential Paradigm Shift

scientific article published on 13 November 2015

Role of glycogenolysis in stimulation of ATP release from cultured mouse astrocytes by transmitters and high K+ concentrations

scientific article published on 13 January 2014

Role of the Astrocytic Na(+), K(+)-ATPase in K(+) Homeostasis in Brain: K(+) Uptake, Signaling Pathways and Substrate Utilization

scientific article published on 03 January 2015

Role of the intracellular nucleoside transporter ENT3 in transmitter and high K+ stimulation of astrocytic ATP release investigated using siRNA against ENT3.

scientific article

Roles of astrocytic Na(+),K(+)-ATPase and glycogenolysis for K(+) homeostasis in mammalian brain

scientific article

Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation

scientific article published on January 2015

Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors

scientific journal article

Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick

scientific article published on April 2014

Severe Convulsions and Dysmyelination in Both Jimpy and Cx32/47 -/- Mice may Associate Astrocytic L-Channel Function with Myelination and Oligodendrocytic Connexins with Internodal Kv Channels

scientific article

Signal Transduction in Astrocytes during Chronic or Acute Treatment with Drugs (SSRIs, Antibipolar Drugs, GABA-ergic Drugs, and Benzodiazepines) Ameliorating Mood Disorders

scientific article

Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent

scientific article published on 5 October 2010

Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent

scientific article published on 3 April 2008

The Glutamate–Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation ⬇️

scientific article published on May 27, 2013

The astrocyte-neuron lactate shuttle: a challenge of a challenge

scientific article published in November 2004

The astrocytic GABA(A)/benzodiazepine-like receptor: the Joker receptor for benzodiazepine-mimetic drugs?

scientific article published on January 2006

Up-regulation of 5-HT2B receptor density and receptor-mediated glycogenolysis in mouse astrocytes by long-term fluoxetine administration

scientific article

Up-regulation of cPLA(2) gene expression in astrocytes by all three conventional anti-bipolar drugs is drug-specific and enzyme-specific

scientific article published on 27 June 2007

What learning in day-old chickens can teach a neurochemist: focus on astrocyte metabolism

scientific article published on May 2009

When can AQP4 assist transporter-mediated K+ uptake? ⬇️

scientific article published on June 10, 2013

Why are astrocytes important?

scientific article

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